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GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu13581 NM_001166425 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu14225 NM_001282619 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 5, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu14246 NM_001282617 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu14271 NM_001282618 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu14309 NM_001282620 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 6, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu20814 NM_002070 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu13581C NM_001166425 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 2, mRNA. Customized vector On-demand 7-9 $209.00
OHu14225C NM_001282619 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 5, mRNA. Customized vector On-demand 7-9 $269.00
OHu14246C NM_001282617 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 3, mRNA. Customized vector On-demand 7-9 $209.00
OHu14271C NM_001282618 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 4, mRNA. Customized vector On-demand 7-9 $209.00
OHu14309C NM_001282620 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 6, mRNA. Customized vector On-demand 7-9 $269.00
OHu20814C NM_002070 Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol GNAI2
Entrez Gene ID 2771
Full Name guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Synonyms GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1
General protein information
Preferred Names
guanine nucleotide-binding protein G(i) subunit alpha-2
Names
guanine nucleotide-binding protein G(i) subunit alpha-2
adenylate cyclase-inhibiting G alpha protein
GTP-binding regulatory protein Gi alpha-2 chain
guanine nucleotide-binding protein G(i), alpha-2 subunit
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p21.31

Summary The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013].
Disorder

MIM: 139360

Pituitary ACTH-secreting adenoma (3); Ventricular tachycardia,

mRNA Protein Product Sequence Price Select
NM_001166425, 261878574 NP_001159897, 261878575 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 2 ORF Sequence $400.00
NM_001282617, 543583772 NP_001269546, 543583773 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 3 ORF Sequence $300.00
NM_001282618, 543583774 NP_001269547, 543583775 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 4 ORF Sequence $300.00
NM_001282619, 543583776 NP_001269548, 543583777 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 5 ORF Sequence $400.00
NM_001282620, 543583778 NP_001269549, 543583779 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 6 ORF Sequence $400.00
NM_002070, 543583771 NP_002061, 4504041 guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 1 ORF Sequence $269.00
KEGG
hsa04360Axon guidance
hsa04530Tight junction
hsa04730Long-term depression
hsa04670Leukocyte transendothelial migration
hsa04916Melanogenesis
hsa05012Parkinson's disease
hsa04540Gap junction
hsa04062Chemokine signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa05142Chagas disease (American trypanosomiasis)
hsa05145Toxoplasmosis
hsa04971Gastric acid secretion
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa05133Pertussis
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04726Serotonergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa04713Circadian entrainment
hsa05030Cocaine addiction
hsa04915Estrogen signaling pathway
hsa05034Alcoholism
hsa05032Morphine addiction
hsa04261Adrenergic signaling in cardiomyocytes
hsa04921Oxytocin signaling pathway
hsa04611Platelet activation
hsa04015Rap1 signaling pathway
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP35G Protein Signaling Pathways
WP26Signal Transduction of S1P Receptor
WP536Calcium Regulation in the Cardiac Cell
WP2032TSH signaling pathway
WP2355Corticotropin-releasing hormone
Pathway Interaction Database
lysophospholipid_pathwayLPA receptor mediated events
s1p_meta_pathwaySphingosine 1-phosphate (S1P) pathway
s1p_s1p1_pathwayS1P1 pathway
s1p_s1p5_pathwayS1P5 pathway
cxcr3pathwayCXCR3-mediated signaling events
txa2pathwayThromboxane A2 receptor signaling
s1p_s1p3_pathwayS1P3 pathway
s1p_s1p2_pathwayS1P2 pathway
s1p_s1p4_pathwayS1P4 pathway
Reactome
REACT_19184GPCR downstream signaling
REACT_19327G alpha (s) signalling events
REACT_19231G alpha (i) signalling events
REACT_19333G alpha (z) signalling events
REACT_18339Adrenaline,noradrenaline inhibits insulin secretion
REACT_18325Regulation of insulin secretion
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_1505Integration of energy metabolism
REACT_14797Signaling by GPCR
REACT_15295Opioid Signalling
REACT_15526G-protein mediated events
REACT_15426PLC beta mediated events
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_15457G-protein activation
REACT_13477Transmission across Chemical Synapses
REACT_15333Adenylate cyclase inhibitory pathway
REACT_13685Neuronal System
REACT_20524Signal amplification
REACT_20653ADP signalling through P2Y purinoceptor 12
REACT_25031GABA B receptor activation
REACT_25330Activation of GABAB receptors
REACT_25199GABA receptor activation
REACT_25282Inhibition of adenylate cyclase pathway
REACT_111217Metabolism
REACT_111102Signal Transduction
Homo sapiens (human)GNAI2NP_002061.1
Pan troglodytes (chimpanzee)GNAI2XP_001167942.1
Macaca mulatta (Rhesus monkey)GNAI2XP_001103122.1
Canis lupus familiaris (dog)GNAI2NP_001003364.1
Bos taurus (cattle)GNAI2NP_001094510.1
Mus musculus (house mouse)Gnai2NP_032164.2
Rattus norvegicus (Norway rat)Gnai2NP_112297.1
Gallus gallus (chicken)GNAI2NP_990733.1
Danio rerio (zebrafish)gnai2bNP_956136.1
Xenopus (Silurana) tropicalis (western clawed frog)gnai2NP_989250.1
Process
IDNameEvidence
GO:0000186activation of MAPKK activityIEA
GO:0001973adenosine receptor signaling pathwayIBA
GO:0006184GTP catabolic processIEA
GO:0007049cell cycleIEA
GO:0007165signal transductionTAS
GO:0007186G-protein coupled receptor signaling pathwayTAS
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayIBA
GO:0007193adenylate cyclase-inhibiting G-protein coupled receptor signaling pathwayTAS
GO:0007194negative regulation of adenylate cyclase activityTAS
GO:0007213G-protein coupled acetylcholine receptor signaling pathwayIEA
GO:0007214gamma-aminobutyric acid signaling pathwayIBA
GO:0007268synaptic transmissionTAS
GO:0007584response to nutrientTAS
GO:0007596blood coagulationTAS
GO:0008283cell proliferationIEA
GO:0008284positive regulation of cell proliferationIEA
GO:0030168platelet activationTAS
GO:0050805negative regulation of synaptic transmissionIEA
GO:0051301cell divisionIMP
GO:0051924regulation of calcium ion transportIEA
Component
IDNameEvidence
GO:0005634nucleusIDA
GO:0005730nucleolusIDA
GO:0005737cytoplasmIDA
GO:0005813centrosomeIDA
GO:0005829cytosolIEA
GO:0005834heterotrimeric G-protein complexIBA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0016020membraneIDA
GO:0030496midbodyIDA
GO:0045121membrane raftIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0001664G-protein coupled receptor bindingIBA
GO:0003924GTPase activityIBA
GO:0004871signal transducer activityIBA
GO:0005515protein bindingIPI
GO:0005525GTP bindingIEA
GO:0031683G-protein beta/gamma-subunit complex bindingIBA
GO:0046872metal ion bindingIEA
GeneCards GNAI2
UniProt F5GZL8, B3KX51, P04899, B3KP24
Vega OTTHUMG00000156940
MIM 139360
Ensembl ENSG00000114353
HGNC 4385
HPRD 00764

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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