GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 [Homo sapiens (human)]

Gene Symbol	GNAI2
Entrez Gene ID	2771
Full Name	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2
Synonyms	GIP, GNAI2B, H_LUCA15.1, H_LUCA16.1
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:3 Map Location:3p21
Summary	The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been detected for this gene, but the full-length nature of only two are known so far. [provided by RefSeq].
Disorder	MIM: 139360 Pituitary ACTH-secreting adenoma (3); Ventricular tachycardia,

mRNA	NM_002070, 49574535
Protein	NP_002061, 4504041
Product	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 1
RefSeq Status	REVIEWED
mRNA	NM_001166425, 261878574
Protein	NP_001159897, 261878575
Product	guanine nucleotide-binding protein G(i) subunit alpha-2 isoform 2
RefSeq Status	REVIEWED

KEGG

hsa04062	Chemokine signaling pathway
hsa04730	Long-term depression
hsa04670	Leukocyte transendothelial migration
hsa04971	Gastric acid secretion
hsa04916	Melanogenesis
hsa05145	Toxoplasmosis
hsa04360	Axon guidance
hsa04914	Progesterone-mediated oocyte maturation
hsa05142	Chagas disease (American trypanosomiasis)
hsa04540	Gap junction
hsa04530	Tight junction

WikiPathways

WP26	Signal Transduction of S1P Receptor
WP536	Calcium Regulation in the Cardiac Cell
WP35	G Protein Signaling Pathways

Pathway Interaction Database

s1p_s1p2_pathway	S1P2 pathway
lysophospholipid_pathway	LPA receptor mediated events
s1p_s1p3_pathway	S1P3 pathway
cxcr3pathway	CXCR3-mediated signaling events
s1p_s1p5_pathway	S1P5 pathway
s1p_s1p1_pathway	S1P1 pathway
s1p_meta_pathway	Sphingosine 1-phosphate (S1P) pathway
txa2pathway	Thromboxane A2 receptor signaling
s1p_s1p4_pathway	S1P4 pathway

Reactome

REACT_20653	ADP signalling through P2Y purinoceptor 12
REACT_18339	Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
REACT_15333	Adenylate cyclase inhibitory pathway
REACT_25282	Inhibition of adenylate cyclase pathway
REACT_1505	Integration of energy metabolism
REACT_25199	GABA receptor activation
REACT_19231	G alpha (i) signalling events
REACT_19333	G alpha (z) signalling events
REACT_13477	Transmission across Chemical Synapses
REACT_25031	GABA B receptor activation
REACT_19184	GPCR downstream signaling
REACT_798	Platelet Activation
REACT_13685	Synaptic Transmission
REACT_15380	Diabetes pathways
REACT_19327	G alpha (s) signalling events
REACT_18325	Regulation of Insulin Secretion
REACT_15526	G-protein mediated events
REACT_20	Formation of Platelet plug
REACT_15457	G-protein activation
REACT_25330	Activation of GABAB receptors
REACT_14797	Signaling by GPCR
REACT_15426	PLC beta mediated events
REACT_15370	Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_20524	Signal amplification
REACT_604	Hemostasis
REACT_15295	Opioid Signalling
REACT_622	Platelet activation triggers

Homo sapiens (human)	GNAI2	NP_002061.1
Pan troglodytes (chimpanzee)	GNAI2	XP_001167942.1
Canis lupus familiaris (dog)	GNAI2	NP_001003364.1
Bos taurus (cattle)	GNAI2	XP_589440.3
Mus musculus (house mouse)	Gnai2	NP_032164.2
Rattus norvegicus (Norway rat)	Gnai2	NP_112297.1
Gallus gallus (chicken)	GNAI2	NP_990733.1
Danio rerio (zebrafish)	gnai2	NP_956136.1

Process

ID	Name	Evidence
GO:0000186	activation of MAPKK activity	IEA
GO:0001973	adenosine receptor signaling pathway	ISS
GO:0006184	GTP catabolic process	ISS
GO:0006184	GTP catabolic process	TAS
GO:0007165	signal transduction	TAS
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS
GO:0007193	inhibition of adenylate cyclase activity by G-protein signaling pathway	EXP
GO:0007194	negative regulation of adenylate cyclase activity	TAS
GO:0007213	muscarinic acetylcholine receptor signaling pathway	IEA
GO:0007214	gamma-aminobutyric acid signaling pathway	ISS
GO:0007243	intracellular protein kinase cascade	IEA
GO:0007268	synaptic transmission	TAS
GO:0007584	response to nutrient	TAS
GO:0007596	blood coagulation	TAS
GO:0008284	positive regulation of cell proliferation	IEA
GO:0030168	platelet activation	TAS
GO:0050805	negative regulation of synaptic transmission	IEA
GO:0051301	cell division	IMP
GO:0051927	negative regulation of calcium ion transport via voltage-gated calcium channel activity	ISS

Component

ID	Name	Evidence
GO:0005624	membrane fraction	IEA
GO:0005634	nucleus	IEA
GO:0005737	cytoplasm	IDA
GO:0005813	centrosome	IDA
GO:0005829	cytosol	IEA
GO:0005834	heterotrimeric G-protein complex	ISS
GO:0005886	plasma membrane	EXP
GO:0005886	plasma membrane	IDA
GO:0005886	plasma membrane	TAS
GO:0030496	midbody	IDA
GO:0031234	extrinsic to internal side of plasma membrane	ISS
GO:0045121	membrane raft	IEA

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	IEA
GO:0001664	G-protein-coupled receptor binding	ISS
GO:0003924	GTPase activity	ISS
GO:0003924	GTPase activity	TAS
GO:0004871	signal transducer activity	ISS
GO:0005515	protein binding	IPI
GO:0005525	GTP binding	EXP
GO:0019001	guanyl nucleotide binding	IEA
GO:0031683	G-protein beta/gamma-subunit complex binding	ISS

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RefSeq Accession	Definition	Sequence	Price	Select
NM_002070	Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 1, mRNA.	Full Length	$638.00
NM_002070		ORF Sequence	$309.72
NM_001166425	Homo sapiens guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 (GNAI2), transcript variant 2, mRNA.	Full Length	$621.47
NM_001166425		ORF Sequence	$277.53