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GNAT2 guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005272 Homo sapiens guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2 (GNAT2), mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol GNAT2
Entrez Gene ID 2780
Full Name guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 2
Synonyms ACHM4, GNATC
General protein information
Preferred Names
guanine nucleotide-binding protein G(t) subunit alpha-2
guanine nucleotide-binding protein G(t) subunit alpha-2
transducin alpha-2 chain
cone-type transducin alpha subunit
transducin, cone-specific, alpha polypeptide
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Transducin is a 3-subunit guanine nucleotide-binding protein (G protein) which stimulates the coupling of rhodopsin and cGMP-phoshodiesterase during visual impulses. The transducin alpha subunits in rods and cones are encoded by separate genes. This gene encodes the alpha subunit in cones. [provided by RefSeq, Jul 2008].

MIM: 139340

Achromatopsia-4 (3)

mRNA Protein Product Sequence Price Select
NM_005272, 109148540 NP_005263, 20330805 guanine nucleotide-binding protein G(t) subunit alpha-2 ORF Sequence $400.00
Pathway Interaction Database
cone_pathwayVisual signal transduction: Cones
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_14797Signaling by GPCR
REACT_15295Opioid Signalling
REACT_15526G-protein mediated events
REACT_15426PLC beta mediated events
REACT_11045Signaling by Wnt
REACT_15457G-protein activation
REACT_111102Signal Transduction
REACT_172761Ca2+ pathway
REACT_172694beta-catenin independent WNT signaling
Homo sapiens (human)GNAT2NP_005263.1
Pan troglodytes (chimpanzee)GNAT2XP_524787.2
Macaca mulatta (Rhesus monkey)GNAT2XP_001091580.1
Canis lupus familiaris (dog)GNAT2XP_547240.2
Bos taurus (cattle)GNAT2NP_776751.1
Mus musculus (house mouse)Gnat2NP_032167.1
Rattus norvegicus (Norway rat)Gnat2NP_001102420.2
Gallus gallus (chicken)GNAT2NP_990021.1
Danio rerio (zebrafish)gnat2NP_571944.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100216126NP_001135577.1
GO:0001580detection of chemical stimulus involved in sensory perception of bitter tasteIBA
GO:0006184GTP catabolic processIEA
GO:0007186G-protein coupled receptor signaling pathwayNAS
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathwayIBA
GO:0007204positive regulation of cytosolic calcium ion concentrationIEA
GO:0007601visual perceptionNAS
GO:0009642response to light intensityIEA
GO:0046549retinal cone cell developmentIEA
GO:0050908detection of light stimulus involved in visual perceptionIMP
GO:0001750photoreceptor outer segmentIDA
GO:0001750photoreceptor outer segmentISS
GO:0001917photoreceptor inner segmentIDA
GO:0005834heterotrimeric G-protein complexNAS
GO:0005886plasma membraneTAS
GO:0042622photoreceptor outer segment membraneISS
GO:0001664G-protein coupled receptor bindingIBA
GO:0003924GTPase activityIBA
GO:0005525GTP bindingNAS
GO:0008020G-protein coupled photoreceptor activityNAS
GO:0031683G-protein beta/gamma-subunit complex bindingIBA
GO:0046872metal ion bindingIEA
GeneCards GNAT2
UniProt Q5T697, P19087
Vega OTTHUMG00000011639
MIM 139340
Ensembl ENSG00000134183
HGNC 4394
HPRD 00762

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the GNAT2 gene?

The GNAT2 gene provides instructions for making one part (the alpha subunit) of a protein called transducin. This protein, which is necessary for normal vision, is present in light receptor cells called cones. As part of the light-sensitive tissue at the back of the eye (the retina), cones provide vision in bright light, including color vision. Other light receptor cells in the retina, called rods, are responsible for vision in low light.

Transducin plays an essential role in transmitting visual signals from cones in the retina to the brain. Three types of cones each contain a special pigment (a photopigment) that is most sensitive to a particular wavelength of light. When any of the three photopigments absorbs light, it activates the transducin protein. Transducin then triggers a series of chemical reactions within a cone cell. These reactions ultimately alter the cell's electrical charge, generating a signal that the brain interprets as vision.


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