• THAT   AND

Sequence in raw or FASTA format:


Blast Method:


GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu28823 NM_002075 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), transcript variant 1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu28836 NM_001297571 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), transcript variant 2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu28823C NM_002075 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), transcript variant 1, mRNA. Customized vector On-demand 7-9 $269.00
OHu28836C NM_001297571 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), transcript variant 2, mRNA. Customized vector On-demand 7-9 $269.00

*Business Day

Mutation services

Gene Symbol GNB3
Entrez Gene ID 2784
Full Name guanine nucleotide binding protein (G protein), beta polypeptide 3
General protein information
Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
transducin beta chain 3
G protein, beta-3 subunit
hypertension associated protein
GTP-binding regulatory protein beta-3 chain
guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit which belongs to the WD repeat G protein beta family. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Alternative splicing results in multiple transcript variants. Additional alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2014].

MIM: 139130

{Hypertension, essential, susceptibility to}, 145500 (3)

mRNA Protein Product Sequence Price Select
NM_001297571, 662033914 NP_001284500, 662033915 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 2 ORF Sequence $400.00
NM_002075, 662033911 NP_002066, 4504053 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1 ORF Sequence $400.00
hsa04742Taste transduction
hsa04062Chemokine signaling pathway
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04151PI3K-Akt signaling pathway
hsa04726Serotonergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa04713Circadian entrainment
hsa05032Morphine addiction
hsa04014Ras signaling pathway
WP289Myometrial Relaxation and Contraction Pathways
WP35G Protein Signaling Pathways
WP706SIDS Susceptibility Pathways
WP536Calcium Regulation in the Cardiac Cell
WP2355Corticotropin-releasing hormone
Pathway Interaction Database
cone_pathwayVisual signal transduction: Cones
REACT_19184GPCR downstream signaling
REACT_19145G beta:gamma signalling through PLC beta
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19388G-protein beta:gamma signalling
REACT_19327G alpha (s) signalling events
REACT_19231G alpha (i) signalling events
REACT_19333G alpha (z) signalling events
REACT_18339Adrenaline,noradrenaline inhibits insulin secretion
REACT_18274Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REACT_18325Regulation of insulin secretion
REACT_18407G alpha (12/13) signalling events
REACT_18283G alpha (q) signalling events
REACT_798Platelet activation, signaling and aggregation
REACT_1505Integration of energy metabolism
REACT_1665Glucagon signaling in metabolic regulation
REACT_17015Metabolism of proteins
REACT_14797Signaling by GPCR
REACT_18372Class B/2 (Secretin family receptors)
REACT_18377Glucagon-type ligand receptors
REACT_15295Opioid Signalling
REACT_11045Signaling by Wnt
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_15457G-protein activation
REACT_15518Transmembrane transport of small molecules
REACT_13477Transmission across Chemical Synapses
REACT_13685Neuronal System
REACT_21340GPCR ligand binding
REACT_21312Activation of Kainate Receptors upon glutamate binding
REACT_20524Signal amplification
REACT_19140ADP signalling through P2Y purinoceptor 1
REACT_20647Thromboxane signalling through TP receptor
REACT_20653ADP signalling through P2Y purinoceptor 12
REACT_21384Thrombin signalling through proteinase activated receptors (PARs)
REACT_21254Presynaptic function of Kainate receptors
REACT_75908Potassium Channels
REACT_75780G protein gated Potassium channels
REACT_75831Activation of G protein gated Potassium channels
REACT_75918Inwardly rectifying K+ channels
REACT_24019Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
REACT_23946Prostacyclin signalling through prostacyclin receptor
REACT_25199GABA receptor activation
REACT_25031GABA B receptor activation
REACT_23876Platelet homeostasis
REACT_24023Regulation of water balance by renal Aquaporins
REACT_25330Activation of GABAB receptors
REACT_25004Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
REACT_23974Incretin synthesis, secretion, and inactivation
REACT_23887Aquaporin-mediated transport
REACT_111102Signal Transduction
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_160078Peptide hormone metabolism
REACT_172761Ca2+ pathway
REACT_172694beta-catenin independent WNT signaling
Homo sapiens (human)GNB3NP_002066.1
Pan troglodytes (chimpanzee)GNB3XP_003313511.1
Macaca mulatta (Rhesus monkey)GNB3XP_001110494.1
Canis lupus familiaris (dog)GNB3NP_001003004.1
Bos taurus (cattle)GNB3NP_001179276.1
Mus musculus (house mouse)Gnb3NP_038558.1
Rattus norvegicus (Norway rat)Gnb3NP_068630.1
Gallus gallus (chicken)GNB3XP_004938175.1
Danio rerio (zebrafish)gnb3aNP_001002437.1
Xenopus (Silurana) tropicalis (western clawed frog)gnb3NP_001011107.1
GO:0006112energy reserve metabolic processTAS
GO:0006184GTP catabolic processTAS
GO:0007186G-protein coupled receptor signaling pathwayTAS
GO:0007268synaptic transmissionTAS
GO:0008217regulation of blood pressureTAS
GO:0044281small molecule metabolic processTAS
GO:0071377cellular response to glucagon stimulusTAS
GO:0005886plasma membraneTAS
GO:0043005neuron projectionIEA
GO:0044297cell bodyIEA
GO:0003924GTPase activityTAS
GO:0004871signal transducer activityIEA
GO:0005515protein bindingIPI
GO:0051020GTPase bindingIPI
GeneCards GNB3
UniProt F1T0G5, E9PCP0, P16520
Vega OTTHUMG00000168517
MIM 139130
Ensembl ENSG00000111664
HGNC 4400
HPRD 00743

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.