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GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002075 Homo sapiens guanine nucleotide binding protein (G protein), beta polypeptide 3 (GNB3), mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol GNB3
Entrez Gene ID 2784
Full Name guanine nucleotide binding protein (G protein), beta polypeptide 3
Gene Type protein-coding
Organism Homo sapiens (human)



Summary Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described. [provided by RefSeq, Jul 2008].

MIM: 139130

{Hypertension, essential, susceptibility to}, 145500 (3)

mRNA Protein Product Sequence Price Select
NM_002075, 21071080 NP_002066, 4504053 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 ORF Sequence $400.00
hsa04728Dopaminergic synapse
hsa04727GABAergic synapse
hsa04725Cholinergic synapse
hsa04724Glutamatergic synapse
hsa04713Circadian entrainment
hsa05032Morphine addiction
hsa04062Chemokine signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04723Retrograde endocannabinoid signaling
hsa04726Serotonergic synapse
hsa04742Taste transduction
Pathway Interaction Database
cone_pathwayVisual signal transduction: Cones
WP289Myometrial Relaxation and Contraction Pathways
WP706SIDS Susceptibility Pathways
WP35G Protein Signaling Pathways
WP536Calcium Regulation in the Cardiac Cell
REACT_19333G alpha (z) signalling events
REACT_23974Incretin Synthesis, Secretion, and Inactivation
REACT_24023Regulation of Water Balance by Renal Aquaporins
REACT_19388G-protein beta:gamma signalling
REACT_18407G alpha (12/13) signalling events
REACT_25199GABA receptor activation
REACT_75831Activation of G protein gated Potassium channels
REACT_20647Thromboxane signalling through TP receptor
REACT_24019Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_1505Integration of energy metabolism
REACT_13477Transmission across Chemical Synapses
REACT_25031GABA B receptor activation
REACT_23887Aquaporin-mediated transport
REACT_18339Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
REACT_20653ADP signalling through P2Y purinoceptor 12
REACT_75908Potassium Channels
REACT_111102Signal Transduction
REACT_21254Presynaptic function of Kainate receptors
REACT_14797Signaling by GPCR
REACT_19184GPCR downstream signaling
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_15295Opioid Signalling
REACT_19231G alpha (i) signalling events
REACT_20524Signal amplification
REACT_18372Class B/2 (Secretin family receptors)
REACT_19145G beta:gamma signalling through PLC beta
REACT_18377Glucagon-type ligand receptors
REACT_1665Glucagon signaling in metabolic regulation
REACT_15457G-protein activation
REACT_23876Platelet homeostasis
REACT_75918Inwardly rectifying K+ channels
REACT_21312Activation of Kainate Receptors upon glutamate binding
REACT_18274Regulation of Insulin Secretion by Glucagon-like Peptide-1
REACT_798Platelet activation, signaling and aggregation
REACT_21384Thrombin signalling through proteinase activated receptors (PARs)
REACT_23946Prostacyclin signalling through prostacyclin receptor
REACT_21340GPCR ligand binding
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_25330Activation of GABAB receptors
REACT_13685Neuronal System
REACT_75780G protein gated Potassium channels
REACT_18283G alpha (q) signalling events
REACT_15518Transmembrane transport of small molecules
REACT_25004Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
REACT_19140ADP signalling through P2Y purinoceptor 1
REACT_19327G alpha (s) signalling events
REACT_18325Regulation of Insulin Secretion
Homo sapiens (human)GNB3NP_002066.1
Pan troglodytes (chimpanzee)GNB3XP_003313511.1
Macaca mulatta (Rhesus monkey)GNB3XP_001110494.1
Canis lupus familiaris (dog)GNB3NP_001003004.1
Bos taurus (cattle)GNB3NP_001179276.1
Mus musculus (house mouse)Gnb3NP_038558.1
Rattus norvegicus (Norway rat)Gnb3NP_068630.1
Gallus gallus (chicken)GNB3XP_425517.3
Danio rerio (zebrafish)gnb3aNP_001002437.1
GeneCards GNB3
UniProt F1T0G5, P16520
MIM 139130
Ensembl ENSG00000111664
HGNC 4400
HPRD 00743

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3
transducin beta chain 3
G protein, beta-3 subunit
hypertension associated protein
GTP-binding regulatory protein beta-3 chain
guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3


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