GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3 [Homo sapiens (human)]
| Gene Symbol | GNB3 |
| Entrez Gene ID | 2784 |
| Full Name | guanine nucleotide binding protein (G protein), beta polypeptide 3 |
| Synonyms | |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
12 12p13 |
| Summary | Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described. [provided by RefSeq]. |
| Disorder | MIM: 139130 {Hypertension, essential, susceptibility to}, 145500 (3) |
| mRNA | NM_002075, 21071080 |
| Protein | NP_002066, 4504053 |
| Product | guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 |
| RefSeq Status | REVIEWED |
| hsa04062 | Chemokine signaling pathway |
| hsa04742 | Taste transduction |
Pathway Interaction Database
| cone_pathway | Visual signal transduction: Cones |
WikiPathways
| WP289 | Myometrial Relaxation and Contraction Pathways |
| WP706 | SIDS Susceptibility Pathways |
| WP35 | G Protein Signaling Pathways |
| WP536 | Calcium Regulation in the Cardiac Cell |
Reactome
| REACT_18372 | Class B/2 (Secretin family receptors) |
| REACT_24019 | Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1) |
| REACT_19145 | G beta:gamma signalling through PLC beta |
| REACT_13477 | Transmission across Chemical Synapses |
| REACT_19184 | GPCR downstream signaling |
| REACT_18377 | Glucagon-type ligand receptors |
| REACT_15457 | G-protein activation |
| REACT_21254 | Presynaptic function of Kainate receptors |
| REACT_14797 | Signaling by GPCR |
| REACT_15370 | Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
| REACT_20524 | Signal amplification |
| REACT_19231 | G alpha (i) signalling events |
| REACT_15295 | Opioid Signalling |
| REACT_604 | Hemostasis |
| REACT_622 | Platelet activation triggers |
| REACT_23876 | Platelet homeostasis |
| REACT_1665 | Glucagon signaling in metabolic regulation |
| REACT_21312 | Activation of Kainate Receptors upon glutamate binding |
| REACT_18274 | Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| REACT_798 | Platelet Activation |
| REACT_21384 | Thrombin signalling through proteinase activated receptors (PARs) |
| REACT_23946 | Prostacyclin signalling through prostacyclin receptor |
| REACT_20 | Formation of Platelet plug |
| REACT_21340 | GPCR ligand binding |
| REACT_13685 | Synaptic Transmission |
| REACT_19290 | G beta:gamma signalling through PI3Kgamma |
| REACT_25330 | Activation of GABAB receptors |
| REACT_18283 | G alpha (q) signalling events |
| REACT_19140 | ADP signalling through P2Y purinoceptor 1 |
| REACT_25004 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| REACT_15518 | Transmembrane transport of small molecules |
| REACT_19327 | G alpha (s) signalling events |
| REACT_18325 | Regulation of Insulin Secretion |
| REACT_15380 | Diabetes pathways |
| REACT_19388 | G-protein beta:gamma signalling |
| REACT_18339 | Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| REACT_23887 | Aquaporin-mediated transport |
| REACT_20653 | ADP signalling through P2Y purinoceptor 12 |
| REACT_20647 | Thromboxane signalling through TP receptor |
| REACT_1505 | Integration of energy metabolism |
| REACT_23974 | Incretin Synthesis, Secretion, and Inactivation |
| REACT_25199 | GABA receptor activation |
| REACT_18407 | G alpha (12/13) signalling events |
| REACT_24023 | Regulation of Water Balance by Renal Aquaporins |
| REACT_19333 | G alpha (z) signalling events |
| REACT_25031 | GABA B receptor activation |
| Homo sapiens (human) | GNB3 | NP_002066.1 |
| Canis lupus familiaris (dog) | GNB3 | XP_855554.1 |
| Bos taurus (cattle) | GNB3 | XP_591008.3 |
| Mus musculus (house mouse) | Gnb3 | NP_038558.1 |
| Rattus norvegicus (Norway rat) | Gnb3 | NP_068630.1 |
| Gallus gallus (chicken) | GNB3 | XP_425517.2 |
| Danio rerio (zebrafish) | gnb3a | NP_001002437.1 |
| ID | Name | Evidence |
| GO:0006112 | energy reserve metabolic process | TAS |
| GO:0006184 | GTP catabolic process | TAS |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | TAS |
| GO:0007268 | synaptic transmission | TAS |
| GO:0008217 | regulation of blood pressure | TAS |
| GO:0071377 | cellular response to glucagon stimulus | EXP |
Component
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | TAS |
Function
| ID | Name | Evidence |
| GO:0003924 | GTPase activity | TAS |
| GO:0004871 | signal transducer activity | IEA |
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