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GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu04853 NM_021955 Homo sapiens guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 (GNGT1), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu04853C NM_021955 Homo sapiens guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 (GNGT1), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol GNGT1
Entrez Gene ID 2792
Full Name guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1
Synonyms GNG1
General protein information
Preferred Names
guanine nucleotide-binding protein G(T) subunit gamma-T1
Names
guanine nucleotide-binding protein G(T) subunit gamma-T1
transducin gamma chain
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7q21.3

Summary Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. Transducin is a guanine nucleotide-binding protein found specifically in rod outer segments, where it mediates activation by rhodopsin of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase. Transducin is also referred to as GMPase. GNGT1 encodes the gamma subunit of transducin (Hurley et al., 1984 [PubMed 6438626]; Scherer et al., 1996 [PubMed 8661128]).[supplied by OMIM, Mar 2008].
Disorder

MIM: 189970

mRNA Protein Product Sequence Price Select
NM_021955, 74316012 NP_068774, 11386179 guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor ORF Sequence $99.00
KEGG
hsa04062Chemokine signaling pathway
hsa04744Phototransduction
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04727GABAergic synapse
hsa04728Dopaminergic synapse
hsa04151PI3K-Akt signaling pathway
hsa04726Serotonergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa04713Circadian entrainment
hsa05034Alcoholism
hsa05032Morphine addiction
hsa04014Ras signaling pathway
WikiPathways
WP289Myometrial Relaxation and Contraction Pathways
WP712Estrogen signaling pathway
WP35G Protein Signaling Pathways
WP536Calcium Regulation in the Cardiac Cell
Pathway Interaction Database
rhodopsin_pathwayVisual signal transduction: Rods
Reactome
REACT_19184GPCR downstream signaling
REACT_19145G beta:gamma signalling through PLC beta
REACT_19290G beta:gamma signalling through PI3Kgamma
REACT_19388G-protein beta:gamma signalling
REACT_19327G alpha (s) signalling events
REACT_19231G alpha (i) signalling events
REACT_19333G alpha (z) signalling events
REACT_18339Adrenaline,noradrenaline inhibits insulin secretion
REACT_18274Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REACT_18325Regulation of insulin secretion
REACT_18407G alpha (12/13) signalling events
REACT_18283G alpha (q) signalling events
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_1505Integration of energy metabolism
REACT_14797Signaling by GPCR
REACT_18372Class B/2 (Secretin family receptors)
REACT_18377Glucagon-type ligand receptors
REACT_15488Olfactory Signaling Pathway
REACT_15295Opioid Signalling
REACT_11045Signaling by Wnt
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_15457G-protein activation
REACT_15518Transmembrane transport of small molecules
REACT_13477Transmission across Chemical Synapses
REACT_13685Neuronal System
REACT_21340GPCR ligand binding
REACT_21312Activation of Kainate Receptors upon glutamate binding
REACT_20524Signal amplification
REACT_19140ADP signalling through P2Y purinoceptor 1
REACT_20647Thromboxane signalling through TP receptor
REACT_20653ADP signalling through P2Y purinoceptor 12
REACT_21384Thrombin signalling through proteinase activated receptors (PARs)
REACT_21254Presynaptic function of Kainate receptors
REACT_75908Potassium Channels
REACT_75780G protein gated Potassium channels
REACT_75831Activation of G protein gated Potassium channels
REACT_75918Inwardly rectifying K+ channels
REACT_23946Prostacyclin signalling through prostacyclin receptor
REACT_25199GABA receptor activation
REACT_25031GABA B receptor activation
REACT_23876Platelet homeostasis
REACT_24023Regulation of water balance by renal Aquaporins
REACT_25330Activation of GABAB receptors
REACT_25004Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
REACT_23887Aquaporin-mediated transport
REACT_111217Metabolism
REACT_111102Signal Transduction
REACT_116125Disease
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_163722The phototransduction cascade
REACT_163919Inactivation, recovery and regulation of the phototransduction cascade
REACT_163932Activation of the phototransduction cascade
REACT_160102Diseases associated with visual transduction
REACT_160125Visual phototransduction
REACT_172761Ca2+ pathway
REACT_172694beta-catenin independent WNT signaling
Homo sapiens (human)GNGT1NP_068774.1
Pan troglodytes (chimpanzee)GNGT1XP_001168330.1
Macaca mulatta (Rhesus monkey)GNGT1XP_001098610.2
Canis lupus familiaris (dog)GNGT1NP_001003225.1
Bos taurus (cattle)GNGT1NP_776752.1
Mus musculus (house mouse)Gngt1NP_034444.1
Rattus norvegicus (Norway rat)Gngt1NP_001129249.1
Danio rerio (zebrafish)gngt1NP_956261.1
Xenopus (Silurana) tropicalis (western clawed frog)gngt1NP_001165112.1
Process
IDNameEvidence
GO:0006184GTP catabolic processTAS
GO:0007165signal transductionNAS
GO:0007268synaptic transmissionTAS
GO:0007603phototransduction, visible lightTAS
GO:0008104protein localizationIEA
GO:0010659cardiac muscle cell apoptotic processIEA
GO:0016056rhodopsin mediated signaling pathwayTAS
GO:0022400regulation of rhodopsin mediated signaling pathwayTAS
GO:0042462eye photoreceptor cell developmentIEA
GO:0071456cellular response to hypoxiaIEA
Component
IDNameEvidence
GO:0001917photoreceptor inner segmentIEA
GO:0005834heterotrimeric G-protein complexIEA
GO:0005886plasma membraneTAS
GO:0097381photoreceptor disc membraneTAS
Function
IDNameEvidence
GO:0003924GTPase activityTAS
GO:0004871signal transducer activityIEA
GeneCards GNGT1
UniProt P63211
Vega OTTHUMG00000022908
MIM 189970
Ensembl ENSG00000127928
HGNC 4411
HPRD 01805

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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