Sequence in raw or FASTA format:
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 [Homo sapiens (human)]
| Gene Symbol | GNGT1 |
| Entrez Gene ID | 2792 |
| Full Name | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 |
| Synonyms | GNG1 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
7 7q21.3 |
| Summary | Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. Transducin is a guanine nucleotide-binding protein found specifically in rod outer segments, where it mediates activation by rhodopsin of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase. Transducin is also referred to as GMPase. GNGT1 encodes the gamma subunit of transducin (Hurley et al., 1984 [PubMed 6438626]; Scherer et al., 1996 [PubMed 8661128]).[supplied by OMIM]. |
| Disorder | MIM: 189970 |
| mRNA | NM_021955, 74316012 |
| Protein | NP_068774, 11386179 |
| Product | guanine nucleotide-binding protein G(T) subunit gamma-T1 precursor |
| RefSeq Status | VALIDATED |
| hsa04062 | Chemokine signaling pathway |
| hsa04744 | Phototransduction |
Pathway Interaction Database
| rhodopsin_pathway | Visual signal transduction: Rods |
WikiPathways
| WP536 | Calcium Regulation in the Cardiac Cell |
| WP289 | Myometrial Relaxation and Contraction Pathways |
| WP35 | G Protein Signaling Pathways |
| WP712 | Estrogen signaling pathway |
Reactome
| REACT_19231 | G alpha (i) signalling events |
| REACT_24023 | Regulation of Water Balance by Renal Aquaporins |
| REACT_15518 | Transmembrane transport of small molecules |
| REACT_15370 | Neuroransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell |
| REACT_19327 | G alpha (s) signalling events |
| REACT_14797 | Signaling by GPCR |
| REACT_21384 | Thrombin signalling through proteinase activated receptors (PARs) |
| REACT_21340 | GPCR ligand binding |
| REACT_18325 | Regulation of Insulin Secretion |
| REACT_21254 | Presynaptic function of Kainate receptors |
| REACT_19333 | G alpha (z) signalling events |
| REACT_15380 | Diabetes pathways |
| REACT_25199 | GABA receptor activation |
| REACT_19290 | G beta:gamma signalling through PI3Kgamma |
| REACT_18339 | Inhibition of Insulin Secretion by Adrenaline/Noradrenaline |
| REACT_25004 | Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| REACT_19140 | ADP signalling through P2Y purinoceptor 1 |
| REACT_20524 | Signal amplification |
| REACT_15295 | Opioid Signalling |
| REACT_25330 | Activation of GABAB receptors |
| REACT_20647 | Thromboxane signalling through TP receptor |
| REACT_19184 | GPCR downstream signaling |
| REACT_18372 | Class B/2 (Secretin family receptors) |
| REACT_19145 | G beta:gamma signalling through PLC beta |
| REACT_23876 | Platelet homeostasis |
| REACT_18377 | Glucagon-type ligand receptors |
| REACT_20653 | ADP signalling through P2Y purinoceptor 12 |
| REACT_15457 | G-protein activation |
| REACT_622 | Platelet activation triggers |
| REACT_604 | Hemostasis |
| REACT_19388 | G-protein beta:gamma signalling |
| REACT_1505 | Integration of energy metabolism |
| REACT_21312 | Activation of Kainate Receptors upon glutamate binding |
| REACT_15488 | Olfactory Signaling Pathway |
| REACT_13477 | Transmission across Chemical Synapses |
| REACT_798 | Platelet Activation |
| REACT_20 | Formation of Platelet plug |
| REACT_18274 | Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| REACT_18407 | G alpha (12/13) signalling events |
| REACT_23887 | Aquaporin-mediated transport |
| REACT_13685 | Synaptic Transmission |
| REACT_23946 | Prostacyclin signalling through prostacyclin receptor |
| REACT_25031 | GABA B receptor activation |
| REACT_18283 | G alpha (q) signalling events |
| Homo sapiens (human) | GNGT1 | NP_068774.1 |
| Pan troglodytes (chimpanzee) | GNGT1 | XP_001168303.1 |
| Canis lupus familiaris (dog) | GNGT1 | NP_001003225.1 |
| Bos taurus (cattle) | GNGT1 | NP_776752.1 |
| Mus musculus (house mouse) | Gngt1 | NP_034444.1 |
| Rattus norvegicus (Norway rat) | Gngt1 | XP_001054602.1 |
| Danio rerio (zebrafish) | gngt1 | NP_956261.1 |
| ID | Name | Evidence |
| GO:0006184 | GTP catabolic process | TAS |
| GO:0007165 | signal transduction | NAS |
| GO:0007186 | G-protein coupled receptor protein signaling pathway | IEA |
| GO:0007268 | synaptic transmission | TAS |
| GO:0007602 | phototransduction | IEA |
| GO:0008104 | protein localization | IEA |
| GO:0042462 | eye photoreceptor cell development | IEA |
Component
| ID | Name | Evidence |
| GO:0005834 | heterotrimeric G-protein complex | IEA |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | TAS |
Function
| ID | Name | Evidence |
| GO:0003924 | GTPase activity | TAS |
| GO:0004871 | signal transducer activity | IEA |
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