GP9 glycoprotein IX (platelet) [Homo sapiens (human)]
| Gene Symbol | GP9 |
| Entrez Gene ID | 2815 |
| Full Name | glycoprotein IX (platelet) |
| Synonyms | CD42a, GPIX |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
3 3q21.3 |
| Summary | This gene encodes a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 noncovalent complex with glycoprotein Ib, a platelet surface membrane glycoprotein complex that functions as a receptor for von Willebrand factor. The complete receptor complex includes noncovalent association of the alpha and beta subunits with the protein encoded by this gene and platelet glycoprotein V. Defects in this gene are a cause of Bernard-Soulier syndrome, also known as giant platelet disease. These patients have unusually large platelets and have a clinical bleeding tendency. [provided by RefSeq]. |
| Disorder | MIM: 173515 Bernard-Soulier syndrome, type C, 231200 (3) |
| mRNA | NM_000174, 208609983 |
| Protein | NP_000165, 4504077 |
| Product | platelet glycoprotein IX precursor |
| RefSeq Status | REVIEWED |
| hsa04512 | ECM-receptor interaction |
| hsa04640 | Hematopoietic cell lineage |
Reactome
| REACT_2051 | Formation of Fibrin Clot (Clotting Cascade) |
| REACT_326 | Intrinsic Pathway |
| REACT_604 | Hemostasis |
| REACT_1230 | Platelet Adhesion to exposed collagen |
| REACT_350 | vWF interaction with collagen |
| REACT_622 | Platelet activation triggers |
| REACT_23847 | GP1b-IX-V activation signalling |
| REACT_20 | Formation of Platelet plug |
| REACT_798 | Platelet Activation |
| REACT_278 | Platelet Aggregation (Plug Formation) |
| Homo sapiens (human) | GP9 | NP_000165.1 |
| Pan troglodytes (chimpanzee) | GP9 | XP_001140600.1 |
| Canis lupus familiaris (dog) | GP9 | XP_852017.1 |
| Bos taurus (cattle) | GP9 | XP_875064.2 |
| Mus musculus (house mouse) | Gp9 | NP_061232.1 |
| Rattus norvegicus (Norway rat) | Gp9 | NP_001026995.1 |
| Gallus gallus (chicken) | GP9 | XP_414314.1 |
| ID | Name | Evidence |
| GO:0007155 | cell adhesion | IEA |
| GO:0007596 | blood coagulation | TAS |
| GO:0007597 | blood coagulation, intrinsic pathway | TAS |
| GO:0030168 | platelet activation | TAS |
Component
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | TAS |
| GO:0005887 | integral to plasma membrane | TAS |
Function
| ID | Name | Evidence |
| GO:0005515 | protein binding | IPI |
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