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SLCO1B3 solute carrier organic anion transporter family, member 1B3 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_019844 Homo sapiens solute carrier organic anion transporter family, member 1B3 (SLCO1B3), mRNA. GenEZ ORF Cloning On-demand $849.00 20

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Gene Symbol SLCO1B3
Entrez Gene ID 28234
Full Name solute carrier organic anion transporter family, member 1B3
Synonyms HBLRR, LST-2, LST-3TM13, LST3, OATP-8, OATP1B3, OATP8, SLC21A8
General protein information
Preferred Names
solute carrier organic anion transporter family member 1B3
solute carrier organic anion transporter family member 1B3
organic anion transporter 8
organic anion transporter LST-3c
organic anion-transporting polypeptide 8
liver-specific organic anion transporter 2
liver-specific organic anion transporter 3TM13
solute carrier family 21 (organic anion transporter), member 8
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a liver-specific member of the organic anion transporter family. The encoded protein is a transmembrane receptor that mediates the sodium-independent uptake of endogenous and xenobiotic compounds and plays a critical role in bile acid and bilirubin transport. Mutations in this gene are a cause of Rotor type hyperbilirubinemia. [provided by RefSeq, Feb 2012].

MIM: 605495

mRNA Protein Product Sequence Price Select
NM_019844, 375065831 NP_062818, 9790233 solute carrier organic anion transporter family member 1B3 ORF Sequence $700.00
hsa04976Bile secretion
REACT_19118SLC-mediated transmembrane transport
REACT_11040Bile acid and bile salt metabolism
REACT_11042Recycling of bile acids and salts
REACT_15518Transmembrane transport of small molecules
REACT_22258Metabolism of lipids and lipoproteins
REACT_22285Transport of vitamins, nucleosides, and related molecules
REACT_23988Transport of organic anions
Homo sapiens (human)SLCO1B3NP_062818.1
Macaca mulatta (Rhesus monkey)SLCO1B3NP_001028113.1
Canis lupus familiaris (dog)SLCO1B3NP_001159519.1
Bos taurus (cattle)SLCO1B3NP_991373.1
Mus musculus (house mouse)Slco1b2NP_065241.1
Rattus norvegicus (Norway rat)Slco1b2NP_113838.1
GO:0008206bile acid metabolic processTAS
GO:0015711organic anion transportTAS
GO:0015721bile acid and bile salt transportTAS
GO:0043252sodium-independent organic anion transportTAS
GO:0044281small molecule metabolic processTAS
GO:0055085transmembrane transportTAS
GO:0005886plasma membraneIDA
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0016323basolateral plasma membraneIEA
GO:0008514organic anion transmembrane transporter activityTAS
GeneCards SLCO1B3
UniProt B3KP78, Q9NPD5
Vega OTTHUMG00000169011
MIM 605495
Ensembl ENSG00000111700
HGNC 10961
HPRD 12021

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the SLCO1B3 gene?

The SLCO1B3 gene provides instructions for making a protein called organic anion transporting polypeptide 1B3, or OATP1B3. This protein is found in liver cells; it transports compounds from the blood into the liver so that they can be cleared from the body. For example, the OATP1B3 protein transports bilirubin, which is a yellowish substance that is produced when red blood cells are broken down. In the liver, bilirubin is dissolved in a digestive fluid called bile and then excreted from the body. The OATP1B3 protein also transports certain hormones, toxins, and drugs into the liver for removal from the body. Some of the drugs transported by the OATP1B3 protein include statins, which are used to treat high cholesterol; heart disease medications; certain antibiotics; and some drugs used for the treatment of cancer.


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