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GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000834 Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), mRNA. GenEZ ORF Cloning On-demand $1699.00 25

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Related Services

Gene Symbol GRIN2B
Entrez Gene ID 2904
Full Name glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Synonyms MGC142178, MGC142180, NMDAR2B, NR2B, hNR3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p12

Summary N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008].
Disorder

MIM: 138252

mRNA Protein Product Sequence Price Select
NM_000834, 167003330 NP_000825, 167003331 glutamate receptor ionotropic, NMDA 2B precursor ORF Sequence $1500.00
KEGG
hsa04713Circadian entrainment
hsa04080Neuroactive ligand-receptor interaction
hsa05030Cocaine addiction
hsa05322Systemic lupus erythematosus
hsa05010Alzheimer's disease
hsa05034Alcoholism
hsa05031Amphetamine addiction
hsa04720Long-term potentiation
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa04724Glutamatergic synapse
hsa05033Nicotine addiction
hsa04728Dopaminergic synapse
hsa05016Huntington's disease
WikiPathways
WP666Hypothetical Network for Drug Addiction
WP2059Alzheimers Disease
Pathway Interaction Database
reelinpathwayReelin signaling pathway
erbb4_pathwayErbB4 signaling events
Reactome
REACT_20594Unblocking of NMDA receptor, glutamate binding and activation
REACT_20568CREB phosphorylation through the activation of Ras
REACT_20593Post NMDA receptor activation events
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_13685Neuronal System
REACT_20642CREB phosphorylation through the activation of CaMKII
REACT_13477Transmission across Chemical Synapses
REACT_20546Ras activation uopn Ca2+ infux through NMDA receptor
Homo sapiens (human)GRIN2BNP_000825.2
Pan troglodytes (chimpanzee)GRIN2BXP_528744.2
Macaca mulatta (Rhesus monkey)GRIN2BXP_001088140.1
Canis lupus familiaris (dog)GRIN2BNP_001008719.1
Bos taurus (cattle)GRIN2BNP_001179850.1
Mus musculus (house mouse)Grin2bNP_032197.3
Rattus norvegicus (Norway rat)Grin2bNP_036706.1
Gallus gallus (chicken)GRIN2BXP_416204.2
Danio rerio (zebrafish)LOC559976NP_001121809.1
Danio rerio (zebrafish)LOC100334883XP_003198060.1
GeneCards GRIN2B
PDB 1S11, 1S2S, 2IPV
UniProt Q13224
MIM 138252
Ensembl ENSG00000150086
HGNC 4586
HPRD 00697

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
glutamate receptor ionotropic, NMDA 2B
Names
glutamate receptor ionotropic, NMDA 2B
NR3
glutamate receptor subunit epsilon-2
N-methyl-D-aspartate receptor subunit 3
N-methyl D-aspartate receptor subtype 2B
glutamate [NMDA] receptor subunit epsilon-2

Interactant



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