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GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu26128 NM_000834 Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), mRNA. pcDNA3.1+-DYK On-demand 25 $1699.00
OHu46089 XM_005253351 PREDICTED: Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 12-14 $279.00
OHu26128C NM_000834 Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), mRNA. Customized vector On-demand 25 $1699.00
OHu46089C XM_005253351 PREDICTED: Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2B (GRIN2B), transcript variant X1, mRNA. Customized vector On-demand 12-14 $329.00

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Gene Symbol GRIN2B
Entrez Gene ID 2904
Full Name glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Synonyms GluN2B, MRD6, NMDAR2B, NR2B, hNR3
General protein information
Preferred Names
glutamate receptor ionotropic, NMDA 2B
Names
glutamate receptor ionotropic, NMDA 2B
NR3
glutamate receptor subunit epsilon-2
N-methyl-D-aspartate receptor subunit 3
N-methyl D-aspartate receptor subtype 2B
glutamate [NMDA] receptor subunit epsilon-2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

12

12p12

Summary N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain. [provided by RefSeq, Jul 2008].
Disorder

MIM: 138252

mRNA Protein Product Sequence Price Select
NM_000834, 167003330 NP_000825, 167003331 glutamate receptor ionotropic, NMDA 2B precursor ORF Sequence $1500.00
XM_005253351, 530399103 XP_005253408, 530399104 glutamate receptor ionotropic, NMDA 2B isoform X1 ORF Sequence $700.00
KEGG
hsa04080Neuroactive ligand-receptor interaction
hsa04720Long-term potentiation
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05016Huntington's disease
hsa05322Systemic lupus erythematosus
hsa05010Alzheimer's disease
hsa04724Glutamatergic synapse
hsa04728Dopaminergic synapse
hsa04713Circadian entrainment
hsa05033Nicotine addiction
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
WikiPathways
WP666Hypothetical Network for Drug Addiction
WP2380BDNF signaling pathway
WP2059Alzheimers Disease
Pathway Interaction Database
erbb4_pathwayErbB4 signaling events
reelinpathwayReelin signaling pathway
Reactome
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_13477Transmission across Chemical Synapses
REACT_13685Neuronal System
REACT_20594Unblocking of NMDA receptor, glutamate binding and activation
REACT_20568CREB phosphorylation through the activation of Ras
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_20546Ras activation uopn Ca2+ infux through NMDA receptor
REACT_20593Post NMDA receptor activation events
REACT_20642CREB phosphorylation through the activation of CaMKII
Homo sapiens (human)GRIN2BNP_000825.2
Pan troglodytes (chimpanzee)GRIN2BXP_528744.2
Macaca mulatta (Rhesus monkey)GRIN2BXP_001088140.1
Canis lupus familiaris (dog)GRIN2BNP_001008719.1
Bos taurus (cattle)GRIN2BNP_001179850.1
Mus musculus (house mouse)Grin2bNP_032197.3
Rattus norvegicus (Norway rat)Grin2bNP_036706.1
Gallus gallus (chicken)GRIN2BXP_416204.2
Danio rerio (zebrafish)LOC559976NP_001121809.1
Danio rerio (zebrafish)LOC100334883XP_003198060.2
Xenopus (Silurana) tropicalis (western clawed frog)grin2bXP_002932208.2
Process
IDNameEvidence
GO:0001662behavioral fear responseIEA
GO:0001701in utero embryonic developmentIEA
GO:0001964startle responseIEA
GO:0001967suckling behaviorIEA
GO:0006810transportTAS
GO:0007215glutamate receptor signaling pathwayTAS
GO:0007268synaptic transmissionTAS
GO:0007423sensory organ developmentIEA
GO:0007611learning or memoryTAS
GO:0007612learningIEA
GO:0007613memoryIEA
GO:0034220ion transmembrane transportIBA
GO:0035235ionotropic glutamate receptor signaling pathwayIBA
GO:0035249synaptic transmission, glutamatergicIBA
GO:0045471response to ethanolIDA
GO:0048167regulation of synaptic plasticityIEA
GO:0048266behavioral response to painIEA
GO:0050966detection of mechanical stimulus involved in sensory perception of painIEA
GO:0060079regulation of excitatory postsynaptic membrane potentialIEA
GO:0070588calcium ion transmembrane transportIEA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0008021synaptic vesicleIEA
GO:0009986cell surfaceISS
GO:0014069postsynaptic densityIEA
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexIDA
GO:0030054cell junctionIEA
GO:0030425dendriteIBA
GO:0043005neuron projectionISS
GO:0045211postsynaptic membraneIBA
Function
IDNameEvidence
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityIBA
GO:0005234extracellular-glutamate-gated ion channel activityIBA
GO:0005262calcium channel activityIEA
GO:0005515protein bindingIPI
GO:0008270zinc ion bindingISS
GO:0016594glycine bindingIDA
GeneCards GRIN2B
PDB 1S11, 1S2S, 2IPV
UniProt Q13224
MIM 138252
HGNC 4586
HPRD 00697

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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