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GRIN2D glutamate receptor, ionotropic, N-methyl D-aspartate 2D [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu30647 NM_000836 Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2D (GRIN2D), mRNA. pcDNA3.1+-DYK On-demand -1 TBD
OHu30647C NM_000836 Homo sapiens glutamate receptor, ionotropic, N-methyl D-aspartate 2D (GRIN2D), mRNA. Customized vector On-demand -1 TBD

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Gene Symbol GRIN2D
Entrez Gene ID 2906
Full Name glutamate receptor, ionotropic, N-methyl D-aspartate 2D
Synonyms EB11, GluN2D, NMDAR2D, NR2D
General protein information
Preferred Names
glutamate receptor ionotropic, NMDA 2D
Names
glutamate receptor ionotropic, NMDA 2D
estrogen receptor binding CpG island
N-methyl D-aspartate receptor subtype 2D
N-methyl-d-aspartate receptor subunit 2D
glutamate [NMDA] receptor subunit epsilon-4
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.33

Summary N-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of the key receptor subunit NMDAR1 (GRIN1) and 1 or more of the 4 NMDAR2 subunits: NMDAR2A (GRIN2A), NMDAR2B (GRIN2B), NMDAR2C (GRIN2C), and NMDAR2D (GRIN2D). [provided by RefSeq, Mar 2010].
Disorder

MIM: 602717

mRNA Protein Product Sequence Price Select
NM_000836, 153946390 NP_000827, 153946391 glutamate receptor ionotropic, NMDA 2D precursor ORF Sequence $1500.00
KEGG
hsa04020Calcium signaling pathway
hsa04080Neuroactive ligand-receptor interaction
hsa04720Long-term potentiation
hsa05014Amyotrophic lateral sclerosis (ALS)
hsa05010Alzheimer's disease
hsa04724Glutamatergic synapse
hsa04713Circadian entrainment
hsa05033Nicotine addiction
hsa05030Cocaine addiction
hsa05031Amphetamine addiction
hsa05034Alcoholism
WikiPathways
WP666Hypothetical Network for Drug Addiction
WP2059Alzheimers Disease
Reactome
REACT_15370Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
REACT_13477Transmission across Chemical Synapses
REACT_13685Neuronal System
REACT_20594Unblocking of NMDA receptor, glutamate binding and activation
REACT_20568CREB phosphorylation through the activation of Ras
REACT_20563Activation of NMDA receptor upon glutamate binding and postsynaptic events
REACT_20546Ras activation uopn Ca2+ infux through NMDA receptor
REACT_20593Post NMDA receptor activation events
REACT_20642CREB phosphorylation through the activation of CaMKII
Homo sapiens (human)GRIN2DNP_000827.2
Canis lupus familiaris (dog)GRIN2DXP_005616409.1
Bos taurus (cattle)GRIN2DXP_002695241.2
Mus musculus (house mouse)Grin2dNP_032198.2
Rattus norvegicus (Norway rat)Grin2dNP_073634.1
Drosophila melanogaster (fruit fly)Nmdar2NP_001162637.1
Caenorhabditis elegansnmr-2NP_001256640.1
Xenopus (Silurana) tropicalis (western clawed frog)grin2dXP_002935032.1
Process
IDNameEvidence
GO:0001964startle responseIEA
GO:0007165signal transductionNAS
GO:0007268synaptic transmissionTAS
GO:0008344adult locomotory behaviorIEA
GO:0034220ion transmembrane transportIBA
GO:0035235ionotropic glutamate receptor signaling pathwayIBA
GO:0035249synaptic transmission, glutamatergicIBA
GO:0051930regulation of sensory perception of painIEA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0017146N-methyl-D-aspartate selective glutamate receptor complexIBA
GO:0030054cell junctionIEA
GO:0030425dendriteIBA
GO:0045211postsynaptic membraneIBA
Function
IDNameEvidence
GO:0004972N-methyl-D-aspartate selective glutamate receptor activityIBA
GO:0005234extracellular-glutamate-gated ion channel activityIBA
GO:0005515protein bindingIPI
GeneCards GRIN2D
UniProt Q59G17, O15399
Vega OTTHUMG00000183304
MIM 602717
Ensembl ENSG00000105464
HGNC 4588
HPRD 04095

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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