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CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001511 Homo sapiens chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) (CXCL1), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

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Gene Symbol CXCL1
Entrez Gene ID 2919
Full Name chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
Synonyms FSP, GRO1, GROa, MGSA, MGSA-a, NAP-3, SCYB1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q21

Summary This gene encodes a member of the CXC subfamily of chemokines. The encoded protein is a secreted growth factor that signal through the G-protein coupled receptor, CXC receptor 2. This protein plays a role in inflammation and as a chemoattractant for neutrophils. Aberrant expression this protein is associated with the growth and progression of certain tumors. A naturally occurring processed form of this protein has increased chemotactic activity. Alternate splicing results in coding and non-coding variants of this gene. A pseudogene of this gene is found on chromosome 4. [provided by RefSeq, Jan 2012].
Disorder

MIM: 155730

mRNA Protein Product Sequence Price Select
NM_001511, 373432598 NP_001502, 4504153 growth-regulated alpha protein precursor ORF Sequence $99.00
KEGG
hsa05146Amoebiasis
hsa04621NOD-like receptor signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa05134Legionellosis
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa04062Chemokine signaling pathway
hsa05323Rheumatoid arthritis
hsa05132Salmonella infection
Pathway Interaction Database
il23pathwayIL23-mediated signaling events
WikiPathways
WP530Cytokines and Inflammatory Response
WP615Senescence and Autophagy
Reactome
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_15344Chemokine receptors bind chemokines
REACT_14819Peptide ligand-binding receptors
REACT_19231G alpha (i) signalling events
REACT_14797Signaling by GPCR
REACT_111102Signal Transduction
REACT_19184GPCR downstream signaling
REACT_21340GPCR ligand binding
Homo sapiens (human)CXCL1NP_001502.1
Pan troglodytes (chimpanzee)CXCL1XP_001156094.1
Macaca mulatta (Rhesus monkey)CXCL1NP_001028050.1
Mus musculus (house mouse)Cxcl3NP_976065.1
Rattus norvegicus (Norway rat)Cxcl3NP_612531.1
GeneCards CXCL1
PDB 1MSG, 1ROD, 1MGS, 1MSH
UniProt P09341
MIM 155730
Ensembl ENSG00000163739
HGNC 4602
HPRD 01119

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
growth-regulated alpha protein
Names
growth-regulated alpha protein
MGSA alpha
GRO-alpha(1-73)
C-X-C motif chemokine 1
fibroblast secretory protein
neutrophil-activating protein 3
melanoma growth stimulatory activity alpha
GRO1 oncogene (melanoma growth-stimulating activity)
GRO1 oncogene (melanoma growth stimulating activity, alpha)

Interactant



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