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Sequence in raw or FASTA format:

Database:

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GSN gelsolin [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000177 Homo sapiens gelsolin (GSN), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_001127662 Homo sapiens gelsolin (GSN), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
NM_001127663 Homo sapiens gelsolin (GSN), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001127664 Homo sapiens gelsolin (GSN), transcript variant 5, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
NM_001127665 Homo sapiens gelsolin (GSN), transcript variant 6, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
NM_001127666 Homo sapiens gelsolin (GSN), transcript variant 7, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001127667 Homo sapiens gelsolin (GSN), transcript variant 8, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001258029 Homo sapiens gelsolin (GSN), transcript variant 9, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001258030 Homo sapiens gelsolin (GSN), transcript variant 10, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_198252 Homo sapiens gelsolin (GSN), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $639.00 $590.00 15
XM_005251940 PREDICTED: Homo sapiens gelsolin (GSN), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005251943 PREDICTED: Homo sapiens gelsolin (GSN), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005251944 PREDICTED: Homo sapiens gelsolin (GSN), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005251945 PREDICTED: Homo sapiens gelsolin (GSN), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006717075 PREDICTED: Homo sapiens gelsolin (GSN), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_006717076 PREDICTED: Homo sapiens gelsolin (GSN), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006717077 PREDICTED: Homo sapiens gelsolin (GSN), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006717078 PREDICTED: Homo sapiens gelsolin (GSN), transcript variant X10, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006717079 PREDICTED: Homo sapiens gelsolin (GSN), transcript variant X11, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

Related Services

Gene Symbol GSN
Entrez Gene ID 2934
Full Name gelsolin
Synonyms ADF, AGEL
General protein information
Preferred Names
gelsolin
Names
gelsolin
brevin
actin-depolymerizing factor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q33

Summary The protein encoded by this gene binds to the 'plus' ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 137350

Amyloidosis, Finnish type, 105120 (3)

mRNA Protein Product Sequence Price Select
NM_000177, 89276753 NP_000168, 4504165 gelsolin isoform a precursor ORF Sequence $750.00
NM_001127662, 189083771 NP_001121134, 189083772 gelsolin isoform b ORF Sequence $490.00
NM_001127663, 189083773 NP_001121135, 390517030 gelsolin isoform f ORF Sequence $750.00
NM_001127664, 189083775 NP_001121136, 189083776 gelsolin isoform b ORF Sequence $490.00
NM_001127665, 189083777 NP_001121137, 189083778 gelsolin isoform b ORF Sequence $490.00
NM_001127666, 189083779 NP_001121138, 189083780 gelsolin isoform c ORF Sequence $700.00
NM_001127667, 189083781 NP_001121139, 189083782 gelsolin isoform c ORF Sequence $700.00
NM_001258029, 384475527 NP_001244958, 384475528 gelsolin isoform d ORF Sequence $700.00
NM_001258030, 427918082 NP_001244959, 427918083 gelsolin isoform e ORF Sequence $700.00
NM_198252, 89276752 NP_937895, 38044288 gelsolin isoform b ORF Sequence $490.00
XM_005251940, 530391017 XP_005251997, 530391018 gelsolin isoform X1 ORF Sequence $700.00
XM_005251943, 530391023 XP_005252000, 530391024 gelsolin isoform X4 ORF Sequence $700.00
XM_005251944, 530391025 XP_005252001, 530391026 gelsolin isoform X5 ORF Sequence $700.00
XM_005251945, 578817392 XP_005252002, 530391028 gelsolin isoform X6 ORF Sequence $700.00
XM_006717075, 578817382 XP_006717138, 578817383 gelsolin isoform X7 ORF Sequence $750.00
XM_006717076, 578817384 XP_006717139, 578817385 gelsolin isoform X8 ORF Sequence $700.00
XM_006717077, 578817386 XP_006717140, 578817387 gelsolin isoform X9 ORF Sequence $700.00
XM_006717078, 578817388 XP_006717141, 578817389 gelsolin isoform X10 ORF Sequence $700.00
XM_006717079, 578817390 XP_006717142, 578817391 gelsolin isoform X11 ORF Sequence $700.00
KEGG
hsa04810Regulation of actin cytoskeleton
hsa04666Fc gamma R-mediated phagocytosis
hsa05203Viral carcinogenesis
WikiPathways
WP615Senescence and Autophagy
WP51Regulation of Actin Cytoskeleton
Pathway Interaction Database
erbb1_receptor_proximal_pathwayEGF receptor (ErbB1) signaling pathway
caspase_pathwayCaspase cascade in apoptosis
avb3_opn_pathwayOsteopontin-mediated events
ncadherinpathwayN-cadherin signaling events
ar_pathwayCoregulation of Androgen receptor activity
Reactome
REACT_578Apoptosis
REACT_107Apoptotic cleavage of cellular proteins
REACT_13541Caspase-mediated cleavage of cytoskeletal proteins
REACT_995Apoptotic execution phase
REACT_75925Amyloids
REACT_116125Disease
Homo sapiens (human)GSNNP_000168.1
Pan troglodytes (chimpanzee)GSNXP_001161890.1
Macaca mulatta (Rhesus monkey)GSNXP_001093567.1
Canis lupus familiaris (dog)GSNXP_005627064.1
Bos taurus (cattle)GSNNP_001106755.1
Mus musculus (house mouse)GsnNP_666232.2
Rattus norvegicus (Norway rat)GsnNP_001004080.1
Gallus gallus (chicken)GSNNP_990265.1
Danio rerio (zebrafish)gsnaNP_001012312.1
Xenopus (Silurana) tropicalis (western clawed frog)gsnNP_001016856.1
Process
IDNameEvidence
GO:0006915apoptotic processTAS
GO:0006921cellular component disassembly involved in execution phase of apoptosisTAS
GO:0007568agingIEA
GO:0014003oligodendrocyte developmentIEA
GO:0016192vesicle-mediated transportIEA
GO:0030041actin filament polymerizationIDA
GO:0030041actin filament polymerizationISS
GO:0030155regulation of cell adhesionIEA
GO:0042246tissue regenerationIEA
GO:0045471response to ethanolIEA
GO:0048015phosphatidylinositol-mediated signalingIEA
GO:0051014actin filament severingIDA
GO:0051014actin filament severingISS
GO:0051016barbed-end actin filament cappingTAS
GO:0051593response to folic acidIEA
GO:0060271cilium morphogenesisIMP
GO:0071276cellular response to cadmium ionIEA
Component
IDNameEvidence
GO:0001726ruffleIEA
GO:0005576extracellular regionIDA
GO:0005576extracellular regionISS
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005829cytosolIDA
GO:0005829cytosolISS
GO:0005829cytosolTAS
GO:0015629actin cytoskeletonIEA
GO:0030027lamellipodiumIEA
GO:0043234protein complexIEA
GO:0048471perinuclear region of cytoplasmIEA
GO:0070062extracellular vesicular exosomeIDA
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0003779actin bindingIEA
GO:0005509calcium ion bindingTAS
GO:0005515protein bindingIPI
GeneCards GSN
UniProt P06396, B7Z4U6
Vega OTTHUMG00000020584
MIM 137350
Ensembl ENSG00000148180
HGNC 4620
HPRD 00674

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the GSN gene?

The GSN gene provides instructions for making two forms of a protein called gelsolin. One form remains inside the cell (cellular gelsolin) and the other form is released from the cell (secreted gelsolin). Both forms of the gelsolin protein attach (bind) to another protein called actin. Actin proteins are organized into filaments, which form a network (the cytoskeleton) that gives structure to cells and allows them to change shape and move. Gelsolin helps assemble or disassemble actin filaments. It is thought that, through this function, the gelsolin protein regulates the formation of the actin cytoskeleton.

Interactant

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