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Sequence in raw or FASTA format:


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GYS2 glycogen synthase 2 (liver) [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_021957 Homo sapiens glycogen synthase 2 (liver) (GYS2), mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005253352 PREDICTED: Homo sapiens glycogen synthase 2 (liver) (GYS2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005253353 PREDICTED: Homo sapiens glycogen synthase 2 (liver) (GYS2), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_005253354 PREDICTED: Homo sapiens glycogen synthase 2 (liver) (GYS2), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006719062 PREDICTED: Homo sapiens glycogen synthase 2 (liver) (GYS2), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
XM_006719063 PREDICTED: Homo sapiens glycogen synthase 2 (liver) (GYS2), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

Related Services

Gene Symbol GYS2
Entrez Gene ID 2998
Full Name glycogen synthase 2 (liver)
General protein information
Preferred Names
glycogen [starch] synthase, liver
glycogen [starch] synthase, liver
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene, liver glycogen synthase, catalyzes the rate-limiting step in the synthesis of glycogen - the transfer of a glucose molecule from UDP-glucose to a terminal branch of the glycogen molecule. Mutations in this gene cause glycogen storage disease type 0 (GSD-0) - a rare type of early childhood fasting hypoglycemia with decreased liver glycogen content. [provided by RefSeq, Dec 2009].

MIM: 138571

Glycogen storage disease, type 0, 240600 (3)

mRNA Protein Product Sequence Price Select
NM_021957, 119372285 NP_068776, 119372286 glycogen [starch] synthase, liver ORF Sequence $700.00
XM_005253352, 530399106 XP_005253409, 530399107 glycogen [starch] synthase, liver isoform X1 ORF Sequence $700.00
XM_005253353, 578822830 XP_005253410, 530399109 glycogen [starch] synthase, liver isoform X2 ORF Sequence $700.00
XM_005253354, 530399110 XP_005253411, 530399111 glycogen [starch] synthase, liver isoform X3 ORF Sequence $700.00
XM_006719062, 578822828 XP_006719125, 578822829 glycogen [starch] synthase, liver isoform X4 ORF Sequence $700.00
XM_006719063, 578822831 XP_006719126, 578822832 glycogen [starch] synthase, liver isoform X5 ORF Sequence $700.00
hsa00500Starch and sucrose metabolism
hsa04910Insulin signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04152AMPK signaling pathway
WP481Insulin Signaling
WP500Glycogen Metabolism
WP1403AMPK signaling
HUMAN_PWY-5067glycogen biosynthesis II (from UDP-D-Glucose)
REACT_474Metabolism of carbohydrates
REACT_723Glucose metabolism
REACT_169208Glycogen synthesis
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)GYS2NP_068776.2
Pan troglodytes (chimpanzee)GYS2XP_520790.2
Macaca mulatta (Rhesus monkey)GYS2XP_001098578.1
Canis lupus familiaris (dog)GYS2XP_534869.2
Bos taurus (cattle)GYS2NP_001179834.1
Mus musculus (house mouse)Gys2NP_663547.2
Rattus norvegicus (Norway rat)Gys2NP_037221.1
Gallus gallus (chicken)GYS2XP_004938048.1
Danio rerio (zebrafish)gys2NP_001018199.1
GO:0005975carbohydrate metabolic processTAS
GO:0005978glycogen biosynthetic processIDA
GO:0005978glycogen biosynthetic processIEA
GO:0005978glycogen biosynthetic processISS
GO:0005978glycogen biosynthetic processTAS
GO:0006006glucose metabolic processTAS
GO:0006091generation of precursor metabolites and energyTAS
GO:0009749response to glucoseISS
GO:0044281small molecule metabolic processTAS
GO:0005938cell cortexISS
GO:0030864cortical actin cytoskeletonISS
GO:0004373glycogen (starch) synthase activityEXP
GO:0004373glycogen (starch) synthase activityIDA
GO:0004373glycogen (starch) synthase activityISS
GO:0042803protein homodimerization activityTAS
GO:0061547glycogen synthase activity, transferring glucose-1-phosphateTAS
GeneCards GYS2
UniProt P54840
Vega OTTHUMG00000169135
MIM 138571
Ensembl ENSG00000111713
HGNC 4707
HPRD 00722

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the GYS2 gene?

The GYS2 gene provides instructions for making an enzyme called liver glycogen synthase. Liver glycogen synthase is produced solely in liver cells, where it helps form the complex sugar glycogen by linking together molecules of the simple sugar glucose. Glucose that is taken in from food is stored in the body as glycogen, which is a major source of energy. Glycogen that is stored in the liver can be broken down rapidly when glucose is needed to maintain normal blood sugar levels between meals.


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