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ANXA1 annexin A1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000700 Homo sapiens annexin A1 (ANXA1), mRNA. GenEZ ORF Cloning On-demand $549.00 14

*Business Day

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Gene Symbol ANXA1
Entrez Gene ID 301
Full Name annexin A1
Synonyms ANX1, LPC1
General protein information
Preferred Names
annexin A1
Names
annexin A1
p35
annexin-1
calpactin-2
calpactin II
lipocortin I
chromobindin-9
annexin I (lipocortin I)
phospholipase A2 inhibitory protein
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

9

9q21.13

Summary Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq, Jul 2008].
Disorder

MIM: 151690

mRNA Protein Product Sequence Price Select
NM_000700, 4502100 NP_000691, 4502101 annexin A1 ORF Sequence $400.00
WikiPathways
WP1984Integrated Breast Cancer Pathway
WP98Prostaglandin Synthesis and Regulation
WP2377Integrated Pancreatic Cancer Pathway
WP2431Spinal Cord Injury
Reactome
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_18283G alpha (q) signalling events
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_21340GPCR ligand binding
REACT_21264Formyl peptide receptors bind formyl peptides and many other ligands
REACT_111102Signal Transduction
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
Homo sapiens (human)ANXA1NP_000691.1
Pan troglodytes (chimpanzee)ANXA1NP_001092037.1
Macaca mulatta (Rhesus monkey)ANXA1XP_001098693.2
Canis lupus familiaris (dog)ANXA1XP_533524.2
Bos taurus (cattle)ANXA1NP_786978.2
Mus musculus (house mouse)Anxa1NP_034860.2
Rattus norvegicus (Norway rat)Anxa1NP_037036.1
Gallus gallus (chicken)ANXA1NP_996789.1
Danio rerio (zebrafish)anxa1aNP_861423.1
Xenopus (Silurana) tropicalis (western clawed frog)anxa1NP_001006702.1
Process
IDNameEvidence
GO:0001780neutrophil homeostasisIMP
GO:0002674negative regulation of acute inflammatory responseIEA
GO:0006928cellular component movementTAS
GO:0006954inflammatory responseTAS
GO:0007165signal transductionTAS
GO:0007166cell surface receptor signaling pathwayIEA
GO:0010165response to X-rayIEA
GO:0018149peptide cross-linkingIDA
GO:0030073insulin secretionIEA
GO:0030216keratinocyte differentiationIDA
GO:0031018endocrine pancreas developmentIEA
GO:0031340positive regulation of vesicle fusionIDA
GO:0031394positive regulation of prostaglandin biosynthetic processIEA
GO:0032355response to estradiolIEA
GO:0033031positive regulation of neutrophil apoptotic processIEA
GO:0042063gliogenesisIEA
GO:0042127regulation of cell proliferationIEA
GO:0042493response to drugIEA
GO:0043066negative regulation of apoptotic processTAS
GO:0043086negative regulation of catalytic activityIDA
GO:0043086negative regulation of catalytic activityIEA
GO:0043434response to peptide hormoneIEA
GO:0046632alpha-beta T cell differentiationISS
GO:0050482arachidonic acid secretionIEA
GO:0060206estrous cycle phaseIEA
GO:0070301cellular response to hydrogen peroxideIEA
GO:0070365hepatocyte differentiationIEA
GO:0070555response to interleukin-1IEA
GO:0071385cellular response to glucocorticoid stimulusIDA
GO:0097350neutrophil clearanceIMP
GO:1900087positive regulation of G1/S transition of mitotic cell cycleIEA
GO:2000483negative regulation of interleukin-8 secretionIMP
Component
IDNameEvidence
GO:0001533cornified envelopeIDA
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005737cytoplasmTAS
GO:0005886plasma membraneIDA
GO:0005929ciliumIEA
GO:0009986cell surfaceIDA
GO:0016323basolateral plasma membraneIEA
GO:0031966mitochondrial membraneIEA
GO:0042383sarcolemmaIEA
GO:0043234protein complexIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005102receptor bindingTAS
GO:0005198structural molecule activityIDA
GO:0005509calcium ion bindingIEA
GO:0005515protein bindingIPI
GO:0005543phospholipid bindingTAS
GO:0005544calcium-dependent phospholipid bindingIDA
GO:0019834phospholipase A2 inhibitor activityIDA
GO:0030674protein binding, bridgingIDA
GO:0042803protein homodimerization activityIEA
GO:0048306calcium-dependent protein bindingIPI
GeneCards ANXA1
PDB 1QLS, 1BO9, 1AIN
UniProt Q5TZZ9, P04083
Vega OTTHUMG00000020016
MIM 151690
Ensembl ENSG00000135046
HGNC 533
HPRD 01060

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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