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ANXA1 annexin A1 [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	ANXA1
Entrez Gene ID	301
Full Name	annexin A1
Synonyms	ANX1, LPC1
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:9 Map Location:9q12-q21.2\|9q21.13
Summary	Annexin I belongs to a family of Ca(2+)-dependent phospholipid binding proteins which have a molecular weight of approximately 35,000 to 40,000 and are preferentially located on the cytosolic face of the plasma membrane. Annexin I protein has an apparent relative molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity. [provided by RefSeq].
Disorder	MIM: 151690

mRNA	NM_000700, 4502100
Protein	NP_000691, 4502101
Product	annexin A1
RefSeq Status	REVIEWED

WikiPathways

WP98	Prostaglandin Synthesis and Regulation

Reactome

REACT_14819	Peptide ligand-binding receptors
REACT_21340	GPCR ligand binding
REACT_19184	GPCR downstream signaling
REACT_19231	G alpha (i) signalling events
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_21264	Formyl peptide receptors bind formyl peptides and many other ligands
REACT_18283	G alpha (q) signalling events
REACT_14797	Signaling by GPCR

Homo sapiens (human)	ANXA1	NP_000691.1
Pan troglodytes (chimpanzee)	ANXA1	XP_001143668.1
Canis lupus familiaris (dog)	ANXA1	XP_533524.2
Bos taurus (cattle)	ANXA1	NP_786978.2
Mus musculus (house mouse)	Anxa1	NP_034860.2
Rattus norvegicus (Norway rat)	Anxa1	NP_037036.1
Gallus gallus (chicken)	ANXA1	NP_996789.1
Danio rerio (zebrafish)	anxa1a	NP_861423.1

Process

ID	Name	Evidence
GO:0006629	lipid metabolic process	TAS
GO:0006916	anti-apoptosis	TAS
GO:0006928	cellular component movement	TAS
GO:0006954	inflammatory response	TAS
GO:0007049	cell cycle	IEA
GO:0007165	signal transduction	TAS
GO:0007166	cell surface receptor linked signaling pathway	TAS
GO:0018149	peptide cross-linking	IDA
GO:0030216	keratinocyte differentiation	IDA
GO:0031340	positive regulation of vesicle fusion	IDA
GO:0042127	regulation of cell proliferation	IEA
GO:0046632	alpha-beta T cell differentiation	ISS
GO:0050482	arachidonic acid secretion	IEA

Component

ID	Name	Evidence
GO:0001533	cornified envelope	IDA
GO:0005576	extracellular region	EXP
GO:0005576	extracellular region	TAS
GO:0005634	nucleus	IEA
GO:0005737	cytoplasm	TAS
GO:0005929	cilium	IEA
GO:0016323	basolateral plasma membrane	IEA
GO:0042383	sarcolemma	IEA

Function

ID	Name	Evidence
GO:0004859	phospholipase inhibitor activity	TAS
GO:0005102	receptor binding	TAS
GO:0005198	structural molecule activity	IDA
GO:0005509	calcium ion binding	IEA
GO:0005515	protein binding	IPI
GO:0005543	phospholipid binding	TAS
GO:0005544	calcium-dependent phospholipid binding	IDA
GO:0019834	phospholipase A2 inhibitor activity	IEA
GO:0030674	protein binding, bridging	IDA

GeneCards	ANXA1
PDB	1QLS, 1BO9, 1AIN
UniProt	Q5TZZ9, P04083
MIM	151690
Ensembl	ENSG00000135046
HGNC	533
HPRD	01060

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