Sequence in raw or FASTA format:
HIST1H2AE histone cluster 1, H2ae [Homo sapiens (human)]
| Gene Symbol | HIST1H2AE |
| Entrez Gene ID | 3012 |
| Full Name | histone cluster 1, H2ae |
| Synonyms | H2A.1, H2A.2, H2A/a, H2AFA |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
6 6p22.1 |
| Summary | Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq]. |
| Disorder | MIM: 602786 |
| mRNA | NM_021052, 19557649 |
| Protein | NP_066390, 10645195 |
| Product | histone H2A type 1-B/E |
| RefSeq Status | REVIEWED |
| hsa05322 | Systemic lupus erythematosus |
WikiPathways
| WP183 | Proteasome Degradation |
Reactome
| REACT_22172 | Chromosome Maintenance |
| REACT_7963 | Packaging Of Telomere Ends |
| REACT_21352 | RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription |
| REACT_2204 | RNA Polymerase I Chain Elongation |
| REACT_22186 | Deposition of New CENPA-containing Nucleosomes at the Centromere |
| REACT_1309 | RNA Polymerase I Transcription |
| REACT_7970 | Telomere Maintenance |
| REACT_22344 | Nucleosome assembly |
| REACT_2232 | RNA Polymerase I Promoter Opening |
| REACT_1788 | Transcription |
| REACT_1974 | RNA Polymerase I Promoter Clearance |
| Homo sapiens (human) | HIST1H2AB | NP_003504.2 |
| Homo sapiens (human) | HIST1H2AE | NP_066390.1 |
| Pan troglodytes (chimpanzee) | LOC471884 | XP_527262.2 |
| Pan troglodytes (chimpanzee) | LOC748495 | XP_001172704.1 |
| Canis lupus familiaris (dog) | LOC611082 | XP_853809.1 |
| Canis lupus familiaris (dog) | LOC611132 | XP_853867.1 |
| Bos taurus (cattle) | LOC618147 | XP_875566.1 |
| Mus musculus (house mouse) | Hist1h2an | NP_835491.1 |
| Mus musculus (house mouse) | Hist1h2ab | NP_783591.2 |
| Mus musculus (house mouse) | Hist1h2ao | XP_983435.1 |
| Mus musculus (house mouse) | Hist1h2ac | NP_835496.1 |
| Mus musculus (house mouse) | Hist1h2ai | NP_835489.1 |
| Mus musculus (house mouse) | Hist1h2ad | NP_835495.1 |
| Mus musculus (house mouse) | Hist1h2ae | NP_835494.1 |
| Mus musculus (house mouse) | Gm11276 | NP_835492.1 |
| Mus musculus (house mouse) | Hist1h2ag | NP_835493.1 |
| Rattus norvegicus (Norway rat) | Hist1h2ac | XP_225372.3 |
| Rattus norvegicus (Norway rat) | Hist1h2ai | XP_577577.1 |
| Rattus norvegicus (Norway rat) | Hist1h2an | XP_225386.3 |
| GeneCards | HIST1H2AE |
| MIM | 602786 |
| Ensembl | ENSG00000168274 |
| HGNC | 4724 |
| HPRD | 04152 |
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