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HBA1 hemoglobin, alpha 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000558 Homo sapiens hemoglobin, alpha 1 (HBA1), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

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Related Services

Gene Symbol HBA1
Entrez Gene ID 3039
Full Name hemoglobin, alpha 1
Synonyms CD31, MGC126895, MGC126897
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

16

16p13.3

Summary The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008].
Disorder

MIM: 141800

Thalassemias, alpha-, 604131 (3); Methemoglobinemias, alpha- (3);

mRNA Protein Product Sequence Price Select
NM_000558, 14456711 NP_000549, 4504347 hemoglobin subunit alpha ORF Sequence $99.00
KEGG
hsa05143African trypanosomiasis
hsa05144Malaria
WikiPathways
WP15Selenium Pathway
Reactome
REACT_121329Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
REACT_120969O2/CO2 exchange in erythrocytes
REACT_111217Metabolism
REACT_121380Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
Homo sapiens (human)HBA2NP_000508.1
Homo sapiens (human)HBA1NP_000549.1
Macaca mulatta (Rhesus monkey)HBA2XP_001094404.1
Macaca mulatta (Rhesus monkey)HBA2NP_001038189.1
Canis lupus familiaris (dog)LOC100855540XP_003639174.1
Canis lupus familiaris (dog)LOC100855558XP_003639175.1
Bos taurus (cattle)HBANP_001070890.2
Bos taurus (cattle)HBA1XP_003585623.1
Mus musculus (house mouse)Hba-a2NP_001077424.1
Mus musculus (house mouse)Hba-a1NP_032244.2
Rattus norvegicus (Norway rat)Hba2NP_001007723.1
Rattus norvegicus (Norway rat)Hba-a2NP_037228.1
Gallus gallus (chicken)LOC100858011XP_003643239.1
Gallus gallus (chicken)HBAANP_001004376.1
GeneCards HBA1
MIM 141800
Ensembl ENSG00000206172
HGNC 4823
HPRD 00784

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
hemoglobin subunit alpha
Names
hemoglobin subunit alpha
alpha-globin
alpha-1 globin
alpha-1-globin
alpha one globin
hemoglobin alpha chain
hemoglobin alpha-1 chain
hemoglobin alpha 1 globin chain

Interactant



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