• THAT   AND

Sequence in raw or FASTA format:


Blast Method:


HBA1 hemoglobin, alpha 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000558 Homo sapiens hemoglobin, alpha 1 (HBA1), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

*Business Day

Related Services

Gene Symbol HBA1
Entrez Gene ID 3039
Full Name hemoglobin, alpha 1
Synonyms HBA-T3, HBH
General protein information
Preferred Names
hemoglobin subunit alpha
hemoglobin subunit alpha
alpha-1 globin
alpha one globin
hemoglobin alpha chain
hemoglobin alpha-1 chain
hemoglobin alpha 1 globin chain
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The human alpha globin gene cluster located on chromosome 16 spans about 30 kb and includes seven loci: 5'- zeta - pseudozeta - mu - pseudoalpha-1 - alpha-2 - alpha-1 - theta - 3'. The alpha-2 (HBA2) and alpha-1 (HBA1) coding sequences are identical. These genes differ slightly over the 5' untranslated regions and the introns, but they differ significantly over the 3' untranslated regions. Two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin; alpha chains combine with delta chains to constitute HbA-2, which with HbF (fetal hemoglobin) makes up the remaining 3% of adult hemoglobin. Alpha thalassemias result from deletions of each of the alpha genes as well as deletions of both HBA2 and HBA1; some nondeletion alpha thalassemias have also been reported. [provided by RefSeq, Jul 2008].

MIM: 141800

Thalassemias, alpha-, 604131 (3); Methemoglobinemias, alpha- (3);

mRNA Protein Product Sequence Price Select
NM_000558, 14456711 NP_000549, 4504347 hemoglobin subunit alpha ORF Sequence $99.00
hsa05143African trypanosomiasis
WP15Selenium Pathway
REACT_121329Erythrocytes take up carbon dioxide and release oxygen
REACT_120969O2/CO2 exchange in erythrocytes
REACT_121380Erythrocytes take up oxygen and release carbon dioxide
REACT_160300Binding and Uptake of Ligands by Scavenger Receptors
REACT_160163Scavenging of heme from plasma
Homo sapiens (human)HBA2NP_000508.1
Homo sapiens (human)HBA1NP_000549.1
Macaca mulatta (Rhesus monkey)HBA2NP_001038189.1
Macaca mulatta (Rhesus monkey)HBA2XP_001094404.1
Canis lupus familiaris (dog)LOC100855558NP_001257814.1
Canis lupus familiaris (dog)LOC100855540NP_001257815.1
Bos taurus (cattle)HBANP_001070890.2
Bos taurus (cattle)HBA1XP_003585623.1
Mus musculus (house mouse)Hba-a2NP_001077424.1
Mus musculus (house mouse)Hba-a1NP_032244.2
Rattus norvegicus (Norway rat)LOC287167NP_001013875.1
Gallus gallus (chicken)HBAANP_001004376.1
Gallus gallus (chicken)LOC100858011XP_004949966.1
Xenopus (Silurana) tropicalis (western clawed frog)hba1NP_988860.1
GeneCards HBA1
Vega OTTHUMG00000060138
MIM 141800
Ensembl ENSG00000206172
HGNC 4823
HPRD 00784

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the HBA1 gene?

The HBA1 gene provides instructions for making a protein called alpha-globin. This protein is also produced from a nearly identical gene called HBA2. These two alpha-globin genes are located close together in a region of chromosome 16 known as the alpha-globin locus.

Alpha-globin is a component (subunit) of a larger protein called hemoglobin, which is the protein in red blood cells that carries oxygen to cells and tissues throughout the body. Hemoglobin is made up of four subunits: two subunits of alpha-globin and two subunits of another type of globin. Alpha-globin is a component of both fetal hemoglobin, which is active only before birth and in the newborn period, and adult hemoglobin, which is active throughout the rest of life.

Each of the four protein subunits of hemoglobin carries an iron-containing molecule called heme. Heme molecules are necessary for red blood cells to pick up oxygen in the lungs and deliver it to the body's tissues. A complete hemoglobin protein is capable of carrying four oxygen molecules at a time (one attached to each heme molecule). Oxygen attached to hemoglobin gives blood its bright red color.


Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.