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HBB hemoglobin, beta [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25936 NM_000518 Homo sapiens hemoglobin, beta (HBB), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu25936C NM_000518 Homo sapiens hemoglobin, beta (HBB), mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol HBB
Entrez Gene ID 3043
Full Name hemoglobin, beta
Synonyms CD113t-C, beta-globin
General protein information
Preferred Names
hemoglobin subunit beta
Names
hemoglobin subunit beta
beta globin chain
hemoglobin beta chain
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.5

Summary The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008].
Disorder

MIM: 141900

Sickle cell anemia, 603903 (3); Thalassemias, beta-, 604131 (3);

mRNA Protein Product Sequence Price Select
NM_000518, 28302128 NP_000509, 4504349 hemoglobin subunit beta ORF Sequence $99.00
KEGG
hsa05144Malaria
hsa05143African trypanosomiasis
WikiPathways
WP15Selenium Pathway
WP176Folate Metabolism
WP1533Vitamin B12 Metabolism
Reactome
REACT_604Hemostasis
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_111217Metabolism
REACT_121329Erythrocytes take up carbon dioxide and release oxygen
REACT_120969O2/CO2 exchange in erythrocytes
REACT_121380Erythrocytes take up oxygen and release carbon dioxide
REACT_160300Binding and Uptake of Ligands by Scavenger Receptors
REACT_160163Scavenging of heme from plasma
Homo sapiens (human)HBBNP_000509.1
Pan troglodytes (chimpanzee)HBBXP_508242.1
Macaca mulatta (Rhesus monkey)HBBNP_001157900.1
Canis lupus familiaris (dog)LOC609402NP_001257812.1
Canis lupus familiaris (dog)LOC476825XP_534029.2
Canis lupus familiaris (dog)LOC480784NP_001257813.1
Mus musculus (house mouse)Hbb-bsNP_001188320.1
Mus musculus (house mouse)Hbb-btNP_032246.2
Rattus norvegicus (Norway rat)LOC100134871NP_001106694.1
Rattus norvegicus (Norway rat)LOC689064NP_001104739.1
Rattus norvegicus (Norway rat)HbbNP_150237.1
Rattus norvegicus (Norway rat)Hbb-b1NP_942071.1
Process
IDNameEvidence
GO:0007596blood coagulationTAS
GO:0008217regulation of blood pressureIEA
GO:0010942positive regulation of cell deathIDA
GO:0015671oxygen transportNAS
GO:0015671oxygen transportTAS
GO:0015701bicarbonate transportTAS
GO:0030185nitric oxide transportNAS
GO:0042542response to hydrogen peroxideIDA
GO:0042744hydrogen peroxide catabolic processIDA
GO:0044281small molecule metabolic processTAS
GO:0045429positive regulation of nitric oxide biosynthetic processNAS
GO:0050880regulation of blood vessel sizeIEA
GO:0051291protein heterooligomerizationIDA
GO:0055114oxidation-reduction processIDA
GO:0070293renal absorptionIMP
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005829cytosolTAS
GO:0005833hemoglobin complexIDA
GO:0005833hemoglobin complexNAS
GO:0005833hemoglobin complexTAS
GO:0031838haptoglobin-hemoglobin complexIDA
GO:0070062extracellular vesicular exosomeIDA
GO:0071682endocytic vesicle lumenTAS
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0004601peroxidase activityIDA
GO:0005344oxygen transporter activityNAS
GO:0005506iron ion bindingIEA
GO:0005515protein bindingIPI
GO:0019825oxygen bindingIDA
GO:0020037heme bindingIEA
GO:0030492hemoglobin bindingIDA
GO:0031720haptoglobin bindingIDA

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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