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HBB hemoglobin, beta [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000518 Homo sapiens hemoglobin, beta (HBB), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

*Business Day

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Gene Symbol HBB
Entrez Gene ID 3043
Full Name hemoglobin, beta
Synonyms CD113t-C, beta-globin
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.5

Summary The alpha (HBA) and beta (HBB) loci determine the structure of the 2 types of polypeptide chains in adult hemoglobin, Hb A. The normal adult hemoglobin tetramer consists of two alpha chains and two beta chains. Mutant beta globin causes sickle cell anemia. Absence of beta chain causes beta-zero-thalassemia. Reduced amounts of detectable beta globin causes beta-plus-thalassemia. The order of the genes in the beta-globin cluster is 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008].
Disorder

MIM: 141900

Sickle cell anemia, 603903 (3); Thalassemias, beta-, 604131 (3);

mRNA Protein Product Sequence Price Select
NM_000518, 28302128 NP_000509, 4504349 hemoglobin subunit beta ORF Sequence $99.00
KEGG
hsa05144Malaria
hsa05143African trypanosomiasis
WikiPathways
WP15Selenium Pathway
WP176Folate Metabolism
Reactome
REACT_604Hemostasis
REACT_120969O2/CO2 exchange in erythrocytes
REACT_121380Uptake of Oxygen and Release of Carbon Dioxide by Erythrocytes
REACT_111217Metabolism
REACT_24970Factors involved in megakaryocyte development and platelet production
REACT_121329Uptake of Carbon Dioxide and Release of Oxygen by Erythrocytes
Homo sapiens (human)HBBNP_000509.1
Pan troglodytes (chimpanzee)HBBXP_508242.1
Macaca mulatta (Rhesus monkey)HBBNP_001157900.1
Canis lupus familiaris (dog)LOC609402XP_862442.1
Canis lupus familiaris (dog)LOC480784XP_003433067.1
Canis lupus familiaris (dog)HBDXP_534029.2
Bos taurus (cattle)LOC100337028XP_002693271.1
Bos taurus (cattle)HBBNP_776342.1
Bos taurus (cattle)LOC781674XP_003587018.1
Mus musculus (house mouse)Beta-sNP_001188320.1
Mus musculus (house mouse)Hbb-b1NP_032246.2
Rattus norvegicus (Norway rat)Hbb-b1NP_942071.1
Rattus norvegicus (Norway rat)LOC689064NP_001104739.1
Rattus norvegicus (Norway rat)HbbNP_150237.1
Rattus norvegicus (Norway rat)LOC100134871NP_001106694.1

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
hemoglobin subunit beta
Names
hemoglobin subunit beta
beta globin chain
hemoglobin beta chain

Interactant



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