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HK1 hexokinase 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000188 Homo sapiens hexokinase 1 (HK1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_033496 Homo sapiens hexokinase 1 (HK1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_033497 Homo sapiens hexokinase 1 (HK1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_033498 Homo sapiens hexokinase 1 (HK1), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand TBD TBD
NM_033500 Homo sapiens hexokinase 1 (HK1), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005269735 PREDICTED: Homo sapiens hexokinase 1 (HK1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005269736 PREDICTED: Homo sapiens hexokinase 1 (HK1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand TBD TBD
XM_005269737 PREDICTED: Homo sapiens hexokinase 1 (HK1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand TBD TBD

*Business Day

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Gene Symbol HK1
Entrez Gene ID 3098
Full Name hexokinase 1
Synonyms HK1-ta, HK1-tb, HK1-tc, HKD, HKI, HMSNR, HXK1
General protein information
Preferred Names
hexokinase-1
Names
hexokinase-1
HK I
glycolytic enzyme
hexokinase type I
brain form hexokinase
NP_000179.2
NP_277031.1
NP_277032.1
NP_277033.1
NP_277035.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

10

10q22

Summary Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes a ubiquitous form of hexokinase which localizes to the outer membrane of mitochondria. Mutations in this gene have been associated with hemolytic anemia due to hexokinase deficiency. Alternative splicing of this gene results in five transcript variants which encode different isoforms, some of which are tissue-specific. Each isoform has a distinct N-terminus; the remainder of the protein is identical among all the isoforms. A sixth transcript variant has been described, but due to the presence of several stop codons, it is not thought to encode a protein. [provided by RefSeq, Apr 2009].
Disorder

MIM: 142600

Hemolytic anemia due to hexokinase deficiency, 235700 (3)

mRNA Protein Product Sequence Price Select
NM_000188, 188497753 NP_000179, 188497754 hexokinase-1 isoform HKI ORF Sequence $750.00
NM_033496, 188497748 NP_277031, 15991827 hexokinase-1 isoform HKI-R ORF Sequence $750.00
NM_033497, 188497752 NP_277032, 15991829 hexokinase-1 isoform HKI-ta/tb ORF Sequence $750.00
NM_033498, 188497751 NP_277033, 15991831 hexokinase-1 isoform HKI-ta/tb ORF Sequence $750.00
NM_033500, 188497749 NP_277035, 188497750 hexokinase-1 isoform HKI-td ORF Sequence $750.00
XM_005269735, 530393495 XP_005269792, 530393496 hexokinase-1 isoform X1 ORF Sequence $750.00
XM_005269736, 530393497 XP_005269793, 530393498 hexokinase-1 isoform X2 ORF Sequence $750.00
XM_005269737, 530393499 XP_005269794, 530393500 hexokinase-1 isoform X3 ORF Sequence $750.00
KEGG
hsa00052Galactose metabolism
hsa00051Fructose and mannose metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00520Amino sugar and nucleotide sugar metabolism
hsa00500Starch and sucrose metabolism
hsa04910Insulin signaling pathway
hsa04930Type II diabetes mellitus
hsa00524Butirosin and neomycin biosynthesis
hsa04973Carbohydrate digestion and absorption
hsa_M00001Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa04066HIF-1 signaling pathway
hsa_M00549Nucleotide sugar biosynthesis, glucose => UDP-glucose
hsa01200Carbon metabolism
WikiPathways
WP534Glycolysis and Gluconeogenesis
WP698Glucuronidation
WP1946Cori Cycle
Pathway Interaction Database
hif1_tfpathwayHIF-1-alpha transcription factor network
BIOCYC
META_PWY66-400glycolysis VI (metazoan)
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_212Glucose transport
REACT_9441Hexose transport
REACT_474Metabolism of carbohydrates
REACT_15518Transmembrane transport of small molecules
REACT_111217Metabolism
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)HK1NP_000179.2
Pan troglodytes (chimpanzee)HK1XP_001169264.2
Macaca mulatta (Rhesus monkey)HK1XP_001110396.2
Canis lupus familiaris (dog)HK1XP_536376.3
Bos taurus (cattle)HK1NP_001012686.1
Mus musculus (house mouse)Hk1NP_001139572.1
Rattus norvegicus (Norway rat)Hk1NP_036866.1
Gallus gallus (chicken)HK1NP_989432.1
Danio rerio (zebrafish)hk1NP_998417.1
Drosophila melanogaster (fruit fly)Hex-t2NP_733151.2
Drosophila melanogaster (fruit fly)Hex-CNP_524674.1
Drosophila melanogaster (fruit fly)Hex-ANP_524848.1
Arabidopsis thaliana (thale cress)HXK2NP_179576.1
Arabidopsis thaliana (thale cress)HXK1NP_194642.1
Xenopus (Silurana) tropicalis (western clawed frog)hk1NP_001096201.1
Process
IDNameEvidence
GO:0001678cellular glucose homeostasisIBA
GO:0005975carbohydrate metabolic processTAS
GO:0006096glycolytic processIBA
GO:0008219cell deathIEA
GO:0008645hexose transportTAS
GO:0015758glucose transportTAS
GO:0019318hexose metabolic processIEA
GO:0044281small molecule metabolic processTAS
GO:0046835carbohydrate phosphorylationIBA
GO:0046835carbohydrate phosphorylationIEA
GO:0046835carbohydrate phosphorylationTAS
GO:0051156glucose 6-phosphate metabolic processIBA
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005739mitochondrionIDA
GO:0005741mitochondrial outer membraneIEA
GO:0005829cytosolTAS
GO:0045121membrane raftIEA
Function
IDNameEvidence
GO:0004340glucokinase activityIBA
GO:0004396hexokinase activityTAS
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0008865fructokinase activityIBA
GO:0019158mannokinase activityIBA
GeneCards HK1
UniProt B3KXY9, P19367, A8K7J7, Q59FD4, P78542
Vega OTTHUMG00000018380
MIM 142600
Ensembl ENSG00000156515
HGNC 4922
HPRD 00809

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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