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HK2 hexokinase 2 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000189 Homo sapiens hexokinase 2 (HK2), mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
XM_005264280 PREDICTED: Homo sapiens hexokinase 2 (HK2), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol HK2
Entrez Gene ID 3099
Full Name hexokinase 2
Synonyms HKII, HXK2
General protein information
Preferred Names
hexokinase-2
Names
hexokinase-2
HK II
hexokinase type II
hexokinase-2, muscle
muscle form hexokinase
NP_000180.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2p13

Summary Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. This gene encodes hexokinase 2, the predominant form found in skeletal muscle. It localizes to the outer membrane of mitochondria. Expression of this gene is insulin-responsive, and studies in rat suggest that it is involved in the increased rate of glycolysis seen in rapidly growing cancer cells. [provided by RefSeq, Apr 2009].
Disorder

MIM: 601125

mRNA Protein Product Sequence Price Select
NM_000189, 40806188 NP_000180, 15553127 hexokinase-2 ORF Sequence $660.00
XM_005264280, 530367514 XP_005264337, 530367515 hexokinase-2 isoform X1 ORF Sequence $750.00
KEGG
hsa00052Galactose metabolism
hsa00051Fructose and mannose metabolism
hsa00010Glycolysis / Gluconeogenesis
hsa00520Amino sugar and nucleotide sugar metabolism
hsa00500Starch and sucrose metabolism
hsa04910Insulin signaling pathway
hsa04930Type II diabetes mellitus
hsa00524Butirosin and neomycin biosynthesis
hsa04973Carbohydrate digestion and absorption
hsa_M00001Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
hsa04066HIF-1 signaling pathway
hsa_M00549Nucleotide sugar biosynthesis, glucose => UDP-glucose
hsa01200Carbon metabolism
WikiPathways
WP534Glycolysis and Gluconeogenesis
Pathway Interaction Database
hif1_tfpathwayHIF-1-alpha transcription factor network
Reactome
REACT_19118SLC-mediated transmembrane transport
REACT_212Glucose transport
REACT_9441Hexose transport
REACT_474Metabolism of carbohydrates
REACT_15518Transmembrane transport of small molecules
REACT_111217Metabolism
REACT_116125Disease
REACT_200783Myoclonic epilepsy of Lafora
REACT_200833Glycogen storage diseases
Homo sapiens (human)HK2NP_000180.2
Pan troglodytes (chimpanzee)HK2XP_001162535.1
Macaca mulatta (Rhesus monkey)HK2XP_001111706.1
Canis lupus familiaris (dog)HK2XP_005630567.1
Bos taurus (cattle)HK2XP_002691235.1
Mus musculus (house mouse)Hk2NP_038848.1
Rattus norvegicus (Norway rat)Hk2NP_036867.1
Gallus gallus (chicken)HK2NP_989543.1
Danio rerio (zebrafish)hk2NP_998231.1
Caenorhabditis elegansF14B4.2NP_001021107.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100485269XP_002935347.1
Process
IDNameEvidence
GO:0001678cellular glucose homeostasisIBA
GO:0005975carbohydrate metabolic processTAS
GO:0006006glucose metabolic processIEA
GO:0006096glycolytic processIBA
GO:0007595lactationIEA
GO:0008637apoptotic mitochondrial changesIDA
GO:0008645hexose transportTAS
GO:0015758glucose transportTAS
GO:0044281small molecule metabolic processTAS
GO:0046324regulation of glucose importIEA
GO:0046835carbohydrate phosphorylationIEA
GO:0051156glucose 6-phosphate metabolic processIBA
GO:0055085transmembrane transportTAS
Component
IDNameEvidence
GO:0005741mitochondrial outer membraneIDA
GO:0005829cytosolTAS
GO:0016020membraneIDA
Function
IDNameEvidence
GO:0004340glucokinase activityIBA
GO:0004396hexokinase activityTAS
GO:0005524ATP bindingIEA
GO:0005536glucose bindingIEA
GO:0008865fructokinase activityIBA
GO:0019158mannokinase activityIBA
GeneCards HK2
PDB 2NZT
UniProt P52789
Vega OTTHUMG00000129972
MIM 601125
Ensembl ENSG00000159399
HGNC 4923
HPRD 03080

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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