HLA-DOB major histocompatibility complex, class II, DO beta [Homo sapiens (human)]
| Gene Symbol | HLA-DOB |
| Entrez Gene ID | 3112 |
| Full Name | major histocompatibility complex, class II, DO beta |
| Synonyms | DOB, FLJ57033 |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
6 6p21.3 |
| Summary | HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq]. |
| Disorder | MIM: 600629 |
| mRNA | NM_002120, 118402587 |
| Protein | NP_002111, 4504403 |
| Product | HLA class II histocompatibility antigen, DO beta chain precursor |
| RefSeq Status | REVIEWED |
| hsa05332 | Graft-versus-host disease |
| hsa04672 | Intestinal immune network for IgA production |
| hsa04940 | Type I diabetes mellitus |
| hsa05140 | Leishmaniasis |
| hsa05416 | Viral myocarditis |
| hsa05310 | Asthma |
| hsa05145 | Toxoplasmosis |
| hsa05322 | Systemic lupus erythematosus |
| hsa05320 | Autoimmune thyroid disease |
| hsa04514 | Cell adhesion molecules (CAMs) |
| hsa05150 | Staphylococcus aureus infection |
| hsa04612 | Antigen processing and presentation |
| hsa04145 | Phagosome |
| hsa05330 | Allograft rejection |
| hsa05323 | Rheumatoid arthritis |
Reactome
| REACT_12582 | Phosphorylation of CD3 and TCR zeta chains |
| REACT_12623 | Generation of second messenger molecules |
| REACT_25229 | Interferon Signaling |
| REACT_19344 | Costimulation by the CD28 family |
| REACT_12526 | TCR signaling |
| REACT_12596 | Translocation of ZAP-70 to Immunological synapse |
| REACT_12555 | Downstream TCR signaling |
| REACT_6900 | Signaling in Immune system |
| REACT_25078 | Interferon gamma signaling |
| REACT_19324 | PD-1 signaling |
| Homo sapiens (human) | HLA-DOB | NP_002111.1 |
| Pan troglodytes (chimpanzee) | HLA-DOB | XP_527355.2 |
| Canis lupus familiaris (dog) | HLA-DOB | XP_850395.1 |
| Mus musculus (house mouse) | H2-Ob | NP_034519.2 |
| Rattus norvegicus (Norway rat) | RT1-DOb | NP_001008846.1 |
| ID | Name | Evidence |
| GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | IEA |
| GO:0006955 | immune response | IEA |
| GO:0019221 | cytokine-mediated signaling pathway | TAS |
| GO:0031295 | T cell costimulation | TAS |
| GO:0050852 | T cell receptor signaling pathway | TAS |
| GO:0060333 | interferon-gamma-mediated signaling pathway | TAS |
Component
| ID | Name | Evidence |
| GO:0005764 | lysosome | IDA |
| GO:0005765 | lysosomal membrane | IEA |
| GO:0005768 | endosome | IEA |
| GO:0005886 | plasma membrane | EXP |
| GO:0005886 | plasma membrane | TAS |
| GO:0010008 | endosome membrane | IEA |
| GO:0016021 | integral to membrane | IEA |
| GO:0042613 | MHC class II protein complex | IEA |
Function
| ID | Name | Evidence |
| GO:0032395 | MHC class II receptor activity | TAS |
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