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HLA-DOB major histocompatibility complex, class II, DO beta [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002120 Homo sapiens major histocompatibility complex, class II, DO beta (HLA-DOB), mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10

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Related Services

Gene Symbol HLA-DOB
Entrez Gene ID 3112
Full Name major histocompatibility complex, class II, DO beta
Synonyms DOB
General protein information
Preferred Names
HLA class II histocompatibility antigen, DO beta chain
Names
HLA class II histocompatibility antigen, DO beta chain
MHC class II antigen DOB
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600629

mRNA Protein Product Sequence Price Select
NM_002120, 118402587 NP_002111, 4504403 HLA class II histocompatibility antigen, DO beta chain precursor ORF Sequence $199.00
KEGG
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa05320Autoimmune thyroid disease
hsa05332Graft-versus-host disease
hsa05310Asthma
hsa05322Systemic lupus erythematosus
hsa04940Type I diabetes mellitus
hsa05330Allograft rejection
hsa05416Viral myocarditis
hsa04672Intestinal immune network for IgA production
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa04145Phagosome
hsa05150Staphylococcus aureus infection
hsa05323Rheumatoid arthritis
hsa05166HTLV-I infection
hsa05152Tuberculosis
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05321Inflammatory bowel disease (IBD)
WikiPathways
WP2328Allograft Rejection
Reactome
REACT_6900Immune System
REACT_75774Adaptive Immune System
REACT_121399MHC class II antigen presentation
Homo sapiens (human)HLA-DOBNP_002111.1
Pan troglodytes (chimpanzee)PATR-DOBNP_001123943.1
Macaca mulatta (Rhesus monkey)MAMU-DOBXP_001115393.1
Canis lupus familiaris (dog)DLA-DOBNP_001041592.1
Bos taurus (cattle)BOLA-DOBNP_001013618.1
Mus musculus (house mouse)H2-ObNP_034519.2
Rattus norvegicus (Norway rat)RT1-DObNP_001008846.1
Process
IDNameEvidence
GO:0002587negative regulation of antigen processing and presentation of peptide antigen via MHC class IIIDA
GO:0006955immune responseIEA
GO:0007165signal transductionTAS
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
Component
IDNameEvidence
GO:0005764lysosomeIDA
GO:0005765lysosomal membraneTAS
GO:0010008endosome membraneIEA
GO:0016021integral component of membraneIEA
GO:0042613MHC class II protein complexIDA
Function
IDNameEvidence
GO:0023026MHC class II protein complex bindingIDA
GO:0032395MHC class II receptor activityTAS
GeneCards HLA-DOB
PDB 4I0P
UniProt Q5QNS2, P13765
Vega OTTHUMG00000031213
MIM 600629
Ensembl ENSG00000241106
HGNC 4937
HPRD 08368

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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