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HLA-DOB major histocompatibility complex, class II, DO beta [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002120 Homo sapiens major histocompatibility complex, class II, DO beta (HLA-DOB), mRNA. ORF Sequence $238.38
Peptide Services
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Gene Symbol HLA-DOB
Entrez Gene ID 3112
Full Name major histocompatibility complex, class II, DO beta
Synonyms DOB, FLJ57033
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary HLA-DOB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DOA) and a beta chain (DOB), both anchored in the membrane. It is located in intracellular vesicles. DO suppresses peptide loading of MHC class II molecules by inhibiting HLA-DM. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. [provided by RefSeq, Jul 2008].
Disorder

MIM: 600629

mRNA Protein Product Sequence Price Select
NM_002120, 118402587 NP_002111, 4504403 HLA class II histocompatibility antigen, DO beta chain precursor Full Length $402.52
ORF Sequence $238.38
KEGG
hsa04612Antigen processing and presentation
hsa05166HTLV-I infection
hsa05164Influenza A
hsa05150Staphylococcus aureus infection
hsa05320Autoimmune thyroid disease
hsa04514Cell adhesion molecules (CAMs)
hsa05168Herpes simplex infection
hsa04145Phagosome
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa04672Intestinal immune network for IgA production
hsa04940Type I diabetes mellitus
hsa05140Leishmaniasis
hsa05416Viral myocarditis
hsa05145Toxoplasmosis
hsa05310Asthma
hsa05152Tuberculosis
hsa05322Systemic lupus erythematosus
Reactome
REACT_75774Adaptive Immune System
REACT_121399MHC class II antigen presentation
REACT_6900Immune System
Homo sapiens (human)HLA-DOBNP_002111.1
Pan troglodytes (chimpanzee)PATR-DOBNP_001123943.1
Macaca mulatta (Rhesus monkey)MAMU-DOBXP_001115393.1
Canis lupus familiaris (dog)DLA-DOBNP_001041592.1
Bos taurus (cattle)BOLA-DOBNP_001013618.1
Mus musculus (house mouse)H2-ObNP_034519.2
Rattus norvegicus (Norway rat)RT1-DObNP_001008846.1
GeneCards HLA-DOB
PDB 4I0P
UniProt Q5QNS2, P13765
MIM 600629
Ensembl ENSG00000241106
HGNC 4937
HPRD 08368

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
HLA class II histocompatibility antigen, DO beta chain
Names
HLA class II histocompatibility antigen, DO beta chain
MHC class II antigen DOB

Interactant

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