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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


HLA-DPB1 major histocompatibility complex, class II, DP beta 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu20874 NM_002121 Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40286 XM_006715077 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40287 XM_006715078 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu54616 XM_006725039 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu54617 XM_006725040 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40286 XM_006725698 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40287 XM_006725699 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40286 XM_006725816 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40287 XM_006725817 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu54616 XM_006725907 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu54617 XM_006725908 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40286 XM_006725997 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40287 XM_006725998 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40286 XM_006726087 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40287 XM_006726088 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu20874C NM_002121 Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), mRNA. Customized vector On-demand 7-9 $209.00
OHu40286C XM_006715077 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu40287C XM_006715078 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00
OHu54616C XM_006725039 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu54617C XM_006725040 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00
OHu40286C XM_006725698 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu40287C XM_006725699 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00
OHu40286C XM_006725816 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu40287C XM_006725817 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00
OHu54616C XM_006725907 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu54617C XM_006725908 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00
OHu40286C XM_006725997 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu40287C XM_006725998 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00
OHu40286C XM_006726087 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu40287C XM_006726088 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00

*Business Day

Related Services

Gene Symbol HLA-DPB1
Entrez Gene ID 3115
Full Name major histocompatibility complex, class II, DP beta 1
Synonyms DPB1, HLA-DP, HLA-DP1B, HLA-DPB
General protein information
Preferred Names
HLA class II histocompatibility antigen, DP beta 1 chain
Names
HLA class II histocompatibility antigen, DP beta 1 chain
MHC HLA DPB1
HLA DP14-beta chain
MHC class II HLA-DRB1
class II HLA beta chain
MHC class II antigen DPB1
MHC class II HLA-DP-beta-1
MHC class II antigen DPbeta1
MHC class II antigen beta chain
beta1 domain MHC class II HLA DPB
MHC class II antigen DP beta 1 chain
HLA-DP histocompatibility type, beta-1 subunit
HLA class II histocompatibility antigen, DP(W4) beta chain
major histocompatibility complex class II antigen beta chain
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008].
Disorder

MIM: 142858

{Beryllium disease, chronic, susceptibility to} (3)

mRNA Protein Product Sequence Price Select
NM_002121, 334688863 NP_002112, 24797076 HLA class II histocompatibility antigen, DP beta 1 chain precursor ORF Sequence $300.00
XM_006715077, 578811639 XP_006715140, 578811640 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006715078, 578811641 XP_006715141, 578811642 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006725039, 578839597 XP_006725102, 578839598 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006725040, 578839599 XP_006725103, 578839600 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006725698, 578841355 XP_006725761, 578841356 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006725699, 578841357 XP_006725762, 578841358 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006725816, 578841632 XP_006725879, 578841633 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006725817, 578841634 XP_006725880, 578841635 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006725907, 578841857 XP_006725970, 578841858 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006725908, 578841859 XP_006725971, 578841860 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006725997, 578842073 XP_006726060, 578842074 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006725998, 578842075 XP_006726061, 578842076 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006726087, 578842306 XP_006726150, 578842307 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006726088, 578842308 XP_006726151, 578842309 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
KEGG
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa05320Autoimmune thyroid disease
hsa05332Graft-versus-host disease
hsa05310Asthma
hsa05322Systemic lupus erythematosus
hsa04940Type I diabetes mellitus
hsa05330Allograft rejection
hsa05416Viral myocarditis
hsa04672Intestinal immune network for IgA production
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa04145Phagosome
hsa05150Staphylococcus aureus infection
hsa05323Rheumatoid arthritis
hsa05166HTLV-I infection
hsa05152Tuberculosis
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05321Inflammatory bowel disease (IBD)
WikiPathways
WP2328Allograft Rejection
Reactome
REACT_19344Costimulation by the CD28 family
REACT_19324PD-1 signaling
REACT_6900Immune System
REACT_12555Downstream TCR signaling
REACT_12623Generation of second messenger molecules
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_12526TCR signaling
REACT_75774Adaptive Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_25229Interferon Signaling
REACT_25078Interferon gamma signaling
REACT_121399MHC class II antigen presentation
Homo sapiens (human)HLA-DPB1NP_002112.3
Pan troglodytes (chimpanzee)PATR-DPB1XP_518391.3
Macaca mulatta (Rhesus monkey)MAMU-DPBNP_001127765.1
Gallus gallus (chicken)BLB3XP_423039.4
Gallus gallus (chicken)BLB2XP_004945723.1
Process
IDNameEvidence
GO:0019221cytokine-mediated signaling pathwayTAS
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IIIMP
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
GO:0031295T cell costimulationTAS
GO:0032729positive regulation of interferon-gamma productionIMP
GO:0042102positive regulation of T cell proliferationIMP
GO:0050852T cell receptor signaling pathwayTAS
GO:0050870positive regulation of T cell activationIMP
GO:0060333interferon-gamma-mediated signaling pathwayTAS
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0005765lysosomal membraneTAS
GO:0005886plasma membraneTAS
GO:0009986cell surfaceIMP
GO:0010008endosome membraneIEA
GO:0012507ER to Golgi transport vesicle membraneTAS
GO:0016020membraneIDA
GO:0030658transport vesicle membraneTAS
GO:0030666endocytic vesicle membraneTAS
GO:0030669clathrin-coated endocytic vesicle membraneTAS
GO:0032588trans-Golgi network membraneTAS
GO:0042613MHC class II protein complexIDA
GO:0071556integral component of lumenal side of endoplasmic reticulum membraneTAS
Function
IDNameEvidence
GO:0042605peptide antigen bindingIDA
GeneCards HLA-DPB1
PDB 3LQZ
UniProt I4EC15, P04440
MIM 142858
HGNC 4940
HPRD 00832

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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