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HLA-DPB1 major histocompatibility complex, class II, DP beta 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002121 Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), mRNA. GenEZ ORF Cloning On-demand $449.00 14

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Related Services

Gene Symbol HLA-DPB1
Entrez Gene ID 3115
Full Name major histocompatibility complex, class II, DP beta 1
Synonyms DPB1, HLA-DP1B, HLA-DPB
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008].
Disorder

MIM: 142858

{Beryllium disease, chronic, susceptibility to} (3)

mRNA Protein Product Sequence Price Select
NM_002121, 334688863 NP_002112, 24797076 HLA class II histocompatibility antigen, DP beta 1 chain precursor ORF Sequence $300.00
KEGG
hsa05166HTLV-I infection
hsa05150Staphylococcus aureus infection
hsa04672Intestinal immune network for IgA production
hsa04145Phagosome
hsa05164Influenza A
hsa05330Allograft rejection
hsa04514Cell adhesion molecules (CAMs)
hsa04940Type I diabetes mellitus
hsa05310Asthma
hsa05323Rheumatoid arthritis
hsa05320Autoimmune thyroid disease
hsa05169Epstein-Barr virus infection
hsa05168Herpes simplex infection
hsa05140Leishmaniasis
hsa04612Antigen processing and presentation
hsa05332Graft-versus-host disease
hsa05152Tuberculosis
hsa05145Toxoplasmosis
hsa05416Viral myocarditis
hsa05322Systemic lupus erythematosus
Reactome
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_19344Costimulation by the CD28 family
REACT_25229Interferon Signaling
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_19324PD-1 signaling
REACT_12623Generation of second messenger molecules
REACT_75774Adaptive Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_12526TCR signaling
REACT_121399MHC class II antigen presentation
REACT_12555Downstream TCR signaling
REACT_25078Interferon gamma signaling
REACT_6900Immune System
Homo sapiens (human)HLA-DPB1NP_002112.3
Pan troglodytes (chimpanzee)PATR-DPB1XP_518391.3
Macaca mulatta (Rhesus monkey)MAMU-DPBNP_001127765.1
GeneCards HLA-DPB1
PDB 3LQZ
UniProt I4EC15, P04440
MIM 142858
Ensembl ENSG00000223865
HGNC 4940
HPRD 00832

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
HLA class II histocompatibility antigen, DP beta 1 chain
Names
HLA class II histocompatibility antigen, DP beta 1 chain
MHC HLA DPB1
HLA DP14-beta chain
MHC class II HLA-DRB1
class II HLA beta chain
MHC class II antigen DPB1
MHC class II HLA-DP-beta-1
MHC class II antigen DPbeta1
MHC class II antigen beta chain
beta1 domain MHC class II HLA DPB
MHC class II antigen DP beta 1 chain
HLA-DP histocompatibility type, beta-1 subunit
HLA class II histocompatibility antigen, DP(W4) beta chain
major histocompatibility complex class II antigen beta chain

Interactant



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