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Sequence in raw or FASTA format:

Database:

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HLA-DPB1 major histocompatibility complex, class II, DP beta 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002121 Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_006715077 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006715078 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $299.00 14
XM_006725039 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006725040 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $299.00 14
XM_006725698 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006725699 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $299.00 14
XM_006725816 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006725817 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $299.00 14
XM_006725907 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006725908 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $299.00 14
XM_006725997 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006725998 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $299.00 14
XM_006726087 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $399.00 14
XM_006726088 PREDICTED: Homo sapiens major histocompatibility complex, class II, DP beta 1 (HLA-DPB1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $299.00 14

*Business Day

Related Services

Gene Symbol HLA-DPB1
Entrez Gene ID 3115
Full Name major histocompatibility complex, class II, DP beta 1
Synonyms DPB1, HLA-DP, HLA-DP1B, HLA-DPB
General protein information
Preferred Names
HLA class II histocompatibility antigen, DP beta 1 chain
Names
HLA class II histocompatibility antigen, DP beta 1 chain
MHC HLA DPB1
HLA DP14-beta chain
MHC class II HLA-DRB1
class II HLA beta chain
MHC class II antigen DPB1
MHC class II HLA-DP-beta-1
MHC class II antigen DPbeta1
MHC class II antigen beta chain
beta1 domain MHC class II HLA DPB
MHC class II antigen DP beta 1 chain
HLA-DP histocompatibility type, beta-1 subunit
HLA class II histocompatibility antigen, DP(W4) beta chain
major histocompatibility complex class II antigen beta chain
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules. [provided by RefSeq, Jul 2008].
Disorder

MIM: 142858

{Beryllium disease, chronic, susceptibility to} (3)

mRNA Protein Product Sequence Price Select
NM_002121, 334688863 NP_002112, 24797076 HLA class II histocompatibility antigen, DP beta 1 chain precursor ORF Sequence $300.00
XM_006715077, 578811639 XP_006715140, 578811640 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006715078, 578811641 XP_006715141, 578811642 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006725039, 578839597 XP_006725102, 578839598 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006725040, 578839599 XP_006725103, 578839600 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006725698, 578841355 XP_006725761, 578841356 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006725699, 578841357 XP_006725762, 578841358 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006725816, 578841632 XP_006725879, 578841633 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006725817, 578841634 XP_006725880, 578841635 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006725907, 578841857 XP_006725970, 578841858 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006725908, 578841859 XP_006725971, 578841860 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006725997, 578842073 XP_006726060, 578842074 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006725998, 578842075 XP_006726061, 578842076 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
XM_006726087, 578842306 XP_006726150, 578842307 HLA class II histocompatibility antigen, DP beta 1 chain isoform X1 ORF Sequence $250.00
XM_006726088, 578842308 XP_006726151, 578842309 HLA class II histocompatibility antigen, DP beta 1 chain isoform X2 ORF Sequence $150.00
KEGG
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa05320Autoimmune thyroid disease
hsa05332Graft-versus-host disease
hsa05310Asthma
hsa05322Systemic lupus erythematosus
hsa04940Type I diabetes mellitus
hsa05330Allograft rejection
hsa05416Viral myocarditis
hsa04672Intestinal immune network for IgA production
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa04145Phagosome
hsa05150Staphylococcus aureus infection
hsa05323Rheumatoid arthritis
hsa05166HTLV-I infection
hsa05152Tuberculosis
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05321Inflammatory bowel disease (IBD)
WikiPathways
WP2328Allograft Rejection
Reactome
REACT_19344Costimulation by the CD28 family
REACT_19324PD-1 signaling
REACT_6900Immune System
REACT_12555Downstream TCR signaling
REACT_12623Generation of second messenger molecules
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_12526TCR signaling
REACT_75774Adaptive Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_25229Interferon Signaling
REACT_25078Interferon gamma signaling
REACT_121399MHC class II antigen presentation
Homo sapiens (human)HLA-DPB1NP_002112.3
Pan troglodytes (chimpanzee)PATR-DPB1XP_518391.3
Macaca mulatta (Rhesus monkey)MAMU-DPBNP_001127765.1
Gallus gallus (chicken)BLB3XP_423039.4
Gallus gallus (chicken)BLB2XP_004945723.1
Process
IDNameEvidence
GO:0019221cytokine-mediated signaling pathwayTAS
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IIIMP
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
GO:0031295T cell costimulationTAS
GO:0032729positive regulation of interferon-gamma productionIMP
GO:0042102positive regulation of T cell proliferationIMP
GO:0050852T cell receptor signaling pathwayTAS
GO:0050870positive regulation of T cell activationIMP
GO:0060333interferon-gamma-mediated signaling pathwayTAS
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0005765lysosomal membraneTAS
GO:0005886plasma membraneTAS
GO:0009986cell surfaceIMP
GO:0010008endosome membraneIEA
GO:0012507ER to Golgi transport vesicle membraneTAS
GO:0016020membraneIDA
GO:0030658transport vesicle membraneTAS
GO:0030666endocytic vesicle membraneTAS
GO:0030669clathrin-coated endocytic vesicle membraneTAS
GO:0032588trans-Golgi network membraneTAS
GO:0042613MHC class II protein complexIDA
GO:0071556integral component of lumenal side of endoplasmic reticulum membraneTAS
Function
IDNameEvidence
GO:0042605peptide antigen bindingIDA
GeneCards HLA-DPB1
PDB 3LQZ
UniProt I4EC15, P04440
MIM 142858
HGNC 4940
HPRD 00832

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the HLA-DPB1 gene?

The HLA-DPB1 gene provides instructions for making a protein that plays a critical role in the immune system. The HLA-DPB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. The HLA-DPB1 gene belongs to a group of MHC genes called MHC class II. MHC class II genes provide instructions for making proteins that are present on the surface of certain immune system cells. These proteins attach to protein fragments (peptides) outside the cell. MHC class II proteins display these peptides to the immune system. If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it triggers a response to attack the invading viruses or bacteria.

The protein produced from the HLA-DPB1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DPA1. Together, they form a functional protein complex called an antigen-binding DPαβ heterodimer. This complex displays foreign peptides to the immune system to trigger the body's immune response.

Each MHC class II gene has many possible variations, allowing the immune system to react to a wide range of foreign invaders. Researchers have identified hundreds of different versions (alleles) of the HLA-DPB1 gene, each of which is given a particular number (such as HLA-DPB1*03:01).

Interactant

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