• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu18636 NM_002122 Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu40288 XM_006715079 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu54837 XM_006725484 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu32852 XM_005274953 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu32852 XM_005275108 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu55023 XM_003846468 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X2, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu55024 XM_005275333 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X4, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu54837 XM_006725999 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu55079 XM_005275542 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu55080 XM_005275544 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X3, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu18636C NM_002122 Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), mRNA. Customized vector On-demand 7-9 $209.00
OHu40288C XM_006715079 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu54837C XM_006725484 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu32852C XM_005274953 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu32852C XM_005275108 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu55023C XM_003846468 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X2, mRNA. Customized vector On-demand 7-9 $209.00
OHu55024C XM_005275333 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X4, mRNA. Customized vector On-demand 7-9 $209.00
OHu54837C XM_006725999 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu55079C XM_005275542 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00
OHu55080C XM_005275544 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), transcript variant X3, mRNA. Customized vector On-demand 7-9 $209.00

*Business Day

Related Services

Gene Symbol HLA-DQA1
Entrez Gene ID 3117
Full Name major histocompatibility complex, class II, DQ alpha 1
Synonyms CD, CELIAC1, DQ-A1, GSE, HLA-DQA
General protein information
Preferred Names
HLA class II histocompatibility antigen, DQ alpha 1 chain
Names
HLA class II histocompatibility antigen, DQ alpha 1 chain
HLA-DCA
DC-alpha
DC-1 alpha chain
MHC HLA-DQ alpha
MHC class II DQA1
MHC class II antigen
leucocyte antigen DQA1
MHC class II HLA-DQ-alpha-1
leukocyte antigen alpha chain
MHC class II surface glycoprotein
MHC class II HLA-D alpha glycoprotein
HLA class II histocompatibility antigen, DQ(W3) alpha chain
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008].
Disorder

MIM: 146880

{Celiac disease, susceptibility to}, 212750 (3)

mRNA Protein Product Sequence Price Select
NM_002122, 52426772 NP_002113, 18426975 HLA class II histocompatibility antigen, DQ alpha 1 chain precursor ORF Sequence $300.00
XM_003846468, 578841861 XP_003846516, 397140048 HLA class II histocompatibility antigen, DQ alpha 1 chain isoformX2 ORF Sequence $300.00
XM_005274953, 578841359 XP_005275010, 530428319 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X1 ORF Sequence $300.00
XM_005275108, 578841636 XP_005275165, 530428646 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X1 ORF Sequence $300.00
XM_005275333, 578841862 XP_005275390, 530429128 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X4 ORF Sequence $250.00
XM_005275542, 578842310 XP_005275599, 530429572 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X1 ORF Sequence $300.00
XM_005275544, 578842311 XP_005275601, 530429576 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X3 ORF Sequence $250.00
XM_006715079, 578811643 XP_006715142, 578811644 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X1 ORF Sequence $250.00
XM_006725484, 578840832 XP_006725547, 578840833 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X1 ORF Sequence $300.00
XM_006725999, 578842077 XP_006726062, 578842078 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform X1 ORF Sequence $300.00
KEGG
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa05320Autoimmune thyroid disease
hsa05332Graft-versus-host disease
hsa05310Asthma
hsa05322Systemic lupus erythematosus
hsa04940Type I diabetes mellitus
hsa05330Allograft rejection
hsa05416Viral myocarditis
hsa04672Intestinal immune network for IgA production
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa04145Phagosome
hsa05150Staphylococcus aureus infection
hsa05323Rheumatoid arthritis
hsa05166HTLV-I infection
hsa05152Tuberculosis
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05321Inflammatory bowel disease (IBD)
WikiPathways
WP2328Allograft Rejection
Reactome
REACT_19344Costimulation by the CD28 family
REACT_19324PD-1 signaling
REACT_6900Immune System
REACT_12555Downstream TCR signaling
REACT_12623Generation of second messenger molecules
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_12526TCR signaling
REACT_75774Adaptive Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_25229Interferon Signaling
REACT_25078Interferon gamma signaling
REACT_121399MHC class II antigen presentation
Homo sapiens (human)HLA-DQA1NP_002113.2
Pan troglodytes (chimpanzee)PATR-DQA1XP_003950844.1
Macaca mulatta (Rhesus monkey)HLA-DQA1XP_001115365.1
Macaca mulatta (Rhesus monkey)MAMU-DQA1NP_001127767.1
Bos taurus (cattle)LOC100848815XP_003587740.1
Mus musculus (house mouse)H2-AaNP_034508.2
Rattus norvegicus (Norway rat)RT1-BaNP_001008831.1
Process
IDNameEvidence
GO:0006955immune responseNAS
GO:0019221cytokine-mediated signaling pathwayTAS
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
GO:0031295T cell costimulationTAS
GO:0050852T cell receptor signaling pathwayTAS
GO:0060333interferon-gamma-mediated signaling pathwayTAS
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0005765lysosomal membraneTAS
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneNAS
GO:0010008endosome membraneIEA
GO:0012507ER to Golgi transport vesicle membraneTAS
GO:0016020membraneIDA
GO:0030658transport vesicle membraneTAS
GO:0030666endocytic vesicle membraneTAS
GO:0030669clathrin-coated endocytic vesicle membraneTAS
GO:0032588trans-Golgi network membraneTAS
GO:0042613MHC class II protein complexISS
GO:0071556integral component of lumenal side of endoplasmic reticulum membraneTAS
Function
IDNameEvidence
GO:0032395MHC class II receptor activityNAS
GO:0032395MHC class II receptor activityTAS
GO:0042605peptide antigen bindingISS
GeneCards HLA-DQA1
UniProt Q5Y7H0, Q30063, Q5Y7D2, L8E864, Q8MH44
Vega OTTHUMG00000031106
MIM 146880
Ensembl ENSG00000196735
HGNC 4942
HPRD 06765

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.