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HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002122 Homo sapiens major histocompatibility complex, class II, DQ alpha 1 (HLA-DQA1), mRNA. ORF Sequence $222.72
Peptide Services
Antibody Services
Protein Services
XM_003846467 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1, transcript variant 1 (HLA-DQA1), mRNA. ORF Sequence $222.72
Peptide Services
Antibody Services
Protein Services
XM_003846468 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1, transcript variant 2 (HLA-DQA1), mRNA. ORF Sequence $222.72
Peptide Services
Antibody Services
Protein Services
XM_003846469 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1, transcript variant 3 (HLA-DQA1), mRNA. ORF Sequence $218.37
Peptide Services
Antibody Services
Protein Services
XM_003846470 PREDICTED: Homo sapiens major histocompatibility complex, class II, DQ alpha 1, transcript variant 4 (HLA-DQA1), mRNA. ORF Sequence $181.83
Peptide Services
Antibody Services
Protein Services


Gene Symbol HLA-DQA1
Entrez Gene ID 3117
Full Name major histocompatibility complex, class II, DQ alpha 1
Synonyms CD, CELIAC1, DQ-A1, FLJ27088, FLJ27328, GSE, HLA-DQA, MGC149527
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes, dendritic cells, macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. [provided by RefSeq, Jul 2008].
Disorder

MIM: 146880

{Celiac disease, susceptibility to}, 212750 (3)

mRNA Protein Product Sequence Price Select
NM_002122, 52426772 NP_002113, 18426975 HLA class II histocompatibility antigen, DQ alpha 1 chain Full Length $447.18
ORF Sequence $222.72
XM_003846467, 397140045 XP_003846515, 397140046 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform 1 Full Length $385.99
ORF Sequence $222.72
XM_003846468, 397140047 XP_003846516, 397140048 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform 2 Full Length $335.53
ORF Sequence $222.72
XM_003846469, 397140049 XP_003846517, 397140050 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform 3 Full Length $370.04
ORF Sequence $218.37
XM_003846470, 397140051 XP_003846518, 397140052 HLA class II histocompatibility antigen, DQ alpha 1 chain isoform 4 Full Length $216.34
ORF Sequence $181.83
KEGG
hsa04145Phagosome
hsa05416Viral myocarditis
hsa05330Allograft rejection
hsa05332Graft-versus-host disease
hsa05145Toxoplasmosis
hsa05169Epstein-Barr virus infection
hsa05310Asthma
hsa05150Staphylococcus aureus infection
hsa05168Herpes simplex infection
hsa04672Intestinal immune network for IgA production
hsa05152Tuberculosis
hsa05322Systemic lupus erythematosus
hsa04612Antigen processing and presentation
hsa04940Type I diabetes mellitus
hsa05140Leishmaniasis
hsa05323Rheumatoid arthritis
hsa05164Influenza A
hsa05320Autoimmune thyroid disease
hsa04514Cell adhesion molecules (CAMs)
hsa05166HTLV-I infection
Reactome
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_75774Adaptive Immune System
REACT_12526TCR signaling
REACT_19344Costimulation by the CD28 family
REACT_121399MHC class II antigen presentation
REACT_25229Interferon Signaling
REACT_6900Immune System
REACT_19324PD-1 signaling
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_75790Cytokine Signaling in Immune system
REACT_25078Interferon gamma signaling
REACT_12555Downstream TCR signaling
REACT_12623Generation of second messenger molecules
Homo sapiens (human)HLA-DQA1NP_002113.2
Pan troglodytes (chimpanzee)PATR-DQA1XP_527352.2
Macaca mulatta (Rhesus monkey)HLA-DQA1XP_001115365.1
Canis lupus familiaris (dog)DLA-DQA1NP_001011726.1
Bos taurus (cattle)BOLA-DQA5NP_001012693.1
Mus musculus (house mouse)H2-AaNP_034508.2
Rattus norvegicus (Norway rat)RT1-BaNP_001008831.1
GeneCards HLA-DQA1
UniProt Q5Y7H0, Q8MH44
MIM 146880
Ensembl ENSG00000196735
HGNC 4942
HPRD 06765

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
HLA class II histocompatibility antigen, DQ alpha 1 chain
Names
HLA class II histocompatibility antigen, DQ alpha 1 chain
HLA-DCA
DC-alpha
DC-1 alpha chain
MHC HLA-DQ alpha
MHC class II DQA1
MHC class II antigen
leucocyte antigen DQA1
MHC class II HLA-DQ-alpha-1
leukocyte antigen alpha chain
MHC class II surface glycoprotein
MHC class II HLA-D alpha glycoprotein
HLA class II histocompatibility antigen, DQ(W3) alpha chain

Interactant

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