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HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001243961 Homo sapiens major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $449.00 14
NM_001243962 Homo sapiens major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_002123 Homo sapiens major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $449.00 14

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Gene Symbol HLA-DQB1
Entrez Gene ID 3119
Full Name major histocompatibility complex, class II, DQ beta 1
General protein information
Preferred Names
HLA class II histocompatibility antigen, DQ beta 1 chain
HLA class II histocompatibility antigen, DQ beta 1 chain
MHC DQ beta
MHC class2 antigen
lymphocyte antigen
MHC class II antigen DQB1
MHC class II DQ beta chain
MHC class II antigen HLA-DQ-beta-1
MHC class II HLA-DQ beta glycoprotein
Gene Type protein-coding
Organism Homo sapiens (human)



Summary HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].

MIM: 604305

{Creutzfeldt-Jakob disease, variant, resistance to}, 123400 (3);

mRNA Protein Product Sequence Price Select
NM_001243961, 345461080 NP_001230890, 345461081 HLA class II histocompatibility antigen, DQ beta 1 chain isoform 2 precursor ORF Sequence $300.00
NM_001243962, 345461078 NP_001230891, 345461079 HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor ORF Sequence $199.00
NM_002123, 345461082 NP_002114, 150418002 HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor ORF Sequence $300.00
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa05320Autoimmune thyroid disease
hsa05332Graft-versus-host disease
hsa05322Systemic lupus erythematosus
hsa04940Type I diabetes mellitus
hsa05330Allograft rejection
hsa05416Viral myocarditis
hsa04672Intestinal immune network for IgA production
hsa05150Staphylococcus aureus infection
hsa05323Rheumatoid arthritis
hsa05166HTLV-I infection
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05321Inflammatory bowel disease (IBD)
WP2328Allograft Rejection
REACT_19344Costimulation by the CD28 family
REACT_19324PD-1 signaling
REACT_6900Immune System
REACT_12555Downstream TCR signaling
REACT_12623Generation of second messenger molecules
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_12526TCR signaling
REACT_75774Adaptive Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_25229Interferon Signaling
REACT_25078Interferon gamma signaling
REACT_121399MHC class II antigen presentation
Homo sapiens (human)HLA-DQB1NP_001230890.1
Pan troglodytes (chimpanzee)LOC100616520XP_003339166.1
Macaca mulatta (Rhesus monkey)MAMU-DQB1NP_001127769.1
Canis lupus familiaris (dog)LOC100856137XP_003639463.1
Canis lupus familiaris (dog)DLA-DQB1NP_001014403.1
Bos taurus (cattle)LA-DQBNP_001074392.1
Bos taurus (cattle)BOLA-DQBNP_001012694.2
Bos taurus (cattle)BLA-DQBNP_001029840.2
Mus musculus (house mouse)H2-Ab1NP_996988.2
Rattus norvegicus (Norway rat)RT1-BbNP_001004084.1
Xenopus (Silurana) tropicalis (western clawed frog)hla-drb1NP_001039259.1
GO:0002381immunoglobulin production involved in immunoglobulin mediated immune responseIDA
GO:0002455humoral immune response mediated by circulating immunoglobulinIDA
GO:0006955immune responseNAS
GO:0019221cytokine-mediated signaling pathwayTAS
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
GO:0031295T cell costimulationTAS
GO:0050852T cell receptor signaling pathwayTAS
GO:0060333interferon-gamma-mediated signaling pathwayTAS
GO:0000139Golgi membraneTAS
GO:0005765lysosomal membraneTAS
GO:0005886plasma membraneTAS
GO:0010008endosome membraneIEA
GO:0012507ER to Golgi transport vesicle membraneTAS
GO:0030658transport vesicle membraneTAS
GO:0030666endocytic vesicle membraneTAS
GO:0030669clathrin-coated endocytic vesicle membraneTAS
GO:0032588trans-Golgi network membraneTAS
GO:0042613MHC class II protein complexISS
GO:0071556integral component of lumenal side of endoplasmic reticulum membraneTAS
GO:0032395MHC class II receptor activityNAS
GO:0042605peptide antigen bindingISS
GeneCards HLA-DQB1
PDB 1UVQ, 1NBN, 1JK8, 4GG6, 1S9V, 2NNA
UniProt Q5Y7A9, Q5Y7D3, P01920, Q5Y7D6, Q5SU54
Vega OTTHUMG00000031124
MIM 604305
Ensembl ENSG00000179344
HGNC 4944
HPRD 05054

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the HLA-DQB1 gene?

The HLA-DQB1 gene provides instructions for making a protein that plays a critical role in the immune system. The HLA-DQB1 gene is part of a family of genes called the human leukocyte antigen (HLA) complex. The HLA complex helps the immune system distinguish the body's own proteins from proteins made by foreign invaders such as viruses and bacteria.

The HLA complex is the human version of the major histocompatibility complex (MHC), a gene family that occurs in many species. The HLA-DQB1 gene belongs to a group of MHC genes called MHC class II. MHC class II genes provide instructions for making proteins that are present on the surface of certain immune system cells. These proteins attach to protein fragments (peptides) outside the cell. MHC class II proteins display these peptides to the immune system. If the immune system recognizes the peptides as foreign (such as viral or bacterial peptides), it triggers a response to attack the invading viruses or bacteria.

The protein produced from the HLA-DQB1 gene attaches (binds) to the protein produced from another MHC class II gene, HLA-DQA1. Together, they form a functional protein complex called an antigen-binding DQαβ heterodimer. This complex displays foreign peptides to the immune system to trigger the body's immune response.

Each MHC class II gene has many possible variations, allowing the immune system to react to a wide range of foreign invaders. Researchers have identified hundreds of different versions (alleles) of the HLA-DQB1 gene, each of which is given a particular number (such as HLA-DQB1*06:02).


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