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HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001243961 Homo sapiens major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), transcript variant 2, mRNA. ORF Sequence $234.90
Peptide Services
Antibody Services
Protein Services
NM_001243962 Homo sapiens major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), transcript variant 3, mRNA. ORF Sequence $227.94
Peptide Services
Antibody Services
Protein Services
NM_002123 Homo sapiens major histocompatibility complex, class II, DQ beta 1 (HLA-DQB1), transcript variant 1, mRNA. ORF Sequence $227.94
Peptide Services
Antibody Services
Protein Services


Gene Symbol HLA-DQB1
Entrez Gene ID 3119
Full Name major histocompatibility complex, class II, DQ beta 1
Synonyms CELIAC1, HLA-DQB, IDDM1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary HLA-DQB1 belongs to the HLA class II beta chain paralogs. This class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and it contains six exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011].
Disorder

MIM: 604305

{Creutzfeldt-Jakob disease, variant, resistance to}, 123400 (3);

mRNA Protein Product Sequence Price Select
NM_001243961, 345461080 NP_001230890, 345461081 HLA class II histocompatibility antigen, DQ beta 1 chain isoform 2 Full Length $482.56
ORF Sequence $234.90
NM_001243962, 345461078 NP_001230891, 345461079 HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor Full Length $475.02
ORF Sequence $227.94
NM_002123, 345461082 NP_002114, 150418002 HLA class II histocompatibility antigen, DQ beta 1 chain isoform 1 precursor Full Length $480.24
ORF Sequence $227.94
KEGG
hsa04612Antigen processing and presentation
hsa05332Graft-versus-host disease
hsa05322Systemic lupus erythematosus
hsa05145Toxoplasmosis
hsa05320Autoimmune thyroid disease
hsa05164Influenza A
hsa05166HTLV-I infection
hsa05416Viral myocarditis
hsa04145Phagosome
hsa05152Tuberculosis
hsa05168Herpes simplex infection
hsa05140Leishmaniasis
hsa05323Rheumatoid arthritis
hsa05330Allograft rejection
hsa04514Cell adhesion molecules (CAMs)
hsa05310Asthma
hsa04672Intestinal immune network for IgA production
hsa05169Epstein-Barr virus infection
hsa05150Staphylococcus aureus infection
hsa04940Type I diabetes mellitus
Reactome
REACT_12623Generation of second messenger molecules
REACT_121399MHC class II antigen presentation
REACT_12555Downstream TCR signaling
REACT_6900Immune System
REACT_25078Interferon gamma signaling
REACT_19324PD-1 signaling
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_25229Interferon Signaling
REACT_75790Cytokine Signaling in Immune system
REACT_12526TCR signaling
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_19344Costimulation by the CD28 family
REACT_75774Adaptive Immune System
Homo sapiens (human)HLA-DQB1NP_002114.3
Pan troglodytes (chimpanzee)LOC100616520XP_003339166.1
Macaca mulatta (Rhesus monkey)MAMU-DQB1NP_001127769.1
Canis lupus familiaris (dog)DLA-DQB1NP_001014403.1
Canis lupus familiaris (dog)LOC100856137XP_003639463.1
Bos taurus (cattle)BLA-DQBNP_001029840.2
Bos taurus (cattle)BOLA-DQBNP_001012694.2
Mus musculus (house mouse)H2-Ab1NP_996988.2
Rattus norvegicus (Norway rat)RT1-BbNP_001004084.1
GeneCards HLA-DQB1
UniProt Q5Y7A9, Q5Y7D3, Q5Y7D6, Q5SU54
MIM 604305
Ensembl ENSG00000179344
HGNC 4944
HPRD 05054

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
HLA class II histocompatibility antigen, DQ beta 1 chain
Names
HLA class II histocompatibility antigen, DQ beta 1 chain
MHC DQ beta
MHC class2 antigen
lymphocyte antigen
MHC class II antigen DQB1
MHC class II DQ beta chain
MHC class II antigen HLA-DQ-beta-1
MHC class II HLA-DQ beta glycoprotein

Interactant

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