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HLA-DRB1 major histocompatibility complex, class II, DR beta 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu27047 NM_002124 Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu29136 NM_001243965 Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu32855 XM_006710243 PREDICTED: Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu27047C NM_002124 Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu29136C NM_001243965 Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00
OHu32855C XM_006710243 PREDICTED: Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol HLA-DRB1
Entrez Gene ID 3123
Full Name major histocompatibility complex, class II, DR beta 1
Synonyms DRB1, DRw10, HLA-DR1B, HLA-DRB, SS1
General protein information
Preferred Names
major histocompatibility complex, class II, DR beta 1
Names
major histocompatibility complex, class II, DR beta 1
DW2.2/DR2.2
MHC class II antigen
lymphocyte antigen DRB1
MHC class II HLA-DRw10-beta
human leucocyte antigen DRB1
MHC class II HLA-DR beta 1 chain
MHC class II HLA-DR-beta cell surface glycoprotein
HLA class II histocompatibility antigen, DR-1 beta chain
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
Disorder

MIM: 142857

{Pemphigoid, susceptibility to} (2); {Sarcoidosis, susceptibility

mRNA Protein Product Sequence Price Select
NM_001243965, 345461075 NP_001230894, 345461076 major histocompatibility complex, class II, DR beta 1 precursor ORF Sequence $199.00
NM_002124, 345461077 NP_002115, 155030211 major histocompatibility complex, class II, DR beta 1 precursor ORF Sequence $199.00
XM_006710243, 578798059 XP_006710306, 578798060 HLA class II histocompatibility antigen, DRB1-7 beta chain ORF Sequence $400.00
KEGG
hsa04612Antigen processing and presentation
hsa04514Cell adhesion molecules (CAMs)
hsa04640Hematopoietic cell lineage
hsa05320Autoimmune thyroid disease
hsa05332Graft-versus-host disease
hsa05310Asthma
hsa05322Systemic lupus erythematosus
hsa04940Type I diabetes mellitus
hsa05330Allograft rejection
hsa05416Viral myocarditis
hsa04672Intestinal immune network for IgA production
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa04145Phagosome
hsa05150Staphylococcus aureus infection
hsa05323Rheumatoid arthritis
hsa05166HTLV-I infection
hsa05152Tuberculosis
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05169Epstein-Barr virus infection
hsa05321Inflammatory bowel disease (IBD)
WikiPathways
WP530Cytokines and Inflammatory Response
WP2328Allograft Rejection
Pathway Interaction Database
cxcr4_pathwayCXCR4-mediated signaling events
il12_stat4pathwayIL12 signaling mediated by STAT4
tcr_pathwayTCR signaling in naive CD4+ T cells
il12_2pathwayIL12-mediated signaling events
Reactome
REACT_19344Costimulation by the CD28 family
REACT_19324PD-1 signaling
REACT_6900Immune System
REACT_12555Downstream TCR signaling
REACT_12623Generation of second messenger molecules
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_12526TCR signaling
REACT_75774Adaptive Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_25229Interferon Signaling
REACT_25078Interferon gamma signaling
REACT_121399MHC class II antigen presentation
Homo sapiens (human)HLA-DRB1NP_002115.2
Pan troglodytes (chimpanzee)PATR-DQB1NP_001258000.1
Macaca mulatta (Rhesus monkey)LOC705588XP_001089877.1
Macaca mulatta (Rhesus monkey)MAMU-DRB5XP_002803731.1
Process
IDNameEvidence
GO:0002381immunoglobulin production involved in immunoglobulin mediated immune responseIDA
GO:0002381immunoglobulin production involved in immunoglobulin mediated immune responseISS
GO:0002437inflammatory response to antigenic stimulusISS
GO:0002455humoral immune response mediated by circulating immunoglobulinIDA
GO:0002455humoral immune response mediated by circulating immunoglobulinISS
GO:0002503peptide antigen assembly with MHC class II protein complexIDA
GO:0002506polysaccharide assembly with MHC class II protein complexIDA
GO:0006955immune responseISS
GO:0006955immune responseNAS
GO:0016045detection of bacteriumISS
GO:0019221cytokine-mediated signaling pathwayTAS
GO:0019886antigen processing and presentation of exogenous peptide antigen via MHC class IITAS
GO:0031295T cell costimulationTAS
GO:0032673regulation of interleukin-4 productionISS
GO:0032689negative regulation of interferon-gamma productionISS
GO:0035774positive regulation of insulin secretion involved in cellular response to glucose stimulusISS
GO:0042088T-helper 1 type immune responseISS
GO:0042130negative regulation of T cell proliferationISS
GO:0050852T cell receptor signaling pathwayTAS
GO:0051262protein tetramerizationISS
GO:0060333interferon-gamma-mediated signaling pathwayTAS
GO:2001179regulation of interleukin-10 secretionISS
Component
IDNameEvidence
GO:0000139Golgi membraneTAS
GO:0005765lysosomal membraneIDA
GO:0005765lysosomal membraneTAS
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0009897external side of plasma membraneISS
GO:0009986cell surfaceIDA
GO:0012507ER to Golgi transport vesicle membraneTAS
GO:0016020membraneIDA
GO:0016020membraneNAS
GO:0030658transport vesicle membraneTAS
GO:0030666endocytic vesicle membraneTAS
GO:0030669clathrin-coated endocytic vesicle membraneTAS
GO:0031902late endosome membraneIDA
GO:0032588trans-Golgi network membraneTAS
GO:0042613MHC class II protein complexIDA
GO:0042613MHC class II protein complexIEA
GO:0042613MHC class II protein complexISS
GO:0070062extracellular vesicular exosomeIDA
GO:0071556integral component of lumenal side of endoplasmic reticulum membraneTAS
Function
IDNameEvidence
GO:0023026MHC class II protein complex bindingIDA
GO:0032395MHC class II receptor activityNAS
GO:0032395MHC class II receptor activityTAS
GO:0042605peptide antigen bindingIDA
GO:0042605peptide antigen bindingISS
GeneCards HLA-DRB1
PDB 1BX2, 2WBJ, 1YMM, 1A6A
UniProt X5DNQ0, P01912, Q5Y7D1, D7RIH8, P01911, Q29974
Vega OTTHUMG00000031196
MIM 142857
Ensembl ENSG00000196126
HGNC 4948
HPRD 08349

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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