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HLA-DRB1 major histocompatibility complex, class II, DR beta 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_001243965 Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), transcript variant 2, mRNA. ORF Sequence $232.29
Peptide Services
Antibody Services
Protein Services
NM_002124 Homo sapiens major histocompatibility complex, class II, DR beta 1 (HLA-DRB1), transcript variant 1, mRNA. ORF Sequence $232.29
Peptide Services
Antibody Services
Protein Services


Gene Symbol HLA-DRB1
Entrez Gene ID 3123
Full Name major histocompatibility complex, class II, DR beta 1
Synonyms DRB1, DRw10, FLJ75017, FLJ76359, HLA-DR1B, HLA-DRB, HLA-DRB1*, SS1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

6

6p21.3

Summary HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; exon 4 encodes the transmembrane domain; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
Disorder

MIM: 142857

{Pemphigoid, susceptibility to} (2); {Sarcoidosis, susceptibility

mRNA Protein Product Sequence Price Select
NM_001243965, 345461075 NP_001230894, 345461076 major histocompatibility complex, class II, DR beta 1 precursor Full Length $357.57
ORF Sequence $232.29
NM_002124, 345461077 NP_002115, 155030211 major histocompatibility complex, class II, DR beta 1 precursor Full Length $371.20
ORF Sequence $232.29
KEGG
hsa05416Viral myocarditis
hsa04940Type I diabetes mellitus
hsa04640Hematopoietic cell lineage
hsa04672Intestinal immune network for IgA production
hsa05310Asthma
hsa05169Epstein-Barr virus infection
hsa05145Toxoplasmosis
hsa04514Cell adhesion molecules (CAMs)
hsa05152Tuberculosis
hsa05150Staphylococcus aureus infection
hsa05322Systemic lupus erythematosus
hsa05168Herpes simplex infection
hsa04612Antigen processing and presentation
hsa05140Leishmaniasis
hsa05332Graft-versus-host disease
hsa05164Influenza A
hsa05330Allograft rejection
hsa05323Rheumatoid arthritis
hsa05320Autoimmune thyroid disease
hsa04145Phagosome
hsa05166HTLV-I infection
WikiPathways
WP530Cytokines and Inflammatory Response
Pathway Interaction Database
il12_stat4pathwayIL12 signaling mediated by STAT4
il12_2pathwayIL12-mediated signaling events
cxcr4_pathwayCXCR4-mediated signaling events
tcr_pathwayTCR signaling in naive CD4+ T cells
Reactome
REACT_75774Adaptive Immune System
REACT_25229Interferon Signaling
REACT_12582Phosphorylation of CD3 and TCR zeta chains
REACT_12623Generation of second messenger molecules
REACT_19344Costimulation by the CD28 family
REACT_12526TCR signaling
REACT_6900Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_12596Translocation of ZAP-70 to Immunological synapse
REACT_25078Interferon gamma signaling
REACT_12555Downstream TCR signaling
REACT_121399MHC class II antigen presentation
REACT_19324PD-1 signaling
Homo sapiens (human)HLA-DRB1NP_002115.2
Macaca mulatta (Rhesus monkey)MAMU-DRB5XP_002803731.1
Bos taurus (cattle)BOLA-DRB2XP_002697362.1
Mus musculus (house mouse)H2-Eb1NP_034512.2
Rattus norvegicus (Norway rat)RT1-Db1NP_001008884.1
GeneCards HLA-DRB1
PDB 1BX2, 2WBJ, 1YMM, 1A6A
UniProt P01912, Q5Y7D1, D7RIH8, P01911, Q29974
MIM 142857
Ensembl ENSG00000196126
HGNC 4948
HPRD 08349

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
major histocompatibility complex, class II, DR beta 1
Names
major histocompatibility complex, class II, DR beta 1
DW2.2/DR2.2
MHC class II antigen
lymphocyte antigen DRB1
MHC class II HLA-DRw10-beta
human leucocyte antigen DRB1
MHC class II HLA-DR beta 1 chain
MHC class II HLA-DR-beta cell surface glycoprotein
HLA class II histocompatibility antigen, DR-1 beta chain

Interactant

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