FOXA3 forkhead box A3 [Homo sapiens (human)]

Gene Symbol	FOXA3
Entrez Gene ID	3171
Full Name	forkhead box A3
Synonyms	FKHH3, HNF3G, MGC10179, TCF3G
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:19 Map Location:19q13.2-q13.4
Summary	This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq].
Disorder	MIM: 602295

mRNA	NM_004497, 24497505
Protein	NP_004488, 24497506
Product	hepatocyte nuclear factor 3-gamma
RefSeq Status	REVIEWED

KEGG

hsa04950

Maturity onset diabetes of the young

Pathway Interaction Database

hnf3bpathway	FOXA2 and FOXA3 transcription factor networks
hnf3pathway	FOXA transcription factor networks
hnf3apathway	FOXA1 transcription factor network

Reactome

REACT_13819	Regulation of gene expression in beta cells
REACT_13698	Regulation of beta-cell development

Homo sapiens (human)	FOXA3	NP_004488.2
Pan troglodytes (chimpanzee)	FOXA3	XP_512763.2
Canis lupus familiaris (dog)	FOXA3	XP_541549.2
Bos taurus (cattle)	FOXA3	NP_001028291.1
Mus musculus (house mouse)	Foxa3	NP_032286.1
Rattus norvegicus (Norway rat)	Foxa3	NP_058773.1
Danio rerio (zebrafish)	foxa3	NP_571374.1

Process

ID	Name	Evidence
GO:0001678	cellular glucose homeostasis	ISS
GO:0001678	cellular glucose homeostasis	TAS
GO:0006351	transcription, DNA-dependent	IDA
GO:0006351	transcription, DNA-dependent	TAS
GO:0007283	spermatogenesis	IEA
GO:0007420	brain development	ISS
GO:0008285	negative regulation of cell proliferation	ISS
GO:0009267	cellular response to starvation	ISS
GO:0009790	embryo development	ISS
GO:0016568	chromatin modification	IEA
GO:0021999	neural plate anterior/posterior regionalization	ISS
GO:0030154	cell differentiation	IEA
GO:0031018	endocrine pancreas development	TAS
GO:0031667	response to nutrient levels	IEA
GO:0045944	positive regulation of transcription from RNA polymerase II promoter	IDA
GO:0048665	neuron fate specification	ISS
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity	ISS
GO:0060441	epithelial tube branching involved in lung morphogenesis	ISS
GO:0060487	lung epithelial cell differentiation	ISS
GO:0070368	positive regulation of hepatocyte differentiation	ISS

Component

ID	Name	Evidence
GO:0005634	nucleus	TAS
GO:0005667	transcription factor complex	ISS
GO:0044428	nuclear part	IEA

Function

ID	Name	Evidence
GO:0003690	double-stranded DNA binding	ISS
GO:0003700	sequence-specific DNA binding transcription factor activity	IDA
GO:0003700	sequence-specific DNA binding transcription factor activity	TAS
GO:0003705	sequence-specific enhancer binding RNA polymerase II transcription factor activity	ISS
GO:0008134	transcription factor binding	ISS
GO:0008301	DNA bending activity	ISS
GO:0019904	protein domain specific binding	ISS
GO:0043565	sequence-specific DNA binding	IEA

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RefSeq Accession	Definition	Sequence	Price	Select
NM_004497	Homo sapiens forkhead box A3 (FOXA3), mRNA.	Full Length	$593.34
NM_004497	Homo sapiens forkhead box A3 (FOXA3), mRNA.	ORF Sequence	$305.37