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FOXA3 forkhead box A3 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25423 NM_004497 Homo sapiens forkhead box A3 (FOXA3), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu25423C NM_004497 Homo sapiens forkhead box A3 (FOXA3), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol FOXA3
Entrez Gene ID 3171
Full Name forkhead box A3
Synonyms FKHH3, HNF3G, TCF3G
General protein information
Preferred Names
hepatocyte nuclear factor 3-gamma
Names
hepatocyte nuclear factor 3-gamma
HNF-3G
TCF-3G
HNF-3-gamma
forkhead box protein A3
transcription factor 3G
fork head-related protein FKH H3
hepatocyte nuclear factor 3, gamma
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.2-q13.4

Summary This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008].
Disorder

MIM: 602295

mRNA Protein Product Sequence Price Select
NM_004497, 24497505 NP_004488, 24497506 hepatocyte nuclear factor 3-gamma ORF Sequence $400.00
KEGG
hsa04950Maturity onset diabetes of the young
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
hnf3apathwayFOXA1 transcription factor network
hnf3pathwayFOXA transcription factor networks
Reactome
REACT_13698Regulation of beta-cell development
REACT_13819Regulation of gene expression in beta cells
REACT_111045Developmental Biology
Homo sapiens (human)FOXA3NP_004488.2
Pan troglodytes (chimpanzee)FOXA3XP_512763.2
Macaca mulatta (Rhesus monkey)FOXA3XP_001111513.1
Canis lupus familiaris (dog)FOXA3XP_541549.3
Bos taurus (cattle)FOXA3NP_001028291.1
Mus musculus (house mouse)Foxa3NP_032286.1
Rattus norvegicus (Norway rat)Foxa3NP_058773.1
Danio rerio (zebrafish)foxa3NP_571374.1
Process
IDNameEvidence
GO:0001678cellular glucose homeostasisTAS
GO:0006366transcription from RNA polymerase II promoterIBA
GO:0007283spermatogenesisIEA
GO:0009267cellular response to starvationIEA
GO:0016568chromatin modificationIEA
GO:0030154cell differentiationIEA
GO:0031018endocrine pancreas developmentTAS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
Component
IDNameEvidence
GO:0005634nucleusIEA
Function
IDNameEvidence
GO:0003700sequence-specific DNA binding transcription factor activityIDA
GO:0003700sequence-specific DNA binding transcription factor activityTAS
GO:0008134transcription factor bindingIEA
GO:0019904protein domain specific bindingIEA
GO:0043565sequence-specific DNA bindingIEA
GO:0044212transcription regulatory region DNA bindingIMP
GeneCards FOXA3
PDB 1VTN
UniProt P55318
Vega OTTHUMG00000182484
MIM 602295
Ensembl ENSG00000170608
HGNC 5023
HPRD 03802

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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