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APC adenomatous polyposis coli [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000038 Homo sapiens adenomatous polyposis coli (APC), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
NM_001127510 Homo sapiens adenomatous polyposis coli (APC), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
NM_001127511 Homo sapiens adenomatous polyposis coli (APC), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $4749.00 40

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Gene Symbol APC
Entrez Gene ID 324
Full Name adenomatous polyposis coli
Synonyms BTPS2, DP2, DP2.5, DP3, GS, PPP1R46
General protein information
Preferred Names
adenomatous polyposis coli protein
Names
adenomatous polyposis coli protein
deleted in polyposis 2.5
adenomatosis polyposis coli tumor suppressor
protein phosphatase 1, regulatory subunit 46
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q21-q22

Summary This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008].
Disorder

MIM: 611731

Adenomatous polyposis coli, 175100 (3); Gastric cancer, somatic,

mRNA Protein Product Sequence Price Select
NM_000038, 307133686 NP_000029, 53759122 adenomatous polyposis coli protein isoform b ORF Sequence $4500.00
NM_001127510, 307133685 NP_001120982, 189011566 adenomatous polyposis coli protein isoform b ORF Sequence $4500.00
NM_001127511, 306922385 NP_001120983, 306922386 adenomatous polyposis coli protein isoform a ORF Sequence $4500.00
KEGG
hsa04310Wnt signaling pathway
hsa05217Basal cell carcinoma
hsa04810Regulation of actin cytoskeleton
hsa05213Endometrial cancer
hsa05200Pathways in cancer
hsa05210Colorectal cancer
hsa05166HTLV-I infection
hsa04390Hippo signaling pathway
hsa05206MicroRNAs in cancer
WikiPathways
WP428Wnt Signaling Pathway
WP363Wnt Signaling Pathway NetPath
WP51Regulation of Actin Cytoskeleton
WP399Wnt Signaling Pathway and Pluripotency
WP710DNA damage response (only ATM dependent)
WP229Irinotecan Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2380BDNF signaling pathway
WP2038Regulation of Microtubule Cytoskeleton
WP2361Gastric cancer network 1
Pathway Interaction Database
ps1pathwayPresenilin action in Notch and Wnt signaling
p53downstreampathwayDirect p53 effectors
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
cdc42_pathwayCDC42 signaling events
cdc42_reg_pathwayRegulation of CDC42 activity
wnt_canonical_pathwayCanonical Wnt signaling pathway
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
Reactome
REACT_578Apoptosis
REACT_107Apoptotic cleavage of cellular proteins
REACT_995Apoptotic execution phase
REACT_11045Signaling by Wnt
REACT_11065Beta-catenin phosphorylation cascade
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_111102Signal Transduction
REACT_200731deactivation of the beta-catenin transactivating complex
REACT_200777TCF dependent signaling in response to WNT
REACT_200610disassembly of the destruction complex and recruitment of AXIN to the membrane
Homo sapiens (human)APCNP_001120982.1
Pan troglodytes (chimpanzee)APCXP_001143965.1
Canis lupus familiaris (dog)APCXP_005618091.1
Bos taurus (cattle)APCNP_001069454.2
Mus musculus (house mouse)ApcNP_031488.2
Rattus norvegicus (Norway rat)ApcNP_036631.1
Gallus gallus (chicken)APCXP_004949340.1
Danio rerio (zebrafish)apcNP_001137312.1
Xenopus (Silurana) tropicalis (western clawed frog)apcXP_004910521.1
Process
IDNameEvidence
GO:0000281mitotic cytokinesisIMP
GO:0001822kidney developmentIEA
GO:0001942hair follicle developmentIEA
GO:0006461protein complex assemblyIDA
GO:0006915apoptotic processTAS
GO:0006921cellular component disassembly involved in execution phase of apoptosisTAS
GO:0006974cellular response to DNA damage stimulusIDA
GO:0007026negative regulation of microtubule depolymerizationIDA
GO:0007026negative regulation of microtubule depolymerizationIMP
GO:0007050cell cycle arrestIDA
GO:0007091metaphase/anaphase transition of mitotic cell cycleIEA
GO:0007094mitotic spindle assembly checkpointIMP
GO:0007155cell adhesionNAS
GO:0007409axonogenesisIEA
GO:0008285negative regulation of cell proliferationIDA
GO:0009798axis specificationIEA
GO:0009952anterior/posterior pattern specificationIEA
GO:0009953dorsal/ventral pattern formationIEA
GO:0009954proximal/distal pattern formationIEA
GO:0016477cell migrationIMP
GO:0030335positive regulation of cell migrationIMP
GO:0030858positive regulation of epithelial cell differentiationIEA
GO:0031116positive regulation of microtubule polymerizationIEA
GO:0031122cytoplasmic microtubule organizationIEA
GO:0031274positive regulation of pseudopodium assemblyIMP
GO:0032886regulation of microtubule-based processIMP
GO:0033077T cell differentiation in thymusIEA
GO:0035019somatic stem cell maintenanceIEA
GO:0042483negative regulation of odontogenesisIEA
GO:0043065positive regulation of apoptotic processIMP
GO:0043409negative regulation of MAPK cascadeIEA
GO:0044336canonical Wnt signaling pathway involved in negative regulation of apoptotic processIEA
GO:0044337canonical Wnt signaling pathway involved in positive regulation of apoptotic processIEA
GO:0045667regulation of osteoblast differentiationIEA
GO:0045670regulation of osteoclast differentiationIEA
GO:0045732positive regulation of protein catabolic processIC
GO:0045732positive regulation of protein catabolic processIGI
GO:0045736negative regulation of cyclin-dependent protein serine/threonine kinase activityIDA
GO:0045785positive regulation of cell adhesionIEA
GO:0046716muscle cell cellular homeostasisIEA
GO:0048538thymus developmentIEA
GO:0051171regulation of nitrogen compound metabolic processIEA
GO:0051276chromosome organizationIEA
GO:0051781positive regulation of cell divisionIEA
GO:0051988regulation of attachment of spindle microtubules to kinetochoreIMP
GO:0051988regulation of attachment of spindle microtubules to kinetochoreNAS
GO:0060041retina development in camera-type eyeIEA
GO:0060070canonical Wnt signaling pathwayIC
GO:0060070canonical Wnt signaling pathwayNAS
GO:0060770negative regulation of epithelial cell proliferation involved in prostate gland developmentIEA
GO:0070830tight junction assemblyNAS
GO:0090090negative regulation of canonical Wnt signaling pathwayIGI
Component
IDNameEvidence
GO:0000776kinetochoreIDA
GO:0005634nucleusIDA
GO:0005737cytoplasmIDA
GO:0005813centrosomeIDA
GO:0005829cytosolTAS
GO:0005881cytoplasmic microtubuleIEA
GO:0005886plasma membraneIDA
GO:0005886plasma membraneIDA
GO:0005913cell-cell adherens junctionIDA
GO:0005923tight junctionIDA
GO:0016328lateral plasma membraneIDA
GO:0030027lamellipodiumIDA
GO:0030877beta-catenin destruction complexIDA
GO:0032587ruffle membraneIDA
GO:0035371microtubule plus-endIEA
GO:0044295axonal growth coneIEA
Function
IDNameEvidence
GO:0005515protein bindingIPI
GO:0008013beta-catenin bindingIPI
GO:0008017microtubule bindingIDA
GO:0019887protein kinase regulator activityIDA
GO:0019901protein kinase bindingIPI
GO:0045295gamma-catenin bindingIPI
GO:0045296cadherin bindingIDA
GO:0051010microtubule plus-end bindingIDA
GeneCards APC
UniProt B7Z2B6, Q4LE70, P25054
Vega OTTHUMG00000128806
MIM 611731
Ensembl ENSG00000134982
HGNC 583
HPRD 01439

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the APC gene?

The APC gene provides instructions for making the APC protein, which plays a critical role in several cellular processes. The APC protein acts as a tumor suppressor, which means that it keeps cells from growing and dividing too fast or in an uncontrolled way. It helps control how often a cell divides, how it attaches to other cells within a tissue, and whether a cell moves within or away from a tissue. This protein also helps ensure that the number of chromosomes in a cell is correct following cell division. The APC protein accomplishes these tasks mainly through association with other proteins, especially those that are involved in cell attachment and signaling.

One protein with which APC associates is beta-catenin. Beta-catenin helps control the activity (expression) of particular genes and promotes the growth and division (proliferation) of cells and the process by which cells mature to carry out specific functions (differentiation). Beta-catenin also helps cells attach to one another and is important for tissue formation. Association of APC with beta-catenin signals for beta-catenin to be broken down when it is no longer needed.

Interactant

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