APC adenomatous polyposis coli [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	APC
Entrez Gene ID	324
Full Name	adenomatous polyposis coli
Synonyms	BTPS2, DP2, DP2.5, DP3, GS
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:5 Map Location:5q21-q22
Summary	This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq].
Disorder	MIM: 611731 Adenomatous polyposis coli, 175100 (3); Gastric cancer, somatic,

mRNA	NM_001127510, 307133685
Protein	NP_001120982, 189011566
Product	adenomatous polyposis coli protein isoform b
RefSeq Status	REVIEWED
mRNA	NM_000038, 307133686
Protein	NP_000029, 53759122
Product	adenomatous polyposis coli protein isoform b
RefSeq Status	REVIEWED
mRNA	NM_001127511, 306922385
Protein	NP_001120983, 306922386
Product	adenomatous polyposis coli protein isoform a
RefSeq Status	REVIEWED

KEGG

hsa05210	Colorectal cancer
hsa05200	Pathways in cancer
hsa04310	Wnt signaling pathway
hsa05217	Basal cell carcinoma
hsa05213	Endometrial cancer
hsa04810	Regulation of actin cytoskeleton

Pathway Interaction Database

cdc42_reg_pathway	Regulation of CDC42 activity
ps1pathway	Presenilin action in Notch and Wnt signaling
wnt_canonical_pathway	Canonical Wnt signaling pathway
wnt_beta_catenin_pathway	Regulation of Wnt-mediated beta catenin signaling and target gene transcription
cdc42_pathway	CDC42 signaling events
p53downstreampathway	Direct p53 effectors
met_pathway	Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

WikiPathways

WP428	Wnt Signaling Pathway
WP710	DNA damage response (only ATM dependent)
WP229	Irinotecan Pathway
WP51	Regulation of Actin Cytoskeleton
WP399	Wnt Signaling Pathway and Pluripotency
WP363	Wnt Signaling Pathway NetPath

Reactome

REACT_11045	Signaling by Wnt
REACT_11063	Degradation of beta-catenin by the destruction complex
REACT_11065	Beta-catenin phosphorylation cascade
REACT_107	Apoptotic cleavage of cellular proteins
REACT_578	Apoptosis
REACT_995	Apoptotic execution phase

Homo sapiens (human)	APC	NP_000029.2
Pan troglodytes (chimpanzee)	APC	XP_001143366.1
Canis lupus familiaris (dog)	APC	XP_536285.2
Bos taurus (cattle)	APC	XP_001787655.1
Mus musculus (house mouse)	Apc	NP_031488.2
Rattus norvegicus (Norway rat)	Apc	NP_036631.1
Gallus gallus (chicken)	APC	XP_001233411.1
Danio rerio (zebrafish)	apc	NP_001137312.1

Process

ID	Name	Evidence
GO:0000281	cytokinesis after mitosis	IMP
GO:0001822	kidney development	IEA
GO:0001942	hair follicle development	IEA
GO:0006461	protein complex assembly	IDA
GO:0006915	apoptosis	TAS
GO:0006921	cellular component disassembly involved in apoptosis	TAS
GO:0006974	response to DNA damage stimulus	IDA
GO:0007026	negative regulation of microtubule depolymerization	IDA
GO:0007026	negative regulation of microtubule depolymerization	IMP
GO:0007050	cell cycle arrest	IDA
GO:0007091	mitotic metaphase/anaphase transition	IEA
GO:0007094	mitotic cell cycle spindle assembly checkpoint	IMP
GO:0007155	cell adhesion	NAS
GO:0007163	establishment or maintenance of cell polarity	IEA
GO:0007409	axonogenesis	IEA
GO:0008285	negative regulation of cell proliferation	IDA
GO:0009798	axis specification	IEA
GO:0009952	anterior/posterior pattern formation	IEA
GO:0009953	dorsal/ventral pattern formation	IEA
GO:0009954	proximal/distal pattern formation	IEA
GO:0016477	cell migration	IMP
GO:0030335	positive regulation of cell migration	IMP
GO:0030858	positive regulation of epithelial cell differentiation	IEA
GO:0031016	pancreas development	IEA
GO:0031116	positive regulation of microtubule polymerization	IEA
GO:0031122	cytoplasmic microtubule organization	IEA
GO:0031175	neuron projection development	IEA
GO:0031274	positive regulation of pseudopodium assembly	IMP
GO:0032886	regulation of microtubule-based process	IMP
GO:0033077	T cell differentiation in thymus	IEA
GO:0035019	somatic stem cell maintenance	IEA
GO:0042483	negative regulation of odontogenesis	IEA
GO:0042493	response to drug	IEA
GO:0043065	positive regulation of apoptosis	IMP
GO:0043066	negative regulation of apoptosis	IEA
GO:0043409	negative regulation of MAPKKK cascade	IEA
GO:0043588	skin development	IEA
GO:0045667	regulation of osteoblast differentiation	IEA
GO:0045670	regulation of osteoclast differentiation	IEA
GO:0045732	positive regulation of protein catabolic process	IC
GO:0045732	positive regulation of protein catabolic process	IGI
GO:0045736	negative regulation of cyclin-dependent protein kinase activity	IDA
GO:0045785	positive regulation of cell adhesion	IEA
GO:0046716	muscle cell homeostasis	IEA
GO:0048538	thymus development	IEA
GO:0051171	regulation of nitrogen compound metabolic process	IEA
GO:0051276	chromosome organization	IEA
GO:0051726	regulation of cell cycle	IEA
GO:0051781	positive regulation of cell division	IEA
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	IMP
GO:0051988	regulation of attachment of spindle microtubules to kinetochore	NAS
GO:0060041	retina development in camera-type eye	IEA
GO:0060070	canonical Wnt receptor signaling pathway	IC
GO:0060070	canonical Wnt receptor signaling pathway	NAS
GO:0060770	negative regulation of epithelial cell proliferation involved in prostate gland development	IEA
GO:0070830	tight junction assembly	NAS
GO:0090090	negative regulation of canonical Wnt receptor signaling pathway	IGI

Component

ID	Name	Evidence
GO:0000776	kinetochore	IDA
GO:0005634	nucleus	IDA
GO:0005737	cytoplasm	IDA
GO:0005813	centrosome	IDA
GO:0005829	cytosol	EXP
GO:0005829	cytosol	TAS
GO:0005856	cytoskeleton	IEA
GO:0005881	cytoplasmic microtubule	IEA
GO:0005886	plasma membrane	IDA
GO:0005886	plasma membrane	IDA
GO:0005913	cell-cell adherens junction	IDA
GO:0005923	tight junction	IDA
GO:0016328	lateral plasma membrane	IDA
GO:0030027	lamellipodium	IDA
GO:0030054	cell junction	IEA
GO:0030877	beta-catenin destruction complex	IDA
GO:0032587	ruffle membrane	IDA
GO:0034742	APC-Axin-1-beta-catenin complex	IDA
GO:0034747	Axin-APC-beta-catenin-GSK3B complex	IDA
GO:0034750	Scrib-APC-beta-catenin complex	IEA
GO:0035371	microtubule plus end	IEA
GO:0043025	neuronal cell body	IEA
GO:0044295	axonal growth cone	IEA
GO:0045202	synapse	IEA

Function

ID	Name	Evidence
GO:0005515	protein binding	IPI
GO:0008013	beta-catenin binding	IPI
GO:0008017	microtubule binding	IDA
GO:0019887	protein kinase regulator activity	IDA
GO:0019901	protein kinase binding	IPI
GO:0045295	gamma-catenin binding	IPI
GO:0045296	cadherin binding	IDA
GO:0051010	microtubule plus-end binding	IDA

GeneCards	APC
PDB	1EMU, 1T08, 1TH1, 2RQU, 1JPP, 1M5I, 1V18, 1DEB
UniProt	B7Z2B6, Q4LE70, P25054
MIM	611731
Ensembl	ENSG00000134982
HGNC	583
HPRD	01439

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RefSeq Accession	Definition	Sequence	Price	Select
NM_001127510	Homo sapiens adenomatous polyposis coli (APC), transcript variant 2, mRNA.	Full Length	Quote
NM_001127510		ORF Sequence	Quote
NM_000038	Homo sapiens adenomatous polyposis coli (APC), transcript variant 3, mRNA.	Full Length	Quote
NM_000038		ORF Sequence	Quote
NM_001127511	Homo sapiens adenomatous polyposis coli (APC), transcript variant 1, mRNA.	Full Length	Quote
NM_001127511		ORF Sequence	Quote

Sequence in raw or FASTA format:

APC adenomatous polyposis coli [Homo sapiens (human)]