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APC adenomatous polyposis coli [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000038 Homo sapiens adenomatous polyposis coli (APC), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
NM_001127510 Homo sapiens adenomatous polyposis coli (APC), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
NM_001127511 Homo sapiens adenomatous polyposis coli (APC), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $4749.00 40

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Gene Symbol APC
Entrez Gene ID 324
Full Name adenomatous polyposis coli
Synonyms BTPS2, DP2, DP2.5, DP3, GS
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product. [provided by RefSeq, Jul 2008].

MIM: 611731

Adenomatous polyposis coli, 175100 (3); Gastric cancer, somatic,

mRNA Protein Product Sequence Price Select
NM_000038, 307133686 NP_000029, 53759122 adenomatous polyposis coli protein isoform b ORF Sequence $4500.00
NM_001127510, 307133685 NP_001120982, 189011566 adenomatous polyposis coli protein isoform b ORF Sequence $4500.00
NM_001127511, 306922385 NP_001120983, 306922386 adenomatous polyposis coli protein isoform a ORF Sequence $4500.00
hsa05166HTLV-I infection
hsa05200Pathways in cancer
hsa05217Basal cell carcinoma
hsa04310Wnt signaling pathway
hsa05210Colorectal cancer
hsa05213Endometrial cancer
hsa04810Regulation of actin cytoskeleton
Pathway Interaction Database
cdc42_pathwayCDC42 signaling events
p53downstreampathwayDirect p53 effectors
met_pathwaySignaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
ps1pathwayPresenilin action in Notch and Wnt signaling
cdc42_reg_pathwayRegulation of CDC42 activity
wnt_canonical_pathwayCanonical Wnt signaling pathway
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
WP399Wnt Signaling Pathway and Pluripotency
WP428Wnt Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP363Wnt Signaling Pathway NetPath
WP2256Integrated Pancreatic Cancer Pathway
WP229Irinotecan Pathway
WP710DNA damage response (only ATM dependent)
WP51Regulation of Actin Cytoskeleton
REACT_11045Signaling by Wnt
REACT_995Apoptotic execution phase
REACT_11063Degradation of beta-catenin by the destruction complex
REACT_11065Beta-catenin phosphorylation cascade
REACT_111102Signal Transduction
REACT_107Apoptotic cleavage of cellular proteins
Homo sapiens (human)APCNP_000029.2
Pan troglodytes (chimpanzee)APCXP_001143965.1
Canis lupus familiaris (dog)APCXP_536285.3
Bos taurus (cattle)APCNP_001069454.2
Mus musculus (house mouse)ApcNP_031488.2
Rattus norvegicus (Norway rat)ApcNP_036631.1
Gallus gallus (chicken)APCXP_001233411.2
Danio rerio (zebrafish)apcNP_001137312.1
GeneCards APC
PDB 3AU3, 1T08, 3QHE, 3RL7, 3NMW, 3RL8, 3NMZ, 1DEB, 3NMX, 3T7U, 1EMU, 4G69, 1TH1, 2RQU, 1JPP, 1V18, 1M5I
UniProt B7Z2B6, Q4LE70, P25054
MIM 611731
Ensembl ENSG00000134982
HGNC 583
HPRD 01439

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
adenomatous polyposis coli protein
adenomatous polyposis coli protein
deleted in polyposis 2.5
adenomatosis polyposis coli tumor suppressor
protein phosphatase 1, regulatory subunit 46


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