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HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000860 Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10
NM_001145816 Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001256301 Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_001256305 Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $299.00 14
NM_001256306 Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001256307 Homo sapiens hydroxyprostaglandin dehydrogenase 15-(NAD) (HPGD), transcript variant 6, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

*Business Day

Related Services

Gene Symbol HPGD
Entrez Gene ID 3248
Full Name hydroxyprostaglandin dehydrogenase 15-(NAD)
Synonyms 15-PGDH, PGDH, PGDH1, PHOAR1, SDR36C1
General protein information
Preferred Names
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
Names
15-hydroxyprostaglandin dehydrogenase [NAD(+)]
prostaglandin dehydrogenase 1
NAD+-dependent 15-hydroxyprostaglandin dehydrogenase
short chain dehydrogenase/reductase family 36C, member 1
NP_000851.2
NP_001139288.1
NP_001243230.1
NP_001243234.1
NP_001243235.1
NP_001243236.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q34-q35

Summary This gene encodes a member of the short-chain nonmetalloenzyme alcohol dehydrogenase protein family. The encoded enzyme is responsible for the metabolism of prostaglandins, which function in a variety of physiologic and cellular processes such as inflammation. Mutations in this gene result in primary autosomal recessive hypertrophic osteoarthropathy and cranioosteoarthropathy. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009].
Disorder

MIM: 601688

Cranioosteoarthropathy, 259100 (3); Hypertrophic osteoarthropathy,

mRNA Protein Product Sequence Price Select
NM_000860, 372624400 NP_000851, 31542939 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 ORF Sequence $199.00
NM_001145816, 372624402 NP_001139288, 224922801 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 2 ORF Sequence $250.00
NM_001256301, 372626409 NP_001243230, 372626410 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3 ORF Sequence $99.00
NM_001256305, 372626420 NP_001243234, 372626421 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 4 ORF Sequence $150.00
NM_001256306, 372626418 NP_001243235, 372626419 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 5 ORF Sequence $250.00
NM_001256307, 372626422 NP_001243236, 372626423 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 3 ORF Sequence $99.00
KEGG
hsa05202Transcriptional misregulation in cancer
WikiPathways
WP98Prostaglandin Synthesis and Regulation
Reactome
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_147851Arachidonic acid metabolism
REACT_150320Synthesis of Lipoxins (LX)
REACT_150149Synthesis of Prostaglandins (PG) and Thromboxanes (TX)
Homo sapiens (human)HPGDNP_000851.2
Pan troglodytes (chimpanzee)HPGDXP_517542.2
Macaca mulatta (Rhesus monkey)HPGDXP_001087957.1
Canis lupus familiaris (dog)HPGDXP_543199.1
Bos taurus (cattle)HPGDNP_001029591.1
Mus musculus (house mouse)HpgdNP_032304.2
Rattus norvegicus (Norway rat)HpgdNP_077366.2
Gallus gallus (chicken)HPGDNP_001264713.1
Danio rerio (zebrafish)LOC565975XP_694331.5
Xenopus (Silurana) tropicalis (western clawed frog)hpgdNP_001007992.1
Process
IDNameEvidence
GO:0006693prostaglandin metabolic processIDA
GO:0007179transforming growth factor beta receptor signaling pathwayIDA
GO:0007565female pregnancyIDA
GO:0007567parturitionIDA
GO:0019369arachidonic acid metabolic processTAS
GO:0019371cyclooxygenase pathwayTAS
GO:0019372lipoxygenase pathwayTAS
GO:0030728ovulationISS
GO:0044281small molecule metabolic processTAS
GO:0045786negative regulation of cell cycleIDA
GO:0055114oxidation-reduction processIEA
GO:0070493thrombin receptor signaling pathwayISS
GO:0097070ductus arteriosus closureISS
GO:2001300lipoxin metabolic processTAS
Component
IDNameEvidence
GO:0005829cytosolNAS
GO:0005829cytosolTAS
GO:0016323basolateral plasma membraneIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0003824catalytic activityIDA
GO:0004957prostaglandin E receptor activityIDA
GO:001640415-hydroxyprostaglandin dehydrogenase (NAD+) activityIDA
GO:001640415-hydroxyprostaglandin dehydrogenase (NAD+) activityNAS
GO:001640415-hydroxyprostaglandin dehydrogenase (NAD+) activityTAS
GO:0042803protein homodimerization activityTAS
GO:0051287NAD bindingIDA
GO:0070403NAD+ bindingIDA
GeneCards HPGD
UniProt P15428
Vega OTTHUMG00000160772
MIM 601688
Ensembl ENSG00000164120
HGNC 5154
HPRD 03406

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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