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HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu14034 NM_000198 Homo sapiens hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2), transcript variant 1, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu14034 NM_001166120 Homo sapiens hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2), transcript variant 2, mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu14034C NM_000198 Homo sapiens hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2), transcript variant 1, mRNA. Customized vector In-stock 5-7 $149.00
OHu14034C NM_001166120 Homo sapiens hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (HSD3B2), transcript variant 2, mRNA. Customized vector In-stock 5-7 $149.00

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Gene Symbol HSD3B2
Entrez Gene ID 3284
Full Name hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
Synonyms HSD3B, HSDB, SDR11E2
General protein information
Preferred Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
Names
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2
3-beta-HSD II
3 beta-HSD type II
progesterone reductase
delta 5-delta 4-isomerase type II
3-beta-HSD adrenal and gonadal type
3-beta-hydroxy-5-ene steroid dehydrogenase
3-beta-hydroxy-Delta(5)-steroid dehydrogenase
short chain dehydrogenase/reductase family 11E, member 2
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II
3 beta-hydroxysteroid dehydrogenase type II, delta 5-delta 4-isomerase type II, 3 beta-HSD type II
NP_000189.1
NP_001159592.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1p13.1

Summary The protein encoded by this gene is a bifunctional enzyme that catalyzes the oxidative conversion of delta(5)-ene-3-beta-hydroxy steroid, and the oxidative conversion of ketosteroids. It plays a crucial role in the biosynthesis of all classes of hormonal steroids. This gene is predominantly expressed in the adrenals and the gonads. Mutations in this gene are associated with 3-beta-hydroxysteroid dehydrogenase, type II, deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009].
Disorder

MIM: 613890

mRNA Protein Product Sequence Price Select
NM_000198, 260763929 NP_000189, 4504509 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 ORF Sequence $269.00
NM_001166120, 260763930 NP_001159592, 260763931 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 2 ORF Sequence $269.00
KEGG
hsa00140Steroid hormone biosynthesis
hsa_M00107Steroid hormone biosynthesis, cholesterol => prognenolone => progesterone
hsa_M00110C19/C18-Steroid hormone biosynthesis, pregnenolone => androstenedione => estrone
hsa04913Ovarian steroidogenesis
WikiPathways
WP496Steroid Biosynthesis
WP237Glucocorticoid & Mineralcorticoid Metabolism
WP2263Prostate Cancer
WP2355Corticotropin-releasing hormone
Reactome
REACT_11047Mineralocorticoid biosynthesis
REACT_11057Metabolism of steroid hormones and vitamin D
REACT_11036Glucocorticoid biosynthesis
REACT_11059Androgen biosynthesis
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
Homo sapiens (human)HSD3B2NP_001159592.1
Pan troglodytes (chimpanzee)HSD3B2XP_001142555.1
Macaca mulatta (Rhesus monkey)LOC100424395XP_002801771.1
Canis lupus familiaris (dog)HSD3B2NP_001010954.1
Bos taurus (cattle)HSD3B1NP_776768.1
Mus musculus (house mouse)Hsd3b1NP_032319.1
Rattus norvegicus (Norway rat)Hsd3bNP_001036084.1
Rattus norvegicus (Norway rat)Hsd3b6NP_058961.4
Rattus norvegicus (Norway rat)LOC100911154XP_006233083.1
Gallus gallus (chicken)HSD3B2NP_990449.1
Danio rerio (zebrafish)si:rp71-68n21.10XP_694204.3
Danio rerio (zebrafish)hsd3b1NP_997962.1
Drosophila melanogaster (fruit fly)CG7724NP_648957.1
Xenopus (Silurana) tropicalis (western clawed frog)LOC100490622XP_004920800.1
Process
IDNameEvidence
GO:0006694steroid biosynthetic processIDA
GO:0006702androgen biosynthetic processTAS
GO:0006704glucocorticoid biosynthetic processTAS
GO:0006705mineralocorticoid biosynthetic processTAS
GO:0008202steroid metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0055114oxidation-reduction processIEA
Component
IDNameEvidence
GO:0005743mitochondrial inner membraneISS
GO:0005758mitochondrial intermembrane spaceISS
GO:0005783endoplasmic reticulumNAS
GO:0005789endoplasmic reticulum membraneTAS
GO:0016021integral component of membraneNAS
GO:0030868smooth endoplasmic reticulum membraneISS
GO:0031966mitochondrial membraneNAS
Function
IDNameEvidence
GO:00038543-beta-hydroxy-delta5-steroid dehydrogenase activityIDA
GO:0004769steroid delta-isomerase activityIDA
GeneCards HSD3B2
UniProt P26439
Vega OTTHUMG00000012526
MIM 613890
Ensembl ENSG00000203859
HGNC 5218
HPRD 01941

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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