Sequence in raw or FASTA format:
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 [
Homo sapiens (human)]
Gene Symbol HSP90AA1
Entrez Gene ID
Full Name heat shock protein 90kDa alpha (cytosolic), class A member 1
Synonyms EL52, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP-2, LAP2
General protein information
heat shock protein HSP 90-alpha
heat shock protein HSP 90-alpha
heat shock 86 kDa
heat shock 90kD protein 1, alpha
heat shock 90kDa protein 1, alpha
renal carcinoma antigen NY-REN-38
heat shock 90kD protein, alpha-like 4
epididymis luminal secretory protein 52
heat shock 90kD protein 1, alpha-like 4
Gene Type protein-coding
Homo sapiens (human)
Chromosome:14 Map Location:14q32.33
Summary The protein encoded by this gene is an inducible molecular chaperone that functions as a homodimer. The encoded protein aids in the proper folding of specific target proteins by use of an ATPase activity that is modulated by co-chaperones. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012].
Pathway Interaction Database
Related articles in PubMed Molecular Mechanism of 17-Allylamino-17-demethoxygeldanamycin (17-AAG)-induced AXL Receptor Tyrosine Kinase Degradation. Krishnamoorthy GP, et al. J Biol Chem, 2013 Jun 14. PMID 23629654. Hsp70 and Hsp90 multichaperone complexes sequentially regulate thiazide-sensitive cotransporter endoplasmic reticulum-associated degradation and biogenesis. Donnelly BF, et al. J Biol Chem, 2013 May 3. PMID 23482560. Proteomic analysis of the NOS2 interactome in human airway epithelial cells. Foster MW, et al. Nitric Oxide, 2013 Feb 21. PMID 23438482. Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels. Gao Y, et al. PLoS One, 2013. PMID 23431407. Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex. Erazo T, et al. Mol Cell Biol, 2013 Apr. PMID 23428871. See all (658) citations in PubMed See citations in PubMed for homologs of this gene provided by HomoloGene
GeneRIFs: Gene References Into Functions
What's a GeneRIF?
Mature wild-type CFTR protein is regulated by dexamethasone post transcription, involving cotranslational mechanisms with HSP90 and HSP70, which enhances maturation and expression of wild-type CFTR
Title: Dexamethasone regulates CFTR expression in Calu-3 cells with the involvement of chaperones HSP70 and HSP90.
High level of HSP90AA1 can increase chemoresistance to cisplatin of SKOV3 cells.
Title: Regulation of survival and chemoresistance by HSP90AA1 in ovarian cancer SKOV3 cells.
ERK5 interacts with the Hsp90-Cdc37 chaperone in resting cells, and inhibition of Hsp90 or Cdc37 results in ERK5 ubiquitylation and proteasomal degradation.
Title: Canonical and kinase activity-independent mechanisms for extracellular signal-regulated kinase 5 (ERK5) nuclear translocation require dissociation of Hsp90 from the ERK5-Cdc37 complex.
The CaM KMT is the major, possibly the single, methyltransferase of calmodulin in human cells with a wide tissue distribution and is a novel Hsp90 client protein.
Title: Human calmodulin methyltransferase: expression, activity on calmodulin, and Hsp90 dependence.
Destruction of the beta-tubulin:CCT-beta complex provokes Hsp90-dependent protein ubiquitination and degradation.
Title: Targeting β-tubulin:CCT-β complexes incurs Hsp90- and VCP-related protein degradation and induces ER stress-associated apoptosis by triggering capacitative Ca(2+) entry, mitochondrial perturbation and caspase overactivation.
the CD91/IKK/NF-kappaB signaling cascade is involved in secreted HSP90alpha-induced TCF12 expression, leading to E-cadherin down-regulation and enhanced CRC cell migration/invasion
Title: Secreted heat shock protein 90α (HSP90α) induces nuclear factor-κB-mediated TCF12 protein expression to down-regulate E-cadherin and to enhance colorectal cancer cell migration and invasion.
TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function
Title: TAp73 protein stability is controlled by histone deacetylase 1 via regulation of Hsp90 chaperone function.
Perturbation of the HSP70-HSP90 heat-shock protein axis stimulates degradation of endothelial VEGFR2.
Title: A heat-shock protein axis regulates VEGFR2 proteolysis, blood vessel development and repair.
high-level expression of HSP90AA1 led to higher risk of death from breast cancer in triple-negative breast cancer patients
Title: Amplification and high-level expression of heat shock protein 90 marks aggressive phenotypes of human epidermal growth factor receptor 2 negative breast cancer.
an essential role for surface Cdc37 in concert with HSP90 on the cell surface during cancer cell invasion processes
Title: Cell surface Cdc37 participates in extracellular HSP90 mediated cancer cell invasion.
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