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HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	HSP90AA1
Entrez Gene ID	3320
Full Name	heat shock protein 90kDa alpha (cytosolic), class A member 1
Synonyms	FLJ31884, HSP86, HSP89A, HSP90A, HSP90N, HSPC1, HSPCA, HSPCAL1, HSPCAL4, HSPN, Hsp89, Hsp90, LAP2
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:14 Map Location:14q32.33
Summary	HSP90 proteins are highly conserved molecular chaperones that have key roles in signal transduction, protein folding, protein degradation, and morphologic evolution. HSP90 proteins normally associate with other cochaperones and play important roles in folding newly synthesized proteins or stabilizing and refolding denatured proteins after stress. There are 2 major cytosolic HSP90 proteins, HSP90AA1, an inducible form, and HSP90AB1 (MIM 140572), a constitutive form. Other HSP90 proteins are found in endoplasmic reticulum (HSP90B1; MIM 191175) and mitochondria (TRAP1; MIM 606219) (Chen et al., 2005 [PubMed 16269234]).[supplied by OMIM].
Disorder	MIM: 140571

mRNA	NM_001017963, 153792589
Protein	NP_001017963, 153792590
Product	heat shock protein HSP 90-alpha isoform 1
RefSeq Status	VALIDATED
mRNA	NM_005348, 154146190
Protein	NP_005339, 154146191
Product	heat shock protein HSP 90-alpha isoform 2
RefSeq Status	VALIDATED

KEGG

hsa04914	Progesterone-mediated oocyte maturation
hsa05200	Pathways in cancer
hsa04621	NOD-like receptor signaling pathway
hsa04612	Antigen processing and presentation
hsa05215	Prostate cancer
hsa04141	Protein processing in endoplasmic reticulum

WikiPathways

WP364	IL-6 Signaling Pathway
WP262	EBV LMP1 signaling
WP49	IL-2 Signaling Pathway
WP231	TNF-alpha/NF-kB Signaling Pathway

Pathway Interaction Database

il2_pi3kpathway	IL2 signaling events mediated by PI3K
erbb_network_pathway	ErbB receptor signaling network
lkb1_pathway	LKB1 signaling events
avb3_integrin_pathway	Integrins in angiogenesis
vegfr1_2_pathway	Signaling events mediated by VEGFR1 and VEGFR2
hif1apathway	Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
myc_activpathway	Validated targets of C-MYC transcriptional activation
ar_tf_pathway	Regulation of Androgen receptor activity
pi3kciaktpathway	Class I PI3K signaling events mediated by Akt
telomerasepathway	Regulation of Telomerase
pi3kcipathway	Class I PI3K signaling events
vegfr1_pathway	VEGFR1 specific signals
hdac_classii_pathway	Signaling events mediated by HDAC Class II
reg_gr_pathway	Glucocorticoid receptor regulatory network

Reactome

REACT_15296	Recruitment of mitotic centrosome proteins and complexes
REACT_6167	Influenza Infection
REACT_15451	Loss of proteins required for interphase microtubule organization##from the centrosome
REACT_2203	G2/M Transition
REACT_12389	eNOS activation and regulation
REACT_18266	Axon guidance
REACT_12508	Metabolism of nitric oxide
REACT_15364	Loss of Nlp from mitotic centrosomes
REACT_19236	Sema3A PAK dependent Axon repulsion
REACT_12477	eNOS activation
REACT_6152	Influenza Viral RNA Transcription and Replication
REACT_152	Cell Cycle, Mitotic
REACT_19271	Semaphorin interactions
REACT_21391	Mitotic G2-G2/M phases
REACT_15479	Centrosome maturation
REACT_9434	vRNP Assembly
REACT_6145	Influenza Life Cycle

Homo sapiens (human)	HSP90AA1	NP_001017963.2
Pan troglodytes (chimpanzee)	HSP90AA1	XP_001160832.1
Canis lupus familiaris (dog)	LOC480438	XP_537557.2
Bos taurus (cattle)	HSP90AA1	NP_001012688.1
Mus musculus (house mouse)	Hsp90aa1	NP_034610.1
Rattus norvegicus (Norway rat)	Hsp90aa1	NP_786937.1
Danio rerio (zebrafish)	hsp90a.2	NP_001038538.1
Arabidopsis thaliana (thale cress)	ATHSP90.1	NP_200076.1

Process

ID	Name	Evidence
GO:0000086	G2/M transition of mitotic cell cycle	TAS
GO:0000278	mitotic cell cycle	TAS
GO:0006200	ATP catabolic process	IDA
GO:0006839	mitochondrial transport	TAS
GO:0006986	response to unfolded protein	NAS
GO:0007165	signal transduction	NAS
GO:0007411	axon guidance	TAS
GO:0034619	cellular chaperone-mediated protein complex assembly	IDA
GO:0042026	protein refolding	TAS
GO:0045040	protein import into mitochondrial outer membrane	IDA
GO:0045429	positive regulation of nitric oxide biosynthetic process	ISS
GO:0046209	nitric oxide metabolic process	TAS
GO:0050999	regulation of nitric-oxide synthase activity	TAS

Component

ID	Name	Evidence
GO:0005622	intracellular	IEA
GO:0005737	cytoplasm	IEA
GO:0005829	cytosol	EXP
GO:0005829	cytosol	NAS
GO:0005829	cytosol	TAS
GO:0005886	plasma membrane	EXP
GO:0005886	plasma membrane	TAS
GO:0042470	melanosome	IEA

Function

ID	Name	Evidence
GO:0000166	nucleotide binding	TAS
GO:0005515	protein binding	IPI
GO:0005524	ATP binding	TAS
GO:0016887	ATPase activity	IDA
GO:0030235	nitric-oxide synthase regulator activity	IDA
GO:0030911	TPR domain binding	IDA
GO:0030911	TPR domain binding	TAS
GO:0042803	protein homodimerization activity	TAS
GO:0051082	unfolded protein binding	IEA

GeneCards	HSP90AA1
PDB	2BSM, 1OSF, 3HEK, 3D0B, 2WI3, 2QFO, 3FT8, 2H55, 3HZ5, 2BZ5, 3EKO, 2CCS, 2K5B, 1YC3, 1UYF, 1UYI, 2BYI, 2VCI, 2WI1, 2XJX, 2XDK, 2FWZ, 2XJG, 1UYH, 2FWY, 1UYL, 1UYE, 3INW, 2XAB, 2QG2, 2XHT, 2XHR, 1UY7, 3EKR, 2QF6, 2BYH, 2WI5, 1UY9, 1YES, 2CDD, 3BMY, 1BYQ, 3FT5, 1UY8, 2BUG, 2WI4, 2UWD, 3MNR, 2WI7, 2XHX, 2BT0, 3K99, 1YER, 2XDU, 3HZ1, 1UYG, 2CCU, 2XDS, 2XDX, 2XK2, 2QG0, 2XJJ, 1UYD, 2WI2, 2XDL, 1UY6, 3HYY, 2VCJ, 1YC4, 3HYZ, 2C2L, 1UYK, 2CCT, 3HHU, 3K98, 2WI6, 1YC1, 3INX, 3K97, 1UYC, 3BM9, 1YET, 2JJC
UniProt	P07900, Q86SX1
MIM	140571
Ensembl	ENSG00000080824
HGNC	5253
HPRD	00777

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