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APOA1 apolipoprotein A-I [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000039 Homo sapiens apolipoprotein A-I (APOA1), mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005271539 PREDICTED: Homo sapiens apolipoprotein A-I (APOA1), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005271540 PREDICTED: Homo sapiens apolipoprotein A-I (APOA1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $449.00 14

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Gene Symbol APOA1
Entrez Gene ID 335
Full Name apolipoprotein A-I
Synonyms
General protein information
Preferred Names
apolipoprotein A-I
Names
apolipoprotein A-I
apo-AI
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q23-q24

Summary This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008].
Disorder

MIM: 107680

ApoA-I and apoC-III deficiency, combined (3);

mRNA Protein Product Sequence Price Select
NM_000039, 4557320 NP_000030, 4557321 apolipoprotein A-I preproprotein ORF Sequence $300.00
XM_005271539, 530398066 XP_005271596, 530398067 apolipoprotein A-I isoform X1 ORF Sequence $300.00
XM_005271540, 530398068 XP_005271597, 530398069 apolipoprotein A-I isoform X2 ORF Sequence $300.00
KEGG
hsa03320PPAR signaling pathway
hsa05143African trypanosomiasis
hsa04975Fat digestion and absorption
hsa04977Vitamin digestion and absorption
WikiPathways
WP15Selenium Pathway
WP176Folate Metabolism
WP430Statin Pathway
WP1533Vitamin B12 Metabolism
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
Reactome
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_318Platelet degranulation
REACT_13621HDL-mediated lipid transport
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
REACT_6841Chylomicron-mediated lipid transport
REACT_15518Transmembrane transport of small molecules
REACT_15480ABC-family proteins mediated transport
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_75925Amyloids
REACT_24968Retinoid metabolism and transport
REACT_111102Signal Transduction
REACT_111158ABCA transporters in lipid homeostasis
REACT_111217Metabolism
REACT_116125Disease
REACT_116145PPARA activates gene expression
REACT_163699Scavenging by Class A Receptors
REACT_163679Scavenging by Class B Receptors
REACT_160102Diseases associated with visual transduction
REACT_160300Binding and Uptake of Ligands by Scavenger Receptors
REACT_160125Visual phototransduction
REACT_160163Scavenging of heme from plasma
Homo sapiens (human)APOA1NP_000030.1
Pan troglodytes (chimpanzee)APOA1XP_001153383.1
Macaca mulatta (Rhesus monkey)APOA1XP_001090774.1
Canis lupus familiaris (dog)APOA1XP_536564.2
Bos taurus (cattle)APOA1NP_776667.2
Mus musculus (house mouse)Apoa1NP_033822.2
Rattus norvegicus (Norway rat)Apoa1NP_036870.1
Gallus gallus (chicken)APOA1NP_990856.1
Danio rerio (zebrafish)apoa1aNP_571203.1
Danio rerio (zebrafish)apoa1bNP_001093614.2
Xenopus (Silurana) tropicalis (western clawed frog)apoa1NP_001005127.1
Process
IDNameEvidence
GO:0001523retinoid metabolic processTAS
GO:0001932regulation of protein phosphorylationIEA
GO:0001935endothelial cell proliferationIEA
GO:0002576platelet degranulationTAS
GO:0002740negative regulation of cytokine secretion involved in immune responseIDA
GO:0006656phosphatidylcholine biosynthetic processIDA
GO:0006695cholesterol biosynthetic processIEA
GO:0007186G-protein coupled receptor signaling pathwayIDA
GO:0007584response to nutrientIEA
GO:0007596blood coagulationTAS
GO:0007603phototransduction, visible lightTAS
GO:0008203cholesterol metabolic processIMP
GO:0008211glucocorticoid metabolic processIEA
GO:0010804negative regulation of tumor necrosis factor-mediated signaling pathwayIDA
GO:0010873positive regulation of cholesterol esterificationIDA
GO:0010903negative regulation of very-low-density lipoprotein particle remodelingIDA
GO:0014012peripheral nervous system axon regenerationIEA
GO:0018158protein oxidationIDA
GO:0018206peptidyl-methionine modificationIDA
GO:0019915lipid storageIEA
GO:0030168platelet activationTAS
GO:0030300regulation of intestinal cholesterol absorptionIEA
GO:0030301cholesterol transportIDA
GO:0030325adrenal gland developmentIEA
GO:0031100organ regenerationIEA
GO:0032489regulation of Cdc42 protein signal transductionIDA
GO:0033344cholesterol effluxIDA
GO:0033700phospholipid effluxIDA
GO:0034115negative regulation of heterotypic cell-cell adhesionIDA
GO:0034375high-density lipoprotein particle remodelingIC
GO:0034380high-density lipoprotein particle assemblyIDA
GO:0034384high-density lipoprotein particle clearanceIC
GO:0042157lipoprotein metabolic processTAS
GO:0042158lipoprotein biosynthetic processIEA
GO:0042493response to drugIEA
GO:0042632cholesterol homeostasisIDA
GO:0042632cholesterol homeostasisIMP
GO:0043534blood vessel endothelial cell migrationIEA
GO:0043627response to estrogenIEA
GO:0043691reverse cholesterol transportIMP
GO:0044255cellular lipid metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0050713negative regulation of interleukin-1 beta secretionIDA
GO:0050728negative regulation of inflammatory responseIDA
GO:0050821protein stabilizationIDA
GO:0051345positive regulation of hydrolase activityIDA
GO:0051347positive regulation of transferase activityIEA
GO:0055085transmembrane transportTAS
GO:0055091phospholipid homeostasisIDA
GO:0060192negative regulation of lipase activityIEA
GO:0060354negative regulation of cell adhesion molecule productionIDA
GO:0060761negative regulation of response to cytokine stimulusIDA
GO:0070328triglyceride homeostasisIDA
GO:0070508cholesterol importIMP
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005615extracellular spaceISS
GO:0005634nucleusIEA
GO:0005769early endosomeTAS
GO:0005788endoplasmic reticulum lumenTAS
GO:0005829cytosolTAS
GO:0005886plasma membraneTAS
GO:0030139endocytic vesicleIDA
GO:0031410cytoplasmic vesicleIDA
GO:0034361very-low-density lipoprotein particleIDA
GO:0034364high-density lipoprotein particleIDA
GO:0034366spherical high-density lipoprotein particleIDA
GO:0034774secretory granule lumenTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0071682endocytic vesicle lumenTAS
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0001540beta-amyloid bindingIDA
GO:0005515protein bindingIPI
GO:0005543phospholipid bindingIDA
GO:0005548phospholipid transporter activityIEA
GO:0008035high-density lipoprotein particle bindingIEA
GO:0015485cholesterol bindingIDA
GO:0017127cholesterol transporter activityIDA
GO:0017127cholesterol transporter activityIMP
GO:0019899enzyme bindingIPI
GO:0034190apolipoprotein receptor bindingIPI
GO:0034191apolipoprotein A-I receptor bindingIPI
GO:0042802identical protein bindingIPI
GO:0055102lipase inhibitor activityIEA
GO:0060228phosphatidylcholine-sterol O-acyltransferase activator activityIDA
GO:0070653high-density lipoprotein particle receptor bindingIPI
GeneCards APOA1
PDB 2A01, 3J00, 1ODR, 1ODP, 1GW3, 3K2S, 1AV1, 1GW4, 3R2P, 1ODQ
UniProt P02647
Vega OTTHUMG00000046112
MIM 107680
Ensembl ENSG00000118137
HGNC 600
HPRD 02517

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the APOA1 gene?

The APOA1 gene provides instructions for making a protein called apolipoprotein A-I (apoA-I). ApoA-I is a component of high-density lipoprotein (HDL). HDL is a molecule that transports cholesterol and certain fats called phospholipids through the bloodstream from the body's tissues to the liver. Once in the liver, cholesterol and phospholipids are redistributed to other tissues or removed from the body.

ApoA-I attaches to cell membranes and promotes the movement of cholesterol and phospholipids from inside the cell to the outer surface. Once outside the cell, these substances combine with apoA-I to form HDL. ApoA-I also triggers a reaction called cholesterol esterification that converts cholesterol to a form that can be fully integrated into HDL and transported through the bloodstream.

HDL is often referred to as "good cholesterol" because high levels of this substance reduce the chances of developing heart and blood vessel (cardiovascular) disease. The process of removing excess cholesterol from cells is extremely important for balancing cholesterol levels and maintaining cardiovascular health.

Interactant

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