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APOA1 apolipoprotein A-I [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu27099D NM_000039 Homo sapiens apolipoprotein A-I (APOA1), mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu27099D XM_005271539 PREDICTED: Homo sapiens apolipoprotein A-I (APOA1), transcript variant X1, mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu27099D XM_005271540 PREDICTED: Homo sapiens apolipoprotein A-I (APOA1), transcript variant X2, mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu27099C NM_000039 Homo sapiens apolipoprotein A-I (APOA1), mRNA. Customized vector In-stock 5-7 Starting from $99
OHu27099C XM_005271539 PREDICTED: Homo sapiens apolipoprotein A-I (APOA1), transcript variant X1, mRNA. Customized vector In-stock 5-7 Starting from $99
OHu27099C XM_005271540 PREDICTED: Homo sapiens apolipoprotein A-I (APOA1), transcript variant X2, mRNA. Customized vector In-stock 5-7 Starting from $99

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Gene Symbol APOA1
Entrez Gene ID 335
Full Name apolipoprotein A-I
General protein information
Preferred Names
apolipoprotein A-I
apolipoprotein A-I
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008].

MIM: 107680

ApoA-I and apoC-III deficiency, combined (3);

mRNA Protein Product Sequence Price Select
NM_000039, 4557320 NP_000030, 4557321 apolipoprotein A-I preproprotein ORF Sequence $300.00
XM_005271539, 530398066 XP_005271596, 530398067 apolipoprotein A-I isoform X1 ORF Sequence $300.00
XM_005271540, 530398068 XP_005271597, 530398069 apolipoprotein A-I isoform X2 ORF Sequence $300.00
hsa03320PPAR signaling pathway
hsa05143African trypanosomiasis
hsa04975Fat digestion and absorption
hsa04977Vitamin digestion and absorption
WP15Selenium Pathway
WP176Folate Metabolism
WP430Statin Pathway
WP1533Vitamin B12 Metabolism
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
REACT_19241Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
REACT_798Platelet activation, signaling and aggregation
REACT_318Platelet degranulation
REACT_13621HDL-mediated lipid transport
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
REACT_6841Chylomicron-mediated lipid transport
REACT_15518Transmembrane transport of small molecules
REACT_15480ABC-family proteins mediated transport
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_24968Retinoid metabolism and transport
REACT_111102Signal Transduction
REACT_111158ABCA transporters in lipid homeostasis
REACT_116145PPARA activates gene expression
REACT_163699Scavenging by Class A Receptors
REACT_163679Scavenging by Class B Receptors
REACT_160102Diseases associated with visual transduction
REACT_160300Binding and Uptake of Ligands by Scavenger Receptors
REACT_160125Visual phototransduction
REACT_160163Scavenging of heme from plasma
Homo sapiens (human)APOA1NP_000030.1
Pan troglodytes (chimpanzee)APOA1XP_001153383.1
Macaca mulatta (Rhesus monkey)APOA1XP_001090774.1
Canis lupus familiaris (dog)APOA1XP_536564.2
Bos taurus (cattle)APOA1NP_776667.2
Mus musculus (house mouse)Apoa1NP_033822.2
Rattus norvegicus (Norway rat)Apoa1NP_036870.1
Gallus gallus (chicken)APOA1NP_990856.1
Danio rerio (zebrafish)apoa1aNP_571203.1
Danio rerio (zebrafish)apoa1bNP_001093614.2
Xenopus (Silurana) tropicalis (western clawed frog)apoa1NP_001005127.1
GO:0001523retinoid metabolic processTAS
GO:0001932regulation of protein phosphorylationIEA
GO:0001935endothelial cell proliferationIEA
GO:0002576platelet degranulationTAS
GO:0002740negative regulation of cytokine secretion involved in immune responseIDA
GO:0006656phosphatidylcholine biosynthetic processIDA
GO:0006695cholesterol biosynthetic processIEA
GO:0007186G-protein coupled receptor signaling pathwayIDA
GO:0007584response to nutrientIEA
GO:0007596blood coagulationTAS
GO:0007603phototransduction, visible lightTAS
GO:0008203cholesterol metabolic processIMP
GO:0008211glucocorticoid metabolic processIEA
GO:0010804negative regulation of tumor necrosis factor-mediated signaling pathwayIDA
GO:0010873positive regulation of cholesterol esterificationIDA
GO:0010903negative regulation of very-low-density lipoprotein particle remodelingIDA
GO:0014012peripheral nervous system axon regenerationIEA
GO:0018158protein oxidationIDA
GO:0018206peptidyl-methionine modificationIDA
GO:0019915lipid storageIEA
GO:0030168platelet activationTAS
GO:0030300regulation of intestinal cholesterol absorptionIEA
GO:0030301cholesterol transportIDA
GO:0030325adrenal gland developmentIEA
GO:0031100organ regenerationIEA
GO:0032489regulation of Cdc42 protein signal transductionIDA
GO:0033344cholesterol effluxIDA
GO:0033700phospholipid effluxIDA
GO:0034115negative regulation of heterotypic cell-cell adhesionIDA
GO:0034375high-density lipoprotein particle remodelingIC
GO:0034380high-density lipoprotein particle assemblyIDA
GO:0034384high-density lipoprotein particle clearanceIC
GO:0042157lipoprotein metabolic processTAS
GO:0042158lipoprotein biosynthetic processIEA
GO:0042493response to drugIEA
GO:0042632cholesterol homeostasisIDA
GO:0042632cholesterol homeostasisIMP
GO:0043534blood vessel endothelial cell migrationIEA
GO:0043627response to estrogenIEA
GO:0043691reverse cholesterol transportIMP
GO:0044255cellular lipid metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0050713negative regulation of interleukin-1 beta secretionIDA
GO:0050728negative regulation of inflammatory responseIDA
GO:0050821protein stabilizationIDA
GO:0051345positive regulation of hydrolase activityIDA
GO:0051347positive regulation of transferase activityIEA
GO:0055085transmembrane transportTAS
GO:0055091phospholipid homeostasisIDA
GO:0060192negative regulation of lipase activityIEA
GO:0060354negative regulation of cell adhesion molecule productionIDA
GO:0060761negative regulation of response to cytokine stimulusIDA
GO:0070328triglyceride homeostasisIDA
GO:0070508cholesterol importIMP
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005615extracellular spaceISS
GO:0005769early endosomeTAS
GO:0005788endoplasmic reticulum lumenTAS
GO:0005886plasma membraneTAS
GO:0030139endocytic vesicleIDA
GO:0031410cytoplasmic vesicleIDA
GO:0034361very-low-density lipoprotein particleIDA
GO:0034364high-density lipoprotein particleIDA
GO:0034366spherical high-density lipoprotein particleIDA
GO:0034774secretory granule lumenTAS
GO:0070062extracellular vesicular exosomeIDA
GO:0071682endocytic vesicle lumenTAS
GO:0072562blood microparticleIDA
GO:0001540beta-amyloid bindingIDA
GO:0005515protein bindingIPI
GO:0005543phospholipid bindingIDA
GO:0005548phospholipid transporter activityIEA
GO:0008035high-density lipoprotein particle bindingIEA
GO:0015485cholesterol bindingIDA
GO:0017127cholesterol transporter activityIDA
GO:0017127cholesterol transporter activityIMP
GO:0019899enzyme bindingIPI
GO:0034190apolipoprotein receptor bindingIPI
GO:0034191apolipoprotein A-I receptor bindingIPI
GO:0042802identical protein bindingIPI
GO:0055102lipase inhibitor activityIEA
GO:0060228phosphatidylcholine-sterol O-acyltransferase activator activityIDA
GO:0070653high-density lipoprotein particle receptor bindingIPI
GeneCards APOA1
PDB 2A01, 3J00, 1ODR, 1ODP, 1GW3, 3K2S, 1AV1, 1GW4, 3R2P, 1ODQ
UniProt P02647
Vega OTTHUMG00000046112
MIM 107680
Ensembl ENSG00000118137
HGNC 600
HPRD 02517

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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