Sequence in raw or FASTA format:
KCNK18 potassium channel, subfamily K, member 18 [Homo sapiens (human)]
| Gene Symbol | KCNK18 |
| Entrez Gene ID | 338567 |
| Full Name | potassium channel, subfamily K, member 18 |
| Synonyms | K2p18.1, MGR13, TRESK, TRESK-2, TRESK2, TRIK |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
10 10q25.3 |
| Summary | Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains and the encoded protein functions as an outward rectifying potassium channel. A mutation in this gene has been found to be associated with migraine with aura. |
| Disorder | MIM: 613655 {Migraine, with or without aura, susceptibility to, 13}, 613656 (3) |
| mRNA | NM_181840, 32469494 |
| Protein | NP_862823, 32469495 |
| Product | potassium channel subfamily K member 18 |
| RefSeq Status | REVIEWED |
| Homo sapiens (human) | KCNK18 | NP_862823.1 |
| Pan troglodytes (chimpanzee) | KCNK18 | XP_521614.2 |
| Canis lupus familiaris (dog) | KCNK18 | XP_544037.1 |
| Bos taurus (cattle) | KCNK18 | XP_582736.2 |
| Mus musculus (house mouse) | Kcnk18 | NP_997144.1 |
| Rattus norvegicus (Norway rat) | Kcnk18 | NP_001003820.1 |
| Gallus gallus (chicken) | KCNK18 | XP_001234729.1 |
| Caenorhabditis elegans | twk-28 | NP_508732.3 |
| Caenorhabditis elegans | twk-31 | NP_001022883.1 |
| Caenorhabditis elegans | twk-42 | NP_507483.1 |
| Caenorhabditis elegans | twk-24 | NP_001023980.1 |
| Caenorhabditis elegans | twk-8 | NP_001023596.1 |
| Caenorhabditis elegans | twk-18 | NP_509516.1 |
| Caenorhabditis elegans | twk-2 | NP_494786.4 |
| Caenorhabditis elegans | twk-40 | NP_499790.1 |
| Caenorhabditis elegans | twk-13 | NP_001122984.1 |
| Caenorhabditis elegans | twk-7 | NP_498903.3 |
| Caenorhabditis elegans | twk-17 | NP_001024462.1 |
| Caenorhabditis elegans | F33D11.5 | NP_491692.1 |
| Caenorhabditis elegans | unc-58 | NP_741880.1 |
| Caenorhabditis elegans | twk-30 | NP_492381.3 |
| Caenorhabditis elegans | twk-32 | NP_506416.2 |
| ID | Name | Evidence |
| GO:0006811 | ion transport | IEA |
| GO:0006813 | potassium ion transport | IDA |
Component
| ID | Name | Evidence |
| GO:0005886 | plasma membrane | IDA |
| GO:0016021 | integral to membrane | IEA |
Function
| ID | Name | Evidence |
| GO:0005216 | ion channel activity | IEA |
| GO:0015269 | calcium-activated potassium channel activity | IEA |
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