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IDH1 isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001282386 Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_001282387 Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $549.00 14
NM_005896 Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol IDH1
Entrez Gene ID 3417
Full Name isocitrate dehydrogenase 1 (NADP+), soluble
Synonyms HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD
General protein information
Preferred Names
isocitrate dehydrogenase [NADP] cytoplasmic
Names
isocitrate dehydrogenase [NADP] cytoplasmic
NADP(+)-specific ICDH
oxalosuccinate decarboxylase
NADP-dependent isocitrate dehydrogenase, cytosolic
NADP-dependent isocitrate dehydrogenase, peroxisomal
NP_005887.2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q33.3

Summary Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013].
Disorder

MIM: 147700

mRNA Protein Product Sequence Price Select
NM_001282386, 538917487 NP_001269315, 538917488 isocitrate dehydrogenase [NADP] cytoplasmic ORF Sequence $400.00
NM_001282387, 538917680 NP_001269316, 538917681 isocitrate dehydrogenase [NADP] cytoplasmic ORF Sequence $400.00
NM_005896, 538917457 NP_005887, 28178825 isocitrate dehydrogenase [NADP] cytoplasmic ORF Sequence $400.00
KEGG
hsa00020Citrate cycle (TCA cycle)
hsa00480Glutathione metabolism
hsa04146Peroxisome
hsa_M00010Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
hsa012102-Oxocarboxylic acid metabolism
hsa01230Biosynthesis of amino acids
hsa01200Carbon metabolism
hsa_M00009Citrate cycle (TCA cycle, Krebs cycle)
WikiPathways
WP100Glutathione metabolism
Reactome
REACT_16957Peroxisomal lipid metabolism
REACT_22258Metabolism of lipids and lipoproteins
REACT_16904NADPH regeneration
REACT_111217Metabolism
REACT_116125Disease
REACT_160183Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
Homo sapiens (human)IDH1NP_005887.2
Pan troglodytes (chimpanzee)IDH1XP_001141655.1
Macaca mulatta (Rhesus monkey)IDH1XP_001107934.1
Canis lupus familiaris (dog)IDH1XP_536047.2
Bos taurus (cattle)IDH1NP_851355.2
Mus musculus (house mouse)Idh1NP_034627.3
Rattus norvegicus (Norway rat)Idh1NP_113698.1
Gallus gallus (chicken)IDH1XP_004942738.1
Danio rerio (zebrafish)idh1NP_958907.1
Drosophila melanogaster (fruit fly)IdhNP_652044.1
Caenorhabditis elegansidh-1NP_001255392.1
Arabidopsis thaliana (thale cress)cICDHNP_176768.1
Process
IDNameEvidence
GO:0006097glyoxylate cycleIEA
GO:0006099tricarboxylic acid cycleIEA
GO:0006102isocitrate metabolic processIDA
GO:00061032-oxoglutarate metabolic processIDA
GO:00061032-oxoglutarate metabolic processTAS
GO:0006740NADPH regenerationTAS
GO:0006749glutathione metabolic processIEA
GO:0006979response to oxidative stressIEA
GO:0008585female gonad developmentIEA
GO:0044255cellular lipid metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0048545response to steroid hormoneIEA
Component
IDNameEvidence
GO:0005737cytoplasmIDA
GO:0005739mitochondrionIEA
GO:0005777peroxisomeIDA
GO:0005782peroxisomal matrixTAS
GO:0005829cytosolIDA
GO:0005829cytosolTAS
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0000287magnesium ion bindingIDA
GO:0004450isocitrate dehydrogenase (NADP+) activityEXP
GO:0004450isocitrate dehydrogenase (NADP+) activityIDA
GO:0005102receptor bindingIPI
GO:0042803protein homodimerization activityIPI
GO:0050661NADP bindingIEA
GO:0051287NAD bindingIEA
GeneCards IDH1
PDB 1T09, 4L06, 3MAP, 1T0L, 4KZO, 4I3K, 3INM, 4L03, 3MAS, 3MAR, 4I3L, 4L04
UniProt V9HWJ2, O75874
Vega OTTHUMG00000132943
MIM 147700
Ensembl ENSG00000138413
HGNC 5382
HPRD 00984

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the IDH1 gene?

The IDH1 gene provides instructions for making an enzyme called isocitrate dehydrogenase 1. This enzyme is primarily found in the fluid-filled space inside cells (the cytoplasm). It is also found in cellular structures called peroxisomes, which are small sacs within cells that process many types of molecules. In both the cytoplasm and in peroxisomes, isocitrate dehydrogenase 1 converts a compound called isocitrate to another compound called 2-ketoglutarate. This reaction also produces a molecule called NADPH, which is necessary for many cellular processes. The NADPH produced from isocitrate dehydrogenase 1 is involved in the breakdown of fats for energy, and it also protects cells from potentially harmful molecules called reactive oxygen species.

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