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IDH1 isocitrate dehydrogenase 1 (NADP+), soluble [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_005896 Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), mRNA. GenEZ ORF Cloning On-demand $549.00 14

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Gene Symbol IDH1
Entrez Gene ID 3417
Full Name isocitrate dehydrogenase 1 (NADP+), soluble
Synonyms IDCD, IDH, IDP, IDPC, PICD
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q33.3

Summary Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. [provided by RefSeq, Jul 2008].
Disorder

MIM: 147700

mRNA Protein Product Sequence Price Select
NM_005896, 28178824 NP_005887, 28178825 isocitrate dehydrogenase [NADP] cytoplasmic ORF Sequence $400.00
KEGG
hsa04146Peroxisome
hsa_M00010Citrate cycle, first carbon oxidation, oxaloacetate => 2-oxoglutarate
hsa00480Glutathione metabolism
hsa00020Citrate cycle (TCA cycle)
WikiPathways
WP100Glutathione metabolism
Reactome
REACT_16904NADPH regeneration
REACT_22258Metabolism of lipids and lipoproteins
REACT_111083The citric acid (TCA) cycle and respiratory electron transport
REACT_111217Metabolism
REACT_1046Pyruvate metabolism and Citric Acid (TCA) cycle
REACT_16957Peroxisomal lipid metabolism
REACT_25367Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
Homo sapiens (human)IDH1NP_005887.2
Pan troglodytes (chimpanzee)IDH1XP_001141655.1
Macaca mulatta (Rhesus monkey)IDH1XP_001107810.1
Canis lupus familiaris (dog)IDH1XP_536047.2
Bos taurus (cattle)IDH1NP_851355.2
Mus musculus (house mouse)Idh1NP_001104790.1
Rattus norvegicus (Norway rat)Idh1NP_113698.1
Gallus gallus (chicken)IDH1XP_421965.2
Danio rerio (zebrafish)idh1NP_958907.1
Drosophila melanogaster (fruit fly)IdhNP_652044.1
Caenorhabditis elegansidh-1NP_501665.1
Arabidopsis thaliana (thale cress)cICDHNP_176768.1
GeneCards IDH1
PDB 3MAS, 3MAR, 1T09, 3MAP, 1T0L, 3INM
UniProt O75874, Q6FHQ6
MIM 147700
Ensembl ENSG00000138413
HGNC 5382
HPRD 00984

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
isocitrate dehydrogenase [NADP] cytoplasmic
Names
isocitrate dehydrogenase [NADP] cytoplasmic
NADP(+)-specific ICDH
oxalosuccinate decarboxylase
NADP-dependent isocitrate dehydrogenase, cytosolic
NADP-dependent isocitrate dehydrogenase, peroxisomal
NP_005887.2

Interactant



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