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APOE apolipoprotein E [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000041 Homo sapiens apolipoprotein E (APOE), mRNA. ORF Sequence $276.66
Peptide Services
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Gene Symbol APOE
Entrez Gene ID 348
Full Name apolipoprotein E
Synonyms AD2, LDLCQ5, LPG, MGC1571
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.2

Summary Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008].
Disorder

MIM: 107741

Hyperlipoproteinemia, type III (3); {Myocardial infarction

mRNA Protein Product Sequence Price Select
NM_000041, 48762938 NP_000032, 4557325 apolipoprotein E precursor Full Length $354.67
ORF Sequence $276.66
KEGG
hsa05010Alzheimer's disease
WikiPathways
WP430Statin Pathway
WP2059Alzheimers Disease
Reactome
REACT_6841Chylomicron-mediated lipid transport
REACT_13621HDL-mediated lipid transport
REACT_22258Metabolism of lipids and lipoproteins
REACT_111217Metabolism
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
Homo sapiens (human)APOENP_000032.1
Pan troglodytes (chimpanzee)APOENP_001009007.1
Macaca mulatta (Rhesus monkey)APOEXP_001104482.2
Canis lupus familiaris (dog)APOEXP_866028.1
Bos taurus (cattle)APOENP_776416.1
Mus musculus (house mouse)ApoeNP_033826.2
Rattus norvegicus (Norway rat)ApoeNP_620183.2
Danio rerio (zebrafish)apoeaNP_001018401.1
Danio rerio (zebrafish)apoebNP_571173.1
GeneCards APOE
PDB 1GS9, 1LE4, 1NFN, 1H7I, 1OEG, 1LE2, 1OR2, 1NFO, 2L7B, 1OR3, 2KC3, 2KNY, 1B68, 1OEF, 1LPE, 1EA8, 1BZ4
UniProt P02649
MIM 107741
Ensembl ENSG00000130203
HGNC 613
HPRD 00135

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
apolipoprotein E
Names
apolipoprotein E
apo-E
apolipoprotein E3

Interactant

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