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APOE apolipoprotein E [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu27296 NM_000041 Homo sapiens apolipoprotein E (APOE), mRNA. pcDNA3.1+-DYK In-stock TBD $99.00
OHu52233 XM_005258867 PREDICTED: Homo sapiens apolipoprotein E (APOE), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand TBD $219.00
OHu27296C NM_000041 Homo sapiens apolipoprotein E (APOE), mRNA. Customized vector In-stock TBD $149.00
OHu52233C XM_005258867 PREDICTED: Homo sapiens apolipoprotein E (APOE), transcript variant X1, mRNA. Customized vector On-demand TBD $269.00

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Gene Symbol APOE
Entrez Gene ID 348
Full Name apolipoprotein E
Synonyms AD2, LDLCQ5, LPG
General protein information
Preferred Names
apolipoprotein E
Names
apolipoprotein E
apo-E
apolipoprotein E3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

19

19q13.2

Summary Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008].
Disorder

MIM: 107741

Hyperlipoproteinemia, type III (3); {Myocardial infarction

mRNA Protein Product Sequence Price Select
NM_000041, 48762938 NP_000032, 4557325 apolipoprotein E precursor ORF Sequence $269.00
XM_005258867, 530416440 XP_005258924, 530416441 apolipoprotein E isoform X1 ORF Sequence $400.00
KEGG
hsa05010Alzheimer's disease
WikiPathways
WP430Statin Pathway
WP2059Alzheimers Disease
WP1533Vitamin B12 Metabolism
Reactome
REACT_13621HDL-mediated lipid transport
REACT_602Lipid digestion, mobilization, and transport
REACT_6823Lipoprotein metabolism
REACT_6841Chylomicron-mediated lipid transport
REACT_22258Metabolism of lipids and lipoproteins
REACT_24968Retinoid metabolism and transport
REACT_111102Signal Transduction
REACT_111217Metabolism
REACT_116125Disease
REACT_163699Scavenging by Class A Receptors
REACT_160102Diseases associated with visual transduction
REACT_160300Binding and Uptake of Ligands by Scavenger Receptors
REACT_160125Visual phototransduction
Homo sapiens (human)APOENP_000032.1
Pan troglodytes (chimpanzee)APOENP_001009007.1
Macaca mulatta (Rhesus monkey)APOEXP_001104482.2
Canis lupus familiaris (dog)APOEXP_866043.1
Bos taurus (cattle)APOENP_776416.1
Mus musculus (house mouse)ApoeNP_033826.2
Rattus norvegicus (Norway rat)ApoeNP_620183.2
Xenopus (Silurana) tropicalis (western clawed frog)apoeXP_004912063.1
Process
IDNameEvidence
GO:0000302response to reactive oxygen speciesNAS
GO:0001523retinoid metabolic processTAS
GO:0001937negative regulation of endothelial cell proliferationIDA
GO:0002021response to dietary excessIEA
GO:0006641triglyceride metabolic processIDA
GO:0006641triglyceride metabolic processIMP
GO:0006707cholesterol catabolic processIEA
GO:0006874cellular calcium ion homeostasisIEA
GO:0006898receptor-mediated endocytosisIDA
GO:0007010cytoskeleton organizationTAS
GO:0007186G-protein coupled receptor signaling pathwayIDA
GO:0007263nitric oxide mediated signal transductionIDA
GO:0007271synaptic transmission, cholinergicTAS
GO:0007568agingIEA
GO:0007603phototransduction, visible lightTAS
GO:0008203cholesterol metabolic processIDA
GO:0008203cholesterol metabolic processIMP
GO:0008219cell deathIEA
GO:0010544negative regulation of platelet activationIDA
GO:0010873positive regulation of cholesterol esterificationIDA
GO:0010875positive regulation of cholesterol effluxIDA
GO:0010875positive regulation of cholesterol effluxIGI
GO:0014012peripheral nervous system axon regenerationIEA
GO:0015909long-chain fatty acid transportIDA
GO:0017038protein importIDA
GO:0019934cGMP-mediated signalingIDA
GO:0030195negative regulation of blood coagulationIDA
GO:0030516regulation of axon extensionTAS
GO:0030828positive regulation of cGMP biosynthetic processIDA
GO:0032489regulation of Cdc42 protein signal transductionIDA
GO:0032526response to retinoic acidIEA
GO:0032805positive regulation of low-density lipoprotein particle receptor catabolic processIDA
GO:0032868response to insulinIEA
GO:0033344cholesterol effluxIDA
GO:0033700phospholipid effluxIDA
GO:0034372very-low-density lipoprotein particle remodelingIDA
GO:0034372very-low-density lipoprotein particle remodelingIGI
GO:0034374low-density lipoprotein particle remodelingIEA
GO:0034375high-density lipoprotein particle remodelingIGI
GO:0034380high-density lipoprotein particle assemblyIDA
GO:0034382chylomicron remnant clearanceIMP
GO:0034384high-density lipoprotein particle clearanceIDA
GO:0034447very-low-density lipoprotein particle clearanceIDA
GO:0034447very-low-density lipoprotein particle clearanceIMP
GO:0042157lipoprotein metabolic processTAS
GO:0042158lipoprotein biosynthetic processIEA
GO:0042159lipoprotein catabolic processIEA
GO:0042311vasodilationIEA
GO:0042632cholesterol homeostasisIDA
GO:0043407negative regulation of MAP kinase activityIDA
GO:0043524negative regulation of neuron apoptotic processIEA
GO:0043537negative regulation of blood vessel endothelial cell migrationIDA
GO:0043691reverse cholesterol transportIDA
GO:0044281small molecule metabolic processTAS
GO:0045471response to ethanolIEA
GO:0045541negative regulation of cholesterol biosynthetic processIDA
GO:0045773positive regulation of axon extensionIEA
GO:0046889positive regulation of lipid biosynthetic processIDA
GO:0046907intracellular transportTAS
GO:0048168regulation of neuronal synaptic plasticityTAS
GO:0048709oligodendrocyte differentiationIEA
GO:0048844artery morphogenesisIEA
GO:0050728negative regulation of inflammatory responseIC
GO:0051000positive regulation of nitric-oxide synthase activityIDA
GO:0051044positive regulation of membrane protein ectodomain proteolysisIDA
GO:0051055negative regulation of lipid biosynthetic processIDA
GO:0051651maintenance of location in cellIEA
GO:0055089fatty acid homeostasisIDA
GO:0060999positive regulation of dendritic spine developmentIDA
GO:0061000negative regulation of dendritic spine developmentIDA
GO:0071347cellular response to interleukin-1IEA
GO:0071363cellular response to growth factor stimulusIEA
GO:0071397cellular response to cholesterolIEA
GO:0090370negative regulation of cholesterol effluxIDA
GO:0097113alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor clusteringIDA
GO:0097114N-methyl-D-aspartate receptor clusteringIDA
GO:1900221regulation of beta-amyloid clearanceIDA
GO:1901214regulation of neuron deathIDA
GO:1901215negative regulation of neuron deathIDA
GO:1901216positive regulation of neuron deathIDA
GO:1901627negative regulation of postsynaptic membrane organizationIDA
GO:1901628positive regulation of postsynaptic membrane organizationIDA
GO:1901630negative regulation of presynaptic membrane organizationIDA
GO:1901631positive regulation of presynaptic membrane organizationIDA
GO:1902004positive regulation of beta-amyloid formationIDA
GO:1902430negative regulation of beta-amyloid formationIDA
GO:1902947regulation of tau-protein kinase activityIDA
GO:1902951negative regulation of dendritic spine maintenanceIDA
GO:1902952positive regulation of dendritic spine maintenanceIDA
GO:1902995positive regulation of phospholipid effluxIDA
GO:1902998positive regulation of neurofibrillary tangle assemblyIDA
GO:1902999negative regulation of phospholipid effluxIDA
GO:1903001negative regulation of lipid transport across blood brain barrierIDA
GO:1903002positive regulation of lipid transport across blood brain barrierIDA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005634nucleusIDA
GO:0005737cytoplasmNAS
GO:0005737cytoplasmTAS
GO:0005769early endosomeTAS
GO:0005770late endosomeIEA
GO:0005794Golgi apparatusIEA
GO:0005886plasma membraneTAS
GO:0016020membraneIDA
GO:0030425dendriteNAS
GO:0031232extrinsic component of external side of plasma membraneIEA
GO:0034361very-low-density lipoprotein particleIDA
GO:0034362low-density lipoprotein particleIDA
GO:0034363intermediate-density lipoprotein particleIDA
GO:0034364high-density lipoprotein particleIDA
GO:0042627chylomicronIDA
GO:0043025neuronal cell bodyNAS
GO:0070062extracellular vesicular exosomeIDA
GO:0071682endocytic vesicle lumenTAS
GO:0072562blood microparticleIDA
Function
IDNameEvidence
GO:0001540beta-amyloid bindingIDA
GO:0005319lipid transporter activityIDA
GO:0005515protein bindingIPI
GO:0005543phospholipid bindingIDA
GO:0008201heparin bindingIDA
GO:0008289lipid bindingIDA
GO:0016209antioxidant activityIDA
GO:0017127cholesterol transporter activityIEA
GO:0042802identical protein bindingIDA
GO:0042803protein homodimerization activityIPI
GO:0046848hydroxyapatite bindingIEA
GO:0046911metal chelating activityIDA
GO:0048156tau protein bindingIPI
GO:0050750low-density lipoprotein particle receptor bindingIDA
GO:0050750low-density lipoprotein particle receptor bindingIPI
GO:0060228phosphatidylcholine-sterol O-acyltransferase activator activityIDA
GO:0070326very-low-density lipoprotein particle receptor bindingIDA
GO:0070326very-low-density lipoprotein particle receptor bindingIPI
GO:0071813lipoprotein particle bindingIEA
GeneCards APOE
PDB 1GS9, 1LE4, 1NFN, 1H7I, 1OEG, 1LE2, 1OR2, 1NFO, 2L7B, 1OR3, 2KC3, 2KNY, 1B68, 1OEF, 1LPE, 1EA8, 1BZ4
UniProt P02649
Vega OTTHUMG00000128901
MIM 107741
Ensembl ENSG00000130203
HGNC 613
HPRD 00135

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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