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IGF2 insulin-like growth factor 2 (somatomedin A) [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000612 Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001007139 Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001127598 Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001291861 Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $399.00 14
NM_001291862 Homo sapiens insulin-like growth factor 2 (somatomedin A) (IGF2), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $399.00 14

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Gene Symbol IGF2
Entrez Gene ID 3481
Full Name insulin-like growth factor 2 (somatomedin A)
Synonyms C11orf43, IGF-II, PP9974
General protein information
Preferred Names
insulin-like growth factor II
Names
insulin-like growth factor II
somatomedin-A
insulin-like growth factor type 2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.5

Summary This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in development and growth. It is an imprinted gene, expressed only from the paternal allele, and epigenetic changes at this locus are associated with Wilms tumour, Beckwith-Wiedemann syndrome, rhabdomyosarcoma, and Silver-Russell syndrome. A read-through INS-IGF2 gene exists, whose 5' region overlaps the INS gene and the 3' region overlaps this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2010].
Disorder

MIM: 147470

Intrauterine and postnatal growth retardation (1)

mRNA Protein Product Sequence Price Select
NM_000612, 183603939 NP_000603, 4504609 insulin-like growth factor II isoform 1 preproprotein ORF Sequence $250.00
NM_001007139, 183603938 NP_001007140, 108796063 insulin-like growth factor II isoform 1 preproprotein ORF Sequence $250.00
NM_001127598, 189083845 NP_001121070, 189083846 insulin-like growth factor II isoform 2 ORF Sequence $250.00
NM_001291861, 630044871 NP_001278790, 630044872 insulin-like growth factor II isoform 1 preproprotein ORF Sequence $250.00
NM_001291862, 630044873 NP_001278791, 630044874 insulin-like growth factor II isoform 1 preproprotein ORF Sequence $250.00
KEGG
hsa05205Proteoglycans in cancer
WikiPathways
WP254Apoptosis
WP474Endochondral Ossification
WP47Hedgehog Signaling Pathway
WP2406Cardiac Progenitor Differentiation
Reactome
REACT_15428Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_17015Metabolism of proteins
REACT_111102Signal Transduction
REACT_150359Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
REACT_150139SHC-related events triggered by IGF1R
REACT_150203IRS-related events triggered by IGF1R
REACT_150210IGF1R signaling cascade
Homo sapiens (human)IGF2NP_001121070.1
Pan troglodytes (chimpanzee)IGF2XP_001153640.3
Macaca mulatta (Rhesus monkey)LOC721120XP_002799486.1
Canis lupus familiaris (dog)IGF2NP_001182755.1
Bos taurus (cattle)IGF2NP_776512.2
Mus musculus (house mouse)Igf2NP_034644.2
Rattus norvegicus (Norway rat)Igf2NP_113699.2
Gallus gallus (chicken)IGF2NP_001025513.1
Danio rerio (zebrafish)igf2bNP_001001815.1
Danio rerio (zebrafish)igf2aNP_571508.1
Xenopus (Silurana) tropicalis (western clawed frog)igf2NP_001107144.1
Process
IDNameEvidence
GO:0001501skeletal system developmentTAS
GO:0001649osteoblast differentiationIEA
GO:0001934positive regulation of protein phosphorylationISS
GO:0002576platelet degranulationTAS
GO:0006006glucose metabolic processIEA
GO:0006349regulation of gene expression by genetic imprintingTAS
GO:0006355regulation of transcription, DNA-templatedNAS
GO:0007275multicellular organismal developmentTAS
GO:0007565female pregnancyIEA
GO:0007596blood coagulationTAS
GO:0007613memoryIEA
GO:0008284positive regulation of cell proliferationIC
GO:0008286insulin receptor signaling pathwayTAS
GO:0009314response to radiationIEA
GO:0009887organ morphogenesisIEA
GO:0030168platelet activationTAS
GO:0031017exocrine pancreas developmentIEA
GO:0031667response to nutrient levelsIEA
GO:0032355response to estradiolIEA
GO:0035094response to nicotineIEA
GO:0038028insulin receptor signaling pathway via phosphatidylinositol 3-kinaseISS
GO:0042104positive regulation of activated T cell proliferationIDA
GO:0042493response to drugIEA
GO:0043085positive regulation of catalytic activityISS
GO:0043410positive regulation of MAPK cascadeIDA
GO:0044267cellular protein metabolic processTAS
GO:0045471response to ethanolIEA
GO:0045725positive regulation of glycogen biosynthetic processISS
GO:0045840positive regulation of mitosisIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0046628positive regulation of insulin receptor signaling pathwayIDA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationISS
GO:0051146striated muscle cell differentiationIEA
GO:0051781positive regulation of cell divisionIEA
GO:0051897positive regulation of protein kinase B signalingIDA
GO:0071260cellular response to mechanical stimulusIEA
GO:0071902positive regulation of protein serine/threonine kinase activityIEA
GO:0090031positive regulation of steroid hormone biosynthetic processIEA
GO:2000273positive regulation of receptor activityIEA
GO:2000467positive regulation of glycogen (starch) synthase activityISS
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIEA
GO:0005886plasma membraneTAS
GO:0031093platelet alpha granule lumenTAS
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0005158insulin receptor bindingIPI
GO:0005159insulin-like growth factor receptor bindingIEA
GO:0005179hormone activityIEA
GO:0005515protein bindingIPI
GO:0008083growth factor activityIDA
GO:0030546receptor activator activityISS
GO:0043539protein serine/threonine kinase activator activityISS
GeneCards IGF2
UniProt E3UN46, P01344
Vega OTTHUMG00000009395
MIM 147470
Ensembl ENSG00000167244
HGNC 5466
HPRD 17410

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the IGF2 gene?

The IGF2 gene provides instructions for making a protein called insulin-like growth factor 2. This protein plays an essential role in growth and development before birth. Studies suggest that insulin-like growth factor 2 promotes the growth and division (proliferation) of cells in many different tissues. Although the IGF2 gene is highly active during fetal development, it is much less active in the adult body.

People inherit one copy of most genes from their mother and one copy from their father. Both copies are typically active, or "turned on," in cells. For the IGF2 gene, however, the copy that is inherited from a person's father is the only active copy in most parts of the body. This sort of parent-specific difference in gene activation is caused by a phenomenon called genomic imprinting.

IGF2 is part of a cluster of genes on the short (p) arm of chromosome 11 that undergo genomic imprinting. Another gene in this cluster, H19, is also involved in growth and development. A nearby region of DNA known as imprinting center 1 (ICR1) or the H19 differentially methylated region (H19 DMR) controls the parent-specific genomic imprinting of both the H19 and IGF2 genes.

Interactant

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