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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


APP amyloid beta (A4) precursor protein [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000484 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1, mRNA. ORF Sequence $670.77
Peptide Services
Antibody Services
Protein Services
NM_001136016 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 4, mRNA. ORF Sequence $649.89
Peptide Services
Antibody Services
Protein Services
NM_001136129 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 5, mRNA. ORF Sequence $556.80
Peptide Services
Antibody Services
Protein Services
NM_001136130 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 6, mRNA. ORF Sequence $622.05
Peptide Services
Antibody Services
Protein Services
NM_001136131 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 7, mRNA. ORF Sequence $575.07
Peptide Services
Antibody Services
Protein Services
NM_001204301 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 8, mRNA. ORF Sequence $655.11
Peptide Services
Antibody Services
Protein Services
NM_001204302 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 9, mRNA. ORF Sequence $638.58
Peptide Services
Antibody Services
Protein Services
NM_001204303 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 10, mRNA. ORF Sequence $589.86
Peptide Services
Antibody Services
Protein Services
NM_201413 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 2, mRNA. ORF Sequence $654.24
Peptide Services
Antibody Services
Protein Services
NM_201414 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 3, mRNA. ORF Sequence $605.52
Peptide Services
Antibody Services
Protein Services


Gene Symbol APP
Entrez Gene ID 351
Full Name amyloid beta (A4) precursor protein
Synonyms AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

21

21q21.2|21q21.3

Summary This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 104760

Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic

mRNA Protein Product Sequence Price Select
NM_000484, 228008403 NP_000475, 4502167 amyloid beta A4 protein isoform a precursor Full Length $1276.80
ORF Sequence $670.77
NM_001136016, 324021746 NP_001129488, 209862833 amyloid beta A4 protein isoform d Full Length $1250.20
ORF Sequence $649.89
NM_001136129, 228008402 NP_001129601, 209915570 amyloid beta A4 protein isoform e precursor Full Length $1139.25
ORF Sequence $556.80
NM_001136130, 228008401 NP_001129602, 209915573 amyloid beta A4 protein isoform f precursor Full Length $1218.00
ORF Sequence $622.05
NM_001136131, 324021747 NP_001129603, 209915575 amyloid beta A4 protein isoform g Full Length $1158.50
ORF Sequence $575.07
NM_001204301, 324021737 NP_001191230, 324021738 amyloid beta A4 protein isoform h Full Length $1257.90
ORF Sequence $655.11
NM_001204302, 324021735 NP_001191231, 324021736 amyloid beta A4 protein isoform i Full Length $1237.95
ORF Sequence $638.58
NM_001204303, 324021739 NP_001191232, 324021740 amyloid beta A4 protein isoform j Full Length $1179.15
ORF Sequence $589.86
NM_201413, 228008404 NP_958816, 41406055 amyloid beta A4 protein isoform b precursor Full Length $1256.85
ORF Sequence $654.24
NM_201414, 228008405 NP_958817, 41406057 amyloid beta A4 protein isoform c precursor Full Length $1198.05
ORF Sequence $605.52
KEGG
hsa05010Alzheimer's disease
hsa04726Serotonergic synapse
Pathway Interaction Database
caspase_pathwayCaspase cascade in apoptosis
glypican_1pathwayGlypican 1 network
p75ntrpathwayp75(NTR)-mediated signaling
WikiPathways
WP2256Integrated Pancreatic Cancer Pathway
WP61Delta-Notch Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2059Alzheimers Disease
Reactome
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_75808The NLRP3 inflammasome
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_798Platelet activation, signaling and aggregation
REACT_19184GPCR downstream signaling
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_111102Signal Transduction
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_6890Activated TLR4 signalling
REACT_21340GPCR ligand binding
REACT_118563RIP-mediated NFkB activation via DAI
REACT_75900Inflammasomes
REACT_116125Disease
REACT_18283G alpha (q) signalling events
REACT_75925Amyloids
REACT_6900Immune System
REACT_25195Advanced glycosylation endproduct receptor signaling
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_318Platelet degranulation
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_604Hemostasis
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_118764DAI mediated induction of type I IFNs
REACT_6802Innate Immune System
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_25281NFkB and MAP kinases activation mediated by TLR4 signaling repertoire
REACT_6809MyD88-independent cascade
REACT_21264Formyl peptide receptors bind formyl peptides and many other ligands
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_19231G alpha (i) signalling events
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6966Toll Receptor Cascades
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_24969TRAF6 mediated NF-kB activation
Homo sapiens (human)APPNP_958817.1
Mus musculus (house mouse)AppNP_031497.2
Danio rerio (zebrafish)appbNP_690842.1

Related articles in PubMed

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General protein information

Preferred Names
amyloid beta A4 protein
Names
amyloid beta A4 protein
preA4
protease nexin-II
peptidase nexin-II
beta-amyloid peptide
alzheimer disease amyloid protein
cerebral vascular amyloid peptide

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