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APP amyloid beta (A4) precursor protein [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000484 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
NM_001136016 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001136129 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 5, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001136130 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 6, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001136131 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 7, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001204301 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 8, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001204302 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 9, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_001204303 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 10, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_201413 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $849.00 20
NM_201414 Homo sapiens amyloid beta (A4) precursor protein (APP), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $849.00 20

*Business Day

Related Services

Gene Symbol APP
Entrez Gene ID 351
Full Name amyloid beta (A4) precursor protein
Synonyms AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2
General protein information
Preferred Names
amyloid beta A4 protein
Names
amyloid beta A4 protein
preA4
protease nexin-II
peptidase nexin-II
beta-amyloid peptide
alzheimer disease amyloid protein
cerebral vascular amyloid peptide
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

21

21q21.3

Summary This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Disorder

MIM: 104760

Cerebral amyloid angiopathy, Dutch, Italian, Iowa, Flemish, Arctic

mRNA Protein Product Sequence Price Select
NM_000484, 228008403 NP_000475, 4502167 amyloid beta A4 protein isoform a precursor ORF Sequence $750.00
NM_001136016, 324021746 NP_001129488, 209862833 amyloid beta A4 protein isoform d ORF Sequence $700.00
NM_001136129, 228008402 NP_001129601, 209915570 amyloid beta A4 protein isoform e precursor ORF Sequence $700.00
NM_001136130, 228008401 NP_001129602, 209915573 amyloid beta A4 protein isoform f precursor ORF Sequence $700.00
NM_001136131, 324021747 NP_001129603, 209915575 amyloid beta A4 protein isoform g ORF Sequence $700.00
NM_001204301, 324021737 NP_001191230, 324021738 amyloid beta A4 protein isoform h precursor ORF Sequence $700.00
NM_001204302, 324021735 NP_001191231, 324021736 amyloid beta A4 protein isoform i precursor ORF Sequence $700.00
NM_001204303, 324021739 NP_001191232, 324021740 amyloid beta A4 protein isoform j precursor ORF Sequence $700.00
NM_201413, 228008404 NP_958816, 41406055 amyloid beta A4 protein isoform b precursor ORF Sequence $700.00
NM_201414, 228008405 NP_958817, 41406057 amyloid beta A4 protein isoform c precursor ORF Sequence $700.00
KEGG
hsa05010Alzheimer's disease
hsa04726Serotonergic synapse
WikiPathways
WP61Delta-Notch Signaling Pathway
WP2377Integrated Pancreatic Cancer Pathway
WP2059Alzheimers Disease
Pathway Interaction Database
caspase_pathwayCaspase cascade in apoptosis
glypican_1pathwayGlypican 1 network
p75ntrpathwayp75(NTR)-mediated signaling
Reactome
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_18283G alpha (q) signalling events
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_318Platelet degranulation
REACT_1280Response to elevated platelet cytosolic Ca2+
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_6900Immune System
REACT_6802Innate Immune System
REACT_6966Toll-Like Receptors Cascades
REACT_9027Toll Like Receptor 10 (TLR10) Cascade
REACT_6783Toll Like Receptor 3 (TLR3) Cascade
REACT_6809MyD88-independent cascade
REACT_8005Toll Like Receptor TLR1:TLR2 Cascade
REACT_9061Toll Like Receptor 5 (TLR5) Cascade
REACT_6890Activated TLR4 signalling
REACT_7980Toll Like Receptor 2 (TLR2) Cascade
REACT_6788MyD88:Mal cascade initiated on plasma membrane
REACT_9047Toll Like Receptor 9 (TLR9) Cascade
REACT_6894Toll Like Receptor 4 (TLR4) Cascade
REACT_8006Toll Like Receptor TLR6:TLR2 Cascade
REACT_9020Toll Like Receptor 7/8 (TLR7/8) Cascade
REACT_21281TAK1 activates NFkB by phosphorylation and activation of IKKs complex
REACT_21340GPCR ligand binding
REACT_21264Formyl peptide receptors bind formyl peptides and many other ligands
REACT_27215MyD88 cascade initiated on plasma membrane
REACT_75913Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
REACT_75900Inflammasomes
REACT_75925Amyloids
REACT_75808The NLRP3 inflammasome
REACT_25195Advanced glycosylation endproduct receptor signaling
REACT_24969TRAF6 mediated NF-kB activation
REACT_25222MyD88 dependent cascade initiated on endosome
REACT_25359RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
REACT_25024TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
REACT_25281TRIF-mediated TLR3/TLR4 signaling
REACT_111102Signal Transduction
REACT_116125Disease
REACT_118823Cytosolic sensors of pathogen-associated DNA
REACT_118764ZBP1(DAI) mediated induction of type I IFNs
REACT_118563RIP-mediated NFkB activation via ZBP1
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_163773DEx/H-box helicases activate type I IFN and inflammatory cytokines production
Homo sapiens (human)APPNP_000475.1
Pan troglodytes (chimpanzee)APPNP_001013036.1
Macaca mulatta (Rhesus monkey)APPXP_002803216.1
Canis lupus familiaris (dog)APPNP_001006601.1
Bos taurus (cattle)APPNP_001070264.1
Mus musculus (house mouse)AppNP_001185752.1
Rattus norvegicus (Norway rat)AppNP_062161.1
Gallus gallus (chicken)APPNP_989639.1
Danio rerio (zebrafish)appbNP_690842.1
Caenorhabditis elegansapl-1NP_508870.3
Xenopus (Silurana) tropicalis (western clawed frog)appNP_001005698.1
Process
IDNameEvidence
GO:0000085mitotic G2 phaseISS
GO:0001967suckling behaviorIEA
GO:0002576platelet degranulationTAS
GO:0006378mRNA polyadenylationISS
GO:0006417regulation of translationISS
GO:0006468protein phosphorylationISS
GO:0006878cellular copper ion homeostasisISS
GO:0006897endocytosisISS
GO:0006979response to oxidative stressIEA
GO:0007155cell adhesionIEA
GO:0007176regulation of epidermal growth factor-activated receptor activityISS
GO:0007219Notch signaling pathwayIEA
GO:0007409axonogenesisISS
GO:0007596blood coagulationTAS
GO:0007617mating behaviorISS
GO:0007626locomotory behaviorISS
GO:0008088axon cargo transportISS
GO:0008203cholesterol metabolic processIEA
GO:0008344adult locomotory behaviorISS
GO:0008542visual learningISS
GO:0010951negative regulation of endopeptidase activityIDA
GO:0010951negative regulation of endopeptidase activityIEA
GO:0010952positive regulation of peptidase activityIEA
GO:0010971positive regulation of G2/M transition of mitotic cell cycleIEA
GO:0016199axon midline choice point recognitionISS
GO:0016322neuron remodelingISS
GO:0016358dendrite developmentISS
GO:0030168platelet activationTAS
GO:0030198extracellular matrix organizationISS
GO:0030198extracellular matrix organizationTAS
GO:0030900forebrain developmentIEA
GO:0031175neuron projection developmentISS
GO:0035235ionotropic glutamate receptor signaling pathwayISS
GO:0035872nucleotide-binding domain, leucine rich repeat containing receptor signaling pathwayTAS
GO:0040014regulation of multicellular organism growthISS
GO:0043393regulation of protein bindingIEA
GO:0045087innate immune responseTAS
GO:0045665negative regulation of neuron differentiationIEA
GO:0045931positive regulation of mitotic cell cycleISS
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0048669collateral sprouting in absence of injuryISS
GO:0050803regulation of synapse structure and activityISS
GO:0050885neuromuscular process controlling balanceIEA
GO:0051124synaptic growth at neuromuscular junctionIEA
GO:0051402neuron apoptotic processIMP
GO:0051563smooth endoplasmic reticulum calcium ion homeostasisIEA
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005641nuclear envelope lumenIDA
GO:0005737cytoplasmIDA
GO:0005737cytoplasmISS
GO:0005794Golgi apparatusIDA
GO:0005794Golgi apparatusISS
GO:0005829cytosolTAS
GO:0005886plasma membraneIDA
GO:0005887integral component of plasma membraneTAS
GO:0005905coated pitIEA
GO:0009986cell surfaceIDA
GO:0016021integral component of membraneISS
GO:0030424axonISS
GO:0031093platelet alpha granule lumenTAS
GO:0031594neuromuscular junctionIEA
GO:0035253ciliary rootletIEA
GO:0043197dendritic spineIDA
GO:0043198dendritic shaftIDA
GO:0043231intracellular membrane-bounded organelleIDA
GO:0043235receptor complexIDA
GO:0045121membrane raftIDA
GO:0045177apical part of cellIEA
GO:0045202synapseIDA
GO:0048471perinuclear region of cytoplasmIDA
GO:0051233spindle midzoneIEA
GO:0070062extracellular vesicular exosomeIDA
Function
IDNameEvidence
GO:0003677DNA bindingISS
GO:0004867serine-type endopeptidase inhibitor activityIDA
GO:0005102receptor bindingIPI
GO:0005515protein bindingIPI
GO:0008201heparin bindingIEA
GO:0016504peptidase activator activityIEA
GO:0019899enzyme bindingIPI
GO:0033130acetylcholine receptor bindingIPI
GO:0042802identical protein bindingIPI
GO:0046914transition metal ion bindingIEA
GO:0051425PTB domain bindingIPI
GO:0070851growth factor receptor bindingIEA
GeneCards APP
UniProt E9PG40, E9PEV0, B4DJT9, B4DGD0, P05067
Vega OTTHUMG00000078438
MIM 104760
Ensembl ENSG00000142192
HGNC 620
HPRD 00100

Related articles in PubMed

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the APP gene?

The APP gene provides instructions for making a protein called amyloid precursor protein. This protein is found in many tissues and organs, including the brain and spinal cord (central nervous system). Little is known about the function of amyloid precursor protein. Researchers speculate that it may bind to other proteins on the surface of cells or help cells attach to one another. Studies suggest that in the brain, it helps direct the movement (migration) of nerve cells (neurons) during early development.

Amyloid precursor protein is cut by enzymes to create smaller fragments (peptides), some of which are released outside the cell. Two of these fragments are called soluble amyloid precursor protein (sAPP) and amyloid beta (β) peptide. Recent evidence suggests that sAPP has growth-promoting properties and may play a role in the formation of nerve cells (neurons) in the brain both before and after birth. The sAPP peptide may also control the function of certain other proteins by turning off (inhibiting) their activity. Amyloid β peptide is likely involved in the ability of neurons to change and adapt over time (plasticity). Other functions of sAPP and amyloid β peptide are under investigation.

Interactant

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