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IL1B interleukin 1, beta [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000576 Homo sapiens interleukin 1, beta (IL1B), mRNA. GenEZ ORF Cloning In-stock $348.00 $299.00 10

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Gene Symbol IL1B
Entrez Gene ID 3553
Full Name interleukin 1, beta
Synonyms IL-1, IL1-BETA, IL1F2
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].

MIM: 147720

{Gastric cancer risk after H. pylori infection}, 137215 (3)

mRNA Protein Product Sequence Price Select
NM_000576, 27894305 NP_000567, 10835145 interleukin-1 beta proprotein ORF Sequence $199.00
hsa05164Influenza A
hsa04010MAPK signaling pathway
hsa05010Alzheimer's disease
hsa04640Hematopoietic cell lineage
hsa05323Rheumatoid arthritis
hsa04940Type I diabetes mellitus
hsa05332Graft-versus-host disease
hsa05168Herpes simplex infection
hsa05142Chagas disease (American trypanosomiasis)
hsa04064NF-kappa B signaling pathway
hsa04623Cytosolic DNA-sensing pathway
hsa05020Prion diseases
hsa05143African trypanosomiasis
hsa04620Toll-like receptor signaling pathway
hsa05132Salmonella infection
hsa04621NOD-like receptor signaling pathway
hsa04380Osteoclast differentiation
hsa04060Cytokine-cytokine receptor interaction
WP615Senescence and Autophagy
WP1433NOD pathway
WP75Toll-like receptor signaling pathway
WP706SIDS Susceptibility Pathways
WP382MAPK signaling pathway
WP727Monoamine Transport
WP530Cytokines and Inflammatory Response
WP195IL-1 Signaling Pathway
WP69TCR Signaling Pathway
WP619Type II interferon signaling (IFNG)
WP289Myometrial Relaxation and Contraction Pathways
WP15Selenium Pathway
WP2059Alzheimers Disease
Pathway Interaction Database
il1pathwayIL1-mediated signaling events
il12_2pathwayIL12-mediated signaling events
il27pathwayIL27-mediated signaling events
ifngpathwayIFN-gamma pathway
anthraxpathwayCellular roles of Anthrax toxin
il23pathwayIL23-mediated signaling events
REACT_22232Signaling by Interleukins
REACT_22442Interleukin-1 signaling
REACT_6900Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_23950Interleukin-1 processing
Homo sapiens (human)IL1BNP_000567.1
Pan troglodytes (chimpanzee)IL1BXP_001147075.1
Macaca mulatta (Rhesus monkey)IL1BNP_001036221.1
Canis lupus familiaris (dog)IL1BNP_001033060.1
Bos taurus (cattle)IL1BNP_776518.1
Mus musculus (house mouse)Il1bNP_032387.1
Rattus norvegicus (Norway rat)Il1bNP_113700.2
Gallus gallus (chicken)IL1BNP_989855.1
GeneCards IL1B
PDB 21BI, 1ITB, 1I1B, 31BI, 4DEP, 3POK, 4GAI, 3O4O, 1TWM, 1TOO, 9ILB, 5I1B, 41BI, 4GAF, 2I1B, 1S0L, 1IOB, 6I1B, 3LTQ, 2NVH, 4G6J, 1HIB, 4I1B, 4G6M, 1T4Q, 1TWE, 7I1B, 2KH2, 1L2H, 1TP0
UniProt P01584
MIM 147720
Ensembl ENSG00000125538
HGNC 5992
HPRD 00985

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
interleukin-1 beta
interleukin-1 beta
IL-1 beta
preinterleukin 1 beta


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