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IL1B interleukin 1, beta [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu25334 NM_000576 Homo sapiens interleukin 1, beta (IL1B), mRNA. pcDNA3.1+-DYK In-stock 5-7 $99.00
OHu36205 XM_006712496 PREDICTED: Homo sapiens interleukin 1, beta (IL1B), transcript variant X1, mRNA. pcDNA3.1+-DYK On-demand 7-9 $159.00
OHu25334C NM_000576 Homo sapiens interleukin 1, beta (IL1B), mRNA. Customized vector In-stock 5-7 $149.00
OHu36205C XM_006712496 PREDICTED: Homo sapiens interleukin 1, beta (IL1B), transcript variant X1, mRNA. Customized vector On-demand 7-9 $209.00

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Gene Symbol IL1B
Entrez Gene ID 3553
Full Name interleukin 1, beta
Synonyms IL-1, IL1-BETA, IL1F2
General protein information
Preferred Names
interleukin-1 beta
Names
interleukin-1 beta
IL-1 beta
catabolin
preinterleukin 1 beta
pro-interleukin-1-beta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

2

2q14

Summary The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is produced by activated macrophages as a proprotein, which is proteolytically processed to its active form by caspase 1 (CASP1/ICE). This cytokine is an important mediator of the inflammatory response, and is involved in a variety of cellular activities, including cell proliferation, differentiation, and apoptosis. The induction of cyclooxygenase-2 (PTGS2/COX2) by this cytokine in the central nervous system (CNS) is found to contribute to inflammatory pain hypersensitivity. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. [provided by RefSeq, Jul 2008].
Disorder

MIM: 147720

{Gastric cancer risk after H. pylori infection}, 137215 (3)

mRNA Protein Product Sequence Price Select
NM_000576, 27894305 NP_000567, 10835145 interleukin-1 beta proprotein ORF Sequence $199.00
XM_006712496, 578804252 XP_006712559, 578804253 interleukin-1 beta isoform X1 ORF Sequence $250.00
KEGG
hsa04010MAPK signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04210Apoptosis
hsa04640Hematopoietic cell lineage
hsa05332Graft-versus-host disease
hsa04620Toll-like receptor signaling pathway
hsa04940Type I diabetes mellitus
hsa05010Alzheimer's disease
hsa05020Prion diseases
hsa04623Cytosolic DNA-sensing pathway
hsa04621NOD-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05140Leishmaniasis
hsa05144Malaria
hsa05146Amoebiasis
hsa05143African trypanosomiasis
hsa05323Rheumatoid arthritis
hsa05162Measles
hsa04380Osteoclast differentiation
hsa05152Tuberculosis
hsa05164Influenza A
hsa05132Salmonella infection
hsa05168Herpes simplex infection
hsa05133Pertussis
hsa05134Legionellosis
hsa04064NF-kappa B signaling pathway
hsa05321Inflammatory bowel disease (IBD)
hsa04668TNF signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04750Inflammatory mediator regulation of TRP channels
WikiPathways
WP382MAPK signaling pathway
WP615Senescence and Autophagy
WP289Myometrial Relaxation and Contraction Pathways
WP75Toll-like receptor signaling pathway
WP15Selenium Pathway
WP1433NOD pathway
WP530Cytokines and Inflammatory Response
WP727Monoamine Transport
WP195IL-1 Signaling Pathway
WP619Type II interferon signaling (IFNG)
WP69TCR Signaling Pathway
WP706SIDS Susceptibility Pathways
WP2059Alzheimers Disease
WP2431Spinal Cord Injury
WP1449Regulation of toll-like receptor signaling pathway
WP1455Serotonin Transporter Activity
Pathway Interaction Database
il1pathwayIL1-mediated signaling events
il27pathwayIL27-mediated signaling events
il12_2pathwayIL12-mediated signaling events
il23pathwayIL23-mediated signaling events
ifngpathwayIFN-gamma pathway
anthraxpathwayCellular roles of Anthrax toxin
Reactome
REACT_6900Immune System
REACT_22232Signaling by Interleukins
REACT_22442Interleukin-1 signaling
REACT_75790Cytokine Signaling in Immune system
REACT_23950Interleukin-1 processing
Homo sapiens (human)IL1BNP_000567.1
Pan troglodytes (chimpanzee)IL1BXP_001147075.1
Macaca mulatta (Rhesus monkey)IL1BNP_001036221.1
Canis lupus familiaris (dog)IL1BNP_001033060.1
Bos taurus (cattle)IL1BNP_776518.1
Mus musculus (house mouse)Il1bNP_032387.1
Rattus norvegicus (Norway rat)Il1bNP_113700.2
Xenopus (Silurana) tropicalis (western clawed frog)il1bXP_002932618.1
Process
IDNameEvidence
GO:0000165MAPK cascadeIMP
GO:0000187activation of MAPK activityIDA
GO:0001660fever generationIEA
GO:0001934positive regulation of protein phosphorylationIDA
GO:0001934positive regulation of protein phosphorylationNAS
GO:0002711positive regulation of T cell mediated immunityIC
GO:0006915apoptotic processTAS
GO:0006954inflammatory responseIDA
GO:0006954inflammatory responseNAS
GO:0006955immune responseIEA
GO:0007165signal transductionTAS
GO:0007267cell-cell signalingTAS
GO:0007566embryo implantationTAS
GO:0008285negative regulation of cell proliferationIDA
GO:0009743response to carbohydrateIEA
GO:0010575positive regulation vascular endothelial growth factor productionIDA
GO:0010575positive regulation vascular endothelial growth factor productionISS
GO:0010628positive regulation of gene expressionIDA
GO:0010829negative regulation of glucose transportISS
GO:0014805smooth muscle adaptationNAS
GO:0019221cytokine-mediated signaling pathwayIDA
GO:0030213hyaluronan biosynthetic processIDA
GO:0030593neutrophil chemotaxisIEA
GO:0030730sequestering of triglycerideIDA
GO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathwayIC
GO:0031622positive regulation of fever generationISS
GO:0031663lipopolysaccharide-mediated signaling pathwayIDA
GO:0032308positive regulation of prostaglandin secretionISS
GO:0032611interleukin-1 beta productionIEA
GO:0032725positive regulation of granulocyte macrophage colony-stimulating factor productionIDA
GO:0032729positive regulation of interferon-gamma productionIDA
GO:0032755positive regulation of interleukin-6 productionTAS
GO:0032757positive regulation of interleukin-8 productionIDA
GO:0033129positive regulation of histone phosphorylationNAS
GO:0033198response to ATPIEA
GO:0034116positive regulation of heterotypic cell-cell adhesionIDA
GO:0034116positive regulation of heterotypic cell-cell adhesionNAS
GO:0035066positive regulation of histone acetylationNAS
GO:0035234ectopic germ cell programmed cell deathIEA
GO:0035505positive regulation of myosin light chain kinase activityIDA
GO:0035690cellular response to drugIDA
GO:0042102positive regulation of T cell proliferationIDA
GO:0042346positive regulation of NF-kappaB import into nucleusIDA
GO:0043122regulation of I-kappaB kinase/NF-kappaB signalingIDA
GO:0043123positive regulation of I-kappaB kinase/NF-kappaB signalingIEA
GO:0043407negative regulation of MAP kinase activityISS
GO:0043491protein kinase B signalingIMP
GO:0045080positive regulation of chemokine biosynthetic processIEA
GO:0045086positive regulation of interleukin-2 biosynthetic processIMP
GO:0045410positive regulation of interleukin-6 biosynthetic processIEA
GO:0045429positive regulation of nitric oxide biosynthetic processIDA
GO:0045766positive regulation of angiogenesisISS
GO:0045833negative regulation of lipid metabolic processISS
GO:0045840positive regulation of mitosisIMP
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIEA
GO:0046330positive regulation of JNK cascadeIEA
GO:0046627negative regulation of insulin receptor signaling pathwayISS
GO:0046827positive regulation of protein export from nucleusNAS
GO:0050796regulation of insulin secretionIDA
GO:0050995negative regulation of lipid catabolic processIDA
GO:0050996positive regulation of lipid catabolic processISS
GO:0051044positive regulation of membrane protein ectodomain proteolysisIDA
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIDA
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA
GO:0051781positive regulation of cell divisionIEA
GO:0060355positive regulation of cell adhesion molecule productionNAS
GO:0060559positive regulation of calcidiol 1-monooxygenase activityIDA
GO:0070164negative regulation of adiponectin secretionISS
GO:0070487monocyte aggregationIDA
GO:0071260cellular response to mechanical stimulusIEP
GO:0071310cellular response to organic substanceIDA
GO:0071407cellular response to organic cyclic compoundIDA
GO:0071639positive regulation of monocyte chemotactic protein-1 productionIDA
GO:0097192extrinsic apoptotic signaling pathway in absence of ligandIEA
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligandIDA
Component
IDNameEvidence
GO:0005576extracellular regionIDA
GO:0005576extracellular regionNAS
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005615extracellular spaceIMP
GO:0005829cytosolTAS
GO:0030141secretory granuleIEA
Function
IDNameEvidence
GO:0005125cytokine activityIDA
GO:0005125cytokine activityIMP
GO:0005149interleukin-1 receptor bindingNAS
GO:0019904protein domain specific bindingIPI
GeneCards IL1B
PDB 21BI, 1ITB, 1I1B, 31BI, 4DEP, 3POK, 4GAI, 3O4O, 1TWM, 1TOO, 9ILB, 5I1B, 41BI, 4GAF, 2I1B, 1S0L, 1IOB, 6I1B, 3LTQ, 2NVH, 4G6J, 1HIB, 4I1B, 4G6M, 1T4Q, 1TWE, 7I1B, 2KH2, 1L2H, 1TP0
UniProt P01584
Vega OTTHUMG00000131344
MIM 147720
Ensembl ENSG00000125538
HGNC 5992
HPRD 00985

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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