GenPool^TMSearch
Advanced Search

IL2RA interleukin 2 receptor, alpha [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	IL2RA
Entrez Gene ID	3559
Full Name	interleukin 2 receptor, alpha
Synonyms	CD25, IDDM10, IL2R, TCGFR
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:10 Map Location:10p15-p14
Summary	The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq].
Disorder	MIM: 147730 Interleukin-2 receptor, alpha chain, deficiency of, 606367 (3);

mRNA	NM_000417, 269973860
Protein	NP_000408, 4557667
Product	interleukin-2 receptor subunit alpha precursor
RefSeq Status	REVIEWED

KEGG

hsa04640	Hematopoietic cell lineage
hsa04060	Cytokine-cytokine receptor interaction
hsa04144	Endocytosis
hsa04630	Jak-STAT signaling pathway

WikiPathways

WP453	Inflammatory Response Pathway
WP49	IL-2 Signaling Pathway

Pathway Interaction Database

il12_2pathway	IL12-mediated signaling events
tcrcalciumpathway	Calcium signaling in the CD4+ TCR pathway
il2_1pathway	IL2-mediated signaling events
cd8tcrdownstreampathway	Downstream signaling in naive CD8+ T cells
arf6_traffickingpathway	Arf6 trafficking events
il2_stat5pathway	IL2 signaling events mediated by STAT5
il12_stat4pathway	IL12 signaling mediated by STAT4
nfat_tfpathway	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
il2_pi3kpathway	IL2 signaling events mediated by PI3K

Reactome

REACT_23837	Interleukin-3, 5 and GM-CSF signaling
REACT_6900	Signaling in Immune system
REACT_22232	Signaling by Interleukins
REACT_23891	Interleukin receptor SHC signaling

Homo sapiens (human)	IL2RA	NP_000408.1
Pan troglodytes (chimpanzee)	IL2RA	NP_001030597.1
Canis lupus familiaris (dog)	IL2RA	NP_001003211.1
Bos taurus (cattle)	IL2RA	NP_776783.1
Mus musculus (house mouse)	Il2ra	NP_032393.2
Rattus norvegicus (Norway rat)	Il2ra	NP_037295.1

Process

ID	Name	Evidence
GO:0002437	inflammatory response to antigenic stimulus	IEA
GO:0006915	apoptosis	TAS
GO:0006924	activation-induced cell death of T cells	IEA
GO:0006955	immune response	TAS
GO:0007166	cell surface receptor linked signaling pathway	TAS
GO:0008283	cell proliferation	TAS
GO:0042104	positive regulation of activated T cell proliferation	IEA
GO:0042130	negative regulation of T cell proliferation	IEA
GO:0043065	positive regulation of apoptosis	IEA
GO:0045582	positive regulation of T cell differentiation	IEA
GO:0046013	regulation of T cell homeostatic proliferation	IEA
GO:0050687	negative regulation of defense response to virus	IEA
GO:0050728	negative regulation of inflammatory response	IEA
GO:0050777	negative regulation of immune response	IEA

Component

ID	Name	Evidence
GO:0005886	plasma membrane	EXP
GO:0005886	plasma membrane	TAS
GO:0009897	external side of plasma membrane	IEA
GO:0016021	integral to membrane	IEA

Function

ID	Name	Evidence
GO:0004872	receptor activity	IEA
GO:0004911	interleukin-2 receptor activity	IEA
GO:0008144	drug binding	IEA

GeneCards	IL2RA
PDB	3IU3, 2B5I, 1ILM, 3NFP, 2ERJ, 1Z92, 1ILN
UniProt	P01589
MIM	147730
Ensembl	ENSG00000134460
HGNC	6008
HPRD	00986

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.

	Secured Online Quotation
	Email: gene@genscript.com
	Phone: 1-877-436-7274 (Toll-Free) 1-732-885-9188
	Fax: 1-732-210-0262 1-732-885-5878