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Sequence in raw or FASTA format:

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IL2RB interleukin 2 receptor, beta [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu15617 NM_000878 Homo sapiens interleukin 2 receptor, beta (IL2RB), mRNA. pcDNA3.1+-DYK On-demand 7-9 $219.00
OHu15617C NM_000878 Homo sapiens interleukin 2 receptor, beta (IL2RB), mRNA. Customized vector On-demand 7-9 $269.00

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Gene Symbol IL2RB
Entrez Gene ID 3560
Full Name interleukin 2 receptor, beta
Synonyms CD122, IL15RB, P70-75
General protein information
Preferred Names
interleukin-2 receptor subunit beta
Names
interleukin-2 receptor subunit beta
p75
IL-2RB
CD122 antigen
IL-2R subunit beta
IL-2 receptor subunit beta
interleukin 15 receptor, beta
high affinity IL-2 receptor beta subunit
high affinity IL-2 receptor subunit beta
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

22

22q13.1

Summary The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008].
Disorder

MIM: 146710

mRNA Protein Product Sequence Price Select
NM_000878, 390979670 NP_000869, 4504665 interleukin-2 receptor subunit beta precursor ORF Sequence $550.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04144Endocytosis
hsa05166HTLV-I infection
hsa05162Measles
hsa04151PI3K-Akt signaling pathway
hsa05202Transcriptional misregulation in cancer
WikiPathways
WP453Inflammatory Response Pathway
WP127IL-5 Signaling Pathway
WP49IL-2 Signaling pathway
Pathway Interaction Database
il2_pi3kpathwayIL2 signaling events mediated by PI3K
il2_1pathwayIL2-mediated signaling events
il12_2pathwayIL12-mediated signaling events
il2_stat5pathwayIL2 signaling events mediated by STAT5
cd8tcrdownstreampathwayDownstream signaling in naive CD8+ T cells
Reactome
REACT_6900Immune System
REACT_22232Signaling by Interleukins
REACT_27283Interleukin-2 signaling
REACT_75790Cytokine Signaling in Immune system
REACT_23837Interleukin-3, 5 and GM-CSF signaling
REACT_23891Interleukin receptor SHC signaling
Homo sapiens (human)IL2RBNP_000869.1
Pan troglodytes (chimpanzee)IL2RBNP_001030599.1
Macaca mulatta (Rhesus monkey)IL2RBXP_002798417.1
Canis lupus familiaris (dog)IL2RBXP_003431552.2
Bos taurus (cattle)LOC510185XP_002687736.2
Mus musculus (house mouse)Il2rbNP_032394.1
Rattus norvegicus (Norway rat)Il2rbNP_037327.1
Process
IDNameEvidence
GO:0006461protein complex assemblyTAS
GO:0007165signal transductionTAS
GO:0016032viral processIEA
GO:0019221cytokine-mediated signaling pathwayIDA
GO:0038110interleukin-2-mediated signaling pathwayIDA
GO:0038110interleukin-2-mediated signaling pathwayTAS
GO:0043066negative regulation of apoptotic processIDA
Component
IDNameEvidence
GO:0005886plasma membraneTAS
GO:0005887integral component of plasma membraneTAS
GO:0009897external side of plasma membraneISS
GO:0016020membraneIDA
Function
IDNameEvidence
GO:0004911interleukin-2 receptor activityIDA
GO:0004911interleukin-2 receptor activityTAS
GO:0019976interleukin-2 bindingISS
GeneCards IL2RB
PDB 3QAZ, 2B5I, 1ILM, 2ERJ, 1ILN, 4GS7
UniProt P14784
Vega OTTHUMG00000150534
MIM 146710
Ensembl ENSG00000100385
HGNC 6009
HPRD 00896

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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