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IL2RB interleukin 2 receptor, beta [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000878 Homo sapiens interleukin 2 receptor, beta (IL2RB), mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Gene Symbol IL2RB
Entrez Gene ID 3560
Full Name interleukin 2 receptor, beta
Synonyms CD122, IL15RB, P70-75
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The interleukin 2 receptor, which is involved in T cell-mediated immune responses, is present in 3 forms with respect to ability to bind interleukin 2. The low affinity form is a monomer of the alpha subunit and is not involved in signal transduction. The intermediate affinity form consists of an alpha/beta subunit heterodimer, while the high affinity form consists of an alpha/beta/gamma subunit heterotrimer. Both the intermediate and high affinity forms of the receptor are involved in receptor-mediated endocytosis and transduction of mitogenic signals from interleukin 2. The protein encoded by this gene represents the beta subunit and is a type I membrane protein. [provided by RefSeq, Jul 2008].

MIM: 146710

mRNA Protein Product Sequence Price Select
NM_000878, 390979670 NP_000869, 4504665 interleukin-2 receptor subunit beta precursor ORF Sequence $550.00
hsa05202Transcriptional misregulation in cancer
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa05166HTLV-I infection
hsa04151PI3K-Akt signaling pathway
WP127IL-5 Signaling Pathway
WP49IL-2 Signaling Pathway
WP453Inflammatory Response Pathway
Pathway Interaction Database
il2_1pathwayIL2-mediated signaling events
cd8tcrdownstreampathwayDownstream signaling in naive CD8+ T cells
il2_pi3kpathwayIL2 signaling events mediated by PI3K
il2_stat5pathwayIL2 signaling events mediated by STAT5
il12_2pathwayIL12-mediated signaling events
REACT_23891Interleukin receptor SHC signaling
REACT_6900Immune System
REACT_75790Cytokine Signaling in Immune system
REACT_27283Interleukin-2 signaling
REACT_22232Signaling by Interleukins
REACT_23837Interleukin-3, 5 and GM-CSF signaling
Homo sapiens (human)IL2RBNP_000869.1
Pan troglodytes (chimpanzee)IL2RBNP_001030599.1
Macaca mulatta (Rhesus monkey)IL2RBXP_001085792.1
Canis lupus familiaris (dog)IL2RBXP_003431552.1
Bos taurus (cattle)IL2RBXP_002687736.2
Mus musculus (house mouse)Il2rbNP_032394.1
Danio rerio (zebrafish)il2rbNP_001121739.1
GeneCards IL2RB
PDB 3QAZ, 2B5I, 1ILM, 2ERJ, 1ILN, 4GS7
UniProt P14784
MIM 146710
Ensembl ENSG00000100385
HGNC 6009
HPRD 00896

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
interleukin-2 receptor subunit beta
interleukin-2 receptor subunit beta
CD122 antigen
IL-2R subunit beta
IL-2 receptor subunit beta
interleukin 15 receptor, beta
high affinity IL-2 receptor beta subunit
high affinity IL-2 receptor subunit beta


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