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IL6 interleukin 6 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000600 Homo sapiens interleukin 6 (IL6), mRNA. GenEZ ORF Cloning In-stock $308.00 $259.00 10
XM_005249745 PREDICTED: Homo sapiens interleukin 6 (interferon, beta 2) (IL6), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $449.00 14

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Gene Symbol IL6
Entrez Gene ID 3569
Full Name interleukin 6
Synonyms BSF2, HGF, HSF, IFNB2, IL-6
General protein information
Preferred Names
interleukin-6
Names
interleukin-6
CDF
BSF-2
IFN-beta-2
interferon beta-2
interleukin BSF-2
hybridoma growth factor
CTL differentiation factor
B-cell stimulatory factor 2
B-cell differentiation factor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

7

7p21

Summary This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. [provided by RefSeq, Jun 2011].
Disorder

MIM: 147620

{Rheumatoid arthritis, systemic juvenile}, 604302 (3); {Kaposi

mRNA Protein Product Sequence Price Select
NM_000600, 224831235 NP_000591, 10834984 interleukin-6 precursor ORF Sequence $159.00
XM_005249745, 578813494 XP_005249802, 530384757 interleukin-6 isoform X1 ORF Sequence $300.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04640Hematopoietic cell lineage
hsa05332Graft-versus-host disease
hsa04620Toll-like receptor signaling pathway
hsa05200Pathways in cancer
hsa05020Prion diseases
hsa04623Cytosolic DNA-sensing pathway
hsa04672Intestinal immune network for IgA production
hsa04621NOD-like receptor signaling pathway
hsa05410Hypertrophic cardiomyopathy (HCM)
hsa05142Chagas disease (American trypanosomiasis)
hsa05144Malaria
hsa05146Amoebiasis
hsa05143African trypanosomiasis
hsa05323Rheumatoid arthritis
hsa05166HTLV-I infection
hsa05162Measles
hsa05152Tuberculosis
hsa05164Influenza A
hsa05132Salmonella infection
hsa05168Herpes simplex infection
hsa05133Pertussis
hsa05134Legionellosis
hsa04151PI3K-Akt signaling pathway
hsa05161Hepatitis B
hsa04066HIF-1 signaling pathway
hsa05202Transcriptional misregulation in cancer
hsa05321Inflammatory bowel disease (IBD)
hsa04668TNF signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04068FoxO signaling pathway
WikiPathways
WP615Senescence and Autophagy
WP289Myometrial Relaxation and Contraction Pathways
WP75Toll-like receptor signaling pathway
WP15Selenium Pathway
WP530Cytokines and Inflammatory Response
WP236Adipogenesis
WP69TCR Signaling Pathway
WP706SIDS Susceptibility Pathways
WP364IL-6 Signaling Pathway
WP2036TWEAK Signaling Pathway
WP2203TSLP Signaling Pathway
WP2431Spinal Cord Injury
WP1449Regulation of toll-like receptor signaling pathway
Pathway Interaction Database
lysophospholipid_pathwayLPA receptor mediated events
il6_7pathwayIL6-mediated signaling events
il27pathwayIL27-mediated signaling events
atf2_pathwayATF-2 transcription factor network
amb2_neutrophils_pathwayamb2 Integrin signaling
il23pathwayIL23-mediated signaling events
reg_gr_pathwayGlucocorticoid receptor regulatory network
fra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
Reactome
REACT_6900Immune System
REACT_22232Signaling by Interleukins
REACT_27307Interleukin-6 signaling
REACT_75790Cytokine Signaling in Immune system
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
Homo sapiens (human)IL6NP_000591.1
Pan troglodytes (chimpanzee)IL6XP_518992.2
Macaca mulatta (Rhesus monkey)IL6NP_001036198.1
Canis lupus familiaris (dog)IL6NP_001003301.1
Mus musculus (house mouse)Il6NP_112445.1
Rattus norvegicus (Norway rat)Il6NP_036721.1
Gallus gallus (chicken)IL6NP_989959.1
Process
IDNameEvidence
GO:0001781neutrophil apoptotic processIDA
GO:0002384hepatic immune responseIDA
GO:0002384hepatic immune responseTAS
GO:0002446neutrophil mediated immunityIC
GO:0002548monocyte chemotaxisIC
GO:0002675positive regulation of acute inflammatory responseIDA
GO:0002690positive regulation of leukocyte chemotaxisIC
GO:0006469negative regulation of protein kinase activityIEA
GO:0006953acute-phase responseTAS
GO:0006954inflammatory responseIDA
GO:0006959humoral immune responseIC
GO:0007568agingIEA
GO:0008284positive regulation of cell proliferationIDA
GO:0008284positive regulation of cell proliferationIMP
GO:0008285negative regulation of cell proliferationIEA
GO:0008360regulation of cell shapeIEA
GO:0009408response to heatIEA
GO:0009409response to coldIEA
GO:0009612response to mechanical stimulusIEA
GO:0010574regulation of vascular endothelial growth factor productionIDA
GO:0010888negative regulation of lipid storageNAS
GO:0016049cell growthIEA
GO:0019221cytokine-mediated signaling pathwayIDA
GO:0030168platelet activationTAS
GO:0031000response to caffeineIEA
GO:0031018endocrine pancreas developmentISS
GO:0031175neuron projection developmentIMP
GO:0031667response to nutrient levelsIEA
GO:0032494response to peptidoglycanIEP
GO:0032722positive regulation of chemokine productionIDA
GO:0032722positive regulation of chemokine productionIMP
GO:0032755positive regulation of interleukin-6 productionIDA
GO:0032868response to insulinIEA
GO:0032966negative regulation of collagen biosynthetic processIDA
GO:0033138positive regulation of peptidyl-serine phosphorylationIDA
GO:0033160positive regulation of protein import into nucleus, translocationIEA
GO:0042102positive regulation of T cell proliferationIDA
GO:0042493response to drugIEA
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIDA
GO:0042832defense response to protozoanIEA
GO:0043065positive regulation of apoptotic processIDA
GO:0043066negative regulation of apoptotic processIDA
GO:0043154negative regulation of cysteine-type endopeptidase activity involved in apoptotic processIEA
GO:0043200response to amino acidIEA
GO:0043410positive regulation of MAPK cascadeIDA
GO:0045079negative regulation of chemokine biosynthetic processISS
GO:0045188regulation of circadian sleep/wake cycle, non-REM sleepIEA
GO:0045429positive regulation of nitric oxide biosynthetic processIEA
GO:0045454cell redox homeostasisIEA
GO:0045599negative regulation of fat cell differentiationNAS
GO:0045630positive regulation of T-helper 2 cell differentiationIEA
GO:0045666positive regulation of neuron differentiationIEA
GO:0045669positive regulation of osteoblast differentiationTAS
GO:0045721negative regulation of gluconeogenesisIEA
GO:0045727positive regulation of translationIDA
GO:0045740positive regulation of DNA replicationIEA
GO:0045765regulation of angiogenesisIC
GO:0045893positive regulation of transcription, DNA-templatedIDA
GO:0045944positive regulation of transcription from RNA polymerase II promoterIDA
GO:0046427positive regulation of JAK-STAT cascadeIDA
GO:0046677response to antibioticIEA
GO:0046716muscle cell cellular homeostasisIEA
GO:0046849bone remodelingIEA
GO:0046888negative regulation of hormone secretionIEA
GO:0048635negative regulation of muscle organ developmentIEA
GO:0048661positive regulation of smooth muscle cell proliferationIDA
GO:0050679positive regulation of epithelial cell proliferationIEA
GO:0050710negative regulation of cytokine secretionIEA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA
GO:0050829defense response to Gram-negative bacteriumIEP
GO:0050830defense response to Gram-positive bacteriumIEP
GO:0050871positive regulation of B cell activationIDA
GO:0051024positive regulation of immunoglobulin secretionIDA
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIDA
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA
GO:0051384response to glucocorticoidIDA
GO:0051592response to calcium ionIEA
GO:0051602response to electrical stimulusIEA
GO:0051607defense response to virusIDA
GO:0051897positive regulation of protein kinase B signalingIEA
GO:0051971positive regulation of transmission of nerve impulseIEA
GO:0060445branching involved in salivary gland morphogenesisIEA
GO:0060664epithelial cell proliferation involved in salivary gland morphogenesisIEA
GO:0070091glucagon secretionISS
GO:0070102interleukin-6-mediated signaling pathwayIDA
GO:0070301cellular response to hydrogen peroxideIDA
GO:0070374positive regulation of ERK1 and ERK2 cascadeIEA
GO:0071222cellular response to lipopolysaccharideIMP
GO:0072540T-helper 17 cell lineage commitmentISS
GO:1901215negative regulation of neuron deathIEA
GO:2000366positive regulation of STAT protein import into nucleusIC
GO:2000676positive regulation of type B pancreatic cell apoptotic processTAS
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005896interleukin-6 receptor complexIDA
GO:0009897external side of plasma membraneIEA
Function
IDNameEvidence
GO:0005125cytokine activityIDA
GO:0005125cytokine activityNAS
GO:0005138interleukin-6 receptor bindingIPI
GO:0005138interleukin-6 receptor bindingIPI
GO:0005138interleukin-6 receptor bindingNAS
GO:0005515protein bindingIPI
GO:0008083growth factor activityIDA
GeneCards IL6
PDB 2IL6, 4NI7, 1ALU, 1P9M, 1IL6, 4NI9, 4J4L, 4CNI, 1N2Q
UniProt P05231, B4DNQ5, Q75MH2, B4DVM1
Vega OTTHUMG00000023178
MIM 147620
Ensembl ENSG00000136244
HGNC 6018
HPRD 00970

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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