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Sequence in raw or FASTA format:


Blast Method:


IL7R interleukin 7 receptor [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002185 Homo sapiens interleukin 7 receptor (IL7R), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $699.00 18
XM_005248299 PREDICTED: Homo sapiens interleukin 7 receptor (IL7R), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $449.00 14
XM_005248300 PREDICTED: Homo sapiens interleukin 7 receptor (IL7R), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $449.00 14

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Related Services

Gene Symbol IL7R
Entrez Gene ID 3575
Full Name interleukin 7 receptor
Synonyms CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
General protein information
Preferred Names
interleukin-7 receptor subunit alpha
interleukin-7 receptor subunit alpha
CD127 antigen
IL-7R subunit alpha
IL-7 receptor subunit alpha
interleukin 7 receptor alpha chain
interleukin 7 receptor isoform H5-6
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2014].

MIM: 146661

Severe combined immunodeficiency, T-cell negative, B-cell/natural

mRNA Protein Product Sequence Price Select
NM_002185, 391224479 NP_002176, 28610151 interleukin-7 receptor subunit alpha precursor ORF Sequence $550.00
XM_005248299, 578809917 XP_005248356, 530378801 interleukin-7 receptor subunit alpha isoform X1 ORF Sequence $300.00
XM_005248300, 530378802 XP_005248357, 530378803 interleukin-7 receptor subunit alpha isoform X2 ORF Sequence $300.00
hsa04060Cytokine-cytokine receptor interaction
hsa04640Hematopoietic cell lineage
hsa04630Jak-STAT signaling pathway
hsa05340Primary immunodeficiency
hsa04151PI3K-Akt signaling pathway
hsa04068FoxO signaling pathway
WP205IL-7 Signaling Pathway
WP2203TSLP Signaling Pathway
REACT_6900Immune System
REACT_22232Signaling by Interleukins
REACT_75790Cytokine Signaling in Immune system
REACT_115529Interleukin-7 signaling
Homo sapiens (human)IL7RNP_002176.2
Pan troglodytes (chimpanzee)IL7RXP_517807.2
Macaca mulatta (Rhesus monkey)IL7RXP_001092582.1
Canis lupus familiaris (dog)IL7RXP_855408.1
Bos taurus (cattle)IL7RNP_001192816.1
Mus musculus (house mouse)Il7rNP_032398.3
Rattus norvegicus (Norway rat)Il7rNP_001099888.1
Gallus gallus (chicken)IL7RNP_001073575.1
GO:0000018regulation of DNA recombinationTAS
GO:0000902cell morphogenesisIEA
GO:0001915negative regulation of T cell mediated cytotoxicityIEA
GO:0002377immunoglobulin productionIEA
GO:0006955immune responseTAS
GO:0007165signal transductionTAS
GO:0007166cell surface receptor signaling pathwayTAS
GO:0008361regulation of cell sizeIEA
GO:0010628positive regulation of gene expressionIEA
GO:0016049cell growthIEA
GO:0030217T cell differentiationIEA
GO:0033089positive regulation of T cell differentiation in thymusIEA
GO:0038111interleukin-7-mediated signaling pathwayTAS
GO:0042100B cell proliferationIEA
GO:0048535lymph node developmentIEA
GO:0048872homeostasis of number of cellsIEA
GO:0005576extracellular regionIEA
GO:0005886plasma membraneTAS
GO:0009897external side of plasma membraneIEA
GO:0016021integral component of membraneIEA
GO:0003823antigen bindingTAS
GO:0004917interleukin-7 receptor activityTAS
GO:0005515protein bindingIPI
GeneCards IL7R
PDB 3UP1, 3DI3, 3DI2
UniProt D6RGV2, D9N160, P16871
Vega OTTHUMG00000090791
MIM 146661
Ensembl ENSG00000168685
HGNC 6024
HPRD 00893

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the IL7R gene?

The IL7R gene provides instructions for making a protein called interleukin 7 (IL-7) receptor alpha chain. This protein is one piece of both the IL-7 receptor and the thymic stromal lymphopoietin (TSLP) receptor. These receptors are embedded in the cell membrane of immune system cells. The IL-7 receptor is found in B cells and T cells as well as the early blood-forming cells that give rise to them. The TSLP receptor is found in several types of immune cells, including B cells, T cells, monocytes, and dendritic cells. These cells identify foreign substances and defend the body against infection and disease.

At the cell surface, the IL-7 receptor interacts with a protein called IL-7. IL-7 is a cytokine, which is a protein that regulates the activity of immune system cells. The receptor and cytokine fit together like a lock and its key, triggering a series of chemical signals inside the cell. In early blood-forming cells, signaling through the IL-7 receptor ensures the development of mature B cells and T cells. IL-7 receptor signaling also stimulates the later growth and division (proliferation) and survival of these cells.

Similarly, the TSLP receptor interacts with the cytokine TSLP. Attachment of TSLP to its receptor triggers a set of signals that support proliferation and maturation of a variety of immune system cells.


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