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Sequence in raw or FASTA format:

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IL7R interleukin 7 receptor [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002185 Homo sapiens interleukin 7 receptor (IL7R), mRNA. ORF Sequence $400.20
Peptide Services
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Gene Symbol IL7R
Entrez Gene ID 3575
Full Name interleukin 7 receptor
Synonyms CD127, CDW127, IL-7R-alpha, IL7RA, ILRA
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5p13

Summary The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). [provided by RefSeq, Jul 2008].
Disorder

MIM: 146661

Severe combined immunodeficiency, T-cell negative, B-cell/natural

mRNA Protein Product Sequence Price Select
NM_002185, 391224479 NP_002176, 28610151 interleukin-7 receptor subunit alpha precursor Full Length $1615.95
ORF Sequence $400.20
KEGG
hsa04151PI3K-Akt signaling pathway
hsa04640Hematopoietic cell lineage
hsa05340Primary immunodeficiency
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
WikiPathways
WP205IL-7 Signaling Pathway
WP2203TSLP Signaling Pathway
Reactome
REACT_6900Immune System
REACT_22232Signaling by Interleukins
REACT_115529Interleukin-7 signaling
REACT_75790Cytokine Signaling in Immune system
Homo sapiens (human)IL7RNP_002176.2
Pan troglodytes (chimpanzee)IL7RXP_517807.2
Macaca mulatta (Rhesus monkey)IL7RXP_001092582.1
Canis lupus familiaris (dog)IL7RXP_855408.1
Bos taurus (cattle)IL7RNP_001192816.1
Mus musculus (house mouse)Il7rNP_032398.3
Rattus norvegicus (Norway rat)Il7rNP_001099888.1
Gallus gallus (chicken)IL7RNP_001073575.1
GeneCards IL7R
PDB 3UP1, 3DI3, 3DI2
UniProt P16871
MIM 146661
Ensembl ENSG00000168685
HGNC 6024
HPRD 00893

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
interleukin-7 receptor subunit alpha
Names
interleukin-7 receptor subunit alpha
IL-7RA
CD127 antigen
IL-7R subunit alpha
IL-7 receptor subunit alpha
interleukin 7 receptor alpha chain
interleukin 7 receptor isoform H5-6

Interactant

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