IL8 interleukin 8 [Homo sapiens (human)]

Gene Symbol	IL8
Entrez Gene ID	3576
Full Name	interleukin 8
Synonyms	CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:4 Map Location:4q13-q21
Summary	The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq].
Disorder	MIM: 146930

KEGG

hsa05120	Epithelial cell signaling in Helicobacter pylori infection
hsa04621	NOD-like receptor signaling pathway
hsa04620	Toll-like receptor signaling pathway
hsa05131	Shigellosis
hsa04060	Cytokine-cytokine receptor interaction
hsa05219	Bladder cancer
hsa04622	RIG-I-like receptor signaling pathway
hsa05200	Pathways in cancer
hsa04062	Chemokine signaling pathway
hsa05323	Rheumatoid arthritis
hsa05160	Hepatitis C
hsa05144	Malaria
hsa05142	Chagas disease (American trypanosomiasis)
hsa05146	Amoebiasis

Pathway Interaction Database

syndecan_2_pathway	Syndecan-2-mediated signaling events
nfat_tfpathway	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
syndecan_3_pathway	Syndecan-3-mediated signaling events
lysophospholipid_pathway	LPA receptor mediated events
reg_gr_pathway	Glucocorticoid receptor regulatory network
wnt_beta_catenin_pathway	Regulation of Wnt-mediated beta catenin signaling and target gene transcription
fra_pathway	Validated transcriptional targets of AP1 family members Fra1 and Fra2
atf2_pathway	ATF-2 transcription factor network

WikiPathways

WP706	SIDS Susceptibility Pathways
WP615	Senescence and Autophagy
WP75	Toll-like receptor signaling pathway

Reactome

REACT_14797	Signaling by GPCR
REACT_21340	GPCR ligand binding
REACT_18277	PERK regulated gene expression
REACT_15380	Diabetes pathways
REACT_14819	Peptide ligand-binding receptors
REACT_18356	Unfolded Protein Response
REACT_14828	Class A/1 (Rhodopsin-like receptors)
REACT_19184	GPCR downstream signaling
REACT_15344	Chemokine receptors bind chemokines
REACT_19231	G alpha (i) signalling events

Process

ID	Name	Evidence
GO:0001525	angiogenesis	TAS
GO:0002237	response to molecule of bacterial origin	IDA
GO:0006928	cellular component movement	TAS
GO:0006935	chemotaxis	IEA
GO:0006954	inflammatory response	TAS
GO:0006955	immune response	IEA
GO:0007050	cell cycle arrest	IDA
GO:0007165	signal transduction	TAS
GO:0007186	G-protein coupled receptor protein signaling pathway	TAS
GO:0008285	negative regulation of cell proliferation	TAS
GO:0019722	calcium-mediated signaling	TAS
GO:0030155	regulation of cell adhesion	IDA
GO:0030593	neutrophil chemotaxis	IGI
GO:0035556	intracellular signal transduction	TAS
GO:0042119	neutrophil activation	TAS
GO:0045091	regulation of retroviral genome replication	IDA
GO:0048566	embryonic digestive tract development	IEP
GO:0050930	induction of positive chemotaxis	IGI
GO:0071222	cellular response to lipopolysaccharide	IDA
GO:0090023	positive regulation of neutrophil chemotaxis	TAS

Component

Function

ID	Name	Evidence
GO:0005153	interleukin-8 receptor binding	IPI
GO:0005515	protein binding	IPI
GO:0008009	chemokine activity	IEA

GeneCards	IL8
PDB	1QE6, 1ROD, 1IL8, 1IKL, 3IL8, 1ILQ, 2IL8, 1ICW, 1IKM, 1ILP
UniProt	P10145
MIM	146930
Ensembl	ENSG00000169429
HGNC	6025
HPRD	00909

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RefSeq Accession	Definition	Sequence	Price	Select
NM_000584	Homo sapiens interleukin 8 (IL8), mRNA.	Full Length	$498.22
NM_000584	Homo sapiens interleukin 8 (IL8), mRNA.	ORF Sequence	$159.00