• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


CXCL8 chemokine (C-X-C motif) ligand 8 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000584 Homo sapiens chemokine (C-X-C motif) ligand 8 (CXCL8), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

*Business Day

Related Services

Gene Symbol CXCL8
Entrez Gene ID 3576
Full Name chemokine (C-X-C motif) ligand 8
Synonyms GCP-1, GCP1, IL8, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1
General protein information
Preferred Names
interleukin-8
Names
interleukin-8
emoctakin
T-cell chemotactic factor
neutrophil-activating peptide 1
chemokine (C-X-C motif) ligand 8
beta-thromboglobulin-like protein
granulocyte chemotactic protein 1
tumor necrosis factor-induced gene 1
alveolar macrophage chemotactic factor I
monocyte-derived neutrophil chemotactic factor
monocyte-derived neutrophil-activating peptide
small inducible cytokine subfamily B, member 8
lymphocyte derived neutrophil activating peptide
lung giant cell carcinoma-derived chemotactic protein
beta endothelial cell-derived neutrophil activating peptide
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

4

4q13-q21

Summary The protein encoded by this gene is a member of the CXC chemokine family. This chemokine is one of the major mediators of the inflammatory response. This chemokine is secreted by several cell types. It functions as a chemoattractant, and is also a potent angiogenic factor. This gene is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection. This gene and other ten members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. [provided by RefSeq, Jul 2008].
Disorder

MIM: 146930

mRNA Protein Product Sequence Price Select
NM_000584, 324073503 NP_000575, 10834978 interleukin-8 precursor ORF Sequence $99.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04620Toll-like receptor signaling pathway
hsa05219Bladder cancer
hsa05120Epithelial cell signaling in Helicobacter pylori infection
hsa05200Pathways in cancer
hsa05131Shigellosis
hsa04062Chemokine signaling pathway
hsa04622RIG-I-like receptor signaling pathway
hsa04621NOD-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05144Malaria
hsa05146Amoebiasis
hsa05160Hepatitis C
hsa05323Rheumatoid arthritis
hsa05164Influenza A
hsa05132Salmonella infection
hsa05133Pertussis
hsa05134Legionellosis
hsa05161Hepatitis B
hsa05202Transcriptional misregulation in cancer
hsa04064NF-kappa B signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
WikiPathways
WP615Senescence and Autophagy
WP75Toll-like receptor signaling pathway
WP262EBV LMP1 signaling
WP706SIDS Susceptibility Pathways
WP2203TSLP Signaling Pathway
WP2431Spinal Cord Injury
WP1449Regulation of toll-like receptor signaling pathway
Pathway Interaction Database
lysophospholipid_pathwayLPA receptor mediated events
atf2_pathwayATF-2 transcription factor network
nfat_tfpathwayCalcineurin-regulated NFAT-dependent transcription in lymphocytes
syndecan_3_pathwaySyndecan-3-mediated signaling events
reg_gr_pathwayGlucocorticoid receptor regulatory network
syndecan_2_pathwaySyndecan-2-mediated signaling events
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
fra_pathwayValidated transcriptional targets of AP1 family members Fra1 and Fra2
Reactome
REACT_19184GPCR downstream signaling
REACT_19231G alpha (i) signalling events
REACT_18356Unfolded Protein Response (UPR)
REACT_18277PERK regulates gene expression
REACT_17015Metabolism of proteins
REACT_14828Class A/1 (Rhodopsin-like receptors)
REACT_15344Chemokine receptors bind chemokines
REACT_14797Signaling by GPCR
REACT_14819Peptide ligand-binding receptors
REACT_21340GPCR ligand binding
REACT_111102Signal Transduction
REACT_18355ATF4 activates genes
REACT_120956Cellular responses to stress
REACT_169274Cellular Senescence
REACT_169168Senescence-Associated Secretory Phenotype (SASP)
Homo sapiens (human)IL8NP_000575.1
Pan troglodytes (chimpanzee)IL8XP_001156432.1
Macaca mulatta (Rhesus monkey)IL8NP_001028137.1
Canis lupus familiaris (dog)IL8NP_001003200.1
Bos taurus (cattle)IL8NP_776350.1
Process
IDNameEvidence
GO:0001525angiogenesisTAS
GO:0002237response to molecule of bacterial originIDA
GO:0006928cellular component movementTAS
GO:0006935chemotaxisTAS
GO:0006954inflammatory responseTAS
GO:0006955immune responseIEA
GO:0006987activation of signaling protein activity involved in unfolded protein responseTAS
GO:0007050cell cycle arrestIDA
GO:0007165signal transductionTAS
GO:0007186G-protein coupled receptor signaling pathwayTAS
GO:0008285negative regulation of cell proliferationTAS
GO:0019722calcium-mediated signalingTAS
GO:0030155regulation of cell adhesionIDA
GO:0030593neutrophil chemotaxisIGI
GO:0030968endoplasmic reticulum unfolded protein responseTAS
GO:0031623receptor internalizationIDA
GO:0034976response to endoplasmic reticulum stressIDA
GO:0035556intracellular signal transductionIDA
GO:0042119neutrophil activationTAS
GO:0044267cellular protein metabolic processTAS
GO:0044344cellular response to fibroblast growth factor stimulusIEP
GO:0045091regulation of single stranded viral RNA replication via double stranded DNA intermediateIDA
GO:0045744negative regulation of G-protein coupled receptor protein signaling pathwayIDA
GO:0048566embryonic digestive tract developmentIEP
GO:0050930induction of positive chemotaxisIGI
GO:0071222cellular response to lipopolysaccharideIDA
GO:0071347cellular response to interleukin-1IEP
GO:0071356cellular response to tumor necrosis factorIEP
GO:0090023positive regulation of neutrophil chemotaxisTAS
Component
IDNameEvidence
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIEA
Function
IDNameEvidence
GO:0005153interleukin-8 receptor bindingIPI
GO:0005515protein bindingIPI
GO:0008009chemokine activityTAS
GeneCards CXCL8
UniProt P10145
Vega OTTHUMG00000151316
MIM 146930
Ensembl ENSG00000169429
HGNC 6025
HPRD 00909

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.