• THAT   AND
  • THAT   AND


Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


IL12B interleukin 12B [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002187 Homo sapiens interleukin 12B (IL12B), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

*Business Day

Related Services

Gene Symbol IL12B
Entrez Gene ID 3593
Full Name interleukin 12B
Synonyms CLMF, CLMF2, IL-12B, NKSF, NKSF2
General protein information
Preferred Names
interleukin-12 subunit beta
Names
interleukin-12 subunit beta
CLMF p40
IL-12 subunit p40
IL12, subunit p40
interleukin 12, p40
interleukin-12 beta chain
NK cell stimulatory factor chain 2
cytotoxic lymphocyte maturation factor 40 kDa subunit
natural killer cell stimulatory factor, 40 kD subunit
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q31.1-q33.1

Summary This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
Disorder

MIM: 161561

BCG and salmonella infection, disseminated, 209950 (1); {Asthma,

mRNA Protein Product Sequence Price Select
NM_002187, 24497437 NP_002178, 24497438 interleukin-12 subunit beta precursor ORF Sequence $269.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04630Jak-STAT signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa04940Type I diabetes mellitus
hsa05330Allograft rejection
hsa04622RIG-I-like receptor signaling pathway
hsa05142Chagas disease (American trypanosomiasis)
hsa05140Leishmaniasis
hsa05145Toxoplasmosis
hsa05146Amoebiasis
hsa05143African trypanosomiasis
hsa05162Measles
hsa05152Tuberculosis
hsa05164Influenza A
hsa05168Herpes simplex infection
hsa05133Pertussis
hsa05134Legionellosis
hsa05205Proteoglycans in cancer
hsa05321Inflammatory bowel disease (IBD)
WikiPathways
WP530Cytokines and Inflammatory Response
WP75Toll-like receptor signaling pathway
WP1449Regulation of toll-like receptor signaling pathway
WP2328Allograft Rejection
Pathway Interaction Database
il27pathwayIL27-mediated signaling events
il12_2pathwayIL12-mediated signaling events
il23pathwayIL23-mediated signaling events
Homo sapiens (human)IL12BNP_002178.2
Pan troglodytes (chimpanzee)IL12BXP_527101.2
Macaca mulatta (Rhesus monkey)IL12BNP_001038190.1
Canis lupus familiaris (dog)IL12BNP_001003292.1
Bos taurus (cattle)IL12BNP_776781.1
Mus musculus (house mouse)Il12bNP_032378.1
Rattus norvegicus (Norway rat)Il12bNP_072133.1
Gallus gallus (chicken)IL12BNP_998736.1
Danio rerio (zebrafish)il12baNP_001007109.1
Danio rerio (zebrafish)il12bbXP_002666092.2
Process
IDNameEvidence
GO:0001916positive regulation of T cell mediated cytotoxicityISS
GO:0002230positive regulation of defense response to virus by hostIDA
GO:0002230positive regulation of defense response to virus by hostISS
GO:0002323natural killer cell activation involved in immune responseIEA
GO:0002827positive regulation of T-helper 1 type immune responseIDA
GO:0002827positive regulation of T-helper 1 type immune responseISS
GO:0002860positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell targetIDA
GO:0002862negative regulation of inflammatory response to antigenic stimulusIEA
GO:0007050cell cycle arrestIDA
GO:0010224response to UV-BIDA
GO:0010535positive regulation of activation of JAK2 kinase activityIDA
GO:0016477cell migrationIDA
GO:0019221cytokine-mediated signaling pathwayIEA
GO:0019233sensory perception of painIEA
GO:0019953sexual reproductionTAS
GO:0030101natural killer cell activationIDA
GO:0032693negative regulation of interleukin-10 productionIMP
GO:0032700negative regulation of interleukin-17 productionIDA
GO:0032725positive regulation of granulocyte macrophage colony-stimulating factor productionIDA
GO:0032729positive regulation of interferon-gamma productionIDA
GO:0032733positive regulation of interleukin-10 productionIDA
GO:0032733positive regulation of interleukin-10 productionTAS
GO:0032735positive regulation of interleukin-12 productionIDA
GO:0032740positive regulation of interleukin-17 productionIDA
GO:0032760positive regulation of tumor necrosis factor productionIMP
GO:0032816positive regulation of natural killer cell activationIC
GO:0032816positive regulation of natural killer cell activationIDA
GO:0032819positive regulation of natural killer cell proliferationIDA
GO:0032946positive regulation of mononuclear cell proliferationIMP
GO:0034105positive regulation of tissue remodelingIC
GO:0034393positive regulation of smooth muscle cell apoptotic processIDA
GO:0042035regulation of cytokine biosynthetic processTAS
GO:0042088T-helper 1 type immune responseTAS
GO:0042093T-helper cell differentiationIDA
GO:0042095interferon-gamma biosynthetic processTAS
GO:0042102positive regulation of T cell proliferationIDA
GO:0042104positive regulation of activated T cell proliferationIDA
GO:0042346positive regulation of NF-kappaB import into nucleusTAS
GO:0042510regulation of tyrosine phosphorylation of Stat1 proteinIDA
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIDA
GO:0042520positive regulation of tyrosine phosphorylation of Stat4 proteinIDA
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIDA
GO:0042832defense response to protozoanIEA
GO:0043382positive regulation of memory T cell differentiationISS
GO:0044130negative regulation of growth of symbiont in hostIEA
GO:0045078positive regulation of interferon-gamma biosynthetic processTAS
GO:0045672positive regulation of osteoclast differentiationIDA
GO:0045785positive regulation of cell adhesionIDA
GO:0048662negative regulation of smooth muscle cell proliferationIDA
GO:0050671positive regulation of lymphocyte proliferationIDA
GO:0050729positive regulation of inflammatory responseIC
GO:0050829defense response to Gram-negative bacteriumIDA
GO:0051135positive regulation of NK T cell activationIC
GO:0051135positive regulation of NK T cell activationIDA
GO:0051142positive regulation of NK T cell proliferationIDA
GO:0051607defense response to virusIEA
GO:0071222cellular response to lipopolysaccharideIEA
GO:0071346cellular response to interferon-gammaIEA
GO:2000318positive regulation of T-helper 17 type immune responseISS
GO:2000330positive regulation of T-helper 17 cell lineage commitmentISS
Component
IDNameEvidence
GO:0005615extracellular spaceTAS
GO:0005737cytoplasmIEA
GO:0016020membraneIEA
GO:0043514interleukin-12 complexIDA
GO:0070743interleukin-23 complexIDA
Function
IDNameEvidence
GO:0004896cytokine receptor activityIEA
GO:0005125cytokine activityIDA
GO:0005143interleukin-12 receptor bindingTAS
GO:0005143interleukin-12 receptor bindingTAS
GO:0005515protein bindingIPI
GO:0008083growth factor activityIDA
GO:0042164interleukin-12 alpha subunit bindingIPI
GO:0042802identical protein bindingIPI
GO:0042803protein homodimerization activityIEA
GO:0045519interleukin-23 receptor bindingIDA
GO:0046982protein heterodimerization activityIPI
GeneCards IL12B
PDB 3DUH, 3D87, 3D85, 1F45, 1F42, 3QWR, 3HMX, 4GRW
UniProt P29460
Vega OTTHUMG00000130307
MIM 161561
Ensembl ENSG00000113302
HGNC 5970
HPRD 01194

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

Our customer service representatives are available 24 hours a day, Monday through Friday; please contact us anytime for assistance.