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IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002187 Homo sapiens interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B), mRNA. ORF Sequence $286.23
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Gene Symbol IL12B
Entrez Gene ID 3593
Full Name interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Synonyms CLMF, CLMF2, IL-12B, NKSF, NKSF2
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q31.1-q33.1

Summary This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq, Jul 2008].
Disorder

MIM: 161561

BCG and salmonella infection, disseminated, 209950 (1); {Asthma,

mRNA Protein Product Sequence Price Select
NM_002187, 24497437 NP_002178, 24497438 interleukin-12 subunit beta precursor Full Length $680.63
ORF Sequence $286.23
KEGG
hsa05164Influenza A
hsa05330Allograft rejection
hsa05162Measles
hsa05168Herpes simplex infection
hsa04622RIG-I-like receptor signaling pathway
hsa05140Leishmaniasis
hsa04940Type I diabetes mellitus
hsa05142Chagas disease (American trypanosomiasis)
hsa05133Pertussis
hsa05143African trypanosomiasis
hsa05152Tuberculosis
hsa05145Toxoplasmosis
hsa04630Jak-STAT signaling pathway
hsa04620Toll-like receptor signaling pathway
hsa05134Legionellosis
hsa05146Amoebiasis
hsa04060Cytokine-cytokine receptor interaction
WikiPathways
WP75Toll-like receptor signaling pathway
WP530Cytokines and Inflammatory Response
Pathway Interaction Database
il27pathwayIL27-mediated signaling events
il12_2pathwayIL12-mediated signaling events
il23pathwayIL23-mediated signaling events
Homo sapiens (human)IL12BNP_002178.2
Pan troglodytes (chimpanzee)IL12BXP_527101.2
Macaca mulatta (Rhesus monkey)IL12BNP_001038190.1
Canis lupus familiaris (dog)IL12BNP_001003292.1
Bos taurus (cattle)IL12BNP_776781.1
Mus musculus (house mouse)Il12bNP_032378.1
Rattus norvegicus (Norway rat)Il12bNP_072133.1
Gallus gallus (chicken)IL12BNP_998736.1
Danio rerio (zebrafish)il12baNP_001007109.1
Danio rerio (zebrafish)il12bbXP_002666092.1
GeneCards IL12B
PDB 1F45, 3DUH, 3D87, 3QWR, 1F42, 3HMX, 3D85
UniProt P29460
MIM 161561
Ensembl ENSG00000113302
HGNC 5970
HPRD 01194

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
interleukin-12 subunit beta
Names
interleukin-12 subunit beta
CLMF p40
IL-12 subunit p40
IL12, subunit p40
interleukin 12, p40
interleukin-12 beta chain
NK cell stimulatory factor chain 2
cytotoxic lymphocyte maturation factor 40 kDa subunit
natural killer cell stimulatory factor, 40 kD subunit

Interactant

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