IL12B interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) [Homo sapiens (human)]

Summary
mRNA and Protein
Pathway
Homologues
Gene Ontology
Links to Other Databases

Gene Symbol	IL12B
Entrez Gene ID	3593
Full Name	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
Synonyms	CLMF, CLMF2, IL-12B, NKSF, NKSF2
Gene Type	protein-coding
Organism	Homo sapiens (human)
Genome	Chromosome:5 Map Location:5q31.1-q33.1
Summary	This gene encodes a subunit of interleukin 12, a cytokine that acts on T and natural killer cells, and has a broad array of biological activities. Interleukin 12 is a disulfide-linked heterodimer composed of the 40 kD cytokine receptor like subunit encoded by this gene, and a 35 kD subunit encoded by IL12A. This cytokine is expressed by activated macrophages that serve as an essential inducer of Th1 cells development. This cytokine has been found to be important for sustaining a sufficient number of memory/effector Th1 cells to mediate long-term protection to an intracellular pathogen. Overexpression of this gene was observed in the central nervous system of patients with multiple sclerosis (MS), suggesting a role of this cytokine in the pathogenesis of the disease. The promoter polymorphism of this gene has been reported to be associated with the severity of atopic and non-atopic asthma in children. [provided by RefSeq].
Disorder	MIM: 161561 BCG and salmonella infection, disseminated, 209950 (1); {Asthma,

mRNA	NM_002187, 24497437
Protein	NP_002178, 24497438
Product	interleukin-12 subunit beta precursor
RefSeq Status	REVIEWED

KEGG

hsa05330	Allograft rejection
hsa05143	African trypanosomiasis
hsa05145	Toxoplasmosis
hsa04630	Jak-STAT signaling pathway
hsa04620	Toll-like receptor signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa05146	Amoebiasis
hsa04622	RIG-I-like receptor signaling pathway
hsa04940	Type I diabetes mellitus
hsa05140	Leishmaniasis
hsa05142	Chagas disease (American trypanosomiasis)

WikiPathways

WP75	Toll-like receptor signaling pathway
WP530	Cytokines and Inflammatory Response

Pathway Interaction Database

il27pathway	IL27-mediated signaling events
il12_2pathway	IL12-mediated signaling events
il23pathway	IL23-mediated signaling events

Homo sapiens (human)	IL12B	NP_002178.2
Pan troglodytes (chimpanzee)	IL12B	XP_527101.2
Canis lupus familiaris (dog)	IL12B	NP_001003292.1
Bos taurus (cattle)	IL12B	NP_776781.1
Mus musculus (house mouse)	Il12b	NP_032378.1
Rattus norvegicus (Norway rat)	Il12b	NP_072133.1
Gallus gallus (chicken)	IL12B	NP_998736.1
Danio rerio (zebrafish)	il12ba	NP_001007109.1
Danio rerio (zebrafish)	il12bb	XP_002666092.1

Process

ID	Name	Evidence
GO:0001916	positive regulation of T cell mediated cytotoxicity	ISS
GO:0002230	positive regulation of defense response to virus by host	IDA
GO:0002230	positive regulation of defense response to virus by host	ISS
GO:0002827	positive regulation of T-helper 1 type immune response	IDA
GO:0002827	positive regulation of T-helper 1 type immune response	ISS
GO:0002860	positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target	IDA
GO:0002862	negative regulation of inflammatory response to antigenic stimulus	IEA
GO:0007050	cell cycle arrest	IDA
GO:0007165	signal transduction	TAS
GO:0010224	response to UV-B	IDA
GO:0010535	positive regulation of activation of JAK2 kinase activity	IDA
GO:0016477	cell migration	IDA
GO:0019953	sexual reproduction	TAS
GO:0030101	natural killer cell activation	IDA
GO:0032693	negative regulation of interleukin-10 production	IMP
GO:0032700	negative regulation of interleukin-17 production	IDA
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production	IDA
GO:0032729	positive regulation of interferon-gamma production	IDA
GO:0032733	positive regulation of interleukin-10 production	IDA
GO:0032733	positive regulation of interleukin-10 production	TAS
GO:0032735	positive regulation of interleukin-12 production	IDA
GO:0032740	positive regulation of interleukin-17 production	IDA
GO:0032760	positive regulation of tumor necrosis factor production	IMP
GO:0032816	positive regulation of natural killer cell activation	IC
GO:0032816	positive regulation of natural killer cell activation	IDA
GO:0032819	positive regulation of natural killer cell proliferation	IDA
GO:0034105	positive regulation of tissue remodeling	IC
GO:0034393	positive regulation of smooth muscle cell apoptosis	IDA
GO:0042035	regulation of cytokine biosynthetic process	TAS
GO:0042088	T-helper 1 type immune response	TAS
GO:0042093	T-helper cell differentiation	IDA
GO:0042095	interferon-gamma biosynthetic process	TAS
GO:0042102	positive regulation of T cell proliferation	IDA
GO:0042104	positive regulation of activated T cell proliferation	IDA
GO:0042346	positive regulation of NF-kappaB import into nucleus	TAS
GO:0042510	regulation of tyrosine phosphorylation of Stat1 protein	IDA
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein	IDA
GO:0042520	positive regulation of tyrosine phosphorylation of Stat4 protein	IDA
GO:0042523	positive regulation of tyrosine phosphorylation of Stat5 protein	IDA
GO:0042832	defense response to protozoan	IEA
GO:0043382	positive regulation of memory T cell differentiation	ISS
GO:0044130	negative regulation of growth of symbiont in host	IEA
GO:0045078	positive regulation of interferon-gamma biosynthetic process	TAS
GO:0045672	positive regulation of osteoclast differentiation	IDA
GO:0045785	positive regulation of cell adhesion	IDA
GO:0048662	negative regulation of smooth muscle cell proliferation	IDA
GO:0050671	positive regulation of lymphocyte proliferation	IDA
GO:0050729	positive regulation of inflammatory response	IC
GO:0050829	defense response to Gram-negative bacterium	IDA
GO:0051135	positive regulation of NK T cell activation	IC
GO:0051135	positive regulation of NK T cell activation	IDA
GO:0051142	positive regulation of NK T cell proliferation	IDA
GO:2000318	positive regulation of T-helper 17 type immune response	ISS
GO:2000330	positive regulation of T-helper 17 cell lineage commitment	ISS

Component

ID	Name	Evidence
GO:0005576	extracellular region	IEA
GO:0005615	extracellular space	TAS
GO:0005737	cytoplasm	IEA
GO:0016020	membrane	IEA
GO:0043514	interleukin-12 complex	IDA
GO:0070743	interleukin-23 complex	IDA

Function

ID	Name	Evidence
GO:0004871	signal transducer activity	TAS
GO:0004896	cytokine receptor activity	IEA
GO:0005125	cytokine activity	IDA
GO:0005143	interleukin-12 receptor binding	TAS
GO:0005143	interleukin-12 receptor binding	TAS
GO:0005515	protein binding	IPI
GO:0008083	growth factor activity	IDA
GO:0042164	interleukin-12 alpha subunit binding	IEA
GO:0042803	protein homodimerization activity	IEA
GO:0045519	interleukin-23 receptor binding	IDA
GO:0046982	protein heterodimerization activity	IPI

GeneCards	IL12B
PDB	1F45, 3DUH, 3D87, 1F42, 3HMX, 3D85
UniProt	P29460
MIM	161561
Ensembl	ENSG00000113302
HGNC	5970
HPRD	01194

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RefSeq Accession	Definition	Sequence	Price	Select
NM_002187	Homo sapiens interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) (IL12B), mRNA.	Full Length	$680.63
NM_002187		ORF Sequence	$286.23