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IL13 interleukin 13 [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_002188 Homo sapiens interleukin 13 (IL13), mRNA. Full Length $371.78
ORF Sequence $159.00


Gene Symbol IL13
Entrez Gene ID 3596
Full Name interleukin 13
Synonyms ALRH, BHR1, IL-13, MGC116786, MGC116788, MGC116789, P600
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q31
Summary This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq].
Disorder

MIM: 147683

{Asthma, susceptibility to}, 600807 (3); {Allergic rhinitis,
mRNA NM_002188, 26787977
Protein NP_002179, 26787978
Product interleukin-13 precursor
RefSeq Status REVIEWED
KEGG
hsa05310Asthma
hsa04664Fc epsilon RI signaling pathway
hsa04630Jak-STAT signaling pathway
hsa04060Cytokine-cytokine receptor interaction
WikiPathways
WP530Cytokines and Inflammatory Response
Pathway Interaction Database
il12_stat4pathwayIL12 signaling mediated by STAT4
reg_gr_pathwayGlucocorticoid receptor regulatory network
Homo sapiens (human)IL13NP_002179.2
Pan troglodytes (chimpanzee)IL13NP_001008992.1
Canis lupus familiaris (dog)IL13NP_001003384.1
Bos taurus (cattle)IL13NP_776514.1
Mus musculus (house mouse)Il13NP_032381.1
Rattus norvegicus (Norway rat)Il13NP_446280.1
Process
IDNameEvidence
GO:0002639positive regulation of immunoglobulin productionIEA
GO:0006928cellular component movementTAS
GO:0006954inflammatory responseTAS
GO:0006955immune responseIEA
GO:0007165signal transductionNAS
GO:0007267cell-cell signalingIC
GO:0008284positive regulation of cell proliferationIEA
GO:0009612response to mechanical stimulusIEA
GO:0010155regulation of proton transportIEA
GO:0030890positive regulation of B cell proliferationIEA
GO:0032496response to lipopolysaccharideIEA
GO:0035094response to nicotineIEA
GO:0043032positive regulation of macrophage activationIEA
GO:0043270positive regulation of ion transportIEA
GO:0050714positive regulation of protein secretionIEA
GO:0071635negative regulation of transforming growth factor-beta productionIEA
Component
IDNameEvidence
GO:0005576extracellular regionIEA
GO:0005615extracellular spaceISS
GO:0005625soluble fractionTAS
GO:0005737cytoplasmIEA
Function
IDNameEvidence
GO:0005125cytokine activityIEA
GO:0005144interleukin-13 receptor bindingIEA
GO:0005515protein bindingIPI
GeneCards IL13
PDB 3ITR, 3L5X, 3LB6, 3L5W, 1J9U, 1IJZ, 1GA3, 1IK0, 3ITS, 3L5Y, 3G6D, 3BPO
UniProt P35225
MIM 147683
Ensembl ENSG00000169194
HGNC 5973
HPRD 00981

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