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IL13 interleukin 13 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002188 Homo sapiens interleukin 13 (IL13), mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10

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Gene Symbol IL13
Entrez Gene ID 3596
Full Name interleukin 13
Synonyms IL-13, P600
General protein information
Preferred Names
interleukin-13
Names
interleukin-13
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

5

5q31

Summary This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008].
Disorder

MIM: 147683

{Asthma, susceptibility to}, 600807 (3); {Allergic rhinitis,

mRNA Protein Product Sequence Price Select
NM_002188, 26787977 NP_002179, 26787978 interleukin-13 precursor ORF Sequence $99.00
KEGG
hsa04060Cytokine-cytokine receptor interaction
hsa04664Fc epsilon RI signaling pathway
hsa04630Jak-STAT signaling pathway
hsa05310Asthma
hsa05162Measles
hsa05321Inflammatory bowel disease (IBD)
WikiPathways
WP530Cytokines and Inflammatory Response
WP706SIDS Susceptibility Pathways
Pathway Interaction Database
il12_stat4pathwayIL12 signaling mediated by STAT4
reg_gr_pathwayGlucocorticoid receptor regulatory network
Homo sapiens (human)IL13NP_002179.2
Pan troglodytes (chimpanzee)IL13NP_001008992.1
Macaca mulatta (Rhesus monkey)IL13NP_001028101.1
Canis lupus familiaris (dog)IL13NP_001003384.1
Bos taurus (cattle)IL13NP_776514.1
Mus musculus (house mouse)Il13NP_032381.1
Rattus norvegicus (Norway rat)Il13NP_446280.1
Process
IDNameEvidence
GO:0002639positive regulation of immunoglobulin productionIEA
GO:0006928cellular component movementTAS
GO:0006954inflammatory responseTAS
GO:0006955immune responseIEA
GO:0007165signal transductionNAS
GO:0007267cell-cell signalingIC
GO:0010155regulation of proton transportIEA
GO:0030890positive regulation of B cell proliferationIEA
GO:0032496response to lipopolysaccharideIEA
GO:0032723positive regulation of connective tissue growth factor productionIEA
GO:0035094response to nicotineIEA
GO:0042526positive regulation of tyrosine phosphorylation of Stat6 proteinIEA
GO:0043032positive regulation of macrophage activationIEA
GO:0045471response to ethanolIEA
GO:0048661positive regulation of smooth muscle cell proliferationIEA
GO:0050714positive regulation of protein secretionIEA
GO:0051281positive regulation of release of sequestered calcium ion into cytosolIEA
GO:0071260cellular response to mechanical stimulusIEA
GO:0071345cellular response to cytokine stimulusIEA
GO:0071635negative regulation of transforming growth factor beta productionIEA
GO:1901247negative regulation of lung ciliated cell differentiationNAS
GO:1901251positive regulation of lung goblet cell differentiationNAS
GO:2000231positive regulation of pancreatic stellate cell proliferationIEA
Component
IDNameEvidence
GO:0005576extracellular regionIDA
GO:0005615extracellular spaceISS
GO:0005737cytoplasmIEA
GO:0009897external side of plasma membraneIEA
Function
IDNameEvidence
GO:0005125cytokine activityIEA
GO:0005144interleukin-13 receptor bindingIEA
GO:0005515protein bindingIPI
GeneCards IL13
PDB 3ITR, 3L5X, 4I77, 3LB6, 3L5W, 1J9U, 1IJZ, 1GA3, 1IK0, 3ITS, 3G6D, 4PS4, 3BPO
UniProt P35225
Vega OTTHUMG00000059723
MIM 147683
Ensembl ENSG00000169194
HGNC 5973
HPRD 00981

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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