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IDO1 indoleamine 2,3-dioxygenase 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_002164 Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA. GenEZ ORF Cloning In-stock $418.00 $369.00 10

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Gene Symbol IDO1
Entrez Gene ID 3620
Full Name indoleamine 2,3-dioxygenase 1
Synonyms IDO, IDO-1, INDO
General protein information
Preferred Names
indoleamine 2,3-dioxygenase 1
Names
indoleamine 2,3-dioxygenase 1
indole 2,3-dioxygenase
indolamine 2,3 dioxygenase
indoleamine-pyrrole 2,3-dioxygenase
NP_002155.1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p12-p11

Summary This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011].
Disorder

MIM: 147435

mRNA Protein Product Sequence Price Select
NM_002164, 323668304 NP_002155, 4504577 indoleamine 2,3-dioxygenase 1 ORF Sequence $269.00
KEGG
hsa00380Tryptophan metabolism
hsa05143African trypanosomiasis
WikiPathways
WP465Tryptophan metabolism
BIOCYC
META_PWY-6309tryptophan degradation XI (mammalian, via kynurenine)
Reactome
REACT_13Metabolism of amino acids and derivatives
REACT_916Tryptophan catabolism
REACT_111217Metabolism
Homo sapiens (human)IDO1NP_002155.1
Pan troglodytes (chimpanzee)IDO1XP_001137531.1
Macaca mulatta (Rhesus monkey)IDO1NP_001070951.1
Canis lupus familiaris (dog)IDO1XP_532793.1
Bos taurus (cattle)IDO1NP_001095336.1
Mus musculus (house mouse)Ido1NP_032350.1
Rattus norvegicus (Norway rat)Ido1NP_076463.1
Process
IDNameEvidence
GO:0002534cytokine production involved in inflammatory responseIEA
GO:0002666positive regulation of T cell tolerance inductionIEA
GO:0002678positive regulation of chronic inflammatory responseIEA
GO:0002830positive regulation of type 2 immune responseIEA
GO:0006569tryptophan catabolic processTAS
GO:0007565female pregnancyTAS
GO:0019441tryptophan catabolic process to kynurenineIEA
GO:0032496response to lipopolysaccharideIEA
GO:0032693negative regulation of interleukin-10 productionIEA
GO:0032735positive regulation of interleukin-12 productionIEA
GO:0033555multicellular organismal response to stressIEA
GO:0034276kynurenic acid biosynthetic processIEA
GO:0034641cellular nitrogen compound metabolic processTAS
GO:0036269swimming behaviorIEA
GO:0043065positive regulation of apoptotic processIEA
GO:0044281small molecule metabolic processTAS
GO:0046007negative regulation of activated T cell proliferationIEA
GO:0055114oxidation-reduction processIEA
GO:0070233negative regulation of T cell apoptotic processIEA
Component
IDNameEvidence
GO:0005829cytosolTAS
GO:0030485smooth muscle contractile fiberIEA
GO:0032421stereocilium bundleIEA
Function
IDNameEvidence
GO:0004833tryptophan 2,3-dioxygenase activityEXP
GO:0009055electron carrier activityTAS
GO:0020037heme bindingIEA
GO:0033754indoleamine 2,3-dioxygenase activityIEA
GO:0046872metal ion bindingIEA
GeneCards IDO1
PDB 2D0U, 2D0T
UniProt P14902
MIM 147435
HGNC 6059
HPRD 00935

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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