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Sequence in raw or FASTA format:

Database:

Blast Method:

 
 


IDO1 indoleamine 2,3-dioxygenase 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_002164 Homo sapiens indoleamine 2,3-dioxygenase 1 (IDO1), mRNA. ORF Sequence $351.48
Peptide Services
Antibody Services
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Gene Symbol IDO1
Entrez Gene ID 3620
Full Name indoleamine 2,3-dioxygenase 1
Synonyms IDO, IDO-1, INDO
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

8

8p12-p11

Summary This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011].
Disorder

MIM: 147435

mRNA Protein Product Sequence Price Select
NM_002164, 323668304 NP_002155, 4504577 indoleamine 2,3-dioxygenase 1 Full Length $563.76
ORF Sequence $351.48
KEGG
hsa05143African trypanosomiasis
hsa00380Tryptophan metabolism
WikiPathways
WP465Tryptophan metabolism
Reactome
REACT_13Metabolism of amino acids and derivatives
REACT_916Tryptophan catabolism
REACT_111217Metabolism
Homo sapiens (human)IDO1NP_002155.1
Pan troglodytes (chimpanzee)IDO1XP_001137531.1
Macaca mulatta (Rhesus monkey)IDO1NP_001070951.1
Canis lupus familiaris (dog)IDO1XP_532793.1
Bos taurus (cattle)IDO1NP_001095336.1
Mus musculus (house mouse)Ido1NP_032350.1
Rattus norvegicus (Norway rat)Ido1NP_076463.1
GeneCards IDO1
PDB 2D0U, 2D0T
UniProt P14902
MIM 147435
Ensembl ENSG00000131203
HGNC 6059
HPRD 00935

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
indoleamine 2,3-dioxygenase 1
Names
indoleamine 2,3-dioxygenase 1
indole 2,3-dioxygenase
indolamine 2,3 dioxygenase
indoleamine-pyrrole 2,3-dioxygenase
NP_002155.1

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