IDO1 indoleamine 2,3-dioxygenase 1 [Homo sapiens (human)]
| Gene Symbol | IDO1 |
| Entrez Gene ID | 3620 |
| Full Name | indoleamine 2,3-dioxygenase 1 |
| Synonyms | IDO, IDO-1, INDO |
| Gene Type | protein-coding |
| Organism | Homo sapiens (human) |
| Genome |
8 8p12-p11 |
| Summary | This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan. |
| Disorder | MIM: 147435 |
| mRNA | NM_002164, 323668304 |
| Protein | NP_002155, 4504577 |
| Product | indoleamine 2,3-dioxygenase 1 |
| RefSeq Status | REVIEWED |
| hsa00380 | Tryptophan metabolism |
| hsa01100 | Metabolic pathways |
| hsa05143 | African trypanosomiasis |
WikiPathways
| WP465 | Tryptophan metabolism |
BIOCYC
| META_PWY-6309 | tryptophan degradation XI (mammalian, via kynurenine) |
Reactome
| REACT_13 | Metabolism of amino acids and derivatives |
| REACT_916 | Tryptophan catabolism |
| Homo sapiens (human) | IDO1 | NP_002155.1 |
| Pan troglodytes (chimpanzee) | IDO1 | XP_519723.2 |
| Canis lupus familiaris (dog) | IDO1 | XP_532793.1 |
| Bos taurus (cattle) | IDO1 | NP_001095336.1 |
| Mus musculus (house mouse) | Ido1 | NP_032350.1 |
| Rattus norvegicus (Norway rat) | Ido1 | NP_076463.1 |
| ID | Name | Evidence |
| GO:0006569 | tryptophan catabolic process | TAS |
| GO:0007565 | female pregnancy | TAS |
| GO:0034641 | cellular nitrogen compound metabolic process | TAS |
Component
| ID | Name | Evidence |
| GO:0005829 | cytosol | EXP |
Function
| ID | Name | Evidence |
| GO:0004833 | tryptophan 2,3-dioxygenase activity | EXP |
| GO:0009055 | electron carrier activity | TAS |
| GO:0016491 | oxidoreductase activity | IEA |
| GO:0020037 | heme binding | IEA |
| GO:0033754 | indoleamine 2,3-dioxygenase activity | IEA |
| GO:0046872 | metal ion binding | IEA |
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