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INS insulin [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000207 Homo sapiens insulin (INS), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_001185097 Homo sapiens insulin (INS), transcript variant 2, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_001185098 Homo sapiens insulin (INS), transcript variant 3, mRNA. GenEZ ORF Cloning In-stock $248.00 $199.00 10
NM_001291897 Homo sapiens insulin (INS), transcript variant 4, mRNA. GenEZ ORF Cloning On-demand $299.00 14

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Related Services

Gene Symbol INS
Entrez Gene ID 3630
Full Name insulin
General protein information
Preferred Names
Gene Type protein-coding
Organism Homo sapiens (human)



Summary After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].

MIM: 176730

Hyperproinsulinemia, familial, with or without diabetes (3);

mRNA Protein Product Sequence Price Select
NM_000207, 109148525 NP_000198, 4557671 insulin preproprotein ORF Sequence $99.00
NM_001185097, 297374820 NP_001172026, 297374821 insulin preproprotein ORF Sequence $99.00
NM_001185098, 297374822 NP_001172027, 297374823 insulin preproprotein ORF Sequence $99.00
NM_001291897, 631226407 NP_001278826, 631226408 insulin preproprotein ORF Sequence $150.00
hsa04140Regulation of autophagy
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04930Type II diabetes mellitus
hsa04950Maturity onset diabetes of the young
hsa05215Prostate cancer
hsa04940Type I diabetes mellitus
hsa04914Progesterone-mediated oocyte maturation
hsa04114Oocyte meiosis
hsa04960Aldosterone-regulated sodium reabsorption
hsa04151PI3K-Akt signaling pathway
hsa04066HIF-1 signaling pathway
hsa04913Ovarian steroidogenesis
hsa04917Prolactin signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04911Insulin secretion
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04068FoxO signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04152AMPK signaling pathway
WP615Senescence and Autophagy
WP1982SREBP signalling
WP15Selenium Pathway
WP176Folate Metabolism
WP2324AGE/RAGE pathway
WP2406Cardiac Progenitor Differentiation
WP1533Vitamin B12 Metabolism
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
arf6_traffickingpathwayArf6 trafficking events
hnf3apathwayFOXA1 transcription factor network
insulin_glucose_pathwayInsulin-mediated glucose transport
ptp1bpathwaySignaling events mediated by PTP1B
insulin_pathwayInsulin Pathway
atf2_pathwayATF-2 transcription factor network
tcptp_pathwaySignaling events mediated by TCPTP
REACT_19189Synthesis, secretion, and deacylation of Ghrelin
REACT_15550Insulin processing
REACT_18325Regulation of insulin secretion
REACT_1505Integration of energy metabolism
REACT_17015Metabolism of proteins
REACT_13698Regulation of beta-cell development
REACT_570IRS activation
REACT_1661SHC activation
REACT_762IRS-related events
REACT_1195Insulin receptor signalling cascade
REACT_999SHC-related events
REACT_1109Insulin receptor recycling
REACT_498Signaling by Insulin receptor
REACT_13819Regulation of gene expression in beta cells
REACT_508Signal attenuation
REACT_111045Developmental Biology
REACT_111102Signal Transduction
REACT_160078Peptide hormone metabolism
Homo sapiens (human)INSNP_000198.1
Pan troglodytes (chimpanzee)INSNP_001008996.1
Canis lupus familiaris (dog)INSNP_001123565.1
Mus musculus (house mouse)Ins2NP_032413.1
Rattus norvegicus (Norway rat)Ins2NP_062003.1
Gallus gallus (chicken)INSNP_990553.1
Danio rerio (zebrafish)insNP_571131.1
Xenopus (Silurana) tropicalis (western clawed frog)insNP_001093706.1
GO:0000165MAPK cascadeIDA
GO:0002674negative regulation of acute inflammatory responseIDA
GO:0006006glucose metabolic processIEA
GO:0006112energy reserve metabolic processTAS
GO:0006355regulation of transcription, DNA-templatedNAS
GO:0006521regulation of cellular amino acid metabolic processIMP
GO:0006953acute-phase responseIDA
GO:0007186G-protein coupled receptor signaling pathwayIDA
GO:0007267cell-cell signalingIC
GO:0008284positive regulation of cell proliferationIDA
GO:0008286insulin receptor signaling pathwayTAS
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingIDA
GO:0015758glucose transportIDA
GO:0022898regulation of transmembrane transporter activityIDA
GO:0030307positive regulation of cell growthNAS
GO:0030335positive regulation of cell migrationISS
GO:0031018endocrine pancreas developmentTAS
GO:0031954positive regulation of protein autophosphorylationISS
GO:0032148activation of protein kinase B activityIDA
GO:0032270positive regulation of cellular protein metabolic processIMP
GO:0032460negative regulation of protein oligomerizationIDA
GO:0032880regulation of protein localizationIDA
GO:0033861negative regulation of NAD(P)H oxidase activityIDA
GO:0042060wound healingIDA
GO:0042177negative regulation of protein catabolic processIDA
GO:0042593glucose homeostasisIMP
GO:0043410positive regulation of MAPK cascadeIDA
GO:0044267cellular protein metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0045429positive regulation of nitric oxide biosynthetic processNAS
GO:0045597positive regulation of cell differentiationNAS
GO:0045721negative regulation of gluconeogenesisNAS
GO:0045725positive regulation of glycogen biosynthetic processIDA
GO:0045740positive regulation of DNA replicationIDA
GO:0045818negative regulation of glycogen catabolic processIMP
GO:0045821positive regulation of glycolytic processIDA
GO:0045821positive regulation of glycolytic processIMP
GO:0045840positive regulation of mitosisIDA
GO:0045861negative regulation of proteolysisIMP
GO:0045908negative regulation of vasodilationNAS
GO:0045909positive regulation of vasodilationNAS
GO:0045922negative regulation of fatty acid metabolic processIMP
GO:0046326positive regulation of glucose importIDA
GO:0046628positive regulation of insulin receptor signaling pathwayIDA
GO:0046631alpha-beta T cell activationIDA
GO:0046889positive regulation of lipid biosynthetic processNAS
GO:0050708regulation of protein secretionIDA
GO:0050709negative regulation of protein secretionIDA
GO:0050715positive regulation of cytokine secretionIDA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA
GO:0050796regulation of insulin secretionTAS
GO:0050995negative regulation of lipid catabolic processNAS
GO:0051000positive regulation of nitric-oxide synthase activityNAS
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA
GO:0051897positive regulation of protein kinase B signalingIDA
GO:0055089fatty acid homeostasisIMP
GO:0060266negative regulation of respiratory burst involved in inflammatory responseIDA
GO:0060267positive regulation of respiratory burstIDA
GO:0090277positive regulation of peptide hormone secretionTAS
GO:0090336positive regulation of brown fat cell differentiationTAS
GO:1902176negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressNAS
GO:2000252negative regulation of feeding behaviorIDA
GO:0005576extracellular regionIC
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005788endoplasmic reticulum lumenTAS
GO:0005796Golgi lumenTAS
GO:0031904endosome lumenTAS
GO:0034774secretory granule lumenTAS
GO:0002020protease bindingIPI
GO:0005158insulin receptor bindingIDA
GO:0005158insulin receptor bindingIPI
GO:0005159insulin-like growth factor receptor bindingIPI
GO:0005179hormone activityIC
GO:0005179hormone activityIMP
GO:0005179hormone activityNAS
GO:0005515protein bindingIPI
GO:0042802identical protein bindingIPI
GeneCards INS
UniProt I3WAC9, P01308
Vega OTTHUMG00000009558
MIM 176730
Ensembl ENSG00000254647
HGNC 6081
HPRD 01455

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the INS gene?

The INS gene provides instructions for producing the hormone insulin, which is necessary for the control of glucose levels in the blood. Glucose is a simple sugar and the primary energy source for most cells in the body.

Insulin is produced in a precursor form called proinsulin, which consists of a single chain of protein building blocks (amino acids). The proinsulin chain is cut (cleaved) to form individual pieces called the A and B chains, which are joined together by connections called disulfide bonds to form insulin.


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