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INS insulin [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000207 Homo sapiens insulin (INS), transcript variant 1, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services
NM_001185097 Homo sapiens insulin (INS), transcript variant 2, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services
NM_001185098 Homo sapiens insulin (INS), transcript variant 3, mRNA. ORF Sequence $159.00
Peptide Services
Antibody Services
Protein Services


Gene Symbol INS
Entrez Gene ID 3630
Full Name insulin
Synonyms IDDM2, ILPR, IRDN, MODY10
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.5

Summary After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].
Disorder

MIM: 176730

Hyperproinsulinemia, familial, with or without diabetes (3);

mRNA Protein Product Sequence Price Select
NM_000207, 109148525 NP_000198, 4557671 insulin preproprotein Full Length $159.00
ORF Sequence $159.00
NM_001185097, 297374820 NP_001172026, 297374821 insulin preproprotein Full Length $159.00
ORF Sequence $159.00
NM_001185098, 297374822 NP_001172027, 297374823 insulin preproprotein Full Length $187.92
ORF Sequence $159.00
KEGG
hsa04066HIF-1 signaling pathway
hsa04910Insulin signaling pathway
hsa04151PI3K-Akt signaling pathway
hsa04914Progesterone-mediated oocyte maturation
hsa04940Type I diabetes mellitus
hsa04810Regulation of actin cytoskeleton
hsa04950Maturity onset diabetes of the young
hsa04114Oocyte meiosis
hsa04140Regulation of autophagy
hsa04930Type II diabetes mellitus
hsa04960Aldosterone-regulated sodium reabsorption
hsa05215Prostate cancer
hsa04150mTOR signaling pathway
WikiPathways
WP615Senescence and Autophagy
WP236Adipogenesis
WP176Folate Metabolism
WP1982SREBP signalling
WP2324AGE/RAGE pathway
WP15Selenium Pathway
Pathway Interaction Database
hnf3apathwayFOXA1 transcription factor network
insulin_glucose_pathwayInsulin-mediated glucose transport
ptp1bpathwaySignaling events mediated by PTP1B
tcptp_pathwaySignaling events mediated by TCPTP
arf6_traffickingpathwayArf6 trafficking events
atf2_pathwayATF-2 transcription factor network
insulin_pathwayInsulin Pathway
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
Reactome
REACT_1195Insulin receptor signalling cascade
REACT_111217Metabolism
REACT_976PI3K Cascade
REACT_15380Diabetes pathways
REACT_15550Insulin Synthesis and Processing
REACT_19189Synthesis, Secretion, and Deacylation of Ghrelin
REACT_13698Regulation of beta-cell development
REACT_498Signaling by Insulin receptor
REACT_1109Insulin receptor recycling
REACT_18325Regulation of Insulin Secretion
REACT_999SHC-related events
REACT_332IRS-mediated signalling
REACT_75925Amyloids
REACT_1661SHC activation
REACT_116125Disease
REACT_762IRS-related events
REACT_111045Developmental Biology
REACT_570IRS activation
REACT_13819Regulation of gene expression in beta cells
REACT_1505Integration of energy metabolism
REACT_111102Signal Transduction
REACT_508Signal attenuation
Homo sapiens (human)INSNP_000198.1
Pan troglodytes (chimpanzee)INSNP_001008996.1
Canis lupus familiaris (dog)INSNP_001123565.1
Bos taurus (cattle)INSNP_001172055.1
Mus musculus (house mouse)Ins2NP_001172013.1
Rattus norvegicus (Norway rat)Ins2NP_062003.1
Gallus gallus (chicken)INSNP_990553.1
Danio rerio (zebrafish)insNP_571131.1

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
insulin
Names
insulin
proinsulin
preproinsulin

Interactant

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