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Sequence in raw or FASTA format:


Blast Method:


INS insulin [Homo sapiens (human)]

Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu22288D NM_001185098 Homo sapiens insulin (INS), transcript variant 3, mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu22288D NM_001291897 Homo sapiens insulin (INS), transcript variant 4, mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu22288D NM_000207 Homo sapiens insulin (INS), transcript variant 1, mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu22288D NM_001185097 Homo sapiens insulin (INS), transcript variant 2, mRNA. pcDNA3.1-C-(k)DYK In-stock 5-7 Starting from $99
OHu22288C NM_001185098 Homo sapiens insulin (INS), transcript variant 3, mRNA. Customized vector In-stock 5-7 Starting from $99
OHu22288C NM_001291897 Homo sapiens insulin (INS), transcript variant 4, mRNA. Customized vector In-stock 5-7 Starting from $99
OHu22288C NM_000207 Homo sapiens insulin (INS), transcript variant 1, mRNA. Customized vector In-stock 5-7 Starting from $99
OHu22288C NM_001185097 Homo sapiens insulin (INS), transcript variant 2, mRNA. Customized vector In-stock 5-7 Starting from $99

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Gene Symbol INS
Entrez Gene ID 3630
Full Name insulin
General protein information
Preferred Names
Gene Type protein-coding
Organism Homo sapiens (human)



Summary After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010].

MIM: 176730

Hyperproinsulinemia, familial, with or without diabetes (3);

mRNA Protein Product Sequence Price Select
NM_000207, 109148525 NP_000198, 4557671 insulin preproprotein ORF Sequence $99.00
NM_001185097, 297374820 NP_001172026, 297374821 insulin preproprotein ORF Sequence $99.00
NM_001185098, 297374822 NP_001172027, 297374823 insulin preproprotein ORF Sequence $99.00
NM_001291897, 631226407 NP_001278826, 631226408 insulin preproprotein ORF Sequence $150.00
hsa04140Regulation of autophagy
hsa04150mTOR signaling pathway
hsa04910Insulin signaling pathway
hsa04810Regulation of actin cytoskeleton
hsa04930Type II diabetes mellitus
hsa04950Maturity onset diabetes of the young
hsa05215Prostate cancer
hsa04940Type I diabetes mellitus
hsa04914Progesterone-mediated oocyte maturation
hsa04114Oocyte meiosis
hsa04960Aldosterone-regulated sodium reabsorption
hsa04151PI3K-Akt signaling pathway
hsa04066HIF-1 signaling pathway
hsa04913Ovarian steroidogenesis
hsa04917Prolactin signaling pathway
hsa04932Non-alcoholic fatty liver disease (NAFLD)
hsa04911Insulin secretion
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
hsa04068FoxO signaling pathway
hsa04022cGMP-PKG signaling pathway
hsa04152AMPK signaling pathway
WP615Senescence and Autophagy
WP1982SREBP signalling
WP15Selenium Pathway
WP176Folate Metabolism
WP2324AGE/RAGE pathway
WP2406Cardiac Progenitor Differentiation
WP1533Vitamin B12 Metabolism
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
arf6_traffickingpathwayArf6 trafficking events
hnf3apathwayFOXA1 transcription factor network
insulin_glucose_pathwayInsulin-mediated glucose transport
ptp1bpathwaySignaling events mediated by PTP1B
insulin_pathwayInsulin Pathway
atf2_pathwayATF-2 transcription factor network
tcptp_pathwaySignaling events mediated by TCPTP
REACT_19189Synthesis, secretion, and deacylation of Ghrelin
REACT_15550Insulin processing
REACT_18325Regulation of insulin secretion
REACT_1505Integration of energy metabolism
REACT_17015Metabolism of proteins
REACT_13698Regulation of beta-cell development
REACT_570IRS activation
REACT_1661SHC activation
REACT_762IRS-related events
REACT_1195Insulin receptor signalling cascade
REACT_999SHC-related events
REACT_1109Insulin receptor recycling
REACT_498Signaling by Insulin receptor
REACT_13819Regulation of gene expression in beta cells
REACT_508Signal attenuation
REACT_111045Developmental Biology
REACT_111102Signal Transduction
REACT_160078Peptide hormone metabolism
Homo sapiens (human)INSNP_000198.1
Pan troglodytes (chimpanzee)INSNP_001008996.1
Canis lupus familiaris (dog)INSNP_001123565.1
Mus musculus (house mouse)Ins2NP_032413.1
Rattus norvegicus (Norway rat)Ins2NP_062003.1
Gallus gallus (chicken)INSNP_990553.1
Danio rerio (zebrafish)insNP_571131.1
Xenopus (Silurana) tropicalis (western clawed frog)insNP_001093706.1
GO:0000165MAPK cascadeIDA
GO:0002674negative regulation of acute inflammatory responseIDA
GO:0006006glucose metabolic processIEA
GO:0006112energy reserve metabolic processTAS
GO:0006355regulation of transcription, DNA-templatedNAS
GO:0006521regulation of cellular amino acid metabolic processIMP
GO:0006953acute-phase responseIDA
GO:0007186G-protein coupled receptor signaling pathwayIDA
GO:0007267cell-cell signalingIC
GO:0008284positive regulation of cell proliferationIDA
GO:0008286insulin receptor signaling pathwayTAS
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingIDA
GO:0015758glucose transportIDA
GO:0022898regulation of transmembrane transporter activityIDA
GO:0030307positive regulation of cell growthNAS
GO:0030335positive regulation of cell migrationISS
GO:0031018endocrine pancreas developmentTAS
GO:0031954positive regulation of protein autophosphorylationISS
GO:0032148activation of protein kinase B activityIDA
GO:0032270positive regulation of cellular protein metabolic processIMP
GO:0032460negative regulation of protein oligomerizationIDA
GO:0032880regulation of protein localizationIDA
GO:0033861negative regulation of NAD(P)H oxidase activityIDA
GO:0042060wound healingIDA
GO:0042177negative regulation of protein catabolic processIDA
GO:0042593glucose homeostasisIMP
GO:0043410positive regulation of MAPK cascadeIDA
GO:0044267cellular protein metabolic processTAS
GO:0044281small molecule metabolic processTAS
GO:0045429positive regulation of nitric oxide biosynthetic processNAS
GO:0045597positive regulation of cell differentiationNAS
GO:0045721negative regulation of gluconeogenesisNAS
GO:0045725positive regulation of glycogen biosynthetic processIDA
GO:0045740positive regulation of DNA replicationIDA
GO:0045818negative regulation of glycogen catabolic processIMP
GO:0045821positive regulation of glycolytic processIDA
GO:0045821positive regulation of glycolytic processIMP
GO:0045840positive regulation of mitosisIDA
GO:0045861negative regulation of proteolysisIMP
GO:0045908negative regulation of vasodilationNAS
GO:0045909positive regulation of vasodilationNAS
GO:0045922negative regulation of fatty acid metabolic processIMP
GO:0046326positive regulation of glucose importIDA
GO:0046628positive regulation of insulin receptor signaling pathwayIDA
GO:0046631alpha-beta T cell activationIDA
GO:0046889positive regulation of lipid biosynthetic processNAS
GO:0050708regulation of protein secretionIDA
GO:0050709negative regulation of protein secretionIDA
GO:0050715positive regulation of cytokine secretionIDA
GO:0050731positive regulation of peptidyl-tyrosine phosphorylationIDA
GO:0050796regulation of insulin secretionTAS
GO:0050995negative regulation of lipid catabolic processNAS
GO:0051000positive regulation of nitric-oxide synthase activityNAS
GO:0051092positive regulation of NF-kappaB transcription factor activityIDA
GO:0051897positive regulation of protein kinase B signalingIDA
GO:0055089fatty acid homeostasisIMP
GO:0060266negative regulation of respiratory burst involved in inflammatory responseIDA
GO:0060267positive regulation of respiratory burstIDA
GO:0090277positive regulation of peptide hormone secretionTAS
GO:0090336positive regulation of brown fat cell differentiationTAS
GO:1902176negative regulation of intrinsic apoptotic signaling pathway in response to oxidative stressNAS
GO:2000252negative regulation of feeding behaviorIDA
GO:0005576extracellular regionIC
GO:0005576extracellular regionTAS
GO:0005615extracellular spaceIDA
GO:0005788endoplasmic reticulum lumenTAS
GO:0005796Golgi lumenTAS
GO:0031904endosome lumenTAS
GO:0034774secretory granule lumenTAS
GO:0002020protease bindingIPI
GO:0005158insulin receptor bindingIDA
GO:0005158insulin receptor bindingIPI
GO:0005159insulin-like growth factor receptor bindingIPI
GO:0005179hormone activityIC
GO:0005179hormone activityIMP
GO:0005179hormone activityNAS
GO:0005515protein bindingIPI
GO:0042802identical protein bindingIPI
GeneCards INS
UniProt I3WAC9, P01308
Vega OTTHUMG00000009558
MIM 176730
Ensembl ENSG00000254647
HGNC 6081
HPRD 01455

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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