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PDX1 pancreatic and duodenal homeobox 1 [Homo sapiens (human)]


Clone ID RefSeq Accession Definition Vector Stock Status *Turnaround time Price Order
OHu19441 NM_000209 Homo sapiens pancreatic and duodenal homeobox 1 (PDX1), mRNA. pcDNA3.1+-DYK On-demand TBD TBD
OHu19441C NM_000209 Homo sapiens pancreatic and duodenal homeobox 1 (PDX1), mRNA. Customized vector On-demand TBD $209.00

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Gene Symbol PDX1
Entrez Gene ID 3651
Full Name pancreatic and duodenal homeobox 1
Synonyms GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1
General protein information
Preferred Names
pancreas/duodenum homeobox protein 1
Names
pancreas/duodenum homeobox protein 1
IPF-1
IUF-1
glucose-sensitive factor
insulin upstream factor 1
islet/duodenum homeobox-1
somatostatin transcription factor 1
pancreatic-duodenal homeobox factor 1
somatostatin-transactivating factor 1
insulin promoter factor 1, homeodomain transcription factor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q12.1

Summary The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008].
Disorder

MIM: 600733

Pancreatic agenesis, 260370 (3); MODY, type IV, 606392 (3); {Diabetes

mRNA Protein Product Sequence Price Select
NM_000209, 189095257 NP_000200, 4557673 pancreas/duodenum homeobox protein 1 ORF Sequence $300.00
KEGG
hsa04930Type II diabetes mellitus
hsa04950Maturity onset diabetes of the young
hsa04911Insulin secretion
WikiPathways
WP1584Type II diabetes mellitus
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
Reactome
REACT_13698Regulation of beta-cell development
REACT_13778Regulation of gene expression in early pancreatic precursor cells
REACT_13819Regulation of gene expression in beta cells
REACT_111045Developmental Biology
Homo sapiens (human)PDX1NP_000200.1
Pan troglodytes (chimpanzee)PDX1NP_001074947.1
Macaca mulatta (Rhesus monkey)PDX1XP_001096758.1
Canis lupus familiaris (dog)PDX1XP_543155.3
Bos taurus (cattle)PDX1NP_001179065.1
Mus musculus (house mouse)Pdx1NP_032840.1
Rattus norvegicus (Norway rat)Pdx1NP_074043.3
Gallus gallus (chicken)PDX1XP_001234636.2
Danio rerio (zebrafish)pdx1NP_571518.2
Xenopus (Silurana) tropicalis (western clawed frog)pdx1XP_002934065.1
Process
IDNameEvidence
GO:0000122negative regulation of transcription from RNA polymerase II promoterIEA
GO:0001889liver developmentIEA
GO:0003309type B pancreatic cell differentiationIDA
GO:0003309type B pancreatic cell differentiationISS
GO:0006006glucose metabolic processIEA
GO:0006091generation of precursor metabolites and energyTAS
GO:0006366transcription from RNA polymerase II promoterIEA
GO:0007224smoothened signaling pathwayIEA
GO:0007263nitric oxide mediated signal transductionIDA
GO:0007417central nervous system developmentIEA
GO:0008284positive regulation of cell proliferationIEA
GO:0008285negative regulation of cell proliferationIEA
GO:0009611response to woundingIEA
GO:0009887organ morphogenesisTAS
GO:0010040response to iron(II) ionIEA
GO:0010157response to chlorateIEA
GO:0010260organ senescenceIEA
GO:0010942positive regulation of cell deathIEA
GO:0016331morphogenesis of embryonic epitheliumIEA
GO:0030073insulin secretionIDA
GO:0031017exocrine pancreas developmentIEA
GO:0031018endocrine pancreas developmentTAS
GO:0031100organ regenerationIEA
GO:0032024positive regulation of insulin secretionIEA
GO:0033273response to vitaminIEA
GO:0034097response to cytokineIEA
GO:0035094response to nicotineIEA
GO:0042493response to drugIEA
GO:0042593glucose homeostasisIEA
GO:0043201response to leucineIEA
GO:0043388positive regulation of DNA bindingIEA
GO:0045944positive regulation of transcription from RNA polymerase II promoterISS
GO:0048565digestive tract developmentIEA
GO:0048863stem cell differentiationIEA
GO:0051384response to glucocorticoidIEA
GO:0051594detection of glucoseISS
GO:0060290transdifferentiationIEA
GO:0070542response to fatty acidIEA
Component
IDNameEvidence
GO:0005634nucleusIEA
GO:0005829cytosolIEA
Function
IDNameEvidence
GO:0001046core promoter sequence-specific DNA bindingIEA
GO:0003682chromatin bindingIEA
GO:0003700sequence-specific DNA binding transcription factor activityTAS
GO:0008134transcription factor bindingIEA
GO:0032403protein complex bindingIEA
GO:0046982protein heterodimerization activityIEA
GeneCards PDX1
UniProt P52945
Vega OTTHUMG00000016638
MIM 600733
Ensembl ENSG00000139515
HGNC 6107
HPRD 02843

GeneRIFs: Gene References Into Functions What's a GeneRIF?

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