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PDX1 pancreatic and duodenal homeobox 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000209 Homo sapiens pancreatic and duodenal homeobox 1 (PDX1), mRNA. ORF Sequence $247.08
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Gene Symbol PDX1
Entrez Gene ID 3651
Full Name pancreatic and duodenal homeobox 1
Synonyms GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

13

13q12.1

Summary The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (NIDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Jul 2008].
Disorder

MIM: 600733

Pancreatic agenesis, 260370 (3); MODY, type IV, 606392 (3); {Diabetes

mRNA Protein Product Sequence Price Select
NM_000209, 189095257 NP_000200, 4557673 pancreas/duodenum homeobox protein 1 Full Length $746.17
ORF Sequence $247.08
KEGG
hsa04950Maturity onset diabetes of the young
hsa04930Type II diabetes mellitus
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
WikiPathways
WP1584Type II diabetes mellitus
Reactome
REACT_13698Regulation of beta-cell development
REACT_13819Regulation of gene expression in beta cells
REACT_111045Developmental Biology
REACT_13778Regulation of gene expression in early pancreatic precursor cells
Homo sapiens (human)PDX1NP_000200.1
Pan troglodytes (chimpanzee)PDX1NP_001074947.1
Macaca mulatta (Rhesus monkey)PDX1XP_001096758.1
Canis lupus familiaris (dog)PDX1XP_543155.3
Bos taurus (cattle)PDX1NP_001179065.1
Mus musculus (house mouse)Pdx1NP_032840.1
Gallus gallus (chicken)PDX1XP_001234636.1
Danio rerio (zebrafish)pdx1NP_571518.2
GeneCards PDX1
UniProt P52945
MIM 600733
Ensembl ENSG00000139515
HGNC 6107
HPRD 02843

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
pancreas/duodenum homeobox protein 1
Names
pancreas/duodenum homeobox protein 1
IPF-1
IUF-1
glucose-sensitive factor
insulin upstream factor 1
islet/duodenum homeobox-1
somatostatin transcription factor 1
pancreatic-duodenal homeobox factor 1
somatostatin-transactivating factor 1
insulin promoter factor 1, homeodomain transcription factor

Interactant

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