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ITPKB inositol-trisphosphate 3-kinase B [Homo sapiens (human)]


RefSeq Accession Definition Sequence Price Select
NM_002221 Homo sapiens inositol-trisphosphate 3-kinase B (ITPKB), mRNA. Full Length $2772.90
ORF Sequence $823.89


Gene Symbol ITPKB
Entrez Gene ID 3707
Full Name inositol-trisphosphate 3-kinase B
Synonyms IP3-3KB, IP3K, IP3K-B, IP3KB, PIG37
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

1

1q42.13
Summary The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq].
Disorder

MIM: 147522
mRNA NM_002221, 194272160
Protein NP_002212, 194272161
Product inositol-trisphosphate 3-kinase B
RefSeq Status REVIEWED
KEGG
hsa00562Inositol phosphate metabolism
hsa04070Phosphatidylinositol signaling system
hsa04020Calcium signaling pathway
hsa01100Metabolic pathways
BIOCYC
META_PWY-63621D-myo-inositol hexakisphosphate biosynthesis II (mammalian)
META_PWY-6371superpathway of inositol phosphate compounds
META_PWY-6358superpathway of D-myo-inositol (1,4,5)-trisphosphate metabolism
META_PWY-6364D-myo-inositol (1,3,4)-trisphosphate biosynthesis
Homo sapiens (human)ITPKBNP_002212.3
Pan troglodytes (chimpanzee)ITPKBXP_001141610.1
Canis lupus familiaris (dog)ITPKBXP_547504.2
Bos taurus (cattle)ITPKBXP_613550.4
Mus musculus (house mouse)ItpkbNP_001074644.1
Rattus norvegicus (Norway rat)ItpkbNP_062185.1
Gallus gallus (chicken)ITPKBXP_415039.2
Danio rerio (zebrafish)si:ch211-97m8.1XP_691475.2
Process
IDNameEvidence
GO:0000165MAPKKK cascadeIEA
GO:0007165signal transductionTAS
GO:0007166cell surface receptor linked signaling pathwayIEA
GO:0030217T cell differentiationIEA
GO:0045059positive thymic T cell selectionIEA
GO:0046579positive regulation of Ras protein signal transductionIEA
GO:0046638positive regulation of alpha-beta T cell differentiationIEA
Function
IDNameEvidence
GO:0000166nucleotide bindingIEA
GO:0005516calmodulin bindingIEA
GO:0005524ATP bindingIEA
GO:0008440inositol trisphosphate 3-kinase activityIEA
GO:0016301kinase activityIEA
GO:0016740transferase activityIEA
GeneCards ITPKB
UniProt P27987, B2R9J0
MIM 147522
Ensembl ENSG00000143772
HGNC 6179
HPRD 00942

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