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ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 [Homo sapiens (human)]


RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_001099952 Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant 1, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
NM_001168272 Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant 3, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
NM_002222 Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_005265109 PREDICTED: Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_005265110 PREDICTED: Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_006713131 PREDICTED: Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_006713132 PREDICTED: Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant X5, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_006713133 PREDICTED: Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant X6, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_006713134 PREDICTED: Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant X7, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_006713135 PREDICTED: Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant X8, mRNA. GenEZ ORF Cloning On-demand $4749.00 40
XM_006713136 PREDICTED: Homo sapiens inositol 1,4,5-trisphosphate receptor, type 1 (ITPR1), transcript variant X9, mRNA. GenEZ ORF Cloning On-demand $4749.00 40

*Business Day

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Gene Symbol ITPR1
Entrez Gene ID 3708
Full Name inositol 1,4,5-trisphosphate receptor, type 1
Synonyms ACV, CLA4, INSP3R1, IP3R, IP3R1, PPP1R94, SCA15, SCA16, SCA29
General protein information
Preferred Names
inositol 1,4,5-trisphosphate receptor type 1
Names
inositol 1,4,5-trisphosphate receptor type 1
IP3R 1
IP3 receptor
type 1 InsP3 receptor
inositol 1,4,5-triphosphate receptor, type 1
type 1 inositol 1,4,5-trisphosphate receptor
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

3

3p26.1

Summary This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009].
Disorder

MIM: 147265

Spinocerebellar ataxia 15, 606658 (3)

mRNA Protein Product Sequence Price Select
NM_001099952, 269954689 NP_001093422, 269954690 inositol 1,4,5-trisphosphate receptor type 1 isoform 1 ORF Sequence $4500.00
NM_001168272, 269954693 NP_001161744, 269954694 inositol 1,4,5-trisphosphate receptor type 1 isoform 3 ORF Sequence $4500.00
NM_002222, 269954691 NP_002213, 269954692 inositol 1,4,5-trisphosphate receptor type 1 isoform 2 ORF Sequence $4500.00
XM_005265109, 530372405 XP_005265166, 530372406 inositol 1,4,5-trisphosphate receptor type 1 isoform X2 ORF Sequence $4500.00
XM_005265110, 530372407 XP_005265167, 530372408 inositol 1,4,5-trisphosphate receptor type 1 isoform X3 ORF Sequence $4500.00
XM_006713131, 578806045 XP_006713194, 578806046 inositol 1,4,5-trisphosphate receptor type 1 isoform X4 ORF Sequence $4500.00
XM_006713132, 578806047 XP_006713195, 578806048 inositol 1,4,5-trisphosphate receptor type 1 isoform X5 ORF Sequence $4500.00
XM_006713133, 578806049 XP_006713196, 578806050 inositol 1,4,5-trisphosphate receptor type 1 isoform X6 ORF Sequence $4500.00
XM_006713134, 578806051 XP_006713197, 578806052 inositol 1,4,5-trisphosphate receptor type 1 isoform X7 ORF Sequence $4500.00
XM_006713135, 578806053 XP_006713198, 578806054 inositol 1,4,5-trisphosphate receptor type 1 isoform X8 ORF Sequence $4500.00
XM_006713136, 578806055 XP_006713199, 578806056 inositol 1,4,5-trisphosphate receptor type 1 isoform X9 ORF Sequence $4500.00
KEGG
hsa04020Calcium signaling pathway
hsa04070Phosphatidylinositol signaling system
hsa04720Long-term potentiation
hsa04730Long-term depression
hsa05016Huntington's disease
hsa04912GnRH signaling pathway
hsa04540Gap junction
hsa05010Alzheimer's disease
hsa04270Vascular smooth muscle contraction
hsa04114Oocyte meiosis
hsa04970Salivary secretion
hsa04971Gastric acid secretion
hsa04972Pancreatic secretion
hsa04724Glutamatergic synapse
hsa04725Cholinergic synapse
hsa04728Dopaminergic synapse
hsa04726Serotonergic synapse
hsa04723Retrograde endocannabinoid signaling
hsa05205Proteoglycans in cancer
hsa04713Circadian entrainment
hsa04915Estrogen signaling pathway
hsa04918Thyroid hormone synthesis
hsa04750Inflammatory mediator regulation of TRP channels
hsa04921Oxytocin signaling pathway
hsa04611Platelet activation
hsa04022cGMP-PKG signaling pathway
WikiPathways
WP289Myometrial Relaxation and Contraction Pathways
WP35G Protein Signaling Pathways
WP732Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
WP69TCR Signaling Pathway
WP23B Cell Receptor Signaling Pathway
WP536Calcium Regulation in the Cardiac Cell
WP2059Alzheimers Disease
Reactome
REACT_19184GPCR downstream signaling
REACT_18274Glucagon-like Peptide-1 (GLP1) regulates insulin secretion
REACT_18325Regulation of insulin secretion
REACT_18283G alpha (q) signalling events
REACT_798Platelet activation, signaling and aggregation
REACT_604Hemostasis
REACT_1505Integration of energy metabolism
REACT_2202Effects of PIP2 hydrolysis
REACT_162Elevation of cytosolic Ca2+ levels
REACT_12478EGFR interacts with phospholipase C-gamma
REACT_9470Signaling by FGFR
REACT_9417Signaling by EGFR
REACT_14797Signaling by GPCR
REACT_16888Signaling by PDGF
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_15295Opioid Signalling
REACT_15526G-protein mediated events
REACT_12079PLC-gamma1 signalling
REACT_15426PLC beta mediated events
REACT_11045Signaling by Wnt
REACT_21272Downstream signaling of activated FGFR
REACT_21310Phospholipase C-mediated cascade
REACT_75774Adaptive Immune System
REACT_23876Platelet homeostasis
REACT_23862Nitric oxide stimulates guanylate cyclase
REACT_23767cGMP effects
REACT_23905Platelet calcium homeostasis
REACT_111064DAG and IP3 signaling
REACT_111217Metabolism
REACT_111102Signal Transduction
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_116125Disease
REACT_115720PLCG1 events in ERBB2 signaling
REACT_115871Signaling by EGFR in Cancer
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118700Antigen activates B Cell Receptor (BCR) leading to generation of second messengers
REACT_120736Signaling by FGFR in disease
REACT_120966Gastrin-CREB signalling pathway via PKC and MAPK
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163834FCERI mediated Ca+2 mobilization
REACT_160123Fcgamma receptor (FCGR) dependent phagocytosis
REACT_160158Role of phospholipids in phagocytosis
REACT_172761Ca2+ pathway
REACT_172694beta-catenin independent WNT signaling
Homo sapiens (human)ITPR1NP_001161744.1
Pan troglodytes (chimpanzee)ITPR1XP_003309639.2
Macaca mulatta (Rhesus monkey)ITPR1XP_002802774.1
Canis lupus familiaris (dog)ITPR1XP_003639763.1
Bos taurus (cattle)ITPR1NP_777266.1
Mus musculus (house mouse)Itpr1NP_034715.3
Rattus norvegicus (Norway rat)Itpr1NP_001007236.2
Gallus gallus (chicken)ITPR1NP_001167530.1
Danio rerio (zebrafish)itpr1XP_001921194.3
Drosophila melanogaster (fruit fly)Itp-r83ANP_730941.1
Caenorhabditis elegansitr-1NP_001023172.1
Xenopus (Silurana) tropicalis (western clawed frog)itpr1XP_002938363.2
Process
IDNameEvidence
GO:0001666response to hypoxiaIDA
GO:0006112energy reserve metabolic processTAS
GO:0006816calcium ion transportNAS
GO:0007165signal transductionNAS
GO:0007165signal transductionTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007202activation of phospholipase C activityTAS
GO:0007596blood coagulationTAS
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0009791post-embryonic developmentIEA
GO:0030168platelet activationTAS
GO:0032469endoplasmic reticulum calcium ion homeostasisIEA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisTAS
GO:0044281small molecule metabolic processTAS
GO:0045087innate immune responseTAS
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048016inositol phosphate-mediated signalingIEA
GO:0048016inositol phosphate-mediated signalingISS
GO:0048016inositol phosphate-mediated signalingTAS
GO:0050796regulation of insulin secretionTAS
GO:0050882voluntary musculoskeletal movementIEA
GO:0051209release of sequestered calcium ion into cytosolISS
GO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressISS
GO:0070588calcium ion transmembrane transportIEA
Component
IDNameEvidence
GO:0005637nuclear inner membraneIEA
GO:0005730nucleolusIEA
GO:0005783endoplasmic reticulumNAS
GO:0005789endoplasmic reticulum membraneTAS
GO:0005955calcineurin complexIEA
GO:0014069postsynaptic densityIEA
GO:0016020membraneIDA
GO:0016021integral component of membraneIEA
GO:0016529sarcoplasmic reticulumIEA
GO:0031088platelet dense granule membraneIDA
GO:0031094platelet dense tubular networkIDA
GO:0031095platelet dense tubular network membraneTAS
Function
IDNameEvidence
GO:0005218intracellular ligand-gated calcium channel activityISS
GO:0005220inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityISS
GO:0005220inositol 1,4,5-trisphosphate-sensitive calcium-release channel activityTAS
GO:0005515protein bindingIPI
GO:0015085calcium ion transmembrane transporter activityTAS
GO:0035091phosphatidylinositol bindingISS
GeneCards ITPR1
UniProt Q14643, B4DGH1, B4DER3, Q59H91
Vega OTTHUMG00000154996
MIM 147265
Ensembl ENSG00000150995
HGNC 6180
HPRD 00925

GeneRIFs: Gene References Into Functions What's a GeneRIF?

Interactant

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