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KCNJ11 potassium inwardly-rectifying channel, subfamily J, member 11 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000525 Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11), transcript variant 1, mRNA. ORF Sequence $340.17
Peptide Services
Antibody Services
Protein Services
NM_001166290 Homo sapiens potassium inwardly-rectifying channel, subfamily J, member 11 (KCNJ11), transcript variant 2, mRNA. ORF Sequence $264.48
Peptide Services
Antibody Services
Protein Services


Gene Symbol KCNJ11
Entrez Gene ID 3767
Full Name potassium inwardly-rectifying channel, subfamily J, member 11
Synonyms BIR, HHF2, IKATP, KIR6.2, MGC133230, PHHI, TNDM3
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11p15.1

Summary Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins and is found associated with the sulfonylurea receptor SUR. Mutations in this gene are a cause of familial persistent hyperinsulinemic hypoglycemia of infancy (PHHI), an autosomal recessive disorder characterized by unregulated insulin secretion. Defects in this gene may also contribute to autosomal dominant non-insulin-dependent diabetes mellitus type II (NIDDM), transient neonatal diabetes mellitus type 3 (TNDM3), and permanent neonatal diabetes mellitus (PNDM). Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Oct 2009].
Disorder

MIM: 600937

Hyperinsulinemic hypoglycemia, familial, 2, 601820 (3);

mRNA Protein Product Sequence Price Select
NM_000525, 62388887 NP_000516, 62388888 ATP-sensitive inward rectifier potassium channel 11 isoform 1 Full Length $1196.30
ORF Sequence $340.17
NM_001166290, 261399883 NP_001159762, 261399884 ATP-sensitive inward rectifier potassium channel 11 isoform 2 Full Length $801.27
ORF Sequence $264.48
KEGG
hsa04930Type II diabetes mellitus
WikiPathways
WP1584Type II diabetes mellitus
Pathway Interaction Database
hnf3bpathwayFOXA2 and FOXA3 transcription factor networks
Reactome
REACT_18325Regulation of Insulin Secretion
REACT_75908Potassium Channels
REACT_75775ATP sensitive Potassium channels
REACT_111217Metabolism
REACT_75918Inwardly rectifying K+ channels
REACT_1505Integration of energy metabolism
REACT_13685Neuronal System
Homo sapiens (human)KCNJ11NP_000516.3
Pan troglodytes (chimpanzee)KCNJ11XP_521849.2
Macaca mulatta (Rhesus monkey)KCNJ11XP_001089155.1
Canis lupus familiaris (dog)KCNJ11XP_542519.1
Bos taurus (cattle)KCNJ11NP_001075067.1
Mus musculus (house mouse)Kcnj11NP_034732.1
Rattus norvegicus (Norway rat)Kcnj11NP_112648.2
Gallus gallus (chicken)KCNJ11XP_426402.3
Danio rerio (zebrafish)kcnj11NP_001034916.1
GeneCards KCNJ11
UniProt B2RC52, Q14654
MIM 600937
Ensembl ENSG00000187486
HGNC 6257
HPRD 09022

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
ATP-sensitive inward rectifier potassium channel 11
Names
ATP-sensitive inward rectifier potassium channel 11
beta-cell inward rectifier subunit
inward rectifier K(+) channel Kir6.2
inwardly rectifying potassium channel KIR6.2
potassium channel inwardly rectifing subfamily J member 11
potassium channel, inwardly rectifying subfamily J member 11

Interactant

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