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Sequence in raw or FASTA format:

Database:

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ACAT1 acetyl-CoA acetyltransferase 1 [Homo sapiens (human)]


RefSeq Accession Definition Services Price Order
NM_000019 Homo sapiens acetyl-CoA acetyltransferase 1 (ACAT1), nuclear gene encoding mitochondrial protein, mRNA. ORF Sequence $372.36
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Gene Symbol ACAT1
Entrez Gene ID 38
Full Name acetyl-CoA acetyltransferase 1
Synonyms ACAT, MAT, T2, THIL
Gene Type protein-coding
Organism Homo sapiens (human)
Genome

11

11q22.3

Summary This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq, Feb 2009].
Disorder

MIM: 607809

Alpha-methylacetoacetic aciduria, 203750 (3)

mRNA Protein Product Sequence Price Select
NM_000019, 223890189 NP_000010, 4557237 acetyl-CoA acetyltransferase, mitochondrial precursor Full Length $623.21
ORF Sequence $372.36
KEGG
hsa00900Terpenoid backbone biosynthesis
hsa00630Glyoxylate and dicarboxylate metabolism
hsa_M00095C5 isoprenoid biosynthesis, mevalonate pathway
hsa00072Synthesis and degradation of ketone bodies
hsa00071Fatty acid metabolism
hsa00640Propanoate metabolism
hsa00280Valine, leucine and isoleucine degradation
hsa00310Lysine degradation
hsa00620Pyruvate metabolism
hsa00380Tryptophan metabolism
hsa00650Butanoate metabolism
WikiPathways
WP143Fatty Acid Beta Oxidation
WP311Synthesis and Degradation of Ketone Bodies
WP465Tryptophan metabolism
BIOCYC
HUMAN_ILEUDEG-PWYisoleucine degradation I
META_PWY66-368ketolysis
META_PWY-5177glutaryl-CoA degradation
HUMAN_PWY-922mevalonate pathway I
META_PWY66-5superpathway of cholesterol biosynthesis
HUMAN_PWY-5177glutaryl-CoA degradation
HUMAN_PWY66-368ketolysis
META_PWY-5910superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
HUMAN_PWY-5910superpathway of geranylgeranyldiphosphate biosynthesis I (via mevalonate)
HUMAN_TRYPTOPHAN-DEGRADATION-1tryptophan degradation III (eukaryotic)
META_PWY66-367ketogenesis
HUMAN_PWY66-367ketogenesis
HUMAN_PWY66-5superpathway of cholesterol biosynthesis
META_PWY-5327superpathway of lysine degradation
META_ILEUDEG-PWYisoleucine degradation I
Reactome
REACT_22258Metabolism of lipids and lipoproteins
REACT_1464Synthesis of Ketone Bodies
REACT_59Utilization of Ketone Bodies
REACT_111217Metabolism
REACT_1861Ketone body metabolism
REACT_22279Fatty acid, triacylglycerol, and ketone body metabolism
REACT_197Branched-chain amino acid catabolism
REACT_13Metabolism of amino acids and derivatives
Homo sapiens (human)ACAT1NP_000010.1
Pan troglodytes (chimpanzee)ACAT1XP_508738.2
Macaca mulatta (Rhesus monkey)ACAT1XP_001103928.1
Canis lupus familiaris (dog)ACAT1XP_546539.2
Bos taurus (cattle)ACAT1NP_001039540.1
Mus musculus (house mouse)Acat1NP_659033.1
Rattus norvegicus (Norway rat)Acat1NP_058771.1
Gallus gallus (chicken)ACAT1XP_417162.2
Danio rerio (zebrafish)acat1NP_001003746.1
Drosophila melanogaster (fruit fly)CG10932NP_572414.1
Caenorhabditis eleganskat-1NP_495455.2
Caenorhabditis elegansT02G5.4NP_495461.1
Arabidopsis thaliana (thale cress)ACAT2NP_568694.2
GeneCards ACAT1
PDB 2IBU, 2IB8, 2IBY, 2F2S, 2IB7, 2IBW, 2IB9
UniProt P24752
MIM 607809
Ensembl ENSG00000075239
HGNC 93
HPRD 01946

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
acetyl-CoA acetyltransferase, mitochondrial
Names
acetyl-CoA acetyltransferase, mitochondrial
acetoacetyl-CoA thiolase
acetoacetyl Coenzyme A thiolase
acetyl-Coenzyme A acetyltransferase 1
mitochondrial acetoacetyl-CoA thiolase
NP_000010.1

Interactant

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