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Sequence in raw or FASTA format:


Blast Method:


KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000222 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_001093772 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005265740 PREDICTED: Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant X1, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005265741 PREDICTED: Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant X2, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_005265742 PREDICTED: Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant X3, mRNA. GenEZ ORF Cloning On-demand $899.00 20
XM_006714038 PREDICTED: Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant X4, mRNA. GenEZ ORF Cloning On-demand $699.00 18

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Related Services

Gene Symbol KIT
Entrez Gene ID 3815
Full Name v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Synonyms C-Kit, CD117, PBT, SCFR
General protein information
Preferred Names
mast/stem cell growth factor receptor Kit
mast/stem cell growth factor receptor Kit
p145 c-kit
proto-oncogene c-Kit
piebald trait protein
soluble KIT variant 1
tyrosine-protein kinase Kit
proto-oncogene tyrosine-protein kinase Kit
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

MIM: 164920

Piebaldism (3); Mast cell leukemia (3); Mastocytosis with associated

mRNA Protein Product Sequence Price Select
NM_000222, 148005048 NP_000213, 4557695 mast/stem cell growth factor receptor Kit isoform 1 precursor ORF Sequence $660.00
NM_001093772, 148005038 NP_001087241, 148005039 mast/stem cell growth factor receptor Kit isoform 2 precursor ORF Sequence $750.00
XM_005265740, 530376782 XP_005265797, 530376783 mast/stem cell growth factor receptor Kit isoform X1 ORF Sequence $750.00
XM_005265741, 530376784 XP_005265798, 530376785 mast/stem cell growth factor receptor Kit isoform X2 ORF Sequence $750.00
XM_005265742, 530376786 XP_005265799, 530376787 mast/stem cell growth factor receptor Kit isoform X3 ORF Sequence $750.00
XM_006714038, 578808634 XP_006714101, 578808635 mast/stem cell growth factor receptor Kit isoform X4 ORF Sequence $550.00
hsa04060Cytokine-cytokine receptor interaction
hsa04640Hematopoietic cell lineage
hsa05221Acute myeloid leukemia
hsa05200Pathways in cancer
hsa04151PI3K-Akt signaling pathway
hsa04014Ras signaling pathway
hsa04015Rap1 signaling pathway
WP304Kit Receptor Signaling Pathway
WP2406Cardiac Progenitor Differentiation
Pathway Interaction Database
cmyb_pathwayC-MYB transcription factor network
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
REACT_9470Signaling by FGFR
REACT_12578GAB1 signalosome
REACT_9417Signaling by EGFR
REACT_16888Signaling by PDGF
REACT_6802Innate Immune System
REACT_6900Immune System
REACT_17025Downstream signal transduction
REACT_11061Signalling by NGF
REACT_12464PI3K/AKT activation
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21272Downstream signaling of activated FGFR
REACT_21270PI-3K cascade
REACT_75774Adaptive Immune System
REACT_75829PIP3 activates AKT signaling
REACT_111225Regulation of KIT signaling
REACT_111040Signaling by SCF-KIT
REACT_111102Signal Transduction
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_147723PI3K/AKT Signaling in Cancer
REACT_147694DAP12 interactions
REACT_147814DAP12 signaling
REACT_115755Signaling by ERBB2
REACT_116008PI3K events in ERBB2 signaling
REACT_115871Signaling by EGFR in Cancer
REACT_115596Signaling by ERBB4
REACT_115961PI3K events in ERBB4 signaling
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_118638Downstream signaling events of B Cell Receptor (BCR)
REACT_120736Signaling by FGFR in disease
REACT_163936Fc epsilon receptor (FCERI) signaling
REACT_163769Role of LAT2/NTAL/LAB on calcium mobilization
Homo sapiens (human)KITNP_000213.1
Pan troglodytes (chimpanzee)KITXP_517285.3
Macaca mulatta (Rhesus monkey)KITXP_001089071.1
Canis lupus familiaris (dog)KITNP_001003181.1
Bos taurus (cattle)KITNP_001159956.1
Mus musculus (house mouse)KitNP_001116205.1
Rattus norvegicus (Norway rat)KitNP_071600.1
Gallus gallus (chicken)KITNP_989692.1
Danio rerio (zebrafish)kitaNP_571128.1
Danio rerio (zebrafish)kitbNP_001137390.1
Xenopus (Silurana) tropicalis (western clawed frog)kitNP_001135545.1
GO:0000187activation of MAPK activityIDA
GO:0001541ovarian follicle developmentISS
GO:0002318myeloid progenitor cell differentiationIEA
GO:0002320lymphoid progenitor cell differentiationIEA
GO:0002327immature B cell differentiationISS
GO:0002371dendritic cell cytokine productionISS
GO:0002551mast cell chemotaxisIDA
GO:0006687glycosphingolipid metabolic processIEA
GO:0006954inflammatory responseISS
GO:0007165signal transductionTAS
GO:0007173epidermal growth factor receptor signaling pathwayTAS
GO:0007286spermatid developmentIEA
GO:0008284positive regulation of cell proliferationIEA
GO:0008354germ cell migrationIEA
GO:0008360regulation of cell shapeISS
GO:0008542visual learningIEA
GO:0008543fibroblast growth factor receptor signaling pathwayTAS
GO:0008584male gonad developmentIEP
GO:0010628positive regulation of gene expressionIEA
GO:0010863positive regulation of phospholipase C activityTAS
GO:0014068positive regulation of phosphatidylinositol 3-kinase signalingTAS
GO:0018108peptidyl-tyrosine phosphorylationIDA
GO:0019221cytokine-mediated signaling pathwayIDA
GO:0019827stem cell maintenanceTAS
GO:0023014signal transduction by phosphorylationIEA
GO:0023014signal transduction by phosphorylationTAS
GO:0030032lamellipodium assemblyISS
GO:0030217T cell differentiationISS
GO:0030218erythrocyte differentiationISS
GO:0030318melanocyte differentiationISS
GO:0030318melanocyte differentiationTAS
GO:0030335positive regulation of cell migrationIEA
GO:0031274positive regulation of pseudopodium assemblyIEA
GO:0031532actin cytoskeleton reorganizationIDA
GO:0032762mast cell cytokine productionIDA
GO:0035019somatic stem cell maintenanceIEA
GO:0035162embryonic hemopoiesisISS
GO:0035234ectopic germ cell programmed cell deathIEA
GO:0035855megakaryocyte developmentISS
GO:0038093Fc receptor signaling pathwayIDA
GO:0038095Fc-epsilon receptor signaling pathwayTAS
GO:0038109Kit signaling pathwayIDA
GO:0038162erythropoietin-mediated signaling pathwayISS
GO:0042127regulation of cell proliferationTAS
GO:0042511positive regulation of tyrosine phosphorylation of Stat1 proteinIMP
GO:0042517positive regulation of tyrosine phosphorylation of Stat3 proteinIMP
GO:0042523positive regulation of tyrosine phosphorylation of Stat5 proteinIMP
GO:0043069negative regulation of programmed cell deathIEA
GO:0043303mast cell degranulationIMP
GO:0043410positive regulation of MAPK cascadeIMP
GO:0043552positive regulation of phosphatidylinositol 3-kinase activityTAS
GO:0045087innate immune responseTAS
GO:0045747positive regulation of Notch signaling pathwayIEA
GO:0046427positive regulation of JAK-STAT cascadeIMP
GO:0046777protein autophosphorylationIDA
GO:0048011neurotrophin TRK receptor signaling pathwayTAS
GO:0048015phosphatidylinositol-mediated signalingTAS
GO:0048070regulation of developmental pigmentationIEA
GO:0048103somatic stem cell divisionIEA
GO:0048170positive regulation of long-term neuronal synaptic plasticityIEA
GO:0048565digestive tract developmentISS
GO:0048863stem cell differentiationISS
GO:0050673epithelial cell proliferationIEA
GO:0050910detection of mechanical stimulus involved in sensory perception of soundISS
GO:0051091positive regulation of sequence-specific DNA binding transcription factor activityIMP
GO:0060326cell chemotaxisIDA
GO:0060374mast cell differentiationISS
GO:0060374mast cell differentiationTAS
GO:0070662mast cell proliferationTAS
GO:0097067cellular response to thyroid hormone stimulusIEA
GO:0097324melanocyte migrationISS
GO:0097326melanocyte adhesionISS
GO:0001669acrosomal vesicleIEA
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneTAS
GO:0009897external side of plasma membraneIEA
GO:0009898cytoplasmic side of plasma membraneIEA
GO:0016021integral component of membraneIEA
GO:0042629mast cell granuleIMP
GO:0002020protease bindingIEA
GO:0004713protein tyrosine kinase activityTAS
GO:0004714transmembrane receptor protein tyrosine kinase activityIDA
GO:0004716receptor signaling protein tyrosine kinase activityIEA
GO:0005020stem cell factor receptor activityIEA
GO:0005515protein bindingIPI
GO:0005524ATP bindingIEA
GO:0019955cytokine bindingIDA
GO:0042803protein homodimerization activityIPI
GO:0046872metal ion bindingIEA
GeneCards KIT
UniProt P10721
Vega OTTHUMG00000128713
MIM 164920
Ensembl ENSG00000157404
HGNC 6342
HPRD 01287

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the KIT gene?

The KIT gene provides instructions for making a protein that belongs to a family of proteins called receptor tyrosine kinases. Receptor tyrosine kinases transmit signals from the cell surface into the cell through a process called signal transduction. The KIT protein is found in the cell membrane of certain cell types where a specific protein, called stem cell factor, attaches (binds) to it. This binding turns on (activates) the KIT protein, which then activates other proteins inside the cell by adding a cluster of oxygen and phosphorus atoms (a phosphate group) at specific positions. This process, called phosphorylation, leads to the activation of a series of proteins in multiple signaling pathways.

The signaling pathways stimulated by the KIT protein control many important cellular processes such as cell growth and division (proliferation), survival, and movement (migration). KIT protein signaling is important for the development of certain cell types, including reproductive cells (germ cells), early blood cells (hematopoietic stem cells), immune cells called mast cells, cells in the gastrointestinal tract called interstitial cells of Cajal (ICCs), and cells called melanocytes. Melanocytes produce the pigment melanin, which contributes to hair, eye, and skin color.


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