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KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_000222 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant 1, mRNA. GenEZ ORF Cloning In-stock $809.00 $760.00 15
NM_001093772 Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog (KIT), transcript variant 2, mRNA. GenEZ ORF Cloning On-demand $899.00 20

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Gene Symbol KIT
Entrez Gene ID 3815
Full Name v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Synonyms C-Kit, CD117, PBT, SCFR
Gene Type protein-coding
Organism Homo sapiens (human)



Summary This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

MIM: 164920

Piebaldism (3); Mast cell leukemia (3); Mastocytosis with associated

mRNA Protein Product Sequence Price Select
NM_000222, 148005048 NP_000213, 4557695 mast/stem cell growth factor receptor Kit isoform 1 ORF Sequence $660.00
NM_001093772, 148005038 NP_001087241, 148005039 mast/stem cell growth factor receptor Kit isoform 2 ORF Sequence $750.00
hsa05200Pathways in cancer
hsa04640Hematopoietic cell lineage
hsa04151PI3K-Akt signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa05221Acute myeloid leukemia
WP304Kit Receptor Signaling Pathway
Pathway Interaction Database
cmyb_pathwayC-MYB transcription factor network
kitpathwaySignaling events mediated by Stem cell factor receptor (c-Kit)
REACT_12578GAB1 signalosome
REACT_118773Signaling by the B Cell Receptor (BCR)
REACT_9470Signaling by FGFR
REACT_12056NGF signalling via TRKA from the plasma membrane
REACT_21270PI-3K cascade
REACT_115596Signaling by ERBB4
REACT_16888Signaling by PDGF
REACT_75774Adaptive Immune System
REACT_6900Immune System
REACT_75829PIP3 activates AKT signaling
REACT_147723PI3K/AKT Signaling in Cancer
REACT_120736Signaling by FGFR in disease
REACT_17025Downstream signal transduction
REACT_21272Downstream signaling of activated FGFR
REACT_9417Signaling by EGFR
REACT_147814DAP12 signaling
REACT_6802Innate Immune System
REACT_111102Signal Transduction
REACT_111225Regulation of KIT signaling
REACT_118638Downstream Signaling Events Of B Cell Receptor (BCR)
REACT_116008PI3K events in ERBB2 signaling
REACT_11061Signalling by NGF
REACT_147727Constitutive PI3K/AKT Signaling in Cancer
REACT_115755Signaling by ERBB2
REACT_12464PI3K/AKT activation
REACT_147694DAP12 interactions
REACT_111040Signaling by SCF-KIT
REACT_115961PI3K events in ERBB4 signaling
REACT_115871Signaling by EGFR in Cancer
Homo sapiens (human)KITNP_000213.1
Pan troglodytes (chimpanzee)KITXP_517285.3
Macaca mulatta (Rhesus monkey)KITXP_001089071.1
Canis lupus familiaris (dog)KITNP_001003181.1
Bos taurus (cattle)KITNP_001159956.1
Mus musculus (house mouse)KitNP_001116205.1
Rattus norvegicus (Norway rat)KitNP_071600.1
Gallus gallus (chicken)KITNP_989692.1
Danio rerio (zebrafish)kitaNP_571128.1
Danio rerio (zebrafish)kitbNP_001137390.1
GeneCards KIT
PDB 3G0E, 1R01, 1QZK, 1T45, 2E9W, 2VIF, 2EC8, 1PKG, 1QZJ, 1T46, 3G0F
UniProt P10721
MIM 164920
Ensembl ENSG00000157404
HGNC 6342
HPRD 01287

GeneRIFs: Gene References Into Functions What's a GeneRIF?

General protein information

Preferred Names
mast/stem cell growth factor receptor Kit
mast/stem cell growth factor receptor Kit
p145 c-kit
proto-oncogene c-Kit
piebald trait protein
soluble KIT variant 1
tyrosine-protein kinase Kit
proto-oncogene tyrosine-protein kinase Kit
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene-like protein


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