Sequence in raw or FASTA format:
KRT1 keratin 1 [Homo sapiens (human)]
|Entrez Gene ID||3848|
|Full Name||keratin 1|
|Synonyms||CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK|
|General protein information||
|Organism||Homo sapiens (human)|
|Summary||The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008].|
Epidermolytic hyperkeratosis, 113800 (3); Ichthyosis, cyclic, with
|wnt_beta_catenin_pathway||Regulation of Wnt-mediated beta catenin signaling and target gene transcription|
|Homo sapiens (human)||KRT1||NP_006112.3|
|Pan troglodytes (chimpanzee)||KRT1||NP_001104288.1|
|Macaca mulatta (Rhesus monkey)||KRT1||XP_001098082.2|
|Canis lupus familiaris (dog)||KRT1||NP_001003392.1|
|Bos taurus (cattle)||KRT1||XP_002687292.1|
|Mus musculus (house mouse)||Krt1||NP_032499.2|
|Rattus norvegicus (Norway rat)||Krt1||NP_001008802.2|
|GO:0001867||complement activation, lectin pathway||IPI|
|GO:0006979||response to oxidative stress||NAS|
|GO:0045765||regulation of angiogenesis||NAS|
|GO:0070062||extracellular vesicular exosome||IDA|
|GO:0005198||structural molecule activity||IEA|
What is the normal function of the KRT1 gene?
The KRT1 gene provides instructions for making a protein called keratin 1. Keratins are a group of tough, fibrous proteins that form the structural framework of cells called keratinocytes that make up the skin, hair, and nails. Keratin 1 is produced in keratinocytes in the outer layer of the skin (the epidermis), including the skin on the palms of the hands and soles of the feet.
The keratin 1 protein partners with another keratin protein, either keratin 9 or keratin 10, to form molecules called keratin intermediate filaments. These filaments assemble into strong networks that provide strength and resiliency to the skin and protect it from being damaged by friction and other everyday physical stresses.
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