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KRT1 keratin 1 [Homo sapiens (human)]

RefSeq Accession Definition Service Stock Status Price *Turnaround time Order
NM_006121 Homo sapiens keratin 1 (KRT1), mRNA. GenEZ ORF Cloning On-demand TBD TBD

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Gene Symbol KRT1
Entrez Gene ID 3848
Full Name keratin 1
Synonyms CK1, EHK, EHK1, EPPK, K1, KRT1A, NEPPK
General protein information
Preferred Names
keratin, type II cytoskeletal 1
keratin, type II cytoskeletal 1
cytokeratin 1
67 kDa cytokeratin
hair alpha protein
type-II keratin Kb1
epidermolytic hyperkeratosis 1
Gene Type protein-coding
Organism Homo sapiens (human)



Summary The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq, Jul 2008].

MIM: 139350

Epidermolytic hyperkeratosis, 113800 (3); Ichthyosis, cyclic, with

mRNA Protein Product Sequence Price Select
NM_006121, 119395749 NP_006112, 119395750 keratin, type II cytoskeletal 1 ORF Sequence $700.00
WP2355Corticotropin-releasing hormone
Pathway Interaction Database
wnt_beta_catenin_pathwayRegulation of Wnt-mediated beta catenin signaling and target gene transcription
Homo sapiens (human)KRT1NP_006112.3
Pan troglodytes (chimpanzee)KRT1NP_001104288.1
Macaca mulatta (Rhesus monkey)KRT1XP_001098082.2
Canis lupus familiaris (dog)KRT1NP_001003392.1
Bos taurus (cattle)KRT1XP_002687292.1
Mus musculus (house mouse)Krt1NP_032499.2
Rattus norvegicus (Norway rat)Krt1NP_001008802.2
GO:0001867complement activation, lectin pathwayIPI
GO:0001895retina homeostasisIEP
GO:0006979response to oxidative stressNAS
GO:0045765regulation of angiogenesisNAS
GO:0005615extracellular spaceIDA
GO:0005886plasma membraneIEA
GO:0045095keratin filamentIEA
GO:0070062extracellular vesicular exosomeIDA
GO:0072562blood microparticleIDA
GO:0004872receptor activityNAS
GO:0005198structural molecule activityIEA
GO:0005515protein bindingIPI
GO:0030246carbohydrate bindingIPI
GeneCards KRT1
UniProt P04264
Vega OTTHUMG00000169749
MIM 139350
Ensembl ENSG00000167768
HGNC 6412
HPRD 00763

GeneRIFs: Gene References Into Functions What's a GeneRIF?

What is the normal function of the KRT1 gene?

The KRT1 gene provides instructions for making a protein called keratin 1. Keratins are a group of tough, fibrous proteins that form the structural framework of cells called keratinocytes that make up the skin, hair, and nails. Keratin 1 is produced in keratinocytes in the outer layer of the skin (the epidermis), including the skin on the palms of the hands and soles of the feet.

The keratin 1 protein partners with another keratin protein, either keratin 9 or keratin 10, to form molecules called keratin intermediate filaments. These filaments assemble into strong networks that provide strength and resiliency to the skin and protect it from being damaged by friction and other everyday physical stresses.


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